Searching for up to 100 curated homologs for RR42_RS23090 FitnessBrowser__Cup4G11:RR42_RS23090 (533 a.a.)
Found high-coverage hits (≥70%) to 40 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
KGSD3_AZOBR / Q08IB7 Alpha-ketoglutaric semialdehyde dehydrogenase 3; alphaKGSA dehydrogenase 3; 2,5-dioxovalerate dehydrogenase 3; KGSADH-III; EC 1.2.1.26 from Azospirillum brasilense (see paper)
Q08IB7 2,5-dioxovalerate dehydrogenase (EC 1.2.1.26) from Azospirillum brasilense (see paper)
66% identity, 98% coverage of query (649 bits)
lhpG / Q88NF5 α-ketoglutaric semialdehyde dehydrogenase subunit (EC 1.2.1.26) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see 2 papers)
65% identity, 98% coverage of query (637 bits)
KGSD2_AZOBR / Q08IC0 Alpha-ketoglutaric semialdehyde dehydrogenase 2; alphaKGSA dehydrogenase 2; 2,5-dioxovalerate dehydrogenase 2; KGSADH-II; EC 1.2.1.26 from Azospirillum brasilense (see paper)
Q08IC0 2,5-dioxovalerate dehydrogenase (EC 1.2.1.26) from Azospirillum brasilense (see paper)
61% identity, 98% coverage of query (593 bits)
Ga0059261_1896 Ketoglutarate semialdehyde dehydrogenase (EC 1.2.1.26) from Sphingomonas koreensis DSMZ 15582
56% identity, 98% coverage of query (520 bits)
kgsD / Q9I1Q0 2-ketoglutarate semialdehyde dehydrogenase (EC 1.2.1.26) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
53% identity, 94% coverage of query (472 bits)
Q88GW5 2,5-dioxovalerate dehydrogenase (EC 1.2.1.26) from Pseudomonas putida (see paper)
51% identity, 98% coverage of query (467 bits)
Pf6N2E2_612 Ketoglutarate semialdehyde dehydrogenase (EC 1.2.1.26) from Pseudomonas fluorescens FW300-N2E2
50% identity, 94% coverage of query (450 bits)
PS417_11015 Ketoglutarate semialdehyde dehydrogenase (EC 1.2.1.26) from Pseudomonas simiae WCS417
50% identity, 97% coverage of query (450 bits)
HSERO_RS00735 Ketoglutarate semialdehyde dehydrogenase (EC 1.2.1.26) from Herbaspirillum seropedicae SmR1
50% identity, 98% coverage of query (447 bits)
aldH / AAA89078.1 fatty aldehyde dehydrogenase from Vibrio harveyi (see paper)
48% identity, 95% coverage of query (441 bits)
1eyyA / Q56694 Crystal structure of the NADP+ dependent aldehyde dehydrogenase from vibrio harveyi. (see paper)
48% identity, 95% coverage of query (441 bits)
ACIAD0131 / Q6FFQ0 α-ketoglutarate semialdehyde dehydrogenase subunit (EC 1.2.1.26) from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) (see paper)
KGSDH_ACIAD / Q6FFQ0 Alpha-ketoglutaric semialdehyde dehydrogenase; alphaKGSA dehydrogenase; 2,5-dioxovalerate dehydrogenase; EC 1.2.1.26 from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) (see paper)
Q6FFQ0 2,5-dioxovalerate dehydrogenase (EC 1.2.1.26) from Acinetobacter baylyi (see paper)
48% identity, 97% coverage of query (437 bits)
Build an alignment for RR42_RS23090 and 12 homologs with ≥ 30% identity
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Ac3H11_612 2-ketoglutaric semialdehyde dehydrogenase (EC 1.2.1.26) from Acidovorax sp. GW101-3H11
27% identity, 75% coverage of query (89.7 bits)
5u0lA / A1U5W8 X-ray crystal structure of fatty aldehyde dehydrogenase enzymes from marinobacter aquaeolei vt8 complexed with a substrate (see paper)
27% identity, 74% coverage of query (84.0 bits)
5u0mA Fatty aldehyde dehydrogenase from marinobacter aquaeolei vt8 and cofactor complex
27% identity, 74% coverage of query (84.0 bits)
5ur2B / Q6MNK1 Crystal structure of proline utilization a (puta) from bdellovibrio bacteriovorus inactivated by n-propargylglycine (see paper)
26% identity, 88% coverage of query (80.1 bits)
VDH_CORGL / Q8NMB0 Vanillin dehydrogenase; Aromatic aldehyde dehydrogenase; EC 1.2.1.67; EC 1.2.1.64; EC 1.2.1.96 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see paper)
Q8NMB0 vanillin dehydrogenase (EC 1.2.1.67) from Corynebacterium glutamicum (see paper)
27% identity, 90% coverage of query (79.7 bits)
putA / P10503 trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate γ-semialdehyde dehydrogenase (EC 1.2.1.88; EC 1.5.5.2) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 4 papers)
28% identity, 76% coverage of query (78.2 bits)
SM_b20891 Ketoglutarate semialdehyde dehydrogenase (EC 1.2.1.26) from Sinorhizobium meliloti 1021
27% identity, 72% coverage of query (75.9 bits)
ROCA2_BACSU / P94391 1-pyrroline-5-carboxylate dehydrogenase 2; P5C dehydrogenase 2; L-glutamate gamma-semialdehyde dehydrogenase; EC 1.2.1.88 from Bacillus subtilis (strain 168) (see 3 papers)
25% identity, 85% coverage of query (74.7 bits)
padA / CAA66106.1 phenylacetaldehyde dehydrogenase from Escherichia coli (see paper)
25% identity, 75% coverage of query (74.7 bits)
PS417_04200 2-ketoglutaric semialdehyde dehydrogenase (EC 1.2.1.26) from Pseudomonas simiae WCS417
25% identity, 85% coverage of query (74.3 bits)
4f3xA / Q92ND9 Crystal structure of putative aldehyde dehydrogenase from sinorhizobium meliloti 1021 complexed with NAD
25% identity, 90% coverage of query (73.6 bits)
YdbG / b1385 phenylacetaldehyde dehydrogenase (EC 1.2.1.39) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
feaB / P80668 phenylacetaldehyde dehydrogenase (EC 1.2.1.39) from Escherichia coli (strain K12) (see 10 papers)
P80668 phenylacetaldehyde dehydrogenase (EC 1.2.1.39) from Escherichia coli (see 3 papers)
25% identity, 75% coverage of query (72.4 bits)
Pf1N1B4_1109 2-ketoglutaric semialdehyde dehydrogenase (EC 1.2.1.26) from Pseudomonas fluorescens FW300-N1B4
25% identity, 85% coverage of query (72.0 bits)
PfGW456L13_1974 Succinylglutamic semialdehyde dehydrogenase (EC 1.2.1.71) from Pseudomonas fluorescens GW456-L13
27% identity, 94% coverage of query (71.6 bits)
5n5sB / A9SS48 Crystal structure of aldehyde dehydrogenase 21 (aldh21) from physcomitrella patens in complex with NADP+ (see paper)
24% identity, 73% coverage of query (63.2 bits)
3efvA / Q8ZPI3 Crystal structure of a putative succinate-semialdehyde dehydrogenase from salmonella typhimurium lt2 with bound NAD (see paper)
26% identity, 86% coverage of query (58.9 bits)
BADH1_ORYSJ / O24174 Betaine aldehyde dehydrogenase 1; OsBADH1; EC 1.2.1.8 from Oryza sativa subsp. japonica (Rice) (see 3 papers)
O24174 betaine-aldehyde dehydrogenase (EC 1.2.1.8) from Oryza sativa Japonica Group (see paper)
24% identity, 73% coverage of query (57.8 bits)
ALDH8A1 / Q9H2A2 aminomuconate-semialdehyde dehydrogenase (EC 1.2.1.32) from Homo sapiens (see 2 papers)
AL8A1_HUMAN / Q9H2A2 2-aminomuconic semialdehyde dehydrogenase; Aldehyde dehydrogenase 12; Aldehyde dehydrogenase family 8 member A1; EC 1.2.1.32 from Homo sapiens (Human) (see 2 papers)
Q9H2A2 aldehyde dehydrogenase (NAD+) (EC 1.2.1.3); aminomuconate-semialdehyde dehydrogenase (EC 1.2.1.32) from Homo sapiens (see 2 papers)
22% identity, 71% coverage of query (57.8 bits)
8hapB Crystal structure of thermostable acetaldehyde dehydrogenase from hyperthermophilic archaeon sulfolobus tokodaii
24% identity, 78% coverage of query (56.2 bits)
8hapA / Q976X5 Crystal structure of thermostable acetaldehyde dehydrogenase from hyperthermophilic archaeon sulfolobus tokodaii (see paper)
24% identity, 78% coverage of query (56.2 bits)
AL1A2_RAT / Q63639 Retinal dehydrogenase 2; RALDH 2; RalDH2; Aldehyde dehydrogenase family 1 member A2; ALDH1A2; Retinaldehyde-specific dehydrogenase type 2; RALDH(II); EC 1.2.1.36 from Rattus norvegicus (Rat) (see paper)
Q63639 retinal dehydrogenase (EC 1.2.1.36) from Rattus norvegicus (see 4 papers)
24% identity, 84% coverage of query (50.8 bits)
6b5hA Aldh1a2 liganded with NAD and 1-(4-cyanophenyl)-n-(3-fluorophenyl)-3- [4-(methylsulfonyl)phenyl]-1h-pyrazole-4-carboxamide (compound cm121)
24% identity, 84% coverage of query (50.8 bits)
6b5gA Aldh1a2 liganded with NAD and (3-ethoxythiophen-2-yl){4-[4-nitro-3- (pyrrolidin-1-yl)phenyl]piperazin-1-yl}methanone (compound 6-118)
24% identity, 84% coverage of query (50.8 bits)
6aljA / O94788 Aldh1a2 liganded with NAD and compound win18,446 (see paper)
24% identity, 84% coverage of query (50.8 bits)
ALDH1A2 / O94788 retinal dehydrogenase 2 (EC 1.2.1.36) from Homo sapiens (see 4 papers)
AL1A2_HUMAN / O94788 Retinal dehydrogenase 2; RALDH 2; RalDH2; Aldehyde dehydrogenase family 1 member A2; ALDH1A2; Retinaldehyde-specific dehydrogenase type 2; RALDH(II); EC 1.2.1.36 from Homo sapiens (Human) (see 3 papers)
O94788 retinal dehydrogenase (EC 1.2.1.36) from Homo sapiens (see 6 papers)
24% identity, 84% coverage of query (50.4 bits)
6tryA Crystal structure of human aldehyde dehydrogenase 1a3 in complex with mf13 inhibitor compound
22% identity, 70% coverage of query (45.4 bits)
6te5B Crystal structure of human aldehyde dehydrogenase 1a3 in complex with lq43 inhibitor compound
22% identity, 70% coverage of query (45.4 bits)
6s6wA Crystal structure of human aldh1a3 in complex with 2,6- diphenylimidazo[1,2-a]pyridine (compound ga11) and NAD+
21% identity, 70% coverage of query (45.1 bits)
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Lawrence Berkeley National Laboratory