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Searching for up to 100 curated homologs for RR42_RS28800 FitnessBrowser__Cup4G11:RR42_RS28800 (745 a.a.)

Found high-coverage hits (≥70%) to 20 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

O53611 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Mycobacterium tuberculosis (see paper)
    81% identity, 100% coverage of query (1278 bits)

V5VCI0 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Acinetobacter baumannii (see paper)
    79% identity, 100% coverage of query (1267 bits)

5kvuA / O53611 Crystal structure of isocitrate dehydrogenase-2 in complex with NADP(+) from mycobacterium tuberculosis
    81% identity, 99% coverage of query (1266 bits)

5z16B / V5VCI0 A novel dimeric isocitrate dehydrogenase from acinetobacter baumannii
    80% identity, 99% coverage of query (1263 bits)

4zdaA / A0QSZ3 Crystal structure of isocitrate dehydrogenase in complex with isocitrate and mn from m. Smegmatis
    79% identity, 99% coverage of query (1196 bits)

6g3uA / Q9I0L4 Structure of pseudomonas aeruginosa isocitrate dehydrogenase, idh (see paper)
    70% identity, 98% coverage of query (1071 bits)

1itwA / P16100 Crystal structure of the monomeric isocitrate dehydrogenase in complex with isocitrate and mn (see paper)
    65% identity, 99% coverage of query (998 bits)

1j1wA Crystal structure of the monomeric isocitrate dehydrogenase in complex with NADP+
    65% identity, 99% coverage of query (998 bits)

icd / P16100 isocitrate dehydrogenase (NADP-dependent) (EC 1.1.1.42) from Azotobacter vinelandii (see 5 papers)
IDH_AZOVI / P16100 Isocitrate dehydrogenase [NADP]; IDH; Oxalosuccinate decarboxylase; EC 1.1.1.42 from Azotobacter vinelandii (see paper)
    64% identity, 99% coverage of query (997 bits)

Q1XIQ9 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Colwellia psychrerythraea (see paper)
    63% identity, 100% coverage of query (996 bits)

icd / BAA03134.2 isocitrate dehydrogenase isozyme IDH-II from Colwellia maris (see paper)
    62% identity, 100% coverage of query (984 bits)

idh / Q8L0X8 isocitrate dehydrogenase (EC 1.1.1.42) from Chlorobium limicola (see 3 papers)
    62% identity, 99% coverage of query (950 bits)

A0A0E3SSZ6 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Methanococcoides methylutens (see paper)
    59% identity, 99% coverage of query (912 bits)

B2ZAA4 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Streptomyces lividans (see paper)
    60% identity, 99% coverage of query (905 bits)

IDH_CORGL / P50216 Isocitrate dehydrogenase [NADP]; IDH; Oxalosuccinate decarboxylase; EC 1.1.1.42 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see paper)
P50216 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Corynebacterium glutamicum (see paper)
    58% identity, 99% coverage of query (859 bits)

2b0tA / P50216 Structure of monomeric NADP isocitrate dehydrogenase (see paper)
    58% identity, 99% coverage of query (857 bits)

3mbcA Crystal structure of monomeric isocitrate dehydrogenase from corynebacterium glutamicum in complex with NADP
    58% identity, 99% coverage of query (857 bits)

7y1uA / A0A7M1LFL5 Crystal structure of isocitrate dehydrogenase from campylobacter corcagiensis
    52% identity, 98% coverage of query (759 bits)

A0A0M4S9Q1 isocitrate dehydrogenase (NAD+) (EC 1.1.1.41) from Campylobacter curvus (see paper)
    48% identity, 98% coverage of query (705 bits)

J4X756 isocitrate dehydrogenase (NAD+) (EC 1.1.1.41) from Campylobacter sp. (see paper)
    48% identity, 98% coverage of query (702 bits)

Build an alignment

Build an alignment for RR42_RS28800 and 20 homologs with ≥ 30% identity

Select sequences

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory