Sites on a Tree

 

Searching for up to 100 curated homologs for RR42_RS23515 RR42_RS23515 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase (861 a.a.)

Found high-coverage hits (≥70%) to 6 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

YacI / b0118 AcnB (EC 4.2.1.99) from Escherichia coli K-12 substr. MG1655 (see 20 papers)
acnB / P36683 AcnB (EC 4.2.1.99) from Escherichia coli (strain K12) (see 18 papers)
ACNB_ECOLI / P36683 Aconitate hydratase B; ACN; Aconitase; (2R,3S)-2-methylisocitrate dehydratase; (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase; 2-methyl-cis-aconitate hydratase; Iron-responsive protein-like; IRP-like; RNA-binding protein; EC 4.2.1.3; EC 4.2.1.99 from Escherichia coli (strain K12) (see 9 papers)
P36683 aconitate hydratase (EC 4.2.1.3) from Escherichia coli (see 4 papers)
acnB / GB|AAZ86920.1 aconitate hydratas; EC 4.2.1.3 from Escherichia coli (see paper)
    74% identity, 100% coverage of query (1275 bits)

1l5jA / P36683 Crystal structure of e. Coli aconitase b. (see paper)
    74% identity, 100% coverage of query (1274 bits)

acnB / Q8ZRS8 aconitate hydratase 2 (EC 4.2.1.99) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
ACNB_SALTY / Q8ZRS8 Aconitate hydratase B; ACN; Aconitase; (2R,3S)-2-methylisocitrate dehydratase; (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase; 2-methyl-cis-aconitate hydratase; Iron-responsive protein-like; IRP-like; RNA-binding protein; EC 4.2.1.3; EC 4.2.1.99 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 2 papers)
    74% identity, 100% coverage of query (1273 bits)

A0A2X5AHR8 aconitate hydratase (EC 4.2.1.3) from Helicobacter pylori (see paper)
    61% identity, 99% coverage of query (1065 bits)

acnB / P56418 aconitase (EC 4.2.1.3) from Helicobacter pylori (strain ATCC 700392 / 26695) (see paper)
    61% identity, 99% coverage of query (1064 bits)

Dshi_2060 Aconitate hydratase (EC 4.2.1.3) from Dinoroseobacter shibae DFL-12
    32% identity, 95% coverage of query (331 bits)

Build an alignment

Build an alignment for RR42_RS23515 and 6 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

No additional hits (below 30% identity) were found

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory