Sites on a Tree

 

Searching for up to 100 curated homologs for RR42_RS29530 FitnessBrowser__Cup4G11:RR42_RS29530 (451 a.a.)

Found high-coverage hits (≥70%) to 12 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

TC 2.A.24.2.4 / P94363 L-malate/citrate:H+ symporter (electroneutral) from Bacillus subtilis (see 3 papers)
    59% identity, 97% coverage of query (514 bits)

TC 2.A.24.2.5 / Q8VS41 Citrate:acetate antiporter, CitW from Klebsiella pneumoniae (see paper)
    57% identity, 99% coverage of query (508 bits)

TC 2.A.24.2.1 / Q53787 L-Malate permease from Streptococcus bovis (see paper)
    40% identity, 98% coverage of query (331 bits)

MAEN_BACSU / O05256 Na(+)-malate symporter; Sodium-dependent malate transporter from Bacillus subtilis (strain 168) (see paper)
TC 2.A.24.2.3 / O05256 Malate:Na+ symporter from Bacillus subtilis (see 4 papers)
    38% identity, 97% coverage of query (308 bits)

Build an alignment

Build an alignment for RR42_RS29530 and 4 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

TC 2.A.24.1.1 / P31602 Citrate:Na+ symporter, CitS from Klebsiella pneumoniae (see 2 papers)
citS / AAA25060.1 citrate carrier protein from Klebsiella pneumoniae (see paper)
    29% identity, 99% coverage of query (186 bits)

5a1sD Crystal structure of the sodium-dependent citrate symporter secits form salmonella enterica. (see paper)
    29% identity, 94% coverage of query (182 bits)

5x9rA Structural insights into the elevator-like mechanism of the sodium/citrate symporter cits
    30% identity, 93% coverage of query (177 bits)

TC 2.A.24.2.2 / O07032 Malate:lactate antiporter (substrates include: S-lactate, R-lactate, S-malate and S-citramalate) from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (see paper)
    30% identity, 91% coverage of query (168 bits)

5xarD / P31602 Structural insights into the elevator-like mechanism of the sodium/citrate symporter cits (see paper)
    28% identity, 94% coverage of query (163 bits)

5xasB Structural insights into the elevator-like mechanism of the sodium/citrate symporter cits
    28% identity, 94% coverage of query (159 bits)

TC 2.A.24.3.1 / P21608 Electrogenic citrate:L-lactate exchanger, CitP or CitN from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (see paper)
    29% identity, 95% coverage of query (158 bits)

VC0795 / Q9KTU3 citrate:Na+ symporter from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) (see paper)
    30% identity, 87% coverage of query (139 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory