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Searching for up to 100 curated homologs for RR42_RS24640 FitnessBrowser__Cup4G11:RR42_RS24640 (498 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

8p84B X-ray structure of thermoanaerobacterales bacterium monoamine oxidase (see paper)
    39% identity, 88% coverage of query (264 bits)

3rhaA / A1R0W1 The crystal structure of oxidoreductase from arthrobacter aurescens
    35% identity, 88% coverage of query (217 bits)

Q6Q2J0 monoamine oxidase (EC 1.4.3.4) from Sus scrofa (see paper)
    31% identity, 90% coverage of query (211 bits)

AOFB_MOUSE / Q8BW75 Amine oxidase [flavin-containing] B; Monoamine oxidase type B; MAO-B; EC 1.4.3.21; EC 1.4.3.4 from Mus musculus (Mouse) (see paper)
Q8BW75 monoamine oxidase (EC 1.4.3.4) from Mus musculus (see 4 papers)
    30% identity, 88% coverage of query (211 bits)

P21398 monoamine oxidase (EC 1.4.3.4) from Bos taurus (see 5 papers)
    30% identity, 90% coverage of query (209 bits)

AOFB_RAT / P19643 Amine oxidase [flavin-containing] B; Monoamine oxidase type B; MAO-B; EC 1.4.3.21; EC 1.4.3.4 from Rattus norvegicus (Rat) (see 2 papers)
P19643 monoamine oxidase (EC 1.4.3.4) from Rattus norvegicus (see 26 papers)
    31% identity, 88% coverage of query (209 bits)

1o5wC / P21396 The structure basis of specific recognitions for substrates and inhibitors of rat monoamine oxidase a (see paper)
    30% identity, 88% coverage of query (204 bits)

MAOA / P21397 amine oxidase A (EC 1.4.3.4) from Homo sapiens (see 4 papers)
AOFA_HUMAN / P21397 Amine oxidase [flavin-containing] A; Monoamine oxidase type A; MAO-A; EC 1.4.3.21; EC 1.4.3.4 from Homo sapiens (Human) (see 7 papers)
P21397 monoamine oxidase (EC 1.4.3.4) from Homo sapiens (see 58 papers)
    31% identity, 88% coverage of query (201 bits)

2z5xA / P21397 Crystal structure of human monoamine oxidase a with harmine (see paper)
    31% identity, 88% coverage of query (201 bits)

AOFA_MOUSE / Q64133 Amine oxidase [flavin-containing] A; Monoamine oxidase type A; MAO-A; EC 1.4.3.21; EC 1.4.3.4 from Mus musculus (Mouse) (see paper)
Q64133 monoamine oxidase (EC 1.4.3.4) from Mus musculus (see 5 papers)
    30% identity, 88% coverage of query (200 bits)

4i58A / R4GRV2 Cyclohexylamine oxidase from brevibacterium oxydans ih-35a (see paper)
    33% identity, 86% coverage of query (200 bits)

M5AWH1 cyclohexylamine oxidase (EC 1.4.3.12) from Microbacterium oxydans (see paper)
    33% identity, 86% coverage of query (200 bits)

2yg3B / B0F9F6 Structure-based redesign of cofactor binding in putrescine oxidase: wild type enzyme (see paper)
    33% identity, 87% coverage of query (199 bits)

2yg4A Structure-based redesign of cofactor binding in putrescine oxidase: wild type bound to putrescine
    33% identity, 87% coverage of query (199 bits)

AOFB_BOVIN / P56560 Amine oxidase [flavin-containing] B; Monoamine oxidase type B; MAO-B; EC 1.4.3.21; EC 1.4.3.4 from Bos taurus (Bovine) (see 3 papers)
P56560 monoamine oxidase (EC 1.4.3.4) from Bos taurus (see 9 papers)
    31% identity, 86% coverage of query (196 bits)

6lqcA Crystal structure of cyclohexylamine oxidase from erythrobacteraceae bacterium (see paper)
    33% identity, 88% coverage of query (196 bits)

6lqlA Complex structure of chao with product from erythrobacteraceae bacterium
    33% identity, 88% coverage of query (196 bits)

AOF_DANRE / Q6NSN2 Amine oxidase [flavin-containing]; Monoamine oxidase; MAO; Z-MAO; EC 1.4.3.21; EC 1.4.3.4 from Danio rerio (Zebrafish) (Brachydanio rerio) (see 2 papers)
Q6NSN2 monoamine oxidase (EC 1.4.3.4) from Danio rerio (see 2 papers)
    31% identity, 89% coverage of query (194 bits)

2bxrA Human monoamine oxidase a in complex with clorgyline, crystal form a
    30% identity, 88% coverage of query (194 bits)

6fvzA / P27338 Crystal structure of human monoamine oxidase b (mao b) in complex with dimethylphenyl-chromone-carboxamide (see paper)
    30% identity, 86% coverage of query (189 bits)

MAOB / P27338 monoamine oxidase B subunit (EC 1.4.3.21; EC 1.4.3.4) from Homo sapiens (see paper)
AOFB_HUMAN / P27338 Amine oxidase [flavin-containing] B; Monoamine oxidase type B; MAO-B; EC 1.4.3.21; EC 1.4.3.4 from Homo sapiens (Human) (see 10 papers)
P27338 monoamine oxidase (EC 1.4.3.4) from Homo sapiens (see 55 papers)
    30% identity, 86% coverage of query (189 bits)

7zw3AAA Amine oxidase [flavin-containing] B
    30% identity, 86% coverage of query (189 bits)

6yt2A Crystal structure of human monoamine oxidase b in complex with diphenylene iodonium (dpi)
    30% identity, 86% coverage of query (189 bits)

6fw0A Crystal structure of human monoamine oxidase b (mao b) in complex with chlorophenyl-chromone-carboxamide
    30% identity, 86% coverage of query (189 bits)

7p4hA Crystal structure of monoamine oxidase b in complex with inhibitor (+)-2
    30% identity, 86% coverage of query (189 bits)

7p4fA Crystal structure of monoamine oxidase b in complex with inhibitor 1
    30% identity, 86% coverage of query (189 bits)

6rleA Crystal structure of human monoamine oxidase b in complex with styrylpiperidine analogue 97
    30% identity, 86% coverage of query (189 bits)

6rkpA Crystal structure of human monoamine oxidase b in complex with styrylpiperidine analogue 84
    30% identity, 86% coverage of query (189 bits)

6rkbA Crystal structure of human monoamine oxidase b in complex with styrylpiperidine analogue 1
    30% identity, 86% coverage of query (189 bits)

6fwcA Crystal structure of human monoamine oxidase b (mao b) in complex with fluorophenyl-chromone-carboxamide
    30% identity, 86% coverage of query (189 bits)

5mrlA Crystal structure of human monoamine oxidase b (mao b) in complex with n(furan2ylmethyl)nmethylprop2yn1amine (f2mpa)
    30% identity, 86% coverage of query (189 bits)

4crtA Crystal structure of human monoamine oxidase b in complex with the multi-target inhibitor ass234
    30% identity, 86% coverage of query (189 bits)

4a7aA Crystal structure of human monoamine oxidase b (mao b) in complex with rosiglitazone
    30% identity, 86% coverage of query (189 bits)

4a79A Crystal structure of human monoamine oxidase b (mao b) in complex with pioglitazone
    30% identity, 86% coverage of query (189 bits)

3po7A Human monoamine oxidase b in complex with zonisamide
    30% identity, 86% coverage of query (189 bits)

2xcgA Tranylcypromine-inhibited human monoamine oxidase b in complex with 2- (2-benzofuranyl)-2-imidazoline
    30% identity, 86% coverage of query (189 bits)

2vz2A Human mao b in complex with mofegiline
    30% identity, 86% coverage of query (189 bits)

2vrmA Structure of human mao b in complex with phenyethylhydrazine
    30% identity, 86% coverage of query (189 bits)

2v61A Structure of human mao b in complex with the selective inhibitor 7-(3- chlorobenzyloxy)-4-(methylamino)methyl-coumarin
    30% identity, 86% coverage of query (189 bits)

2v60A Structure of human mao b in complex with the selective inhibitor 7-(3- chlorobenzyloxy)-4-carboxaldehyde-coumarin
    30% identity, 86% coverage of query (189 bits)

2v5zA Structure of human mao b in complex with the selective inhibitor safinamide
    30% identity, 86% coverage of query (189 bits)

2c70A Functional role of the aromatic cage in human monoamine oxidase b: structures and catalytic properties of tyr435 mutant proteins
    30% identity, 86% coverage of query (189 bits)

2c67A Mao inhibition by rasagiline analogues
    30% identity, 86% coverage of query (189 bits)

2c66A Mao inhibition by rasagiline analogues
    30% identity, 86% coverage of query (189 bits)

2c65A Mao inhibition by rasagiline analogues
    30% identity, 86% coverage of query (189 bits)

2bybA Human monoamine oxidase b in complex with deprenyl
    30% identity, 86% coverage of query (189 bits)

2bk3A Human monoamine oxidase b in complex with farnesol
    30% identity, 86% coverage of query (189 bits)

1s3eA Crystal structure of maob in complex with 6-hydroxy-n- propargyl-1(r)-aminoindan
    30% identity, 86% coverage of query (189 bits)

1s3bA Crystal structure of maob in complex with n-methyl-n- propargyl-1(r)-aminoindan
    30% identity, 86% coverage of query (189 bits)

1s2yA Crystal structure of maob in complex with n-propargyl-1(s)- aminoindan
    30% identity, 86% coverage of query (189 bits)

1s2qA Crystal structure of maob in complex with n-propargyl-1(r)-aminoindan (rasagiline)
    30% identity, 86% coverage of query (189 bits)

1ojcA Human monoamine oxidase b in complex with n-(2-aminoethyl)-p-chlorobenzamide
    30% identity, 86% coverage of query (189 bits)

1ojaA Human monoamine oxidase b in complex with isatin
    30% identity, 86% coverage of query (189 bits)

1oj9A Human monoamine oxidase b in complex with 1,4-diphenyl-2-butene
    30% identity, 86% coverage of query (189 bits)

1gosA Human monoamine oxidase b
    30% identity, 86% coverage of query (189 bits)

7b0zA Crystal structure of human monoamine oxidase b in complex with (e)-3- phenyl-1-(4-(trifluoromethyl)phenyl)prop-2-en-1-one
    30% identity, 86% coverage of query (188 bits)

7b0vA Crystal structure of human monoamine oxidase b in complex with (e)-3- phenyl-1-(3-(trifluoromethyl)phenyl)prop-2-en-1-one
    30% identity, 86% coverage of query (188 bits)

2c64B Mao inhibition by rasagiline analogues
    30% identity, 86% coverage of query (188 bits)

Build an alignment

Build an alignment for RR42_RS24640 and 58 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

Maoa / P21396 monoamine oxidase A subunit (EC 1.4.3.4) from Rattus norvegicus (see 4 papers)
AOFA_RAT / P21396 Amine oxidase [flavin-containing] A; Monoamine oxidase type A; MAO-A; EC 1.4.3.21; EC 1.4.3.4 from Rattus norvegicus (Rat) (see 4 papers)
P21396 monoamine oxidase (EC 1.4.3.4) from Rattus norvegicus (see 29 papers)
    29% identity, 83% coverage of query (187 bits)

puo / P40974 putrescine oxidase subunit (EC 1.4.3.10) from Kocuria rosea (see 2 papers)
    33% identity, 89% coverage of query (186 bits)

3zyxA Crystal structure of human monoamine oxidase b in complex with methylene blue and bearing the double mutation i199a-y326a
    30% identity, 86% coverage of query (186 bits)

LAADH_SYNY3 / Q55629 L-amino acid dehydrogenase; L-amino acid:plastoquinone oxidoreductase; L-arginine dehydrogenase; EC 1.4.5.- from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
Q55629 L-amino-acid dehydrogenase (EC 1.4.1.5) from Synechocystis sp. (see paper)
    31% identity, 87% coverage of query (182 bits)

PNAO_PSEP6 / F8G0P1 Pseudooxynicotine dehydrogenase; Pon amine dehydrogenase; Pseudooxynicotine amine oxidase; Pnao; EC 1.4.2.3 from Pseudomonas putida (strain DSM 28022 / S16) (see 3 papers)
    25% identity, 97% coverage of query (95.5 bits)

PNAO_PSESP / H8ZPX1 Pseudooxynicotine dehydrogenase; Pseudooxynicotine amine oxidase; PNAO; EC 1.4.2.3 from Pseudomonas sp. (see paper)
H8ZPX1 pseudooxynicotine oxidase (EC 1.4.3.24) from Pseudomonas sp. (see paper)
    24% identity, 89% coverage of query (95.1 bits)

nicA2 / F8G0P2 nicotine dehydrogenase (EC 1.4.2.2) from Pseudomonas putida (strain DSM 28022 / S16) (see 2 papers)
NICA2_PSEP6 / F8G0P2 Nicotine dehydrogenase; Nicotine oxidoreductase; Nicotine-degrading enzyme NicA2; EC 1.4.2.2 from Pseudomonas putida (strain DSM 28022 / S16) (see 8 papers)
    26% identity, 98% coverage of query (91.7 bits)

M4T5L3 nicotine dehydrogenase (EC 1.5.99.4) from Pseudomonas sp. (see paper)
    28% identity, 95% coverage of query (90.9 bits)

6c71B / F8G0P2 Nicotine oxidoreductase in complex with s-nicotine (see paper)
    26% identity, 83% coverage of query (86.7 bits)

7c49A Nica2 with cofactor fad and substrate nicotine
    26% identity, 83% coverage of query (86.7 bits)

7u6lD / F8G0P1 Pseudooxynicotine amine oxidase (see paper)
    25% identity, 87% coverage of query (86.3 bits)

8dsvB The structure of nica2 in complex with n-methylmyosmine
    26% identity, 83% coverage of query (86.3 bits)

8dq7A The structure of nica2 variant f104l/a107t/s146i/g317d/h368r/l449v/n462s from pseudomonas putida
    26% identity, 83% coverage of query (85.5 bits)

7emeA / A0A4D8SV19 Putative leptospira interrogans recombinant l-amino acid oxidase
    24% identity, 87% coverage of query (79.0 bits)

OXLA_BOTMO / Q6TGQ8 L-amino-acid oxidase BmooLAAO-I; LAO; EC 1.4.3.2 from Bothrops moojeni (Lance-headed viper) (Caissaca) (see 4 papers)
Q6TGQ8 L-amino-acid oxidase (EC 1.4.3.2) from Bothrops moojeni (see paper)
    24% identity, 86% coverage of query (79.0 bits)

5ts5A / P0CC17 Crystal structure of l-amino acid oxidase from bothrops atrox (see paper)
    24% identity, 86% coverage of query (79.0 bits)

OXLA_BOTAT / P0CC17 L-amino-acid oxidase; BatroxLAAO; LAO; EC 1.4.3.2 from Bothrops atrox (Barba amarilla) (Fer-de-lance) (see 3 papers)
P0CC17 L-amino-acid oxidase (EC 1.4.3.2) from Bothrops atrox (see paper)
    24% identity, 86% coverage of query (78.6 bits)

OXLA_BOTPA / B5AR80 L-amino-acid oxidase; Bp-LAAO; LAO; EC 1.4.3.2 from Bothrops pauloensis (Neuwied's lancehead) (Bothrops neuwiedi pauloensis) (see paper)
    24% identity, 86% coverage of query (77.8 bits)

7khoD / F8G0P2 Nica2 variant n462v in complex with (s)-nicotine (see paper)
    25% identity, 83% coverage of query (75.1 bits)

OXLA_NAJAT / A8QL58 L-amino-acid oxidase; LAO; NA-LAAO; EC 1.4.3.2 from Naja atra (Chinese cobra) (see paper)
    25% identity, 86% coverage of query (74.7 bits)

5z2gA / A8QL58 Crystal structure of l-amino acid oxidase from venom of naja atra
    25% identity, 86% coverage of query (74.7 bits)

nctB / A0A075BSX9 (S)-6-hydroxynicotine oxidase (EC 1.5.3.5) from Shinella sp. (strain HZN7) (see 2 papers)
HLNO_SHIS7 / A0A075BSX9 (S)-6-hydroxynicotine oxidase; (S)-6HN oxidase; 6-hydroxy-L-nicotine oxidase; 6-HLNO; L-hydroxynicotine oxidase; LHNO; EC 1.5.3.5 from Shinella sp. (strain HZN7) (see 2 papers)
A0A075BSX9 (S)-6-hydroxynicotine oxidase (EC 1.5.3.5) from Shinella sp. (see paper)
A0A075XFI8 (S)-6-hydroxynicotine oxidase (EC 1.5.3.5) from Ochrobactrum sp. SJY1 (see paper)
    24% identity, 86% coverage of query (73.6 bits)

OXLA_GLOHA / Q6STF1 L-amino-acid oxidase; AHP-LAAO; LAO; EC 1.4.3.2 from Gloydius halys (Chinese water mocassin) (Agkistrodon halys) (see paper)
    24% identity, 86% coverage of query (73.6 bits)

6cr0A / A0A075BSX9 1.55 a resolution structure of (s)-6-hydroxynicotine oxidase from shinella hzn7
    24% identity, 86% coverage of query (73.2 bits)

1tdoA L-amino acid oxidae from agkistrodon halys in complex with l- phenylalanine
    24% identity, 86% coverage of query (73.2 bits)

1tdnA L-amino acid oxidase from agkistrodon halys in complex with l-leucine
    24% identity, 86% coverage of query (73.2 bits)

1tdkA L-amino acid oxidase from agkistrodon halys in complex with suicide substrate l-vinylglycine
    24% identity, 86% coverage of query (73.2 bits)

1reoA / Q6STF1 L-amino acid oxidase from agkistrodon halys pallas (see paper)
    24% identity, 86% coverage of query (73.2 bits)

OXLA_BOTSC / A0A024BTN9 L-amino acid oxidase Bs29; BsLAAO; LAO; EC 1.4.3.2 from Bothriechis schlegelii (Eyelash palm pitviper) (see paper)
    24% identity, 86% coverage of query (72.4 bits)

OXLA1_BOTJR / Q6TGQ9 L-amino-acid oxidase BjussuLAAO-I; BjsuLAAO; LAO; EC 1.4.3.2 from Bothrops jararacussu (Jararacussu) (see 2 papers)
    23% identity, 86% coverage of query (71.2 bits)

OXLA_BOTPC / X2L4E2 L-amino acid oxidase; Bpic-LAAO; LAO; EC 1.4.3.2 from Bothrops pictus (Desert lancehead) (see paper)
    23% identity, 88% coverage of query (70.5 bits)

8eegB / A0A807MR40 C. Ammoniagenes monoamine oxidase (mao) bound to dopamine (see paper)
    22% identity, 88% coverage of query (68.2 bits)

8eemA C. Ammoniagenes monoamine oxidase (mao) bound to norepinephrine
    22% identity, 88% coverage of query (68.2 bits)

8eelA C. Ammoniagenes monoamine oxidase (mao) bound to 5-aminopentanol
    22% identity, 88% coverage of query (68.2 bits)

OXLA_PSEAU / Q4JHE1 L-amino-acid oxidase; LAAO; LAO; EC 1.4.3.2 from Pseudechis australis (Mulga snake) (King brown snake) (see paper)
    23% identity, 86% coverage of query (67.8 bits)

A0A0C6EYL8 L-amino-acid oxidase (EC 1.4.3.2) from Gadus morhua (see paper)
    25% identity, 88% coverage of query (66.2 bits)

8eehA C. Ammoniagenes monoamine oxidase (mao) bound to tryptamine
    22% identity, 88% coverage of query (66.2 bits)

8eefB C. Ammoniagenes monoamine oxidase (mao) bound to octopamine
    22% identity, 88% coverage of query (63.5 bits)

OXLA_MICMP / A0A2U8QPE6 L-amino acid oxidase; LAO; MipLAAO1; EC 1.4.3.2 from Micrurus mipartitus (Red-tailed coral snake) (see 2 papers)
A0A2U8QPE6 L-amino-acid oxidase (EC 1.4.3.2) from Micrurus mipartitus (see paper)
    24% identity, 86% coverage of query (62.4 bits)

8eefA C. Ammoniagenes monoamine oxidase (mao) bound to octopamine
    22% identity, 88% coverage of query (61.2 bits)

2vvmA / P46882 The structure of mao-n-d5, a variant of monoamine oxidase from aspergillus niger. (see paper)
    22% identity, 88% coverage of query (60.5 bits)

8eekA C. Ammoniagenes monoamine oxidase (mao) bound to tyramine
    22% identity, 88% coverage of query (60.1 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory