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Searching for up to 100 curated homologs for RR42_RS31730 FitnessBrowser__Cup4G11:RR42_RS31730 (313 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

HUTGL_PSEAE / Q9HZ59 Formimidoylglutamase; Formiminoglutamase; Formiminoglutamate hydrolase; EC 3.5.3.8 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
    50% identity, 100% coverage of query (257 bits)

BWI76_RS08725 Formiminoglutamase (EC 3.5.3.8) from Klebsiella michiganensis M5al
    49% identity, 97% coverage of query (249 bits)

4mynA / Q4DSA0 Crystal structure of trypanosoma cruzi formiminoglutamase n114h variant with mn2+2 (see paper)
    33% identity, 87% coverage of query (113 bits)

Q4DSA0 formimidoylglutamase (EC 3.5.3.8) from Trypanosoma cruzi (see paper)
    33% identity, 87% coverage of query (111 bits)

Build an alignment

Build an alignment for RR42_RS31730 and 4 homologs with ≥ 30% identity

Select sequences

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Change minimum %identity:

Additional hits (identity < 30%)

ARGI_BACCD / P53608 Arginase; EC 3.5.3.1 from Bacillus caldovelox (see paper)
P53608 arginase (EC 3.5.3.1) from [Bacillus] caldovelox (see paper)
1cevA / P53608 Arginase from bacillus caldovelox, native structure at ph 5.6 (see paper)
    27% identity, 86% coverage of query (78.2 bits)

5cevA Arginase from bacillus caldevelox, l-lysine complex
    27% identity, 86% coverage of query (78.2 bits)

4cevA Arginase from bacillus caldevelox, l-ornithine complex
    27% identity, 86% coverage of query (78.2 bits)

3cevA Arginase from bacillus caldevelox, complexed with l-arginine
    27% identity, 86% coverage of query (78.2 bits)

2cevB Arginase from bacillus caldevelox, native structure at ph 8.5
    27% identity, 86% coverage of query (78.2 bits)

A4IJM8 arginase (EC 3.5.3.1) from Geobacillus thermodenitrificans (see paper)
    27% identity, 86% coverage of query (76.6 bits)

6dktE / P39138 Crystal structure of arginase from bacillus subtilis
    26% identity, 86% coverage of query (75.5 bits)

3pzlB / Q97BB8 The crystal structure of agmatine ureohydrolase of thermoplasma volcanium
    26% identity, 82% coverage of query (74.3 bits)

6dktA Crystal structure of arginase from bacillus subtilis
    26% identity, 86% coverage of query (74.3 bits)

6nfpD 1.7 angstrom resolution crystal structure of arginase from bacillus subtilis subsp. Subtilis str. 168
    25% identity, 86% coverage of query (73.6 bits)

argI / P39138 arginase (EC 3.5.3.1) from Bacillus subtilis (strain 168) (see 3 papers)
ARGI_BACSU / P39138 Arginase; EC 3.5.3.1 from Bacillus subtilis (strain 168) (see 2 papers)
P39138 arginase (EC 3.5.3.1) from Bacillus subtilis (see paper)
    25% identity, 86% coverage of query (71.2 bits)

6nfpA / P39138 1.7 angstrom resolution crystal structure of arginase from bacillus subtilis subsp. Subtilis str. 168
    25% identity, 86% coverage of query (71.2 bits)

I7KJN7 arginase (EC 3.5.3.1) from Oncorhynchus mykiss (see paper)
    25% identity, 94% coverage of query (69.3 bits)

speB / P70999 agmatinase (EC 3.5.3.11) from Bacillus subtilis (strain 168) (see paper)
    27% identity, 81% coverage of query (66.6 bits)

1wogA / Q9RZ04 Crystal structure of agmatinase reveals structural conservation and inhibition mechanism of the ureohydrolase superfamily (see paper)
    29% identity, 81% coverage of query (65.5 bits)

GPUA_PSEAE / Q9I6K2 Guanidinopropionase; EC 3.5.3.17 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
Q9I6K2 Guanidinopropionase (EC 3.5.3.17) from Pseudomonas aeruginosa (see paper)
    28% identity, 86% coverage of query (64.7 bits)

3nipB / Q9I6K2 Crystal structure of pseudomonas aeruginosa guanidinopropionase complexed with 1,6-diaminohexane (see paper)
    28% identity, 86% coverage of query (64.7 bits)

N515DRAFT_0348 Arginase (EC 3.5.3.1) from Dyella japonica UNC79MFTsu3.2
    26% identity, 82% coverage of query (64.3 bits)

3niqA Crystal structure of pseudomonas aeruginosa guanidinopropionase
    28% identity, 86% coverage of query (64.3 bits)

Ac3H11_701 Arginase (EC 3.5.3.1) from Acidovorax sp. GW101-3H11
    26% identity, 90% coverage of query (62.8 bits)

SPEB_PROMI / Q7X3P1 Agmatinase; Agmatine ureohydrolase; AUH; EC 3.5.3.11 from Proteus mirabilis (see paper)
    26% identity, 87% coverage of query (62.0 bits)

Sama_3201 Formiminoglutamase (EC 3.5.3.8) from Shewanella amazonensis SB2B
    29% identity, 81% coverage of query (61.6 bits)

ARGI1_MOUSE / Q61176 Arginase-1; Liver-type arginase; Type I arginase; EC 3.5.3.1 from Mus musculus (Mouse) (see 10 papers)
Q61176 arginase (EC 3.5.3.1) from Mus musculus (see paper)
    24% identity, 89% coverage of query (61.2 bits)

1hq5A Crystal structure of the binuclear manganese metalloenzyme arginase complexed with s-(2-boronoethyl)-l-cysteine, an l-arginine analogue
    24% identity, 86% coverage of query (60.8 bits)

1d3vA Crystal structure of the binuclear manganese metalloenzyme arginase complexed with 2(s)-amino-6-boronohexanoic acid, an l-arginine analog
    24% identity, 86% coverage of query (60.8 bits)

1hqfA / P07824 Crystal structure of the binuclear manganese metalloenzyme arginase complexed with n-hydroxy-l-arginine (see paper)
    24% identity, 85% coverage of query (60.5 bits)

A0A146AXJ2 agmatinase (EC 3.5.3.11) from Apostichopus japonicus (see paper)
    26% identity, 85% coverage of query (60.5 bits)

1t4tA Arginase-dinor-noha complex
    24% identity, 85% coverage of query (60.5 bits)

1t4sA Arginase-l-valine complex
    24% identity, 85% coverage of query (60.5 bits)

1t4rA Arginase-descarboxy-nor-noha complex
    24% identity, 85% coverage of query (60.5 bits)

1t4pA Arginase-dehydro-abh complex
    24% identity, 85% coverage of query (60.5 bits)

1r1oA Amino acid sulfonamides as transition-state analogue inhibitors of arginase
    24% identity, 85% coverage of query (60.5 bits)

1hqhA Crystal structure of the binuclear manganese metalloenzyme arginase complexed with nor-n-hydroxy-l-arginine
    24% identity, 85% coverage of query (60.5 bits)

2ef5A / Q5SI78 Crystal structure of the arginase from thermus thermophilus
    30% identity, 86% coverage of query (60.1 bits)

Q4A3J2 arginase (EC 3.5.3.1) from Cyprinus carpio (see paper)
    24% identity, 83% coverage of query (60.1 bits)

1hqgA Crystal structure of the h141c arginase variant complexed with products ornithine and urea
    24% identity, 85% coverage of query (60.1 bits)

ARGI1_RAT / P07824 Arginase-1; Liver-type arginase; Type I arginase; EC 3.5.3.1 from Rattus norvegicus (Rat) (see 6 papers)
P07824 arginase (EC 3.5.3.1) from Rattus norvegicus (see 5 papers)
    24% identity, 85% coverage of query (59.7 bits)

AGMAT / Q9BSE5 agmatinase (EC 3.5.3.11) from Homo sapiens (see paper)
GDAH_HUMAN / Q9BSE5 Guanidino acid hydrolase, mitochondrial; Arginase, mitochondrial; Guanidinobutyrase, mitochondrial; Guanidinopropionase, mitochondrial; EC 3.5.3.-; EC 3.5.3.1; EC 3.5.3.7; EC 3.5.3.17 from Homo sapiens (Human) (see 3 papers)
Q9BSE5 agmatinase (EC 3.5.3.11) from Homo sapiens (see paper)
    26% identity, 86% coverage of query (59.3 bits)

HUTG_BACSU / P42068 Formimidoylglutamase; Formiminoglutamase; Formiminoglutamate hydrolase; N-formimino-L-glutamate formiminohydrolase; EC 3.5.3.8 from Bacillus subtilis (strain 168) (see paper)
    21% identity, 80% coverage of query (58.9 bits)

3m1rD / P42068 The crystal structure of formimidoylglutamase from bacillus subtilis subsp. Subtilis str. 168
    21% identity, 80% coverage of query (58.9 bits)

arcA / P14012 arginase subunit (EC 3.5.3.1) from Agrobacterium fabrum (strain C58 / ATCC 33970) (see 3 papers)
arc / CAA82964.1 arginase from Agrobacterium tumefaciens (see 3 papers)
    25% identity, 81% coverage of query (58.2 bits)

W5PHZ9 agmatinase (EC 3.5.3.11) from Ovis aries (see 2 papers)
    26% identity, 87% coverage of query (57.8 bits)

A0A060YSI8 arginase (EC 3.5.3.1) from Oncorhynchus mykiss (see paper)
    24% identity, 83% coverage of query (57.8 bits)

7k4gE / P05089 Human arginase 1 in complex with compound 01. (see paper)
    24% identity, 78% coverage of query (57.8 bits)

7k4hA Human arginase 1 in complex with compound 04.
    24% identity, 84% coverage of query (57.8 bits)

6v7fA Human arginase1 complexed with bicyclic inhibitor compound 13
    24% identity, 84% coverage of query (57.8 bits)

6v7dA Human arginase1 complexed with bicyclic inhibitor compound 10
    24% identity, 84% coverage of query (57.8 bits)

6qafA Crystal structure of human arginase-1 at ph 9.0 in complex with cb- 1158/incb001158
    24% identity, 84% coverage of query (57.8 bits)

6q92A Crystal structure of human arginase-1 at ph 7.0 in complex with abh
    24% identity, 84% coverage of query (57.8 bits)

4q41A Crystal structure of schistosoma mansoni arginase in complex with l- lysine
    28% identity, 76% coverage of query (57.8 bits)

4gszA Crystal structure of the zn2+5-human arginase i-abh complex
    24% identity, 78% coverage of query (57.8 bits)

4fciA Crystal structure of the mn2+2-human arginase i-agpa complex
    24% identity, 78% coverage of query (57.8 bits)

4ie1A Crystal structure of human arginase-1 complexed with inhibitor 1h
    24% identity, 78% coverage of query (57.8 bits)

4hxqA Crystal structure of human arginase-1 complexed with inhibitor 14
    24% identity, 78% coverage of query (57.8 bits)

4hwwA Crystal structure of human arginase-1 complexed with inhibitor 9
    24% identity, 78% coverage of query (57.8 bits)

2aebA Crystal structure of human arginase i at 1.29 a resolution and exploration of inhibition in immune response.
    24% identity, 78% coverage of query (57.8 bits)

3th7A Crystal structure of unliganded co2+2-hai (ph 7.0)
    24% identity, 78% coverage of query (57.8 bits)

3skkA Crystal structure of human arginase i in complex with the inhibitor fabh, resolution 1.70 a, twinned structure
    24% identity, 78% coverage of query (57.8 bits)

3mjlA Crystal structure of human arginase i in complex with 2- aminoimidazole. Resolution 1.90 a.
    24% identity, 78% coverage of query (57.8 bits)

1wvaA Crystal structure of human arginase i from twinned crystal
    24% identity, 84% coverage of query (57.8 bits)

3mfwA Crystal structure of human arginase i in complex with l-2- aminohistidine and sulphate
    24% identity, 78% coverage of query (57.8 bits)

3gn0A Crystal structure of human arginase i in complex with difluoromethylornithine (dfmo)
    24% identity, 78% coverage of query (57.8 bits)

3gmzA Crystal of human arginase in complex with l-ornithine. Resolution 1.43 a.
    24% identity, 78% coverage of query (57.8 bits)

ARG1 / P05089 Arginase-1 (EC 3.5.3.1) from Homo sapiens (see 7 papers)
ARGI1_HUMAN / P05089 Arginase-1; Liver-type arginase; Type I arginase; EC 3.5.3.1 from Homo sapiens (Human) (see 15 papers)
P05089 arginase (EC 3.5.3.1) from Homo sapiens (see 12 papers)
    24% identity, 78% coverage of query (57.4 bits)

8aupA Structure of harg1 with a novel inhibitor.
    24% identity, 78% coverage of query (57.4 bits)

3sjtA Crystal structure of human arginase i in complex with the inhibitor me-abh, resolution 1.60 a, twinned structure
    24% identity, 78% coverage of query (57.4 bits)

3mfvA Crystal structure of human arginase i in complex with 2- aminohomohistidine
    24% identity, 78% coverage of query (57.4 bits)

3lp7A Crystal structure of human arginase i in complex with inhibitor n(omega)-hydroxy-l-arginine (noha), 2.04a resolution
    24% identity, 78% coverage of query (57.4 bits)

3lp4A Crystal structure of human arginase i in complex with l-lysine, 1.90a resolution.
    24% identity, 78% coverage of query (57.4 bits)

3kv2A High resolution structure of human arginase i in complex with the strong inhibitor n(omega)-hydroxy-nor-l-arginine (nor-noha)
    24% identity, 78% coverage of query (57.4 bits)

3f80A (S)-2-amino-6-nitrohexanoic acid binds to human arginase i through multiple nitro-metal coordination interactions in the binuclear manganese cluster. Resolution 1.60 a.
    24% identity, 78% coverage of query (57.4 bits)

3dj8A Synthesis of (2s)-2-amino-7,8-epoxyoctanoic acid and structure of its metal-bridging complex with human arginase i
    24% identity, 78% coverage of query (57.4 bits)

2phoA Crystal structure of human arginase i complexed with thiosemicarbazide at 1.95 resolution
    24% identity, 78% coverage of query (57.4 bits)

8e5nA Structure of arg1 complex with pyrrolidine-based non-boronic acid inhibitor 10
    24% identity, 78% coverage of query (57.4 bits)

8e5mA Structure of arg1 complex with pyrrolidine-based non-boronic acid inhibitor 6
    24% identity, 78% coverage of query (57.4 bits)

7klmA Human arginase1 complexed with inhibitor compound 24a
    24% identity, 78% coverage of query (57.4 bits)

7kllA Human arginase1 complexed with inhibitor compound 18
    24% identity, 78% coverage of query (57.4 bits)

7klkA Human arginase1 complexed with inhibitor compound 3a
    24% identity, 78% coverage of query (57.4 bits)

7k4kA Human arginase 1 in complex with compound 52.
    24% identity, 78% coverage of query (57.4 bits)

7k4jA Human arginase 1 in complex with compound 51.
    24% identity, 78% coverage of query (57.4 bits)

7k4iA Human arginase 1 in complex with compound 06.
    24% identity, 78% coverage of query (57.4 bits)

6v7eA Human arginase1 complexed with bicyclic inhibitor compound 12
    24% identity, 78% coverage of query (57.4 bits)

6v7cA Human arginase1 complexed with bicyclic inhibitor compound 3
    24% identity, 78% coverage of query (57.4 bits)

1t5gA Arginase-f2-l-arginine complex
    24% identity, 85% coverage of query (57.4 bits)

1t5fA Arginase i-aoh complex
    24% identity, 85% coverage of query (57.4 bits)

3nioA / Q9I3S3 Crystal structure of pseudomonas aeruginosa guanidinobutyrase (see paper)
    25% identity, 93% coverage of query (56.2 bits)

gbuA / Q9I3S3 guanidinobutyrase subunit (EC 3.5.3.7) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
GBUA_PSEAE / Q9I3S3 Guanidinobutyrase; EC 3.5.3.7 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 2 papers)
Q9I3S3 guanidinobutyrase (EC 3.5.3.7) from Pseudomonas aeruginosa (see paper)
    25% identity, 93% coverage of query (55.8 bits)

C0H9C1 arginase (EC 3.5.3.1) from Salmo salar (see paper)
    24% identity, 83% coverage of query (54.7 bits)

A0A1P8DAN3 arginase (EC 3.5.3.1) from Oncorhynchus mykiss (see paper)
    25% identity, 77% coverage of query (54.7 bits)

gbuA / A0A0A1DPD5 5-guanidino-2-oxopentanoate ureohydrolase (EC 3.5.3.7) from Nocardioides simplex (see paper)
    26% identity, 87% coverage of query (54.7 bits)

A0A1S3R1W2 arginase (EC 3.5.3.1) from Salmo salar (see paper)
    24% identity, 83% coverage of query (54.7 bits)

4q3vC / Q6WVP6 Crystal structure of schistosoma mansoni arginase in complex with inhibitor bec (see paper)
    27% identity, 76% coverage of query (53.5 bits)

GDAH_MOUSE / A2AS89 Guanidino acid hydrolase, mitochondrial; Arginase, mitochondrial; Guanidinobutyrase, mitochondrial; Guanidinopropionase, mitochondrial; EC 3.5.3.-; EC 3.5.3.1; EC 3.5.3.7; EC 3.5.3.17 from Mus musculus (Mouse) (see paper)
    27% identity, 86% coverage of query (53.1 bits)

4q42A Crystal structure of schistosoma mansoni arginase in complex with l- ornithine
    28% identity, 76% coverage of query (53.1 bits)

4q40A Crystal structure of schistosoma mansoni arginase in complex with l- valine
    28% identity, 76% coverage of query (53.1 bits)

4q3sA Crystal structure of schistosoma mansoni arginase in complex with inhibitor abhpe
    28% identity, 76% coverage of query (53.1 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory