Searching for up to 100 curated homologs for RR42_RS33780 FitnessBrowser__Cup4G11:RR42_RS33780 (474 a.a.)
Found high-coverage hits (≥70%) to 67 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
GABP_BACSU / P46349 Gamma-aminobutyric acid permease; GABA permease; 4-aminobutyrate permease; Gamma-aminobutyrate permease; Proline transporter GabP from Bacillus subtilis (strain 168) (see 3 papers)
TC 2.A.3.1.5 / P46349 β-alanine/γ-aminobutyrate/proline/3,4-dehydroproline:H+ symporter, GabP from Bacillus subtilis (see 4 papers)
gabP / AAC44641.1 gamma-aminobutyrate permease from Bacillus subtilis (see 2 papers)
53% identity, 98% coverage of query (488 bits)
gabP / AAB62306.1 GabP from Bacillus subtilis (see 4 papers)
53% identity, 98% coverage of query (488 bits)
GabP / b2663 4-aminobutanoate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 11 papers)
gabP / P25527 4-aminobutanoate:H+ symporter from Escherichia coli (strain K12) (see 10 papers)
GABP_ECOLI / P25527 Gamma-aminobutyric acid permease; GABA permease; 4-aminobutyrate carrier; 4-aminobutyrate permease; Gamma-aminobutyrate permease from Escherichia coli (strain K12) (see 7 papers)
TC 2.A.3.1.4 / P25527 γ-aminobutyrate:H+ symporter, GabP. It also transports a variety of pyridine carboxylates. Phosphatidylethanolamine is required for its proper topological organization(Zhang et al. 2005) from Escherichia coli (see 5 papers)
46% identity, 94% coverage of query (389 bits)
BAUD_PSEAE / Q9I703 Probable GABA permease; 4-amino butyrate transport carrier; Gamma-aminobutyrate permease from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
46% identity, 96% coverage of query (340 bits)
RR42_RS33495 L-phenylalanine:H+ symporter AroP from Cupriavidus basilensis FW507-4G11
38% identity, 98% coverage of query (315 bits)
AO356_17670 L-alanine and D-alanine permease from Pseudomonas fluorescens FW300-N2C3
39% identity, 99% coverage of query (314 bits)
AROP_CORGL / Q46065 Aromatic amino acid transport protein AroP; General aromatic amino acid permease from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see paper)
TC 2.A.3.1.12 / Q46065 Aromatic amino acid permease, AroP from Corynebacterium glutamicum (Brevibacterium flavum) (see 2 papers)
42% identity, 86% coverage of query (308 bits)
AO353_16120 D-alanine and L-alanine transporter from Pseudomonas fluorescens FW300-N2E3
39% identity, 99% coverage of query (305 bits)
H281DRAFT_04042 phenylacetate transporter from Paraburkholderia bryophila 376MFSha3.1
39% identity, 89% coverage of query (301 bits)
PS417_05405 L-alanine and D-alanine permease from Pseudomonas simiae WCS417
38% identity, 99% coverage of query (298 bits)
PfGW456L13_4291 L-tryptophan transporter from Pseudomonas fluorescens GW456-L13
41% identity, 89% coverage of query (297 bits)
AroR / b0112 aromatic amino acid:H+ symporter AroP from Escherichia coli K-12 substr. MG1655 (see 5 papers)
aroP / P15993 aromatic amino acid:H+ symporter AroP from Escherichia coli (strain K12) (see 6 papers)
AROP_ECOLI / P15993 Aromatic amino acid transport protein AroP; Aromatic amino acid:H(+) symporter AroP; General aromatic amino acid permease; General aromatic transport system from Escherichia coli (strain K12) (see 8 papers)
TC 2.A.3.1.3 / P15993 Aromatic amino acid:H+ symporter, AroP of 457 aas and 12 TMSs (Cosgriff and Pittard 1997). Transports phenylalanine, tyrosine and tryptophan from Escherichia coli (see 6 papers)
37% identity, 97% coverage of query (293 bits)
AO356_18530 L-tyrosine transporter from Pseudomonas fluorescens FW300-N2C3
38% identity, 90% coverage of query (291 bits)
RR42_RS28305 L-threonine:H+ symporter from Cupriavidus basilensis FW507-4G11
37% identity, 95% coverage of query (287 bits)
DagA / b4208 D-serine/alanine/glycine/:H+symporter from Escherichia coli K-12 substr. MG1655 (see 13 papers)
cycA / P0AAE0 D-serine/alanine/glycine:H+symporter from Escherichia coli (strain K12) (see 15 papers)
CYCA_ECOLI / P0AAE0 D-serine/D-alanine/glycine transporter; Amino acid carrier CycA from Escherichia coli (strain K12) (see 7 papers)
TC 2.A.3.1.7 / P0AAE0 D-Serine/D-alanine/glycine/D-cycloserine:H+ symporter from Escherichia coli (see 4 papers)
36% identity, 97% coverage of query (281 bits)
PheP / b0576 phenylalanine:H+ symporter PheP from Escherichia coli K-12 substr. MG1655 (see 3 papers)
pheP / P24207 phenylalanine:H+ symporter PheP from Escherichia coli (strain K12) (see 3 papers)
PHEP_ECOLI / P24207 Phenylalanine-specific permease; Phenylalanine:H(+) symporter PheP from Escherichia coli (strain K12) (see 6 papers)
TC 2.A.3.1.1 / P24207 Phenylalanine:H+ symporter, PheP of 458 aas and 12 established TMSs from Escherichia coli (see 6 papers)
35% identity, 92% coverage of query (271 bits)
CYCA_ECOL6 / A0A0H2VDI7 D-serine/D-alanine/glycine transporter from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) (see 2 papers)
36% identity, 97% coverage of query (269 bits)
AO353_05930 L-tryptophan transporter from Pseudomonas fluorescens FW300-N2E3
36% identity, 95% coverage of query (269 bits)
MmuP / b0260 CP4-6 prophage; S-methyl-L-methionine transporter from Escherichia coli K-12 substr. MG1655 (see 3 papers)
mmuP / Q47689 CP4-6 prophage; S-methyl-L-methionine transporter from Escherichia coli (strain K12) (see 2 papers)
TC 2.A.3.1.10 / Q47689 S-Methylmethionine permease, MmuP from Escherichia coli (see 3 papers)
35% identity, 97% coverage of query (269 bits)
AO353_12275 histidine permease from Pseudomonas fluorescens FW300-N2E3
38% identity, 94% coverage of query (268 bits)
TC 2.A.3.1.6 / P37460 Proline-specific permease (ProY) from Salmonella typhimurium (see 2 papers)
35% identity, 97% coverage of query (267 bits)
YncF / b1453 L-asparagine transporter from Escherichia coli K-12 substr. MG1655 (see 2 papers)
ANSP_ECOLI / P77610 L-asparagine permease; L-asparagine transport protein from Escherichia coli (strain K12) (see paper)
TC 2.A.3.1.24 / P77610 Asparagine transporter of 499 aas and 12 TMSs, 91% identical to the orthologue in Salmonella enterica (2.A.3.1.8) from Escherichia coli (strain K12)
37% identity, 97% coverage of query (265 bits)
ROCE_BACSU / P39137 Amino-acid permease RocE from Bacillus subtilis (strain 168) (see paper)
TC 2.A.3.1.11 / P39137 L-Arginine permease, RocE from Bacillus subtilis (see 3 papers)
34% identity, 97% coverage of query (263 bits)
YifK / b3795 putative transporter YifK from Escherichia coli K-12 substr. MG1655 (see 5 papers)
thrP / P27837 threonine/serine:H+ symporter ThrP from Escherichia coli (strain K12) (see 5 papers)
36% identity, 97% coverage of query (263 bits)
YVBW_BACSU / O32257 Uncharacterized amino acid permease YvbW from Bacillus subtilis (strain 168)
35% identity, 96% coverage of query (261 bits)
CadR / b2156 lysine:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 15 papers)
lysP / P25737 lysine:H+ symporter from Escherichia coli (strain K12) (see 13 papers)
LYSP_ECOLI / P25737 Lysine-specific permease LysP; Lysine transporter LysP; Trigger transporter LysP from Escherichia coli (strain K12) (see 7 papers)
TC 2.A.3.1.2 / P25737 Lysine:H+ symporter. Forms a stable complex with CadC to allow lysine-dependent adaptation to acidic stress (Rauschmeier et al. 2013). The Salmonella orthologue is 95% identical to the E. coli protein and is highly specific for Lysine. Residues involved in lysine binding have been identified from Escherichia coli (see 5 papers)
lysP lysine-specific permease from Escherichia coli K12 (see 5 papers)
36% identity, 87% coverage of query (260 bits)
YBXG_BACSU / P54425 Probable threonine/serine transporter YbxG from Bacillus subtilis (strain 168) (see paper)
35% identity, 93% coverage of query (260 bits)
ANSP2_MYCTU / P9WQM7 L-asparagine permease 2; L-asparagine transport protein 2 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
35% identity, 93% coverage of query (260 bits)
TC 2.A.3.1.18 / K7VV21 The lysine specific transporter, LysP of 488 aas and 12 TMSs from Lactococcus lactis subsp. cremoris UC509.9
37% identity, 87% coverage of query (257 bits)
TC 2.A.3.1.8 / P40812 Asparagine permease (AnsP) of 497 aas and 12 TMSs from Salmonella typhimurium (see 2 papers)
ansP / AAA80001.1 L-asparagine permease from Salmonella enterica (see paper)
37% identity, 97% coverage of query (256 bits)
LYSP_LACLM / A2RNZ6 Lysine-specific permease LysP; Lysine transporter LysP from Lactococcus lactis subsp. cremoris (strain MG1363) (see paper)
37% identity, 86% coverage of query (254 bits)
YajM / b0402 putative transporter ProY from Escherichia coli K-12 substr. MG1655 (see 6 papers)
TC 2.A.3.1.23 / P0AAE2 ProY of 457 aas and 12 TMSs from Escherichia coli (strain K12)
35% identity, 96% coverage of query (252 bits)
CAN1_YEAST / P04817 Arginine permease CAN1; Canavanine resistance protein 1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 12 papers)
TC 2.A.3.10.4 / P04817 Arginine permease from Saccharomyces cerevisiae (Baker's yeast) (see 6 papers)
CAN1 / RF|NP_010851.1 arginine permease from Saccharomyces cerevisiae
36% identity, 90% coverage of query (240 bits)
HISP_LACLM / A2RI97 Histidine permease HisP from Lactococcus lactis subsp. cremoris (strain MG1363) (see paper)
35% identity, 86% coverage of query (234 bits)
TC 2.A.3.1.17 / M1IW84 D-serine/L-alanine/D-alanine/glycine/D-cycloserine uptake porter of 556 aas, CycA from Mycobacterium bovis BCG str. Korea 1168P
38% identity, 84% coverage of query (233 bits)
agtA amino acid transporter from Emericella nidulans (see 2 papers)
36% identity, 83% coverage of query (213 bits)
CAN1_CANGA / Q6FNY1 Arginine permease CAN1 from Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus) (see paper)
32% identity, 95% coverage of query (209 bits)
LYP1_YEAST / P32487 Lysine-specific permease from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
TC 2.A.3.10.10 / P32487 Lysine permease of 611 aas and 13 putative TMSs, Lyp1 from Saccharomyces cerevisiae (Baker's yeast) (see 9 papers)
LYP1 / GI|1302328 lysine-specific permease from Saccharomyces cerevisiae
31% identity, 95% coverage of query (207 bits)
CAN2_CANAL / Q59WU0 Probable lysine/arginine permease CAN2; Basic amino acids permease CAN2 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see 7 papers)
33% identity, 86% coverage of query (206 bits)
GAP3_CANAL / A0A1D8PN88 Amino-acid permease GAP3 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see 5 papers)
33% identity, 89% coverage of query (201 bits)
PUT4_YEAST / P15380 Proline-specific permease from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
TC 2.A.3.10.3 / P15380 Proline permease from Saccharomyces cerevisiae (Baker's yeast) (see 4 papers)
PUT4 / RF|NP_014993.1 proline-specific permease from Saccharomyces cerevisiae
32% identity, 90% coverage of query (201 bits)
TC 2.A.3.1.21 / F2HQ25 Serine uptake transporter, SerP1, of 259 aas and 12 TMSs (Trip et al. 2013). L-serine is the highest affinity substrate (Km = 18 μM), but SerP1 also transports L-threonine and L-cysteine (Km values = 20 - 40 μM) from Lactococcus lactis subsp. lactis (strain CV56)
31% identity, 90% coverage of query (196 bits)
TC 2.A.3.10.20 / P43059 The high affinity basic amino acid (Arg, Lys, His) transporter, Can1 from Candida albicans (Yeast) (see paper)
32% identity, 88% coverage of query (195 bits)
SERP1_LACLM / A2RI87 Serine permease SerP1 from Lactococcus lactis subsp. cremoris (strain MG1363) (see 2 papers)
31% identity, 83% coverage of query (194 bits)
CAN1_CANAL / A0A1D8PPI5 Lysine/arginine permease CAN1; Basic amino acids permease CAN1 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see 7 papers)
32% identity, 88% coverage of query (194 bits)
TC 2.A.3.1.20 / F2HQ24 Serine transporter, SerP2 or YdgB, of 459 aas and 12 TMSs (Trip et al. 2013). Transports L-alanine (Km = 20 μM), D-alanine (Km = 38 μM), L-serine, D-serine (Km = 356 μM) and glycine (Noens and Lolkema 2015). The encoding gene is adjacent to the one encoding SerP1 (TC# 2.A.3.1.21) from Lactococcus lactis subsp. lactis (strain CV56)
30% identity, 92% coverage of query (193 bits)
FYWP_LACLM / A2RMP5 Aromatic amino acid permease FywP from Lactococcus lactis subsp. cremoris (strain MG1363) (see paper)
34% identity, 77% coverage of query (192 bits)
TC 2.A.3.1.22 / F2HN33 Transporter for phenylalainine, tyrosine and tryptophan of 449 aas and 12 TMSs, FywP or YsjA from Lactococcus lactis subsp. lactis (strain CV56)
33% identity, 77% coverage of query (191 bits)
ALP1_YEAST / P38971 Basic amino-acid permease from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
TC 2.A.3.10.11 / P38971 Basic amino acid permease from Saccharomyces cerevisiae (Baker's yeast) (see 5 papers)
ALP1 / RF|NP_014129.1 basic amino-acid permease from Saccharomyces cerevisiae
34% identity, 90% coverage of query (191 bits)
SERP2_LACLM / A2RI86 DL-alanine permease SerP2 from Lactococcus lactis subsp. cremoris (strain MG1363) (see 2 papers)
30% identity, 92% coverage of query (190 bits)
CAN3_CANAL / A0A1D8PPG4 Probable lysine/arginine permease CAN3; Basic amino acids permease CAN3 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see 2 papers)
33% identity, 86% coverage of query (188 bits)
GAP2_CANAL / A0A1D8PK89 General amino-acid permease GAP2 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see 6 papers)
TC 2.A.3.10.24 / Q59YT0 General amino and permease and transceptor, GAP2. Transports all amino acids including citruline and eight tested toxic amino acid derivatives from Candida albicans (see paper)
33% identity, 81% coverage of query (185 bits)
GNP1_YEAST / P48813 High-affinity glutamine permease from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 5 papers)
TC 2.A.3.10.5 / P48813 High affinity glutamine permease from Saccharomyces cerevisiae (Baker's yeast) (see 12 papers)
GNP1 / GI|927778 high-affinity glutamine permease from Saccharomyces cerevisiae
30% identity, 91% coverage of query (183 bits)
GAP1_YEAST / P19145 General amino-acid permease GAP1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 19 papers)
TC 2.A.3.10.2 / P19145 General amino acid permease (all L-amino acids and some D-amino acids as well as β-alanine, polyamines and GABA) from Saccharomyces cerevisiae (Baker's yeast) (see 8 papers)
GAP1 / RF|NP_012965.1 general amino-acid permease GAP1 from Saccharomyces cerevisiae
33% identity, 81% coverage of query (174 bits)
CAT1_SCHPO / Q9URZ4 Cationic amino acid transporter 1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
30% identity, 87% coverage of query (173 bits)
Build an alignment for RR42_RS33780 and 55 homologs with ≥ 30% identity
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6f34A / Q5L1G5 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. (see paper)
26% identity, 83% coverage of query (79.0 bits)
5oqtA Crystal structure of a bacterial cationic amino acid transporter (cat) homologue
26% identity, 83% coverage of query (78.2 bits)
SSY1_YEAST / Q03770 SPS-sensor component SSY1; Amino-acid permease homolog SSY1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 9 papers)
TC 2.A.3.10.12 / Q03770 Leucine sensor/transcription factor. Mutants hyper- and hyposensitive to inducer (Poulsen et al., 2008) suggest a sensor mechanism involving outward and inward facing conformations from Saccharomyces cerevisiae (Baker's yeast) (see 12 papers)
SSY1 / RF|NP_010444.1 amino-acid permease SSY1 from Saccharomyces cerevisiae (see paper)
23% identity, 88% coverage of query (74.3 bits)
STET_BACSU / O34739 Serine/threonine exchanger SteT from Bacillus subtilis (strain 168) (see paper)
TC 2.A.3.8.12 / O34739 The Ser/Thr exchange transporter (SteT) (also transports aromatic amino acids with lower efficiency) (Reig et al., 2007). The substrate-bound state of SteT shows increased conformational flexibility and kinetic stability, enabling transport of substrate across the cell membrane (Bippes et al. 2009). TMS8 sculpts the substrate-binding site and undergoes conformational changes during the transport cycle of SteT (Bartoccioni et al., 2010). Mutations allow substrate binding but not translocation. Other mutations stabilize the protein and result in higher production levels from Bacillus subtilis (see 2 papers)
23% identity, 95% coverage of query (61.6 bits)
SLC7A8 / Q9UHI5 large neutral amino acids transporter small subunit 2 from Homo sapiens (see 4 papers)
LAT2_HUMAN / Q9UHI5 Large neutral amino acids transporter small subunit 2; L-type amino acid transporter 2; hLAT2; Solute carrier family 7 member 8 from Homo sapiens (Human) (see 14 papers)
TC 2.A.3.8.20 / Q9UHI5 Large neutral amino acids transporter small subunit 2 (L-type amino acid transporter 2) (hLAT2) (Solute carrier family 7 member 8). Certain detergents stabilize and allow purification of the 4F2hc-LAT2 complex, allowing the measurement of substrate binding. In addition, an improved 3D map could be obtained from Homo sapiens (see 12 papers)
23% identity, 81% coverage of query (57.4 bits)
7b00A Human lat2-4f2hc complex in the apo-state
23% identity, 81% coverage of query (55.8 bits)
7cmiB The lat2-4f2hc complex in complex with leucine
23% identity, 81% coverage of query (55.8 bits)
7cmhB / Q9UHI5 The lat2-4f2hc complex in complex with tryptophan (see paper)
23% identity, 81% coverage of query (55.8 bits)
LAT2_MOUSE / Q9QXW9 Large neutral amino acids transporter small subunit 2; L-type amino acid transporter 2; mLAT2; Solute carrier family 7 member 8 from Mus musculus (Mouse) (see 6 papers)
23% identity, 81% coverage of query (55.5 bits)
YjdD / b4115 arginine:agmatine antiporter from Escherichia coli K-12 substr. MG1655 (see 3 papers)
adiC / P60061 arginine:agmatine antiporter from Escherichia coli (strain K12) (see 2 papers)
ADIC_ECOLI / P60061 Arginine/agmatine antiporter from Escherichia coli (strain K12) (see 6 papers)
ADIC_ECO57 / P60063 Arginine/agmatine antiporter from Escherichia coli O157:H7 (see 3 papers)
TC 2.A.3.2.5 / P60061 Homodimeric electrogenic arginine (Km=80μM):agmatine antiporter, AdiC, involved in extreme acid resistance (Fang et al., 2007; Gong et al., 2003; Iyer et al., 2003). A projection structure at 6.5 Å resolution has been published (Casagrande et al., 2008), and the 3.2 Å resolution X-ray structure was determined by Fang et al., 2009 and Gao et al., 2009 from Escherichia coli (see 6 papers)
adiC / GB|AAN45533.1 arginine/agmatine antiporter from Shigella flexneri (see 6 papers)
22% identity, 87% coverage of query (47.0 bits)
3l1lA Structure of arg-bound escherichia coli adic
22% identity, 85% coverage of query (46.6 bits)
5j4nA / P60061 Crystal structure of the l-arginine/agmatine antiporter adic in complex with agmatine at 2.6 angstroem resolution (see paper)
22% identity, 85% coverage of query (46.6 bits)
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Lawrence Berkeley National Laboratory