Searching for up to 100 curated homologs for RR42_RS27870 FitnessBrowser__Cup4G11:RR42_RS27870 (294 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
flnE / BAC75995.1 meta cleavage compound hydrolase from Terrabacter sp. DBF63 (see paper)
40% identity, 95% coverage of query (191 bits)
cmtE / Q51980 HOMODA hydrolase from Pseudomonas putida (see 2 papers)
cmtE / AAB62292.1 HOMODA hydrolase from Pseudomonas putida (see 3 papers)
34% identity, 95% coverage of query (155 bits)
bphD / BAM76235.1 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase from Janibacter sp. TYM3221 (see paper)
33% identity, 90% coverage of query (117 bits)
hsaD / P9WNH5 4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase monomer (EC 3.7.1.17) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 3 papers)
HSAD_MYCTU / P9WNH5 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase; 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; HOPDA hydrolase; Meta-cleavage product hydrolase; MCP hydrolase; EC 3.7.1.17; EC 3.7.1.8 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 4 papers)
P9WNH5 2,6-dioxo-6-phenylhexa-3-enoate hydrolase (EC 3.7.1.8) from Mycobacterium tuberculosis (see paper)
31% identity, 89% coverage of query (114 bits)
5jz9A / P9WNH5 Crystal structure of hsad bound to 3,5-dichloro-4- hydroxybenzenesulphonic acid (see paper)
31% identity, 89% coverage of query (114 bits)
7zm4A Crystal structure of hsad from mycobacterium tuberculosis in complex with cyclipostin-like inhibitor cyc31
31% identity, 89% coverage of query (114 bits)
7zm3A Crystal structure of hsad from mycobacterium tuberculosis in complex with cyclipostin-like inhibitor cyc17
31% identity, 89% coverage of query (114 bits)
7zm2A Crystal structure of hsad from mycobacterium tuberculosis in complex with cyclophostin-like inhibitor cyc8b
31% identity, 89% coverage of query (114 bits)
7zm1A Crystal structure of hsad from mycobacterium tuberculosis in complex with cyclophostin-like inhibitor cyc7b
31% identity, 89% coverage of query (114 bits)
5jzsB Hsad bound to 3,5-dichloro-4-hydroxybenzoic acid
31% identity, 89% coverage of query (114 bits)
hsaD / Q9KWQ6 4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase monomer (EC 3.7.1.17) from Rhodococcus jostii (strain RHA1) (see paper)
HSAD_RHOJR / Q9KWQ6 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase; Meta-cleavage product hydrolase; MCP hydrolase; EC 3.7.1.17 from Rhodococcus jostii (strain RHA1) (see 2 papers)
31% identity, 88% coverage of query (113 bits)
5jzbA Crystal structure of hsad bound to 3,5-dichlorobenzene sulphonamide
31% identity, 88% coverage of query (113 bits)
2wugA Crystal structure of s114a mutant of hsad from mycobacterium tuberculosis in complex with hopda
31% identity, 89% coverage of query (112 bits)
2wufB Crystal structure of s114a mutant of hsad from mycobacterium tuberculosis in complex with 4,9dsha
31% identity, 88% coverage of query (112 bits)
2wueB Crystal structure of s114a mutant of hsad from mycobacterium tuberculosis in complex with hopoda
31% identity, 88% coverage of query (112 bits)
Build an alignment for RR42_RS27870 and 15 homologs with ≥ 30% identity
Or download the sequences
EstN1 / K0IAM1 pimeloyl-[acyl-carrier protein] methyl ester esterase (EC 3.1.1.85) from Nitrososphaera gargensis (strain Ga9.2) (see paper)
28% identity, 89% coverage of query (108 bits)
bphD / BAA25612.1 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase from Rhodococcus erythropolis (see paper)
31% identity, 91% coverage of query (108 bits)
P96965 2-hydroxymuconate-6-semialdehyde hydrolase (EC 3.7.1.9) from Pseudomonas fluorescens (see 2 papers)
cumD / BAA12150.1 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase from Pseudomonas fluorescens (see paper)
31% identity, 91% coverage of query (108 bits)
1iunB / P96965 Meta-cleavage product hydrolase from pseudomonas fluorescens ip01 (cumd) s103a mutant hexagonal (see paper)
30% identity, 91% coverage of query (107 bits)
2d0dA Crystal structure of a meta-cleavage product hydrolase (cumd) a129v mutant
31% identity, 89% coverage of query (107 bits)
1ukaA Crystal structure of a meta-cleavage product hydrolase (cumd) complexed with (s)-2-methylbutyrate
31% identity, 89% coverage of query (107 bits)
1uk9A Crystal structure of a meta-cleavage product hydrolase (cumd) complexed with isovalerate
31% identity, 89% coverage of query (107 bits)
1uk8A Crystal structure of a meta-cleavage product hydrolase (cumd) complexed with n-valerate
31% identity, 89% coverage of query (107 bits)
1uk7A Crystal structure of a meta-cleavage product hydrolase (cumd) complexed with n-butyrate
31% identity, 89% coverage of query (107 bits)
1iupA Meta-cleavage product hydrolase from pseudomonas fluorescens ip01 (cumd) s103a mutant complexed with isobutyrates
31% identity, 89% coverage of query (107 bits)
AGH13449.1 hybrid C-C meta-cleavage hydrolase-carboxylesterase from Cycloclasticus zancles (see paper)
28% identity, 88% coverage of query (103 bits)
nahN / BAE92169.1 2-hydroxymuconic semialdehyde hydrolase NahN from Pseudomonas putida (see 2 papers)
32% identity, 89% coverage of query (96.3 bits)
hppC / AAB81313.1 2-hydroxy-6-ketonona-2,4-dienoate hydrolase from Rhodococcus globerulus (see paper)
28% identity, 93% coverage of query (95.9 bits)
G3KFX4 2-hydroxymuconate-6-semialdehyde hydrolase (EC 3.7.1.9) from Pseudomonas sp. (see paper)
33% identity, 89% coverage of query (95.1 bits)
xylF / P23106 2-hydroxymuconic semialdehyde hydrolase (EC 3.7.1.9) from Pseudomonas putida (see paper)
XYLF_PSEPU / P23106 2-hydroxymuconate semialdehyde hydrolase; HMSH; 2-hydroxymuconic semialdehyde hydrolase; EC 3.7.1.9 from Pseudomonas putida (Arthrobacter siderocapsulatus)
33% identity, 89% coverage of query (94.7 bits)
hbpD / O06648 2-hydroxy-6-oxo-6-phenyl-2,4-hexadienoate hydrolase [multifunctional] (EC 3.7.1.8) from Pseudomonas nitroreducens (see 2 papers)
28% identity, 90% coverage of query (92.4 bits)
cmpF / CAB06612.1 2-hydroxymuconic semialdehyde hydrolase from Sphingomonas sp (see 2 papers)
30% identity, 88% coverage of query (90.5 bits)
4lxhA Crystal structure of the s105a mutant of a carbon-carbon bond hydrolase, dxnb2 from sphingomonas wittichii rw1, in complex with 3- cl hopda (see paper)
29% identity, 91% coverage of query (90.5 bits)
4lyeA Crystal structure of the s105a mutant of a c-c hydrolase, dxnb2 from sphingomonas wittichii rw1, in complex with substrate hopda
29% identity, 91% coverage of query (90.5 bits)
4lxiA Crystal structure of the s105a mutant of a carbon-carbon bond hydrolase, dxnb2 from sphingomonas wittichii rw1, in complex with 5, 8-dif hopda
29% identity, 91% coverage of query (90.5 bits)
MhpC / b0349 2-hydroxy-6-ketonona-2,4-dienedioate hydrolase (EC 3.7.1.14) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
mhpC / P77044 2-hydroxy-6-ketonona-2,4-dienedioate hydrolase (EC 3.7.1.14) from Escherichia coli (strain K12) (see 10 papers)
MHPC_ECOLI / P77044 2-hydroxy-6-oxononadienedioate/2-hydroxy-6-oxononatrienedioate hydrolase; 2-hydroxy-6-ketonona-2,4-diene-1,9-dioic acid 5,6-hydrolase; 2-hydroxy-6-oxonona-2,4,7-triene-1,9-dioic acid 5,6-hydrolase; 2-hydroxy-6-oxonona-2,4-diene-1,9-dioic acid 5,6-hydrolase; EC 3.7.1.14 from Escherichia coli (strain K12) (see 4 papers)
P77044 2-hydroxy-6-oxonona-2,4-dienedioate hydrolase (EC 3.7.1.14) from Escherichia coli (see 4 papers)
29% identity, 89% coverage of query (88.6 bits)
6i8wB / Q9KJG6 Crystal structure of a membrane phospholipase a, a novel bacterial virulence factor (see paper)
27% identity, 94% coverage of query (87.4 bits)
Q9KJG6 triacylglycerol lipase (EC 3.1.1.3) from Pseudomonas aeruginosa (see paper)
27% identity, 94% coverage of query (87.4 bits)
Q13KT2 3-oxoadipate enol-lactonase (EC 3.1.1.24) from Paraburkholderia xenovorans (see 2 papers)
29% identity, 84% coverage of query (85.9 bits)
2xuaH / Q13KT2 Crystal structure of the enol-lactonase from burkholderia xenovorans lb400 (see paper)
29% identity, 84% coverage of query (85.9 bits)
bpdF / AAB17100.1 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase from Rhodococcus sp. M5 (see paper)
28% identity, 88% coverage of query (85.1 bits)
cbzF / AAX50133.1 CbzF from Pseudomonas putida (see paper)
29% identity, 82% coverage of query (82.4 bits)
todF / P23133 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase (EC 3.7.1.25) from Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1) (see paper)
TODF_PSEP1 / P23133 2-hydroxy-6-oxo-2,4-heptadienoate hydrolase; HOHH; EC 3.7.1.25 from Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1) (see 2 papers)
29% identity, 89% coverage of query (82.0 bits)
tesD / Q83VZ6 4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase (EC 3.7.1.17) from Comamonas testosteroni (see 3 papers)
27% identity, 88% coverage of query (79.7 bits)
6eb3C Structural and enzymatic characterization of an esterase from a metagenomic library
28% identity, 92% coverage of query (79.3 bits)
6eb3B Structural and enzymatic characterization of an esterase from a metagenomic library
28% identity, 92% coverage of query (78.2 bits)
6eb3A Structural and enzymatic characterization of an esterase from a metagenomic library
28% identity, 92% coverage of query (77.8 bits)
Q84II3 2-hydroxy-6-oxo-6-(2-aminophenyl)hexa-2,4-dienoate hydrolase (EC 3.7.1.13) from Janthinobacterium sp. J3 (see paper)
29% identity, 92% coverage of query (72.4 bits)
TGND_ACIAD / Q6F9F4 (E)-2-((N-methylformamido)methylene)succinate hydrolase; MFMS hydrolase; EC 3.5.1.- from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) (see paper)
26% identity, 75% coverage of query (72.0 bits)
bphD / Q75WN8 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase (EC 3.7.1.8) from Rhodococcus jostii (strain RHA1) (see 2 papers)
etbD / BAA18939.1 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase from Rhodococcus sp (see 2 papers)
26% identity, 83% coverage of query (71.2 bits)
carC / Q9AQM4 2-hydroxy-6-oxo-6-(2'-aminophenyl)-hexa-2,4dienoate hydrolase monomer (EC 3.7.1.13) from Pseudomonas resinovorans (see paper)
CARC_PSERE / Q9AQM4 2-hydroxy-6-oxo-6-(2'-aminophenyl)hexa-2,4-dienoic acid hydrolase; HOPDA; EC 3.7.1.13 from Pseudomonas resinovorans (see 3 papers)
Q9AQM4 2-hydroxy-6-oxo-6-(2-aminophenyl)hexa-2,4-dienoate hydrolase (EC 3.7.1.13) from Pseudomonas resinovorans (see paper)
carC / BAC41548.1 meta cleavage compound hydrolase from Pseudomonas resinovorans (see 9 papers)
29% identity, 92% coverage of query (70.1 bits)
YBFK_BACSU / O31452 Carboxylesterase YbfK; EC 3.1.1.1 from Bacillus subtilis (strain 168) (see paper)
24% identity, 88% coverage of query (69.3 bits)
ABHD6_HUMAN / Q9BV23 Monoacylglycerol lipase ABHD6; 2-arachidonoylglycerol hydrolase; Abhydrolase domain-containing protein 6; EC 3.1.1.23 from Homo sapiens (Human) (see 2 papers)
23% identity, 90% coverage of query (68.6 bits)
estRB8 / CAE54381.1 carboxylesterase, partial from Oleispira antarctica (see paper)
estRB8 / CAE54384.1 carboxylesterase from Oleispira antarctica (see paper)
24% identity, 83% coverage of query (68.2 bits)
bioH / BAB39459.1 BioH from Kurthia sp. 538-KA26 (see paper)
25% identity, 87% coverage of query (68.2 bits)
catD / AAC46435.1 beta-ketoadipate enol-lactone hydrolase from Acinetobacter baylyi (see 8 papers)
23% identity, 87% coverage of query (67.0 bits)
AGH13447.1 hybrid C-C meta-cleavage hydrolase-carboxylesterase from Cycloclasticus zancles (see paper)
25% identity, 86% coverage of query (66.6 bits)
pcaL / AAC38246.1 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase from Rhodococcus opacus (see paper)
26% identity, 82% coverage of query (66.2 bits)
ABHD6_MOUSE / Q8R2Y0 Monoacylglycerol lipase ABHD6; 2-arachidonoylglycerol hydrolase; Abhydrolase domain-containing protein 6; EC 3.1.1.23 from Mus musculus (Mouse) (see 4 papers)
23% identity, 90% coverage of query (65.9 bits)
AO353_17230 Beta-ketoadipate enol-lactone hydrolase (EC 3.1.1.24) from Pseudomonas fluorescens FW300-N2E3
26% identity, 87% coverage of query (65.5 bits)
AGH13448.1 hybrid C-C meta-cleavage hydrolase-carboxylesterase from Cycloclasticus zancles (see paper)
24% identity, 87% coverage of query (64.3 bits)
Q8KT44 carboxylesterase (EC 3.1.1.1) from Lacticaseibacillus casei (see paper)
24% identity, 88% coverage of query (64.3 bits)
pcaD / AAF34270.1 beta-ketoadipate enol-lactone hydrolase from Agrobacterium tumefaciens (see 2 papers)
25% identity, 87% coverage of query (63.5 bits)
8hgwA / Q2MHH5 Crystal structure of mehph in complex with mbp (see paper)
25% identity, 87% coverage of query (63.2 bits)
Q0SH24 3-oxoadipate enol-lactonase (EC 3.1.1.24); 4-carboxymuconolactone decarboxylase (EC 4.1.1.44) from Rhodococcus jostii (see paper)
24% identity, 86% coverage of query (62.0 bits)
A0A0H2WW38 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (EC 4.2.99.20) from Staphylococcus aureus (see paper)
23% identity, 87% coverage of query (61.6 bits)
4io0A / G9BEX6 Crystal structure of f128a mutant of an epoxide hydrolase from bacillus megaterium complexed with its product (r)-3-[1]naphthyloxy- propane-1,2-diol (see paper)
21% identity, 92% coverage of query (61.6 bits)
PHAZ_PSEOL / P26495 Poly(3-hydroxyalkanoate) depolymerase; PHA depolymerase; ORF2; PHB depolymerase; EC 3.1.1.- from Pseudomonas oleovorans (see paper)
phaB / AAA25933.1 PHA-depolymerase from Pseudomonas oleovorans (see paper)
26% identity, 90% coverage of query (60.5 bits)
4o08A Crystal structure of bacillus megaterium epoxide hydrolase in complex with an inhibitor
20% identity, 91% coverage of query (60.5 bits)
Q45QT1 soluble epoxide hydrolase (EC 3.3.2.10) from Gallus gallus (see paper)
24% identity, 93% coverage of query (59.7 bits)
CEEH1_CAEEL / G5EBI4 Epoxide hydrolase 1; CEEH1; EC 3.3.2.10 from Caenorhabditis elegans (see paper)
21% identity, 91% coverage of query (59.7 bits)
pcaD / Q88N36 subunit of 3-oxoadipate enol-lactone hydrolase (EC 3.1.1.24) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see 5 papers)
Q88N36 3-oxoadipate enol-lactonase (EC 3.1.1.24) from Pseudomonas putida (see paper)
26% identity, 86% coverage of query (59.3 bits)
phaZ / Q8KQ22 intracellular poly(3-hydroxyoctanoate) depolymerase (EC 3.1.1.76) from Pseudomonas putida (see 6 papers)
26% identity, 90% coverage of query (58.5 bits)
3r3xA Crystal structure of the fluoroacetate dehalogenase rpa1163 - asp110asn/bromoacetate
24% identity, 82% coverage of query (58.5 bits)
catD / BAA75208.1 b-ketoadipate enol-lactone hydrolase from Frateuria sp. ANA-18 (see paper)
catD / BAC82535.1 b-ketoadipate enol-lactone hydrolase from Frateuria sp. ANA-18 (see 3 papers)
25% identity, 86% coverage of query (58.2 bits)
HYES_RAT / P80299 Bifunctional epoxide hydrolase 2; EC 3.3.2.10; EC 3.1.3.76 from Rattus norvegicus (Rat) (see 3 papers)
P80299 soluble epoxide hydrolase (EC 3.3.2.10) from Rattus norvegicus (see 11 papers)
25% identity, 91% coverage of query (57.8 bits)
EPHX3_MOUSE / Q3V1F8 Epoxide hydrolase 3; EH3; Abhydrolase domain-containing protein 9; EC 3.3.2.10 from Mus musculus (Mouse) (see 2 papers)
Q3V1F8 soluble epoxide hydrolase (EC 3.3.2.10) from Mus musculus (see paper)
23% identity, 85% coverage of query (57.8 bits)
Q5Y152 poly(3-hydroxyoctanoate) depolymerase (EC 3.1.1.76) from Pseudomonas putida (see paper)
26% identity, 90% coverage of query (57.4 bits)
sEH / Q9H6B9 epoxide hydrolase 3 (EC 3.3.2.10) from Homo sapiens (see 5 papers)
EPHX3_HUMAN / Q9H6B9 Epoxide hydrolase 3; EH3; Abhydrolase domain-containing protein 9; EC 3.3.2.10 from Homo sapiens (Human) (see paper)
Q9H6B9 soluble epoxide hydrolase (EC 3.3.2.10) from Homo sapiens (see paper)
22% identity, 85% coverage of query (57.4 bits)
1ek2A Crystal structure of murine soluble epoxide hydrolase complexed with cdu inhibitor
25% identity, 91% coverage of query (55.8 bits)
1ek1A Crystal structure of murine soluble epoxide hydrolase complexed with ciu inhibitor
25% identity, 91% coverage of query (55.8 bits)
HYES_MOUSE / P34914 Bifunctional epoxide hydrolase 2; EC 3.3.2.10; EC 3.1.3.76 from Mus musculus (Mouse) (see 6 papers)
P34914 soluble epoxide hydrolase (EC 3.3.2.10) from Mus musculus (see 31 papers)
25% identity, 91% coverage of query (55.5 bits)
1cr6B / P34914 Crystal structure of murine soluble epoxide hydrolase complexed with cpu inhibitor (see paper)
25% identity, 91% coverage of query (55.5 bits)
7p4kA Soluble epoxide hydrolase in complex with fl217
23% identity, 93% coverage of query (52.0 bits)
7ebaA Co-crystal of kurarinone with seh
22% identity, 93% coverage of query (51.6 bits)
6yl4A Soluble epoxide hydrolase in complex with 3-((r)-3-(1-hydroxyureido) but-1-yn-1-yl)-n-((s)-3-phenyl-3-(4-trifluoromethoxy)phenyl)propyl) benzamide
22% identity, 93% coverage of query (51.6 bits)
6hgxA Soluble epoxide hydrolase in complex with 1-(4-((4-(tert-butyl) morpholin-2-yl)methoxy)phenyl)-3-cyclohexylurea
22% identity, 93% coverage of query (51.6 bits)
6hgwA Soluble epoxide hydrolase in complex with 2-(4-fluorophenyl)-n-(4- phenoxybenzyl)ethanamine
22% identity, 93% coverage of query (51.6 bits)
6hgvA Soluble epoxide hydrolase in complex with talinolol
22% identity, 93% coverage of query (51.6 bits)
6fr2A Soluble epoxide hydrolase in complex with lk864
22% identity, 93% coverage of query (51.6 bits)
4c4yA Crystal structure of human bifunctional epoxide hydroxylase 2 complexed with a4
22% identity, 93% coverage of query (51.6 bits)
3pdcA Crystal structure of hydrolase domain of human soluble epoxide hydrolase complexed with a benzoxazole inhibitor
22% identity, 93% coverage of query (51.6 bits)
4c4zA Crystal structure of human bifunctional epoxide hydroxylase 2 complexed with a8
22% identity, 93% coverage of query (51.2 bits)
8qn0A Soluble epoxide hydrolase in complex with rk3
22% identity, 93% coverage of query (51.2 bits)
4c4xA Crystal structure of human bifunctional epoxide hydroxylase 2 complexed with c9
22% identity, 93% coverage of query (51.2 bits)
8qmzA Soluble epoxide hydrolase in complex with rk4
22% identity, 93% coverage of query (51.2 bits)
4jncA Soluble epoxide hydrolase complexed with a carboxamide inhibitor
22% identity, 93% coverage of query (51.2 bits)
6i5gA X-ray structure of human soluble epoxide hydrolasE C-terminal domain (hseh ctd)in complex with 15d-pgj2
22% identity, 91% coverage of query (50.8 bits)
4x6yA Human soluble epoxide hydrolase in complex with a cyclopropyl urea derivative
22% identity, 91% coverage of query (50.8 bits)
4x6xA Human soluble epoxide hydrolase in complex with a three substituted cyclopropane derivative
22% identity, 91% coverage of query (50.8 bits)
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Lawrence Berkeley National Laboratory