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Searching for up to 100 curated homologs for RR42_RS27010 FitnessBrowser__Cup4G11:RR42_RS27010 (403 a.a.)

Found high-coverage hits (≥70%) to 25 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

SerA / b2913 phosphoglycerate dehydrogenase (EC 1.1.1.95; EC 1.1.1.399) from Escherichia coli K-12 substr. MG1655 (see 36 papers)
serA / P0A9T0 phosphoglycerate dehydrogenase (EC 1.1.1.95; EC 1.1.1.399) from Escherichia coli (strain K12) (see 35 papers)
SERA_ECOLI / P0A9T0 D-3-phosphoglycerate dehydrogenase; PGDH; 2-oxoglutarate reductase; EC 1.1.1.95; EC 1.1.1.399 from Escherichia coli (strain K12) (see paper)
P0A9T0 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Escherichia coli (see 6 papers)
serA / RF|NP_417388 D-3-phosphoglycerate dehydrogenase; EC 1.1.1.95 from Escherichia coli K12 (see 5 papers)
    57% identity, 92% coverage of query (412 bits)

1psdA The allosteric ligand site in the vmax-type cooperative enzyme phosphoglycerate dehydrogenase
    57% identity, 92% coverage of query (412 bits)

1ybaA The active form of phosphoglycerate dehydrogenase
    57% identity, 92% coverage of query (412 bits)

2p9eA / P0A9T0 Crystal structure of g336v mutant of e.Coli phosphoglycerate dehydrogenase (see paper)
    57% identity, 92% coverage of query (404 bits)

Echvi_2777 fused D-3-phosphoglycerate dehydrogenase / phosphoserine phosphatase (EC 1.1.1.95; EC 3.1.3.3) from Echinicola vietnamensis KMM 6221, DSM 17526
    47% identity, 98% coverage of query (382 bits)

SER33_YEAST / P40510 D-3-phosphoglycerate dehydrogenase 2; 3-PGDH 2; 2-oxoglutarate reductase; EC 1.1.1.95; EC 1.1.1.399 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
    48% identity, 93% coverage of query (353 bits)

1sc6D / P0A9T0 Crystal structure of w139g d-3-phosphoglycerate dehydrogenase complexed with NAD+ (see paper)
    53% identity, 92% coverage of query (352 bits)

SERA_YEAST / P40054 D-3-phosphoglycerate dehydrogenase 1; 3-PGDH 1; 2-oxoglutarate reductase; EC 1.1.1.95; EC 1.1.1.399 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
    48% identity, 93% coverage of query (351 bits)

U3RH61 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Acanthamoeba castellanii (see paper)
    45% identity, 98% coverage of query (343 bits)

P87228 Putative D-3-phosphoglycerate dehydrogenase; 3-PGDH; 2-oxoglutarate reductase; EC 1.1.1.95; EC 1.1.1.399 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    47% identity, 97% coverage of query (340 bits)

SERA2_ARATH / O04130 D-3-phosphoglycerate dehydrogenase 2, chloroplastic; PGDH; EC 1.1.1.95 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
O04130 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Arabidopsis thaliana (see paper)
    35% identity, 77% coverage of query (160 bits)

serA / GB|AAC83943.1 phosphoglycerate dehydrogenase; EC 1.1.1.95 from Bacillus subtilis (see paper)
serA / AAC83943.1 phosphoglycerate dehydrogenase from Bacillus subtilis (see 3 papers)
    32% identity, 73% coverage of query (158 bits)

HPR_THEMA / Q9X1C1 Hydroxypyruvate reductase; HPR; EC 1.1.1.81 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
    34% identity, 71% coverage of query (154 bits)

SERA3_ARATH / Q9LT69 D-3-phosphoglycerate dehydrogenase 3, chloroplastic; EC 1.1.1.95 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q9LT69 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Arabidopsis thaliana (see 2 papers)
    35% identity, 72% coverage of query (147 bits)

SERA1_ARATH / O49485 D-3-phosphoglycerate dehydrogenase 1, chloroplastic; Protein EMBRYO SAC DEVELOPMENT ARREST 9; EC 1.1.1.95 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
O49485 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Arabidopsis thaliana (see 2 papers)
    33% identity, 72% coverage of query (144 bits)

Q972A9 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Sulfurisphaera tokodaii (see paper)
    30% identity, 72% coverage of query (125 bits)

2eklA / Q972A9 Structure of st1218 protein from sulfolobus tokodaii
    30% identity, 72% coverage of query (125 bits)

hprA / Q59516 hydroxypyruvate reductase subunit (EC 1.1.1.81) from Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1) (see 2 papers)
    30% identity, 73% coverage of query (121 bits)

PGDH1 / A2DLU8 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Trichomonas vaginalis (see paper)
    31% identity, 71% coverage of query (115 bits)

Build an alignment

Build an alignment for RR42_RS27010 and 19 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Additional hits (identity < 30%)

DHD2_LACPA / P17584 D-2-hydroxyisocaproate dehydrogenase; D-HICDH; EC 1.1.1.- from Lacticaseibacillus paracasei (Lactobacillus paracasei) (see paper)
P17584 D-2-hydroxyacid dehydrogenase (NAD+) (EC 1.1.1.345) from Lactobacillus paracasei (see 2 papers)
CH_091798 D-2-hydroxyisocaproate dehydrogenase; EC 1.1.1.- from Lactobacillus paracasei (see 2 papers)
    27% identity, 74% coverage of query (114 bits)

1dxyA / P17584 Structure of d-2-hydroxyisocaproate dehydrogenase (see paper)
    27% identity, 73% coverage of query (113 bits)

5j23A Crystal structure of NADPH-dependent glyoxylate/hydroxypyruvate reductase smc04462 (smghrb) from sinorhizobium meliloti in complex with 2'-phospho-adp-ribose
    29% identity, 76% coverage of query (106 bits)

5v7nA Crystal structure of NADPH-dependent glyoxylate/hydroxypyruvate reductase smc04462 (smghrb) from sinorhizobium meliloti in complex with NADP and 2-keto-d-gluconic acid
    29% identity, 76% coverage of query (105 bits)

5v7gA Crystal structure of NADPH-dependent glyoxylate/hydroxypyruvate reductase smc04462 (smghrb) from sinorhizobium meliloti in complex with NADPH and oxalate
    29% identity, 76% coverage of query (105 bits)

5v6qB / Q92LZ4 Crystal structure of NADPH-dependent glyoxylate/hydroxypyruvate reductase smc04462 (smghrb) from sinorhizobium meliloti in complex with NADP and malonate (see paper)
    29% identity, 76% coverage of query (105 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory