Searching for up to 100 curated homologs for RR42_RS17530 FitnessBrowser__Cup4G11:RR42_RS17530 (426 a.a.)

Found high-coverage hits (≥70%) to 18 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

A7Y114 glutamate-5-semialdehyde dehydrogenase (EC 1.2.1.41) from Halobacillus halophilus (see paper)
    45% identity, 96% coverage of query (343 bits)

ProA / b0243 glutamate-5-semialdehyde dehydrogenase (EC 1.2.1.41) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
proA / P07004 glutamate-5-semialdehyde dehydrogenase (EC 1.2.1.41) from Escherichia coli (strain K12) (see 27 papers)
PROA_ECOLI / P07004 Gamma-glutamyl phosphate reductase; GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase; EC 1.2.1.41 from Escherichia coli (strain K12) (see 3 papers)
    42% identity, 98% coverage of query (338 bits)

PROA_YEAST / P54885 Gamma-glutamyl phosphate reductase; GPR; Glutamate-5-semialdehyde dehydrogenase; GSA dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; EC 1.2.1.41 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
    38% identity, 97% coverage of query (283 bits)

7wxgA / Q9VNW6 Gpr domain closed form of drosophila p5cs filament with glutamate, atp, and NADPH (see paper)
    38% identity, 96% coverage of query (272 bits)

7wxiA Gpr domain of drosophila p5cs filament with glutamate and atpgammas
    38% identity, 96% coverage of query (272 bits)

P5CS1 / P54887 δ1-pyrroline-5-carboxylate synthetase (EC 1.2.1.41; EC 2.7.2.11) from Arabidopsis thaliana (see 4 papers)
    37% identity, 96% coverage of query (268 bits)

P5CS1_ORYSJ / O04226 Delta-1-pyrroline-5-carboxylate synthase 1; OsP5CS1; EC 2.7.2.11; EC 1.2.1.41 from Oryza sativa subsp. japonica (Rice) (see paper)
    35% identity, 96% coverage of query (256 bits)

ALDH18A1 / P54886 δ-1-pyrroline-5-carboxylate synthase (EC 1.2.1.41; EC 2.7.2.11) from Homo sapiens (see 4 papers)
P5CS_HUMAN / P54886 Delta-1-pyrroline-5-carboxylate synthase; P5CS; Aldehyde dehydrogenase family 18 member A1; EC 2.7.2.11; EC 1.2.1.41 from Homo sapiens (Human) (see 8 papers)
    36% identity, 97% coverage of query (253 bits)

P5CS2_ORYSJ / Q941T1 Delta-1-pyrroline-5-carboxylate synthase 2; OsP5CS2; EC 2.7.2.11; EC 1.2.1.41 from Oryza sativa subsp. japonica (Rice)
Q941T1 glutamate-5-semialdehyde dehydrogenase (EC 1.2.1.41) from Oryza sativa (see paper)
    35% identity, 96% coverage of query (253 bits)

P5CS_MOUSE / Q9Z110 Delta-1-pyrroline-5-carboxylate synthase; P5CS; Aldehyde dehydrogenase family 18 member A1; EC 2.7.2.11; EC 1.2.1.41 from Mus musculus (Mouse) (see paper)
Q9Z110 glutamate-5-semialdehyde dehydrogenase (EC 1.2.1.41) from Mus musculus (see paper)
    36% identity, 97% coverage of query (252 bits)

p5cs / CAB40834.1 pyrroline-5-carboxylate synthetase from Vitis vinifera (see paper)
    36% identity, 96% coverage of query (250 bits)

Echvi_2633 gamma-glutamylphosphate reductase (EC 1.2.1.41) from Echinicola vietnamensis KMM 6221, DSM 17526
    36% identity, 94% coverage of query (239 bits)

4jbeB / C7MW73 1.95 angstrom crystal structure of gamma-glutamyl phosphate reductase from saccharomonospora viridis.
    31% identity, 96% coverage of query (135 bits)

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Build an alignment for RR42_RS17530 and 13 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

5j7iB Crystal structure of a geobacillus thermoglucosidasius acetylating aldehyde dehydrogenase in complex with adp (see paper)
    22% identity, 99% coverage of query (56.2 bits)

5j7iC Crystal structure of a geobacillus thermoglucosidasius acetylating aldehyde dehydrogenase in complex with adp
    22% identity, 99% coverage of query (56.2 bits)

ligV / A2PZP3 vanillin dehydrogenase monomer (EC 1.2.1.67) from Sphingomonas paucimobilis (see 2 papers)
A2PZP3 vanillin dehydrogenase (EC 1.2.1.67) from Sphingomonas paucimobilis (see paper)
G2IMC6 vanillin dehydrogenase (EC 1.2.1.67) from Sphingobium sp. SYK-6 (see paper)
    25% identity, 71% coverage of query (53.5 bits)

4yweA / B4E8B7 Crystal structure of a putative aldehyde dehydrogenase from burkholderia cenocepacia
    25% identity, 93% coverage of query (49.3 bits)

AL3H1_ARATH / Q70DU8 Aldehyde dehydrogenase family 3 member H1; AtALDH4; Ath-ALDH4; EC 1.2.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
Q70DU8 aldehyde dehydrogenase (NAD+) (EC 1.2.1.3) from Arabidopsis thaliana (see paper)
    24% identity, 72% coverage of query (47.0 bits)

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