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Searching for up to 100 curated homologs for RR42_RS15935 FitnessBrowser__Cup4G11:RR42_RS15935 (582 a.a.)

Found high-coverage hits (≥70%) to 15 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

TC 2.A.56.3.4 / D5ATK1 TRAP C4-dicarboxylate transport system permease, DctM-2 subunit, component of The 2-ketomonocarboxylate transporter (presented in order of affinity - 2-oxovalerate [highest affinity, KD=0.1 μM], 2-oxoisovalerate, 2-oxobutyrate, 2-oxoisocaproate, 2-oxo-3-methylvalerate, pyruvate [lowest affinity, KD=3 μM]) from Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003) (see paper)
    44% identity, 89% coverage of query (357 bits)

TC 2.A.56.3.1 / P74224 GtrB aka SLL1103, component of Tripartite glutamate:Na+ symporter (see paper)
    39% identity, 88% coverage of query (318 bits)

Build an alignment

Build an alignment for RR42_RS15935 and 2 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

TC 2.A.56.3.2 / Q9RBQ9 FcbT3, component of Tripartite 4-chlorobenzoate symporter (also binds and may transport 4-bromo-, 4-iodo-, and 4-fluorobenzoate and with a lower affinity, 3-chlorobenzoate, 2-chlorobenzoate, 4-hydroxybenzoate, 3-hydroxybenzoate, and benzoate) (see paper)
    26% identity, 77% coverage of query (144 bits)

TC 2.A.56.1.10 / Q6N8W8 TrapT family, dctM subunit, C4-dicarboxylate transport, component of Transporter for lignin derived aromatic compounds, TarPQM from Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
    24% identity, 88% coverage of query (122 bits)

DCTM_RHOCA / O07838 C4-dicarboxylate TRAP transporter large permease protein DctM from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (see paper)
TC 2.A.56.1.1 / O07838 DctM, component of Tripartite dicarboxylate:H+ symporter (substrates include: fumarate, D- and L-malate, succinate, succinamide, orotate, iticonate and mesaconate) from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (see 2 papers)
    26% identity, 87% coverage of query (120 bits)

Sama_2211 alpha-ketoglutarate TRAP transporter, large permease component from Shewanella amazonensis SB2B
    27% identity, 81% coverage of query (120 bits)

Shew_1444 dicarboxylate TRAP transporter (succinate, fumarate, L-malate, and alpha-ketoglutarate), large permease component from Shewanella loihica PV-4
    26% identity, 88% coverage of query (104 bits)

DCTM_PSEAE / Q9HU16 C4-dicarboxylate TRAP transporter large permease protein DctM from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
    24% identity, 85% coverage of query (100 bits)

TC 2.A.56.1.7 / Q930W3 Putative uncharacterized protein, component of The malonate uptake transporter, MatPQM. Regulated by the GtrA transcriptional activator (Chen et al. 2010). MatM is fused in a single protein C-terminal to MatA (malonyl-CoA decarboxylase) from Rhizobium meliloti (strain 1021)
    24% identity, 78% coverage of query (95.9 bits)

DCTMQ_OLEA2 / Q312S1 Isethionate TRAP transporter permease protein DctMQ; TRAP transporter, fused DctMQ subunit from Oleidesulfovibrio alaskensis (strain ATCC BAA-1058 / DSM 17464 / G20) (Desulfovibrio alaskensis) (see paper)
    23% identity, 88% coverage of query (85.1 bits)

PGA1_c20660 TRAP transporter for fumarate, succinate, L-malate, and 2-oxogulatarate, large permease component from Phaeobacter inhibens BS107
    23% identity, 86% coverage of query (82.0 bits)

SIAT2_HAEIF / Q4TVS0 Sialic acid TRAP transporter permease protein SiaT; N-acetylneuraminic acid permease; N-acetylneuraminic acid transporter; Neu5Ac permease from Haemophilus influenzae (see paper)
    22% identity, 86% coverage of query (80.9 bits)

SIAT1_HAEIN / P44543 Sialic acid TRAP transporter permease protein SiaT; N-acetylneuraminic acid permease; N-acetylneuraminic acid transporter; Neu5Ac permease from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (see paper)
TC 2.A.56.1.3 / P44543 SiaT aka Sialic acid TRAP transporter permease protein, component of Na+-dependent (smf-driven) sialic acid (N-acetyl neuraminic acid) transporter, SiaTP (Allen et al., 2005; Severi et al., 2005; Johnston et al., 2008). SiaT is also called SiaQM from Haemophilus influenzae (see 2 papers)
    22% identity, 77% coverage of query (80.1 bits)

Ac3H11_3227 gluconate TRAP transporter, large permease component from Acidovorax sp. GW101-3H11
    22% identity, 77% coverage of query (77.4 bits)

UEHC_RUEPO / Q5LUA9 Ectoine/5-hydroxyectoine TRAP transporter large permease protein UehC; Uptake of ectoine and hydroxyectoine protein C from Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi) (see paper)
    23% identity, 78% coverage of query (64.3 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory