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Searching for up to 100 curated homologs for RR42_RS29445 FitnessBrowser__Cup4G11:RR42_RS29445 (358 a.a.)

Found high-coverage hits (≥70%) to 14 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

TC 3.A.1.4.3 / Q8VM84 BraE aka Bra2E, component of General L- (and D-)amino acid uptake porter (transports acidic, basic, polar, semipolar and hydrophobic amino acids). The amino and carboxyl groups do not need to be α since γ-aminobutyric acid (GABA) is a substrate. The system may function with additional binding proteins since L-alanine uptake is not dependent on BraC from Rhizobium leguminosarum (biovar viciae) (see paper)
    36% identity, 72% coverage of query (152 bits)

braE / CAB75550.1 integral membrane protein from Rhizobium leguminosarum bv. viciae (see 2 papers)
    33% identity, 77% coverage of query (147 bits)

TC 3.A.1.4.11 / Q6N8W1 Putative branched-chain amino acid transport system ATP-binding protein, component of The phenylpropeneoid uptake porter, CouPSTW from Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
    33% identity, 84% coverage of query (142 bits)

TC 3.A.1.4.10 / Q8DQH9 ABC transporter membrane-spanning permease-branched chain amino acid transport, component of The branched chain hydrophobic amino acid transporter, LivJFGHM from Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
    30% identity, 95% coverage of query (136 bits)

Build an alignment

Build an alignment for RR42_RS29445 and 4 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Additional hits (identity < 30%)

HSERO_RS00890 L-proline ABC transporter, permease component 2 from Herbaspirillum seropedicae SmR1
    29% identity, 80% coverage of query (135 bits)

AZOBR_RS08240 L-proline and D-alanine ABC transporter, permease component 2 from Azospirillum brasilense Sp245
    33% identity, 77% coverage of query (134 bits)

Pf6N2E2_2924 ABC transporter for L-leucine/L-isoleucine/L-phenylalanine/D-alanine, permease component 2 LivM from Pseudomonas fluorescens FW300-N2E2
    33% identity, 77% coverage of query (130 bits)

TC 3.A.1.4.8 / P21628 High-affinity branched-chain amino acid transport system permease protein BraE, component of Branched chain amino acid uptake transporter. Transports alanine from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
    31% identity, 85% coverage of query (125 bits)

Ac3H11_1694 ABC transporter for glutamine/isoleucine/leucine/phenylalanine/proline/serine/tyrosine, permease component 2 from Acidovorax sp. GW101-3H11
    29% identity, 73% coverage of query (104 bits)

PGA1_c12650 D-lactate transporter, permease component 1 from Phaeobacter inhibens BS107
    28% identity, 80% coverage of query (90.1 bits)

TC 3.A.1.4.7 / Q92TN2 ABC transporter, permease, component of The protocatechuate (3,4-dihydroxybenzoate) uptake porter, PcaMNVWX from Rhizobium meliloti (strain 1021)
    29% identity, 76% coverage of query (78.6 bits)

TC 3.A.1.4.2 / P74455 NatC aka SLL0146, component of Leucine/proline/alanine/serine/glycine (and possibly histidine) porter, NatABCDE (see paper)
    25% identity, 73% coverage of query (50.4 bits)

TC 3.A.1.4.5 / Q8NRW0 UrtA, component of The high affinity urea/thiourea/hydroxyurea porter from Corynebacterium glutamicum (see paper)
    28% identity, 75% coverage of query (48.5 bits)

TC 3.A.1.4.10 / Q8DQI0 ABC transporter membrane-spanning permease-branched chain amino acid transport, component of The branched chain hydrophobic amino acid transporter, LivJFGHM from Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
    27% identity, 78% coverage of query (46.2 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory