Searching for up to 100 curated homologs for RR42_RS31370 FitnessBrowser__Cup4G11:RR42_RS31370 (584 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
ILVG_MYCTU / P9WG39 Acetolactate synthase large subunit IlvG; ALS; Acetohydroxy-acid synthase large subunit; AHAS; EC 2.2.1.6 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
P9WG39 acetolactate synthase (EC 2.2.1.6) from Mycobacterium tuberculosis (see 2 papers)
35% identity, 96% coverage of query (314 bits)
HACL2_HUMAN / A1L0T0 2-hydroxyacyl-CoA lyase 2; Acetolactate synthase-like protein; IlvB-like protein; EC 4.1.2.- from Homo sapiens (Human) (see 2 papers)
30% identity, 96% coverage of query (272 bits)
HACL_ACTC0 / P0DUV9 2-hydroxyacyl-CoA lyase; AcHACL; HACL; 2-hydroxyisobutyryl-CoA lyase; EC 4.1.-.- from Actinomycetospora chiangmaiensis (strain DSM 45062 / JCM 15998 / CCTCC AA 205017 / NBRC 104400 / YIM 0006) (see 2 papers)
36% identity, 89% coverage of query (261 bits)
7pt4B / P0DUV9 Actinobacterial 2-hydroxyacyl-coa lyase (achacl) structure in complex with a covalently bound reaction intermediate as well as products formyl-coa and acetone (see paper)
36% identity, 89% coverage of query (261 bits)
7pt1A Actinobacterial 2-hydroxyacyl-coa lyase (achacl) structure in complex with substrate 2-hib-coa and inactive cofactor 3-deaza-thdp
36% identity, 89% coverage of query (261 bits)
7pt4A Actinobacterial 2-hydroxyacyl-coa lyase (achacl) structure in complex with a covalently bound reaction intermediate as well as products formyl-coa and acetone
36% identity, 89% coverage of query (261 bits)
Q8U2A4 acetolactate synthase (EC 2.2.1.6) from Pyrococcus furiosus (see paper)
30% identity, 90% coverage of query (231 bits)
Build an alignment for RR42_RS31370 and 7 homologs with ≥ 30% identity
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HACL1_MOUSE / Q9QXE0 2-hydroxyacyl-CoA lyase 1; 2-hydroxyphytanoyl-CoA lyase; 2-HPCL; Phytanoyl-CoA 2-hydroxylase 2; EC 4.1.2.63 from Mus musculus (Mouse) (see 2 papers)
Q9QXE0 2-hydroxyacyl-CoA lyase (EC 4.1.2.63) from Mus musculus (see 2 papers)
27% identity, 96% coverage of query (230 bits)
HACL1 / Q9UJ83 2-hydroxyacyl-CoA lyase 1 (EC 4.1.2.63) from Homo sapiens (see 7 papers)
HACL1_HUMAN / Q9UJ83 2-hydroxyacyl-CoA lyase 1; 2-hydroxyphytanoyl-CoA lyase; 2-HPCL; Phytanoyl-CoA 2-hydroxylase 2; EC 4.1.2.63 from Homo sapiens (Human) (see 3 papers)
Q9UJ83 2-hydroxyacyl-CoA lyase (EC 4.1.2.63) from Homo sapiens (see 3 papers)
26% identity, 96% coverage of query (224 bits)
Hacl1 / Q8CHM7 2-hydroxyacyl-CoA lyase 1 subunit (EC 4.1.2.63) from Rattus norvegicus (see 3 papers)
HACL1_RAT / Q8CHM7 2-hydroxyacyl-CoA lyase 1; 2-hydroxyphytanoyl-CoA lyase; 2-HPCL; Phytanoyl-CoA 2-hydroxylase 2; EC 4.1.2.63 from Rattus norvegicus (Rat) (see paper)
Q8CHM7 2-hydroxyacyl-CoA lyase (EC 4.1.2.63) from Rattus norvegicus (see 5 papers)
26% identity, 96% coverage of query (221 bits)
ilvB / O08353 acetohydroxy-acid synthase large subunit (EC 2.2.1.6) from Methanococcus aeolicus (see 2 papers)
29% identity, 93% coverage of query (214 bits)
IlvI / b0077 acetolactate synthase / acetohydroxybutanoate synthase, catalytic subunit (EC 2.2.1.6) from Escherichia coli K-12 substr. MG1655 (see 9 papers)
ilvI / P00893 acetolactate synthase / acetohydroxybutanoate synthase, catalytic subunit (EC 2.2.1.6) from Escherichia coli (strain K12) (see 7 papers)
P00893 acetolactate synthase (subunit 2/2) (EC 2.2.1.6) from Escherichia coli (see paper)
28% identity, 94% coverage of query (213 bits)
Q6NYI5 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) (EC 1.2.1.12) from Danio rerio (see paper)
26% identity, 93% coverage of query (210 bits)
G0ZSE6 acetolactate synthase (EC 2.2.1.6) from Pseudomonas sp. (see paper)
29% identity, 94% coverage of query (210 bits)
6xn8A / A0A1H8YFL8 Crystal structure of 2-hydroxyacyl coa lyase (hacl) from rhodospirillales bacterium urhd0017
28% identity, 92% coverage of query (208 bits)
P45261 acetolactate synthase (EC 2.2.1.6) from Haemophilus influenzae (see paper)
28% identity, 94% coverage of query (203 bits)
ilvB / Q0KCU4 acetohydroxyacid synthase subunit B (EC 2.2.1.6) from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (see paper)
29% identity, 93% coverage of query (198 bits)
AT5G17380 / Q9LF46 oxalyl-CoA decarboxylase (EC 4.1.1.8) from Arabidopsis thaliana (see 5 papers)
27% identity, 93% coverage of query (196 bits)
thzk0150 / BAO66169.1 2-hydroxy-4-methyl-2-(2-phenylacetyl)pentanoic acid synthase from Thermosporothrix hazakensis (see paper)
28% identity, 90% coverage of query (195 bits)
P37251 acetolactate synthase (EC 2.2.1.6) from Bacillus subtilis (see paper)
30% identity, 86% coverage of query (195 bits)
A0A1X9M8K4 sulfoacetaldehyde acetyltransferase (EC 2.3.3.15) from Alkalihalobacillus krulwichiae (see paper)
27% identity, 94% coverage of query (194 bits)
Q8RL88 acetolactate synthase (subunit 2/2) (EC 2.2.1.6) from Geobacillus stearothermophilus (see paper)
ilvB / AAL99356.1 acetohydroxy acid synthase large subunit from Geobacillus stearothermophilus (see paper)
30% identity, 90% coverage of query (192 bits)
Q0K022 sulfoacetaldehyde acetyltransferase (EC 2.3.3.15) from Cupriavidus necator (see paper)
28% identity, 91% coverage of query (190 bits)
3d7kA Crystal structure of benzaldehyde lyase in complex with the inhibitor mbp
29% identity, 90% coverage of query (190 bits)
D4C4C5 oxalyl-CoA decarboxylase (EC 4.1.1.8) from Providencia rettgeri (see paper)
25% identity, 93% coverage of query (189 bits)
ILVB1_MYCTU / P9WG41 Acetolactate synthase large subunit IlvB1; ALS; Acetohydroxy-acid synthase large subunit; AHAS; EC 2.2.1.6 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 4 papers)
P9WG41 acetolactate synthase (subunit 2/2) (EC 2.2.1.6) from Mycobacterium tuberculosis (see paper)
29% identity, 91% coverage of query (187 bits)
Q5SJ01 acetolactate synthase (EC 2.2.1.6); pyruvate decarboxylase (EC 4.1.1.1) from Thermus thermophilus (see paper)
29% identity, 90% coverage of query (186 bits)
4qq8C / Q9F4L3 Crystal structure of the formolase fls in space group p 43 21 2 (see paper)
29% identity, 90% coverage of query (185 bits)
7b2eA / C5AX46 Quadruple mutant of oxalyl-coa decarboxylase from methylorubrum extorquens with bound tpp and adp (see paper)
28% identity, 93% coverage of query (182 bits)
A4YXN1 oxalyl-CoA decarboxylase (EC 4.1.1.8) from Bradyrhizobium japonicum (see paper)
25% identity, 93% coverage of query (181 bits)
xsc / Q93PS3 sulfoacetaldehyde acetyltransferase subunit (EC 2.3.3.15) from Desulfonispora thiosulfatigenes (see 2 papers)
26% identity, 94% coverage of query (181 bits)
Q5S3P7 acetolactate synthase (EC 2.2.1.6) from Streptomyces cinnamonensis (see 2 papers)
ilvB / AAV52901.1 acetohydroxy acid synthase large subunit from Streptomyces cinnamonensis (see paper)
27% identity, 86% coverage of query (180 bits)
P42463 acetolactate synthase (EC 2.2.1.6) from Corynebacterium glutamicum (see paper)
27% identity, 91% coverage of query (180 bits)
ilvB / AAB38426.1 acetolactate synthase from Mycobacterium avium (see paper)
28% identity, 87% coverage of query (179 bits)
ILVG_ECOLI / P0DP90 Acetolactate synthase isozyme 2 large subunit; AHAS-II; ALS-II; Acetohydroxy-acid synthase II large subunit; EC 2.2.1.6 from Escherichia coli (strain K12) (see 2 papers)
ilvG / GB|CAA28573.1 acetolactate synthase isozyme 2 large subunit; EC 2.2.1.6 from Escherichia coli K12 (see 8 papers)
26% identity, 95% coverage of query (176 bits)
PXP1_SCHPO / Q9Y7M1 Putative 2-hydroxyacyl-CoA lyase; EC 4.1.-.- from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
27% identity, 93% coverage of query (175 bits)
IlvB / b3671 acetohydroxy acid synthase I subunit IlvB (EC 2.2.1.6) from Escherichia coli K-12 substr. MG1655 (see 7 papers)
ilvB / P08142 acetohydroxy acid synthase I subunit IlvB (EC 2.2.1.6) from Escherichia coli (strain K12) (see 4 papers)
P08142 acetolactate synthase (subunit 2/2) (EC 2.2.1.6) from Escherichia coli (see paper)
26% identity, 95% coverage of query (174 bits)
xsc / Q84H44 sulfoacetaldehyde acetyltransferase monomer (EC 2.3.3.15) from Castellaniella defragrans (see paper)
XSC_CASDE / Q84H44 Sulfoacetaldehyde acetyltransferase; EC 2.3.3.15 from Castellaniella defragrans (Alcaligenes defragrans) (see paper)
Q84H44 sulfoacetaldehyde acetyltransferase (EC 2.3.3.15) from Castellaniella defragrans (see paper)
26% identity, 90% coverage of query (174 bits)
ilvB / AAA93098.1 acetolactate synthase from Streptomyces avermitilis (see paper)
27% identity, 87% coverage of query (173 bits)
B2T9D2 oxalyl-CoA decarboxylase (EC 4.1.1.8) from Paraburkholderia phytofirmans (see paper)
25% identity, 96% coverage of query (172 bits)
Q836A5 acetolactate synthase (EC 2.2.1.6) from Enterococcus faecalis (see 2 papers)
28% identity, 92% coverage of query (171 bits)
YfdU / b2373 oxalyl-CoA decarboxylase (EC 4.1.1.8) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
oxc / P0AFI0 oxalyl-CoA decarboxylase (EC 4.1.1.8) from Escherichia coli (strain K12) (see 2 papers)
OXC_ECOLI / P0AFI0 Oxalyl-CoA decarboxylase; EC 4.1.1.8 from Escherichia coli (strain K12) (see 2 papers)
P0AFI0 oxalyl-CoA decarboxylase (EC 4.1.1.8) from Escherichia coli (see paper)
25% identity, 95% coverage of query (171 bits)
Q31Y98 oxalyl-CoA decarboxylase (EC 4.1.1.8) from Shigella boydii (see paper)
25% identity, 95% coverage of query (171 bits)
2q28A / P0AFI0 Crystal structure of oxalyl-coa decarboxylase from escherichia coli in complex with adenosine-5`-diphosphate (see paper)
25% identity, 93% coverage of query (171 bits)
6lpiB / P08142 Crystal structure of ahas holo-enzyme (see paper)
26% identity, 95% coverage of query (171 bits)
2q29A Crystal structure of oxalyl-coa decarboxylase from escherichia coli in complex with acetyl coenzyme a
25% identity, 93% coverage of query (171 bits)
Q5M4L0 acetolactate synthase (EC 2.2.1.6) from Streptococcus thermophilus (see paper)
27% identity, 93% coverage of query (166 bits)
D1NS77 oxalyl-CoA decarboxylase (EC 4.1.1.8) from Bifidobacterium gallicum (see paper)
26% identity, 92% coverage of query (166 bits)
1ozfA The crystal structure of klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactors
28% identity, 93% coverage of query (166 bits)
5d6rB Acetolactate synthase from klebsiella pneumoniae in complex with mechanism-based inhibitor
28% identity, 93% coverage of query (166 bits)
5dx6B / P27696 Acetolactate synthase from klebsiella pneumoniae soaked with beta- fluoropyruvate
27% identity, 93% coverage of query (165 bits)
oxc / P40149 oxalyl-CoA decarboxylase monomer (EC 4.1.1.8) from Oxalobacter formigenes (see 5 papers)
OXC_OXAFO / P40149 Oxalyl-CoA decarboxylase; EC 4.1.1.8 from Oxalobacter formigenes (see 2 papers)
C3XBB9 oxalyl-CoA decarboxylase (EC 4.1.1.8) from Oxalobacter formigenes (see paper)
28% identity, 93% coverage of query (165 bits)
2ji6A / P40149 X-ray structure of oxalyl-coa decarboxylase in complex with 3-deaza- thdp and oxalyl-coa (see paper)
28% identity, 93% coverage of query (165 bits)
1ozgA The crystal structure of klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactor and with an unusual intermediate
27% identity, 93% coverage of query (165 bits)
2jibA X-ray structure of oxalyl-coa decarboxylase in complex with coenzyme- a
28% identity, 93% coverage of query (165 bits)
2ji8A X-ray structure of oxalyl-coa decarboxylase in complex with formyl- coa
28% identity, 93% coverage of query (165 bits)
2ji7A X-ray structure of oxalyl-coa decarboxylase with covalent reaction intermediate
28% identity, 93% coverage of query (165 bits)
2c31A Crystal structure of oxalyl-coa decarboxylase in complex with the cofactor derivative thiamin-2-thiazolone diphosphate and adenosine diphosphate
28% identity, 93% coverage of query (164 bits)
4rjkF Acetolactate synthase from bacillus subtilis bound to lthdp - crystal form ii
26% identity, 90% coverage of query (162 bits)
4rjiC Acetolactate synthase from bacillus subtilis bound to thdp - crystal form i (see paper)
26% identity, 90% coverage of query (162 bits)
4rjkG Acetolactate synthase from bacillus subtilis bound to lthdp - crystal form ii
26% identity, 90% coverage of query (162 bits)
5dx6A Acetolactate synthase from klebsiella pneumoniae soaked with beta- fluoropyruvate
28% identity, 93% coverage of query (162 bits)
P09342 Acetolactate synthase 1, chloroplastic; ALS I; Acetohydroxy-acid synthase I; Acetolactate synthase I; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco)
26% identity, 89% coverage of query (160 bits)
1n0hA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorimuron ethyl
27% identity, 90% coverage of query (160 bits)
P09114 Acetolactate synthase 2, chloroplastic; ALS II; Acetohydroxy-acid synthase II; Acetolactate synthase II; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco)
26% identity, 89% coverage of query (159 bits)
5wkcA Saccharomyces cerevisiae acetohydroxyacid synthase in complex with the herbicide penoxsulam
27% identity, 90% coverage of query (159 bits)
ILVB_YEAST / P07342 Acetolactate synthase catalytic subunit, mitochondrial; Acetohydroxy-acid synthase catalytic subunit; AHAS; ALS; EC 2.2.1.6 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
P07342 acetolactate synthase (EC 2.2.1.6) from Saccharomyces cerevisiae (see 5 papers)
27% identity, 90% coverage of query (159 bits)
6u9dB / P07342 Saccharomyces cerevisiae acetohydroxyacid synthase (see paper)
27% identity, 90% coverage of query (159 bits)
1t9bB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron
27% identity, 90% coverage of query (158 bits)
5wdgA Acetolactate synthase from klebsiella pneumoniae in complex with a reaction intermediate
27% identity, 93% coverage of query (158 bits)
1t9dA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl
27% identity, 90% coverage of query (157 bits)
1t9aA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl
27% identity, 90% coverage of query (157 bits)
1t9cA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl
27% identity, 90% coverage of query (157 bits)
1t9dB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl
27% identity, 90% coverage of query (156 bits)
1t9bA / P07342 Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
27% identity, 90% coverage of query (156 bits)
PXP1_YEAST / P39994 Putative 2-hydroxyacyl-CoA lyase; Peroxisomal protein 1; EC 4.1.-.- from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
24% identity, 92% coverage of query (156 bits)
7tzzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase p197t mutant in complex with bispyribac-sodium
26% identity, 81% coverage of query (155 bits)
8et4A Crystal structure of wild-type arabidopsis thaliana acetohydroxyacid synthase in complex with amidosulfuron
26% identity, 81% coverage of query (155 bits)
5wj1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a triazolopyrimidine herbicide, penoxsulam
26% identity, 81% coverage of query (155 bits)
5k6tA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, propoxycarbazone-sodium
26% identity, 81% coverage of query (155 bits)
5k6rA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, thiencarbazone-methyl
26% identity, 81% coverage of query (155 bits)
1z8nA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with an imidazolinone herbicide, imazaquin
26% identity, 81% coverage of query (155 bits)
1yi1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl
26% identity, 81% coverage of query (155 bits)
1yi0A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl
26% identity, 81% coverage of query (155 bits)
1yhzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron
26% identity, 81% coverage of query (155 bits)
1yhyA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl
26% identity, 81% coverage of query (155 bits)
1ybhA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide chlorimuron ethyl
26% identity, 81% coverage of query (155 bits)
5k3sA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, bispyribac-sodium
26% identity, 81% coverage of query (155 bits)
5k2oA / P17597 Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, pyrithiobac (see paper)
26% identity, 81% coverage of query (155 bits)
ILVB_ARATH / P17597 Acetolactate synthase, chloroplastic; AtALS; Acetohydroxy-acid synthase; Protein CHLORSULFURON RESISTANT 1; EC 2.2.1.6 from Arabidopsis thaliana (Mouse-ear cress) (see 16 papers)
P17597 acetolactate synthase (EC 2.2.1.6) from Arabidopsis thaliana (see 8 papers)
26% identity, 81% coverage of query (155 bits)
3ea4A Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron-ester
26% identity, 81% coverage of query (155 bits)
3e9yA Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron
26% identity, 81% coverage of query (155 bits)
8i07D Crystal structure of escherichia coli glyoxylate carboligase double mutant in complex with glycolaldehyde
26% identity, 91% coverage of query (154 bits)
8i07A Crystal structure of escherichia coli glyoxylate carboligase double mutant in complex with glycolaldehyde
26% identity, 91% coverage of query (154 bits)
8beoB Crystal structure of e. Coli glyoxylate carboligase mutant i393a with map
26% identity, 91% coverage of query (154 bits)
8beoA Crystal structure of e. Coli glyoxylate carboligase mutant i393a with map
26% identity, 91% coverage of query (154 bits)
2ezuA Pyruvate oxidase variant f479w in complex with reaction intermediate 2-acetyl-thiamin diphosphate
27% identity, 86% coverage of query (152 bits)
2ez9A Pyruvate oxidase variant f479w in complex with reaction intermediate analogue 2-phosphonolactyl-thiamin diphosphate
27% identity, 86% coverage of query (152 bits)
2ez8A Pyruvate oxidase variant f479w in complex with reaction intermediate 2-lactyl-thiamin diphosphate
27% identity, 86% coverage of query (152 bits)
2ez4B Pyruvate oxidase variant f479w
27% identity, 86% coverage of query (152 bits)
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