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Searching for up to 100 curated homologs for RR42_RS29935 FitnessBrowser__Cup4G11:RR42_RS29935 (393 a.a.)

Found high-coverage hits (≥70%) to 66 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

pimC / Q6N3I0 pimeloyl-CoA dehydrogenase large subunit (EC 1.3.1.62) from Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009) (see paper)
    51% identity, 100% coverage of query (413 bits)

fadE30 / I6Y3V5 5-hydroxy-3-[(3aS,4S,5R,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA dehydrogenase from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
IPDE1_MYCTU / I6Y3V5 Acyl-CoA dehydrogenase IpdE1; 5OH-HIP-CoA dehydrogenase alpha subunit; EC 1.3.99.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
    34% identity, 98% coverage of query (218 bits)

IPDE1_MYCS2 / A0R4Z9 Acyl-CoA dehydrogenase IpdE1; 5OH-HIP-CoA dehydrogenase alpha subunit; EC 1.3.99.- from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see paper)
    34% identity, 98% coverage of query (215 bits)

ACD17_MYCTU / P95280 Putative acyl-CoA dehydrogenase FadE17; EC 1.3.99.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
    32% identity, 100% coverage of query (206 bits)

4x28A / I6YCA3 Crystal structure of the chse4-chse5 complex from mycobacterium tuberculosis (see paper)
    34% identity, 100% coverage of query (203 bits)

ChsE4 / I6YCA3 3-oxocholest-4-en-26-oyl-CoA dehydrogenase α subunit from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
CHSE4_MYCTU / I6YCA3 Acyl-CoA dehydrogenase FadE26; ACAD; 3-oxocholest-4-en-26-oyl-CoA dehydrogenase alpha subunit; EC 1.3.99.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 3 papers)
    32% identity, 100% coverage of query (199 bits)

6wy8B / D1AB78 Tcur3481-tcur3483 steroid acad (see paper)
    31% identity, 100% coverage of query (177 bits)

6wy9A Tcur3481-tcur3483 steroid acad g363a variant
    31% identity, 98% coverage of query (175 bits)

chsE2 / P71858 3-oxo-23,24-bisnorchol-4-en-22-oyl-CoA dehydrogenase β subunit from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
CHSE2_MYCTU / P71858 Acyl-CoA dehydrogenase FadE29; ACAD; 3-oxo-23,24-bisnorchol-4-en-22-oyl-CoA dehydrogenase beta subunit; 3-oxo-4-pregnene-20-carboxyl-CoA dehydrogenase beta subunit; EC 1.3.99.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 4 papers)
    35% identity, 86% coverage of query (174 bits)

CHSE3_MYCTU / P96855 Acyl-CoA dehydrogenase FadE34; ACAD; 3-oxochol-4-en-24-oyl-CoA dehydrogenase; EC 1.3.99.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 3 papers)
    31% identity, 88% coverage of query (164 bits)

8hk0B / A0A1W5T3Z2 Crystal structure of fic32-33 complex from streptomyces ficellus nrrl 8067 (see paper)
    31% identity, 83% coverage of query (144 bits)

Build an alignment

Build an alignment for RR42_RS29935 and 11 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

atuD / Q9HZV8 citronellyl-CoA dehydrogenase from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 2 papers)
    25% identity, 98% coverage of query (134 bits)

2pg0A / Q5L0D5 Crystal structure of acyl-coa dehydrogenase from geobacillus kaustophilus
    28% identity, 87% coverage of query (118 bits)

1ukwA / Q72JJ3 Crystal structure of medium-chain acyl-coa dehydrogenase from thermus thermophilus hb8
    29% identity, 89% coverage of query (118 bits)

1ukwB Crystal structure of medium-chain acyl-coa dehydrogenase from thermus thermophilus hb8
    29% identity, 89% coverage of query (118 bits)

hlmB / E2PZ80 L-cysteinyl-[NRPS] dehydrogenase from Streptomyces clavuligerus (see paper)
    25% identity, 99% coverage of query (113 bits)

AO356_26355 2-methylbutanoyl-CoA dehydrogenase (EC 1.3.8.5) from Pseudomonas fluorescens FW300-N2C3
    28% identity, 74% coverage of query (110 bits)

Pf6N2E2_1146 2-methylbutanoyl-CoA dehydrogenase (EC 1.3.8.5) from Pseudomonas fluorescens FW300-N2E2
    27% identity, 74% coverage of query (110 bits)

CARC_ACEWD / H6LGM6 Caffeyl-CoA reductase-Etf complex subunit CarC; Caffeoyl-CoA reductase CarC; NADH-dependent caffeyl-CoA reduction; EC 1.3.1.108 from Acetobacterium woodii (strain ATCC 29683 / DSM 1030 / JCM 2381 / KCTC 1655 / WB1) (see paper)
H6LGM6 caffeoyl-CoA reductase (subunit 3/3) (EC 1.3.1.108) from Acetobacterium woodii (see paper)
6fahD / H6LGM6 Molecular basis of the flavin-based electron-bifurcating caffeyl-coa reductase reaction (see paper)
    26% identity, 99% coverage of query (109 bits)

PP_2216 / Q88KS3 short-chain acyl-CoA dehydrogenase monomer (EC 1.3.8.1) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see paper)
    28% identity, 74% coverage of query (108 bits)

AO353_25680 2-methylbutanoyl-CoA dehydrogenase / butanoyl-CoA dehydrogenase / isobutyryl-CoA dehydrogenase (EC 1.3.8.1; EC 1.3.8.5) from Pseudomonas fluorescens FW300-N2E3
    28% identity, 74% coverage of query (108 bits)

Ac3H11_2996 2-methyl-branched-chain-enoyl-CoA reductase (EC 1.3.8.5) from Acidovorax sp. GW101-3H11
    25% identity, 88% coverage of query (108 bits)

Pf1N1B4_4787 2-methylbutanoyl-CoA dehydrogenase (EC 1.3.8.5) from Pseudomonas fluorescens FW300-N1B4
    28% identity, 74% coverage of query (107 bits)

PS417_13850 2-methylbutanoyl-CoA dehydrogenase (EC 1.3.8.5) from Pseudomonas simiae WCS417
    27% identity, 74% coverage of query (106 bits)

mmgC / GI|1303933 acyl-CoA dehydrogenase from Bacillus subtilis (see paper)
    28% identity, 88% coverage of query (106 bits)

ACADL_MOUSE / P51174 Long-chain specific acyl-CoA dehydrogenase, mitochondrial; LCAD; EC 1.3.8.8 from Mus musculus (Mouse) (see 2 papers)
P51174 long-chain acyl-CoA dehydrogenase (EC 1.3.8.8) from Mus musculus (see paper)
    25% identity, 87% coverage of query (105 bits)

ACDB_BACSU / P45857 Acyl-CoA dehydrogenase; EC 1.3.99.- from Bacillus subtilis (strain 168) (see paper)
    28% identity, 88% coverage of query (105 bits)

ACADM_CAEEL / Q22347 Probable medium-chain specific acyl-CoA dehydrogenase 10, mitochondrial; MCAD; EC 1.3.8.7 from Caenorhabditis elegans (see paper)
    25% identity, 87% coverage of query (105 bits)

5iduC / B2JPK4 Crystal structure of an acyl-coa dehydrogenase domain protein from burkholderia phymatum bound to fad
    25% identity, 99% coverage of query (104 bits)

masA / CAO03071.1 MasA protein from Azoarcus sp. HxN1 (see paper)
    25% identity, 99% coverage of query (103 bits)

Q39QF4 cyclohexane-1-carbonyl-CoA dehydrogenase (electron-transfer flavoprotein) (EC 1.3.8.11) from Geobacter metallireducens (see paper)
    26% identity, 86% coverage of query (103 bits)

Tfu_1647 / Q47PD7 5-carboxy-2-pentenoyl-CoA reductase from Thermobifida fusca (strain YX) (see 2 papers)
    25% identity, 84% coverage of query (103 bits)

7w0jE / A0A4D5XMK4 Acyl-coa dehydrogenase, tfu_1647
    25% identity, 84% coverage of query (103 bits)

1egcA Structure of t255e, e376g mutant of human medium chain acyl-coa dehydrogenase complexed with octanoyl-coa
    26% identity, 85% coverage of query (103 bits)

8i4rA Crystal structure of acyl-coa dehydrogenase complexed with acetyl-coa from thermobifida fusca
    25% identity, 84% coverage of query (103 bits)

8i4pA Crystal structure of acyl-coa dehydrogenase from thermobifida fusca
    25% identity, 84% coverage of query (103 bits)

ACADL_RAT / P15650 Long-chain specific acyl-CoA dehydrogenase, mitochondrial; LCAD; EC 1.3.8.8 from Rattus norvegicus (Rat) (see 3 papers)
    25% identity, 87% coverage of query (102 bits)

Shewana3_2769 Branched-chain acyl-CoA dehydrogenase (EC 1.3.99.12) from Shewanella sp. ANA-3
    26% identity, 100% coverage of query (102 bits)

5lnxD / P45857 Crystal structure of mmgc, an acyl-coa dehydrogenase from bacillus subtilis.
    28% identity, 88% coverage of query (102 bits)

4iv6B / A0QTW7 X-ray crystal structure of an isovaleryl-coa dehydrogenase from mycobacterium smegmatis (see paper)
    26% identity, 98% coverage of query (102 bits)

4l1fA / D2RL84 Electron transferring flavoprotein of acidaminococcus fermentans: towards a mechanism of flavin-based electron bifurcation (see paper)
    26% identity, 100% coverage of query (101 bits)

D2RL84 butanoyl-CoA dehydrogenase complex (NAD+, ferredoxin) (subunit 1/3) (EC 1.3.1.109); short-chain acyl-CoA dehydrogenase (subunit 1/2) (EC 1.3.8.1) from Acidaminococcus fermentans (see paper)
    26% identity, 100% coverage of query (101 bits)

2jifA / P45954 Structure of human short-branched chain acyl-coa dehydrogenase (acadsb)
    26% identity, 98% coverage of query (100 bits)

PfGW456L13_2983 2-methylbutanoyl-CoA dehydrogenase (EC 1.3.8.5) from Pseudomonas fluorescens GW456-L13
    26% identity, 74% coverage of query (100 bits)

ACADSB / P45954 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial (EC 1.3.8.5) from Homo sapiens (see 4 papers)
ACDSB_HUMAN / P45954 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial; SBCAD; 2-methyl branched chain acyl-CoA dehydrogenase; 2-MEBCAD; 2-methylbutyryl-coenzyme A dehydrogenase; 2-methylbutyryl-CoA dehydrogenase; EC 1.3.8.5 from Homo sapiens (Human) (see 7 papers)
    26% identity, 98% coverage of query (100 bits)

Q18AQ1 butanoyl-CoA dehydrogenase complex (NAD+, ferredoxin) (subunit 3/3) (EC 1.3.1.109); short-chain acyl-CoA dehydrogenase (EC 1.3.8.1) from Clostridioides difficile (see paper)
5ol2F / A0A125V4E7 The electron transferring flavoprotein/butyryl-coa dehydrogenase complex from clostridium difficile (see paper)
    26% identity, 87% coverage of query (99.0 bits)

ACADL / P28330 long-chain-acyl-CoA dehydrogenase monomer (EC 1.3.8.8; EC 1.3.8.7) from Homo sapiens (see 8 papers)
ACADL_HUMAN / P28330 Long-chain specific acyl-CoA dehydrogenase, mitochondrial; LCAD; EC 1.3.8.8 from Homo sapiens (Human) (see 3 papers)
    25% identity, 99% coverage of query (99.0 bits)

2z1qB / Q5SJW0 Crystal structure of acyl coa dehydrogenase
    25% identity, 99% coverage of query (96.7 bits)

3pfdC / G7CNE7 Crystal structure of an acyl-coa dehydrogenase from mycobacterium thermoresistibile bound to reduced flavin adenine dinucleotide solved by combined iodide ion sad mr (see paper)
    27% identity, 87% coverage of query (94.7 bits)

4n5fA / B4EGC8 Crystal structure of a putative acyl-coa dehydrogenase with bound fadh2 from burkholderia cenocepacia j2315
    25% identity, 99% coverage of query (93.6 bits)

4irnA / C4NCB7 Crystal structure of the prolyl acyl carrier protein oxidase anab (see paper)
    28% identity, 74% coverage of query (89.4 bits)

1jqiA Crystal structure of rat short chain acyl-coa dehydrogenase complexed with acetoacetyl-coa
    27% identity, 87% coverage of query (87.8 bits)

ACADS_RAT / P15651 Short-chain specific acyl-CoA dehydrogenase, mitochondrial; SCAD; Butyryl-CoA dehydrogenase; EC 1.3.8.1 from Rattus norvegicus (Rat) (see 2 papers)
P15651 short-chain acyl-CoA dehydrogenase (EC 1.3.8.1) from Rattus norvegicus (see 2 papers)
    27% identity, 87% coverage of query (87.8 bits)

7y0aC / P16219 Crystal structure of human short-chain acyl-coa dehydrogenase
    28% identity, 87% coverage of query (87.4 bits)

8sgsA Short-chain specific acyl-CoA dehydrogenase, mitochondrial
    28% identity, 87% coverage of query (87.0 bits)

ACADS / P16219 short-chain acyl-CoA dehydrogenase monomer (EC 1.3.8.1) from Homo sapiens (see 11 papers)
ACADS_HUMAN / P16219 Short-chain specific acyl-CoA dehydrogenase, mitochondrial; SCAD; Butyryl-CoA dehydrogenase; EC 1.3.8.1 from Homo sapiens (Human) (see 4 papers)
    28% identity, 87% coverage of query (87.0 bits)

Q39QF5 cyclohex-1-ene-1-carbonyl-CoA dehydrogenase (EC 1.3.8.10) from Geobacter metallireducens (see paper)
7p9aA / Q39QF5 Structure of cyclohex-1-ene-1-carboxyl-coa dehydrogenase complexed with cyclohex-1,5-diene-1-carboxyl-coa (see paper)
    27% identity, 88% coverage of query (87.0 bits)

7y0bA Crystal structure of human short-chain acyl-coa dehydrogenase
    28% identity, 87% coverage of query (87.0 bits)

7p9xA Structure of cyclohex-1-ene-1-carboxyl-coa dehydrogenase complexed with cyclohex-1-ene-1-carboxyl-coa
    27% identity, 88% coverage of query (87.0 bits)

2vigB Crystal structure of human short-chain acyl coa dehydrogenase
    27% identity, 87% coverage of query (84.3 bits)

ACDS_MEGEL / Q06319 Acyl-CoA dehydrogenase, short-chain specific; Butyryl-CoA dehydrogenase; BCAD; SCAD; EC 1.3.8.1 from Megasphaera elsdenii (see paper)
1bucA / Q06319 Three-dimensional structure of butyryl-coa dehydrogenase from megasphaera elsdenii (see paper)
GI|149886 butyryl-CoA dehydrogenase; EC 1.3.99.2 from Megasphaera elsdenii (see 2 papers)
    24% identity, 100% coverage of query (82.4 bits)

5jscA / Q13JS1 Crystal structure of a putative acyl-coa dehydrogenase from burkholderia xenovorans
    24% identity, 73% coverage of query (79.7 bits)

4m9aB / Q2T4A2 Crystal structure of acyl-coa dehydrogenase from burkholderia thailandensis e264
    25% identity, 87% coverage of query (74.3 bits)

4hr3A / B1MFF5 Structure of a putative acyl-coa dehydrogenase from mycobacterium abscessus (see paper)
    25% identity, 75% coverage of query (70.9 bits)

2wbiB / Q709F0 Crystal structure of human acyl-coa dehydrogenase 11
    25% identity, 75% coverage of query (68.6 bits)

ACD11_HUMAN / Q709F0 Acyl-CoA dehydrogenase family member 11; ACAD-11; EC 1.3.8.- from Homo sapiens (Human) (see paper)
    26% identity, 75% coverage of query (66.2 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory