Searching for up to 100 curated homologs for RR42_RS30500 FitnessBrowser__Cup4G11:RR42_RS30500 (447 a.a.)
Found high-coverage hits (≥70%) to 63 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
MHBT_KLEOX / Q5EXK5 3-hydroxybenzoate transporter MhbT from Klebsiella oxytoca (see paper)
54% identity, 94% coverage of query (392 bits)
PCAK_ACIAD / Q43975 4-hydroxybenzoate transporter PcaK; 4-HB transporter from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) (see paper)
47% identity, 90% coverage of query (370 bits)
PCAK_PSEPU / Q51955 4-hydroxybenzoate transporter PcaK from Pseudomonas putida (Arthrobacter siderocapsulatus) (see 3 papers)
TC 2.A.1.15.1 / Q51955 4-Hydroxybenzoate/protocatechuate porter from Pseudomonas putida (see paper)
pcaK / AAA85137.1 PcaK from Pseudomonas putida (see paper)
48% identity, 94% coverage of query (359 bits)
GALT_PSEPU / E8ZB61 Gallate transporter; Gallate permease from Pseudomonas putida (Arthrobacter siderocapsulatus) (see paper)
galT / CBJ94499.1 gallic acid permease from Pseudomonas putida (see paper)
50% identity, 90% coverage of query (349 bits)
proT / BAB32694.1 putative transporter from Pseudomonas straminea (see 2 papers)
43% identity, 98% coverage of query (342 bits)
TC 2.A.1.15.5 / O30513 Benzoate porter, BenK from Acinetobacter calcoaceticus (see 2 papers)
32% identity, 97% coverage of query (244 bits)
TC 2.A.1.15.7 / Q6FBB3 Aromatic compound (benzoate) uptake transporter of 450 aas from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
35% identity, 95% coverage of query (240 bits)
TC 2.A.1.15.3 / Q46M63 2,4-Dichlorophenoxyacetate porter (see 5 papers)
35% identity, 96% coverage of query (229 bits)
TC 2.A.1.15.14 / Q8VUZ0 Probable uptake transporter for 2,4-dichlorophenoxyacetic acid (2,4-D), CadK from Bradyrhizobium sp. HW13
32% identity, 97% coverage of query (219 bits)
TC 2.A.1.15.6 / O24842 Vanillate porter, VanK (see 4 papers)
34% identity, 95% coverage of query (214 bits)
YaiK / b0353 3-hydroxyphenylpropionate/3-hydroxycinnamate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 2 papers)
mhpT / P77589 3-hydroxyphenylpropionate/3-hydroxycinnamate:H+ symporter from Escherichia coli (strain K12) (see 2 papers)
MHPT_ECOLI / P77589 3-(3-hydroxy-phenyl)propionate transporter; 3HPP transporter; 3-(3-hydroxy-phenyl)propionate:H(+) symporter; 3HPP:H(+) symporter from Escherichia coli (strain K12) (see 2 papers)
TC 2.A.1.15.2 / P77589 MhpT. A specific 3-(3-hydroxyphenyl)propionate (3HPP) transporter; vital for E. coli K-12 W3110 to grow on this substrate from Escherichia coli (see 3 papers)
37% identity, 85% coverage of query (191 bits)
NIAP_ACIAD / Q6FFF7 Niacin transporter NiaP from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) (see paper)
30% identity, 96% coverage of query (172 bits)
TC 2.A.1.15.11 / Q6M372 The Vanillate porter, VanK from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025) (see paper)
32% identity, 96% coverage of query (170 bits)
Build an alignment for RR42_RS30500 and 13 homologs with ≥ 30% identity
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TC 2.A.1.15.8 / O24723 Probable 1-hydroxy-2-naphthoate transporter, orf1 (see paper)
28% identity, 98% coverage of query (164 bits)
genK / Q8NLB7 gentisate transporter from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see 3 papers)
GENK_CORGL / Q8NLB7 Gentisate transporter from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see paper)
29% identity, 90% coverage of query (145 bits)
SVOP_BOVIN / Q1JP63 Synaptic vesicle 2-related protein; SV2-related protein from Bos taurus (Bovine) (see paper)
28% identity, 91% coverage of query (127 bits)
NIAP_BACSU / O34691 Putative niacin/nicotinamide transporter NiaP from Bacillus subtilis (strain 168) (see paper)
TC 2.A.1.82.4 / O34691 Niacin uptake porter NiaP from Bacillus subtilis (see 2 papers)
28% identity, 89% coverage of query (126 bits)
SVOP_XENLA / Q2XWK0 Synaptic vesicle 2-related protein; SV2-related protein from Xenopus laevis (African clawed frog) (see paper)
28% identity, 92% coverage of query (125 bits)
SVOP_RAT / Q9Z2I7 Synaptic vesicle 2-related protein; SV2-related protein from Rattus norvegicus (Rat) (see paper)
28% identity, 91% coverage of query (114 bits)
TC 2.A.1.82.3 / Q8BFT9 Synaptic vesicle 2-related protein (SV2-related protein), SVOP from Mus musculus (see 4 papers)
28% identity, 91% coverage of query (111 bits)
TC 2.A.1.82.1 / F2CRE4 The barley copper uptake porter, CT-1 of 749 aas; nearly identical to the wheat orthologue from Hordeum vulgare var. distichum
26% identity, 88% coverage of query (110 bits)
YgcS / b2771 putative transporter YgcS from Escherichia coli K-12 substr. MG1655 (see 2 papers)
TC 2.A.1.1.95 / Q46909 Inner membrane metabolite transport protein YgcS from Escherichia coli (strain K12) (see 3 papers)
27% identity, 86% coverage of query (109 bits)
TC 2.A.1.15.4 / P94131 cis,cis-muconate porter, MucK from Acinetobacter calcoaceticus (see 2 papers)
mucK / AAC27117.1 cis,cis-muconate transport protein MucK from Acinetobacter baylyi (see paper)
26% identity, 87% coverage of query (98.6 bits)
S22AD_HUMAN / Q9Y226 Solute carrier family 22 member 13; Organic anion transporter 10; OAT10; Organic cation transporter-like 3; ORCTL-3; ORCTL3 from Homo sapiens (Human) (see 5 papers)
TC 2.A.1.19.17 / Q9Y226 Kidney organic cation transporter-like 3 ORCTL-3 (OAT10; SLC22A13; Like-3) (Bahn et al., 2008) (transports nicotinate, p-aminohippurate and urate; KM=20-40 mμM) via exchange for lactate) from Homo sapiens (Human) (see 4 papers)
28% identity, 78% coverage of query (92.8 bits)
S22AB_HUMAN / Q9NSA0 Solute carrier family 22 member 11; Organic anion transporter 4; OAT4; Organic anion:dicarboxylate exchanger OAT4 from Homo sapiens (Human) (see 11 papers)
TC 2.A.1.19.10 / Q9NSA0 The apical proximal tubular kidney/placenta organic anion transporter 4, Oat4 (Slc22a11) (transports estrone sulfate (Km = 1 µM), dehydroepiandrosterone sulfate (Km = 60µM), many anionic drugs, diuretics, bile salts, urate and ochratoxin A). Catalyzes Na+-independent efflux, possibly using glutamate as a counter anion in an exchange reaction, especially in the placenta from Homo sapiens (Human) (see 7 papers)
SLC22A11 / GB|BAA95316.1 solute carrier family 22 member 11 from Homo sapiens
28% identity, 78% coverage of query (90.5 bits)
Q49B42 ABC-type phosphate transporter (EC 7.3.2.1) from Zea mays (see paper)
26% identity, 87% coverage of query (87.4 bits)
YdjK / b1775 putative transporter YdjK from Escherichia coli K-12 substr. MG1655 (see 3 papers)
27% identity, 75% coverage of query (87.4 bits)
S22A8_RAT / Q9R1U7 Organic anion transporter 3; Oat3; Organic anion/dicarboxylate exchanger; Solute carrier family 22 member 8 from Rattus norvegicus (Rat) (see 12 papers)
TC 2.A.1.19.7 / Q9R1U7 The polyspecific organic anion (and cation) (anions: p-aminohippurate, ochratoxin A, estrone sulfate, anionic drugs, anionic neurotransmitter metabolites; cation: cimetidine) transporter, Oat3 (slc22a8) (catalyzes organic anion (uptake): dicarboxylate (efflux) antiport in the basolateral membrane of the renal proximal tubule) (Eraly et al., 2003a,b); transports many antiviral agents from Rattus norvegicus (Rat) (see 11 papers)
Slc22a8 / RF|NP_112622.1 solute carrier family 22 member 8 from Rattus norvegicus (see paper)
29% identity, 73% coverage of query (87.0 bits)
S22A8_MOUSE / O88909 Organic anion transporter 3; mOat3; Organic anion/dicarboxylate exchanger; Reduced in osteosclerosis transporter; Roct; Solute carrier family 22 member 8 from Mus musculus (Mouse) (see 8 papers)
TC 2.A.1.19.9 / O88909 The osteosclerosis protein, Roct (organic anion transporter 3, Oat3) (Slc22a8) (catalyzes organic anion (uptake):di-carboxylate (efflux) antiport in the basolateral membrane of the renal proximal tubule) (Eraly et al., 2003a,b); transports glutathione and many antiviral agents from Mus musculus (Mouse) (see 6 papers)
30% identity, 73% coverage of query (86.7 bits)
S22AD_RAT / B2GV36 Solute carrier family 22 member 13; Organic anion transporter 10; OAT10; Organic cation transporter-like 3; ORCTL-3 from Rattus norvegicus (Rat) (see paper)
29% identity, 73% coverage of query (85.1 bits)
S22AD_MOUSE / Q6A4L0 Solute carrier family 22 member 13; Organic anion transporter 10; OAT10; Organic cation transporter-like 3; ORCTL-3 from Mus musculus (Mouse) (see paper)
29% identity, 73% coverage of query (82.8 bits)
NanT / b3224 N-acetylneuraminate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 10 papers)
nanT / P41036 N-acetylneuraminate:H+ symporter from Escherichia coli (strain K12) (see 16 papers)
NANT_ECOLI / P41036 Sialic acid transporter NanT; Sialic acid permease; Sialic acid/H(+) symporter from Escherichia coli (strain K12) (see 4 papers)
TC 2.A.1.12.1 / P41036 The sialic acid porter, NanT. N-acetylneuraminic acid (Neu5Ac) serves as a sole source of carbon and nitrogen for E. coli. It is a mucus-derived carbon source in the mammalian gut. NanT can also take up and allow efficient growth on the related sialic acids, N-glycolylneuraminic acid (Neu5Gc) and 3-keto-3-deoxy-d-glycero-d-galactonononic acid (KDN) from Escherichia coli (see 4 papers)
25% identity, 82% coverage of query (82.8 bits)
S22AK_MOUSE / Q80UJ1 Solute carrier family 22 member 20; Organic anion transporter 6 from Mus musculus (Mouse) (see 5 papers)
TC 2.A.1.19.16 / Q80UJ1 The organic anion transporter, Oat6 or SLC22a20 of 556 aas and 12 TMSs from Mus musculus (Mouse) (see 6 papers)
28% identity, 73% coverage of query (82.8 bits)
S22A8_HUMAN / Q8TCC7 Organic anion transporter 3; hOAT3; Organic anion/dicarboxylate exchanger; Solute carrier family 22 member 8 from Homo sapiens (Human) (see 15 papers)
TC 2.A.1.19.34 / Q8TCC7 Multispecific drug transporter, solute carrier family 22 member 8 (Organic anion transporter 3) (hOAT3) from Homo sapiens (see 9 papers)
28% identity, 74% coverage of query (82.8 bits)
S22A8_MACFA / Q4W8A2 Organic anion transporter 3; mKOAT3; Organic anion/dicarboxylate exchanger; Solute carrier family 22 member 8 from Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) (see paper)
28% identity, 74% coverage of query (82.4 bits)
YaaU / b0045 putative transporter YaaU from Escherichia coli K-12 substr. MG1655 (see 4 papers)
26% identity, 77% coverage of query (82.4 bits)
PHT15_ORYSJ / Q7X7V2 Probable inorganic phosphate transporter 1-5; OsPT5; OsPht1;5; H(+)/Pi cotransporter from Oryza sativa subsp. japonica (Rice) (see paper)
25% identity, 87% coverage of query (79.3 bits)
OCT7_ARATH / Q940M4 Organic cation/carnitine transporter 7; AtOCT7 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
24% identity, 87% coverage of query (79.0 bits)
TC 2.A.1.15.9 / O51798 Probable 4-methylmuconolactone transporter, MmlH from Ralstonia eutropha (strain JMP134) (Alcaligenes eutrophus) (see paper)
25% identity, 81% coverage of query (79.0 bits)
S22A8_PIG / Q70BM6 Organic anion transporter 3; pOAT3; Organic anion/dicarboxylate exchanger; Solute carrier family 22 member 8 from Sus scrofa (Pig) (see paper)
29% identity, 73% coverage of query (77.4 bits)
TC 2.A.1.19.35 / A6NK97 Solute carrier family 22 member 20 (Organic anion transporter 6; OAT6) of 555 aas and 12 probable TMSs. This protein is an apparent anionic odorant transporter in the olfactory epithelium of mice from Homo sapiens (see 3 papers)
27% identity, 84% coverage of query (77.4 bits)
TC 2.A.1.1.120 / E1WAV3 Major myo-inositol transporter, IolT1, of 456 aas from Salmonella typhimurium (strain SL1344)
24% identity, 79% coverage of query (77.0 bits)
S22AL_MOUSE / Q9WTN6 Solute carrier family 22 member 21; Organic cation/carnitine transporter 3; Solute carrier family 22 member 9 from Mus musculus (Mouse) (see 3 papers)
TC 2.A.1.19.41 / Q9WTN6 Organocation transporter, OCTN3. Identified only in mouse; mediates carnitine transport (Pochini et al. 2013). 81% identical to 2.A.1.19.3. Also called SLC22a21 and SLC22a9 from Mus musculus
27% identity, 81% coverage of query (75.9 bits)
8bvsA Cryo-em structure of rat slc22a6 bound to tenofovir
26% identity, 93% coverage of query (75.5 bits)
YdjE / b1769 putative transporter YdjE from Escherichia coli K-12 substr. MG1655 (see 3 papers)
TC 2.A.1.1.92 / P38055 Inner membrane metabolite transport protein YdjE from Escherichia coli (strain K12) (see 6 papers)
24% identity, 88% coverage of query (75.1 bits)
TC 2.A.1.1.75 / Q9XIH7 The fructose/xylose:H+ symporter, PMT1 (polyol monosaccharide transporter-1). Also transports other substrates at lower rates. PMT2 is largely of the same sequence and function. Both are present in pollen and young xylem cells (Klepek et al., 2005). A similar ortholog has been identifed in pollen grains of Petunia hybrida from Arabidopsis thaliana (see 2 papers)
27% identity, 90% coverage of query (74.7 bits)
8bw7A Cryo-em structure of rat slc22a6 bound to alpha-ketoglutaric acid
26% identity, 93% coverage of query (74.3 bits)
S22A3_MOUSE / Q9WTW5 Solute carrier family 22 member 3; Organic cation transporter 3; OCT3 from Mus musculus (Mouse) (see 5 papers)
27% identity, 73% coverage of query (73.6 bits)
8bvtA / O35956 Cryo-em structure of rat slc22a6 bound to probenecid (see paper)
26% identity, 89% coverage of query (73.2 bits)
S22A3_RAT / O88446 Solute carrier family 22 member 3; Extraneuronal monoamine transporter; EMT; Organic cation transporter 3; OCT3 from Rattus norvegicus (Rat) (see 10 papers)
TC 2.A.1.19.6 / O88446 The polyspecific potential-sensitive organic cation uptake transporter, Oct3 (transport substrates include the neurotoxin 1-methyl-4-phenylpyridinium and monoamine neurotransmitters such as dopamine). Mediates paraquat (herbicide) neurotoxicity from Rattus norvegicus (Rat) (see 2 papers)
Slc22a3 / RF|NP_062103.1 solute carrier family 22 member 3 from Rattus norvegicus
27% identity, 73% coverage of query (73.2 bits)
S22A6_PSEAM / O57379 Solute carrier family 22 member 6; Organic anion transporter 1; Renal organic anion transporter 1; ROAT1; fROAT1 from Pseudopleuronectes americanus (Winter flounder) (Pleuronectes americanus) (see paper)
26% identity, 78% coverage of query (72.0 bits)
S22A5_HUMAN / O76082 Organic cation/carnitine transporter 2; High-affinity sodium-dependent carnitine cotransporter; Solute carrier family 22 member 5 from Homo sapiens (Human) (see 28 papers)
TC 2.A.1.19.3 / O76082 The polyspecific organic cation (L- and D-carnitine, butyryl-L-carnitine, acetyl carnitine, γ-butyro-betaine, glycinebetaine, β-lactam antibiotics with a quaternary nitrogen such as cephaloridine, and others):Na+ symporter, OCTN2 (SLC22A5). Carnitine is transporter with high affinity (2 - 20 μM0 (Ingoglia et al. 2015). Associated with Crohn''s disease (Barton et al., 2005) as well as primary carnitine deficiency from Homo sapiens (Human) (see 28 papers)
26% identity, 81% coverage of query (70.1 bits)
S22A1_HUMAN / O15245 Solute carrier family 22 member 1; Organic cation transporter 1; hOCT1 from Homo sapiens (Human) (see 26 papers)
TC 2.A.1.19.29 / O15245 Solute carrier family 22 member 1 (Organic cation transporter 1) (hOCT1) from Homo sapiens (see 18 papers)
29% identity, 74% coverage of query (69.7 bits)
S22A6_MOUSE / Q8VC69 Solute carrier family 22 member 6; Kidney-specific transport protein; Novel kidney transcript; mNKT; Organic anion transporter 1; mOAT1; Renal organic anion transporter 1; mROAT1 from Mus musculus (Mouse) (see 6 papers)
27% identity, 78% coverage of query (67.4 bits)
S22A6_HUMAN / Q4U2R8 Solute carrier family 22 member 6; Organic anion transporter 1; hOAT1; PAH transporter; hPAHT; Renal organic anion transporter 1; hROAT1 from Homo sapiens (Human) (see 20 papers)
TC 2.A.1.19.31 / Q4U2R8 Solute carrier family 22 member 6 (Organic anion transporter 1) (hOAT1) (PAH transporter) (hPAHT) (Renal organic anion transporter 1) (hROAT1), from Homo sapiens (see 17 papers)
27% identity, 85% coverage of query (66.2 bits)
Q9VCA2 Organic cation transporter protein from Drosophila melanogaster (Fruit fly)
26% identity, 73% coverage of query (65.1 bits)
S22A3_HUMAN / O75751 Solute carrier family 22 member 3; Extraneuronal monoamine transporter; EMT; Organic cation transporter 3; OCT3 from Homo sapiens (Human) (see 11 papers)
TC 2.A.1.19.24 / O75751 Solute carrier family 22 member 3 (Extraneuronal monoamine transporter) (EMT) (Organic cation transporter 3) from Homo sapiens (see 3 papers)
27% identity, 73% coverage of query (60.8 bits)
7zh6A Structure of human oct3 in complex with inhibitor corticosterone
26% identity, 81% coverage of query (58.9 bits)
7zhaA / O75751 Structure of human oct3 in complex with inhibitor decynium-22 (see paper)
26% identity, 81% coverage of query (58.9 bits)
OCT1_CAEEL / Q9U539 Organic cation transporter 1; CeOCT1 from Caenorhabditis elegans (see paper)
TC 2.A.1.19.37 / Q9U539 Organic cation transporter 1 (CeOCT1) of 568 aas and 12 TMSs from Caenorhabditis elegans (see 3 papers)
24% identity, 70% coverage of query (55.1 bits)
S22A7_HUMAN / Q9Y694 Solute carrier family 22 member 7; Novel liver transporter; NLT; Organic anion transporter 2; hOAT2 from Homo sapiens (Human) (see 9 papers)
TC 2.A.1.19.25 / Q9Y694 Solute carrier family 22 member 7 (liver transporter) (Organic anion transporter 2) (hOAT2), transports cyclic nucleotodes and the anti-viral drug, acyclovir (Dahlin et al. 2013). Expressed in liver, kidney, brain and red blood cells from Homo sapiens (see 9 papers)
28% identity, 72% coverage of query (52.0 bits)
S22A2_HUMAN / O15244 Solute carrier family 22 member 2; Organic cation transporter 2; hOCT2 from Homo sapiens (Human) (see 25 papers)
TC 2.A.1.19.30 / O15244 Solute carrier family 22 member 2 (Organic cation transporter 2) (hOCT2) from Homo sapiens (see 23 papers)
24% identity, 81% coverage of query (46.6 bits)
PHO84 / P25297 phosphate transporter phoT from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 76 papers)
PHO84_YEAST / P25297 Inorganic phosphate transporter PHO84 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
P25297 ABC-type phosphate transporter (EC 7.3.2.1) from Saccharomyces cerevisiae (see paper)
TC 2.A.1.9.1 / P25297 High affinity Pi from Saccharomyces cerevisiae (Baker's yeast) (see 7 papers)
PHO84 / GB|CAA89157.1 inorganic phosphate transporter PHO84 from Saccharomyces cerevisiae (see paper)
21% identity, 79% coverage of query (46.2 bits)
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Lawrence Berkeley National Laboratory