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Searching for up to 100 curated homologs for SM_b20130 SM_b20130 dehydrogenase (287 a.a.)

Found high-coverage hits (≥70%) to 86 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

XdhB / b2867 putative xanthine dehydrogenase FAD-binding subunit XdhB (EC 1.17.1.4) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
xdhB / Q46800 putative xanthine dehydrogenase FAD-binding subunit XdhB (EC 1.17.1.4) from Escherichia coli (strain K12) (see 2 papers)
Q46800 xanthine dehydrogenase (subunit 1/2) (EC 1.17.1.4) from Escherichia coli (see paper)
    31% identity, 98% coverage of query (148 bits)

DCMM_HYDPS / P19914 Carbon monoxide dehydrogenase medium chain; CO dehydrogenase subunit M; CO-DH M; EC 1.2.5.3 from Hydrogenophaga pseudoflava (Pseudomonas carboxydoflava) (see paper)
P19914 aerobic carbon monoxide dehydrogenase (subunit 2/3) (EC 1.2.5.3) from Hydrogenophaga pseudoflava (see 2 papers)
    34% identity, 98% coverage of query (132 bits)

1ffuC / P19914 Carbon monoxide dehydrogenase from hydrogenophaga pseudoflava which lacks the mo-pyranopterin moiety of the molybdenum cofactor (see paper)
    35% identity, 98% coverage of query (131 bits)

Q974U9 glyceraldehyde dehydrogenase (FAD-containing) (subunit 2/3) (EC 1.2.99.8) from Sulfurisphaera tokodaii (see paper)
    33% identity, 98% coverage of query (124 bits)

Dshi_2958 Xanthine dehydrogenase (EC 1.17.1.4) from Dinoroseobacter shibae DFL-12
    35% identity, 85% coverage of query (120 bits)

4zohB / Q974U9 Crystal structure of glyceraldehyde oxidoreductase (see paper)
    33% identity, 96% coverage of query (116 bits)

SSO2636 / Q97VI7 glycolaldehyde oxidoreductase medium subunit from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (see paper)
    31% identity, 98% coverage of query (115 bits)

1n5wC / P19920 Crystal structure of the cu,mo-co dehydrogenase (codh); oxidized form (see paper)
    30% identity, 96% coverage of query (109 bits)

ndhA / Q59127 NdhA (EC 1.5.99.4) from Paenarthrobacter nicotinovorans (see 2 papers)
Q59127 nicotine dehydrogenase (EC 1.5.99.4) from Paenarthrobacter nicotinovorans (see 2 papers)
AAK64243.1 ndhM from Paenarthrobacter nicotinovorans (see paper)
    31% identity, 95% coverage of query (109 bits)

DCMM_AFIC5 / P19920 Carbon monoxide dehydrogenase medium chain; CO dehydrogenase subunit M; CO-DH M; EC 1.2.5.3 from Afipia carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5) (Oligotropha carboxidovorans) (see 3 papers)
P19920 aerobic carbon monoxide dehydrogenase (EC 1.2.5.3); anaerobic carbon-monoxide dehydrogenase (subunit 2/3) (EC 1.2.7.4) from Afipia carboxidovorans (see 3 papers)
    30% identity, 96% coverage of query (109 bits)

Build an alignment

Build an alignment for SM_b20130 and 10 homologs with ≥ 30% identity

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Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

3hrdG / Q0QLF4 Crystal structure of nicotinate dehydrogenase (see paper)
    29% identity, 96% coverage of query (108 bits)

ndhF / Q0QLF4 nicotinate hydroxylase 33 kD subunit (EC 1.17.1.5) from Eubacterium barkeri (see paper)
NDFS_EUBBA / Q0QLF4 Nicotinate dehydrogenase FAD-subunit; NDH; Nicotinic acid hydroxylase FAD-subunit; NAH; EC 1.17.1.5 from Eubacterium barkeri (Clostridium barkeri) (see 3 papers)
    29% identity, 96% coverage of query (108 bits)

cutB / Q4J6M6 aldehyde dehydrogenase β subunit (EC 1.2.99.8) from Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) (see paper)
CUTB_SULAC / Q4J6M6 Glyceraldehyde dehydrogenase medium chain; Glyceraldehyde dehydrogenase subunit B; Glyceraldehyde dehydrogenase subunit beta; EC 1.2.99.8 from Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) (see paper)
Q4J6M6 glyceraldehyde dehydrogenase (FAD-containing) (subunit 2/3) (EC 1.2.99.8) from Sulfolobus acidocaldarius (see paper)
    29% identity, 96% coverage of query (107 bits)

PS417_20885 Xanthine dehydrogenase (EC 1.17.1.4) from Pseudomonas simiae WCS417
    30% identity, 90% coverage of query (106 bits)

atcB / A0A127F985 1-testosterone hydratase/dehydrogenase β subunit (EC 1.17.99.11) from Steroidobacter denitrificans (see 2 papers)
A0A127F985 3-oxo-DELTA1-steroid hydratase/dehydrogenase (subunit 2/3) (EC 1.17.99.11) from Steroidobacter denitrificans (see paper)
    30% identity, 98% coverage of query (105 bits)

O54050 xanthine dehydrogenase (subunit 2/2) (EC 1.17.1.4); xanthine oxidase (EC 1.17.3.2) from Rhodobacter capsulatus (see 2 papers)
xdhA / CAA04469.1 xanthine dehydrogenase from Rhodobacter capsulatus (see paper)
    32% identity, 94% coverage of query (103 bits)

1jroA / O54050 Crystal structure of xanthine dehydrogenase from rhodobacter capsulatus (see paper)
    32% identity, 94% coverage of query (103 bits)

2w54A Crystal structure of xanthine dehydrogenase from rhodobacter capsulatus in complex with bound inhibitor pterin-6-aldehyde
    32% identity, 94% coverage of query (103 bits)

F9VNL6 glyceraldehyde dehydrogenase (FAD-containing) (subunit 2/3) (EC 1.2.99.8) from Sulfurisphaera tokodaii (see paper)
    29% identity, 98% coverage of query (97.1 bits)

XDH2_ARATH / F4JLI5 Xanthine dehydrogenase 2; AtXDH2; EC 1.17.1.4 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    29% identity, 89% coverage of query (97.1 bits)

AO356_02560 Xanthine dehydrogenase (EC 1.17.1.4) from Pseudomonas fluorescens FW300-N2C3
    29% identity, 90% coverage of query (95.9 bits)

1t3qC / P72222 Crystal structure of quinoline 2-oxidoreductase from pseudomonas putida 86 (see paper)
    32% identity, 99% coverage of query (94.4 bits)

P72222 quinoline 2-oxidoreductase (subunit 3/3) (EC 1.3.99.17) from Pseudomonas putida (see paper)
    32% identity, 99% coverage of query (94.0 bits)

XDH1 / Q8GUQ8 xanthine dehydrogenase monomer (EC 1.17.1.4) from Arabidopsis thaliana (see paper)
XDH1_ARATH / Q8GUQ8 Xanthine dehydrogenase 1; AtXDH1; EC 1.17.1.4 from Arabidopsis thaliana (Mouse-ear cress) (see 6 papers)
    29% identity, 89% coverage of query (93.2 bits)

kdhA / O87681 ketone dehydrogenase medium subunit (EC 1.5.99.14) from Paenarthrobacter nicotinovorans (see paper)
KDHA_PAENI / O87681 6-hydroxypseudooxynicotine dehydrogenase complex subunit alpha; Ketone dehydrogenase medium FAD subunit; EC 1.5.99.14 from Paenarthrobacter nicotinovorans (Arthrobacter nicotinovorans) (see paper)
AAK64248.1 kdhM from Paenarthrobacter nicotinovorans (see paper)
kdhM / CAC37486.2 ketone dehydrogenase medium subunit from Paenarthrobacter nicotinovorans (see paper)
    29% identity, 99% coverage of query (92.8 bits)

7dqxE / O87681 Crystal structure of xanthine dehydrogenase family protein
    29% identity, 99% coverage of query (92.8 bits)

D5G1Y0 anaerobic carbon-monoxide dehydrogenase (subunit 2/3) (EC 1.2.7.4) from Mycobacterium sp. (see paper)
    29% identity, 97% coverage of query (89.0 bits)

A0A1S4F2J6 xanthine dehydrogenase (EC 1.17.1.4) from Aedes aegypti (see paper)
    28% identity, 88% coverage of query (88.2 bits)

CDHB_PSEU3 / D7REY4 Caffeine dehydrogenase subunit beta; Caffeine dehydrogenase medium subunit; EC 1.17.5.2 from Pseudomonas sp. (strain CBB1) (see paper)
    27% identity, 98% coverage of query (88.2 bits)

XDH_DROME / P10351 Xanthine dehydrogenase; XD; Protein rosy locus; EC 1.17.1.4 from Drosophila melanogaster (Fruit fly) (see paper)
    29% identity, 95% coverage of query (88.2 bits)

XDH_CHICK / P47990 Xanthine dehydrogenase/oxidase; EC 1.17.1.4; EC 1.17.3.2 from Gallus gallus (Chicken) (see 2 papers)
    25% identity, 92% coverage of query (87.8 bits)

XDH_BLAAD / R4ZGN4 Xanthine dehydrogenase; XD; Xanthine oxidoreductase; Axorp; XOR; EC 1.17.1.4 from Blastobotrys adeninivorans (Yeast) (Arxula adeninivorans) (see 2 papers)
R4ZGN4 xanthine oxidase (EC 1.17.3.2) from Blastobotrys adeninivorans (see paper)
    28% identity, 86% coverage of query (83.6 bits)

A0A1S4G2F8 xanthine dehydrogenase (EC 1.17.1.4) from Aedes aegypti (see paper)
    26% identity, 86% coverage of query (82.8 bits)

Q17209 xanthine dehydrogenase (EC 1.17.1.4); aldehyde oxidase (EC 1.2.3.1) from Bombyx mori (see paper)
    26% identity, 98% coverage of query (76.3 bits)

XDH / P47989 xanthine dehydrogenase monomer (EC 1.17.1.4) from Homo sapiens (see 14 papers)
XDH_HUMAN / P47989 Xanthine dehydrogenase/oxidase; EC 1.17.1.4; EC 1.17.3.2 from Homo sapiens (Human) (see 6 papers)
P47989 xanthine oxidase (EC 1.17.3.2) from Homo sapiens (see paper)
    27% identity, 78% coverage of query (75.9 bits)

2e1qA / P47989 Crystal structure of human xanthine oxidoreductase mutant, glu803val (see paper)
    27% identity, 78% coverage of query (75.9 bits)

3nrzB / P80457 Crystal structure of bovine xanthine oxidase in complex with hypoxanthine (see paper)
3nrzK / P80457 Crystal structure of bovine xanthine oxidase in complex with hypoxanthine (see paper)
    24% identity, 86% coverage of query (75.5 bits)

XDH_EMENI / Q12553 Xanthine dehydrogenase; Purine hydroxylase I; EC 1.17.1.4 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see paper)
hxA xanthine dehydrogenase (purine hydroxylase I); EC 1.17.1.4 from Emericella nidulans (see 2 papers)
    23% identity, 87% coverage of query (74.7 bits)

F1S3Y7 xanthine oxidase (EC 1.17.3.2) from Sus scrofa (see paper)
    27% identity, 78% coverage of query (73.9 bits)

3ax7A / P80457 Bovine xanthine oxidase, protease cleaved form (see paper)
    25% identity, 78% coverage of query (73.6 bits)

1fo4A / P80457 Crystal structure of xanthine dehydrogenase isolated from bovine milk (see paper)
    25% identity, 78% coverage of query (73.6 bits)

XDH_BOVIN / P80457 Xanthine dehydrogenase/oxidase; EC 1.17.1.4; EC 1.17.3.2 from Bos taurus (Bovine) (see 6 papers)
P80457 xanthine dehydrogenase (EC 1.17.1.4); xanthine oxidase (EC 1.17.3.2) from Bos taurus (see 15 papers)
    25% identity, 78% coverage of query (73.6 bits)

hbaD / G3XCQ8 4-hydroxybenzoyl-CoA reductase HbaD subunit (EC 1.1.7.1) from Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009) (see 7 papers)
    27% identity, 87% coverage of query (73.6 bits)

3unaA Crystal structure of bovine milk xanthine dehydrogenase with NAD bound
    25% identity, 78% coverage of query (73.6 bits)

3amzA Bovine xanthine oxidoreductase urate bound form
    25% identity, 78% coverage of query (73.6 bits)

3am9A Complex of bovine xanthine dehydrogenase and trihydroxy fyx-051
    25% identity, 78% coverage of query (73.6 bits)

1vdvA Bovine milk xanthine dehydrogenase y-700 bound form
    25% identity, 78% coverage of query (73.6 bits)

1v97A Crystal structure of bovine milk xanthine dehydrogenase fyx-051 bound form
    25% identity, 78% coverage of query (73.6 bits)

1n5xA Xanthine dehydrogenase from bovine milk with inhibitor tei-6720 bound
    25% identity, 78% coverage of query (73.6 bits)

3bdjA Crystal structure of bovine milk xanthine dehydrogenase with a covalently bound oxipurinol inhibitor
    25% identity, 78% coverage of query (73.6 bits)

5y6qB / Q84IX9 Crystal structure of an aldehyde oxidase from methylobacillus sp. Ky4400 (see paper)
    25% identity, 88% coverage of query (73.2 bits)

6a7xA Rat xanthine oxidoreductase, d428a variant, NAD bound form
    26% identity, 78% coverage of query (73.2 bits)

2e3tA Crystal structure of rat xanthine oxidoreductase mutant (w335a and f336l)
    25% identity, 86% coverage of query (73.2 bits)

6a7xB Rat xanthine oxidoreductase, d428a variant, NAD bound form
    26% identity, 78% coverage of query (73.2 bits)

Xdh / P22985 xanthine oxidoreductase subunit (EC 1.17.1.4; EC 1.17.3.2) from Rattus norvegicus (see paper)
XDH_RAT / P22985 Xanthine dehydrogenase/oxidase; EC 1.17.1.4; EC 1.17.3.2 from Rattus norvegicus (Rat) (see 4 papers)
P22985 xanthine dehydrogenase (EC 1.17.1.4); xanthine oxidase (EC 1.17.3.2) from Rattus norvegicus (see 4 papers)
    26% identity, 78% coverage of query (72.4 bits)

4yswA Structure of rat xanthine oxidoreductase, c-terminal deletion protein variant, nadh bound form
    26% identity, 78% coverage of query (72.4 bits)

2ckjA / P47989 Human milk xanthine oxidoreductase
    27% identity, 78% coverage of query (71.6 bits)

Xdh / Q00519 xanthine oxidase monomer (EC 1.17.1.4; EC 1.17.3.2) from Mus musculus (see 4 papers)
XDH_MOUSE / Q00519 Xanthine dehydrogenase/oxidase; EC 1.17.1.4; EC 1.17.3.2 from Mus musculus (Mouse) (see paper)
    27% identity, 71% coverage of query (71.6 bits)

YagS / b0285 aldehyde dehydrogenase, FAD-binding subunit (EC 1.2.99.6) from Escherichia coli K-12 substr. MG1655 (see paper)
paoB / P77324 aldehyde dehydrogenase, FAD-binding Fe-S subunit (EC 1.2.99.6) from Escherichia coli (strain K12) (see 3 papers)
PAOB_ECOLI / P77324 Aldehyde oxidoreductase FAD-binding subunit PaoB; EC 1.2.99.6 from Escherichia coli (strain K12) (see 4 papers)
P77324 xanthine dehydrogenase (subunit 2/3) (EC 1.17.1.4) from Escherichia coli (see paper)
    29% identity, 77% coverage of query (70.5 bits)

5g5gB / P77324 Escherichia coli periplasmic aldehyde oxidase (see paper)
    29% identity, 77% coverage of query (70.5 bits)

Q5QE78 aldehyde oxidase (EC 1.2.3.1) from Rattus norvegicus (see paper)
    25% identity, 93% coverage of query (64.3 bits)

AOXB_MOUSE / Q5SGK3 Aldehyde oxidase 2; Aldehyde oxidase homolog 3; Azaheterocycle hydroxylase 2; EC 1.2.3.1; EC 1.17.3.- from Mus musculus (Mouse) (see 2 papers)
Q5SGK3 aldehyde oxidase (EC 1.2.3.1) from Mus musculus (see 4 papers)
    24% identity, 93% coverage of query (61.2 bits)

F6Y8K6 aldehyde oxidase (EC 1.2.3.1) from Callithrix jacchus (see paper)
    24% identity, 86% coverage of query (61.2 bits)

Q2QB49 aldehyde oxidase (EC 1.2.3.1) from Gallus gallus (see 2 papers)
    24% identity, 93% coverage of query (60.5 bits)

AAO2 / Q7G192 aldehyde oxidase subunit (EC 1.2.3.9; EC 1.2.3.1) from Arabidopsis thaliana (see paper)
ALDO2_ARATH / Q7G192 Indole-3-acetaldehyde oxidase; IAA oxidase; Aldehyde oxidase 2; AO-2; AtAO-2; AtAO3; EC 1.2.3.7 from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
Q7G192 aldehyde oxidase (EC 1.2.3.1) from Arabidopsis thaliana (see paper)
    26% identity, 93% coverage of query (60.5 bits)

AOXA_BOVIN / P48034 Aldehyde oxidase 1; Azaheterocycle hydroxylase 1; EC 1.2.3.1; EC 1.17.3.- from Bos taurus (Bovine) (see paper)
P48034 aldehyde oxidase (EC 1.2.3.1) from Bos taurus (see 3 papers)
    25% identity, 80% coverage of query (59.3 bits)

AOXA_MACFA / Q5FB27 Aldehyde oxidase 1; Azaheterocycle hydroxylase 1; EC 1.2.3.1; EC 1.17.3.- from Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) (see paper)
Q5FB27 aldehyde oxidase (EC 1.2.3.1) from Macaca fascicularis (see 2 papers)
    25% identity, 89% coverage of query (59.3 bits)

AOXC_RAT / Q5QE80 Aldehyde oxidase 3; Aldehyde oxidase homolog 1; Azaheterocycle hydroxylase 3; EC 1.2.3.1; EC 1.17.3.- from Rattus norvegicus (Rat) (see 2 papers)
Q5QE80 aldehyde oxidase (EC 1.2.3.1) from Rattus norvegicus (see paper)
    24% identity, 85% coverage of query (57.4 bits)

YgfM / b2880 putative oxidoreductase from Escherichia coli K-12 substr. MG1655 (see paper)
    27% identity, 94% coverage of query (57.4 bits)

AOX1 / Q06278 aldehyde oxidase monomer (EC 1.2.3.1) from Homo sapiens (see 5 papers)
AOXA_HUMAN / Q06278 Aldehyde oxidase; Aldehyde oxidase 1; Azaheterocycle hydroxylase; EC 1.2.3.1; EC 1.17.3.- from Homo sapiens (Human) (see 14 papers)
Q06278 aldehyde oxidase (EC 1.2.3.1) from Homo sapiens (see 5 papers)
    24% identity, 89% coverage of query (56.6 bits)

7orcB / Q06278 Human aldehyde oxidase in complex with raloxifene (see paper)
    24% identity, 89% coverage of query (56.6 bits)

8emtA / Q06278 Cryo-em analysis of the human aldehyde oxidase from liver (see paper)
    24% identity, 89% coverage of query (56.2 bits)

4uhxA Human aldehyde oxidase in complex with phthalazine and thioridazine
    24% identity, 89% coverage of query (56.2 bits)

8emtB / Q06278 Cryo-em analysis of the human aldehyde oxidase from liver (see paper)
    24% identity, 89% coverage of query (55.8 bits)

AOXB_MACFA / C4NYZ3 Aldehyde oxidase 2; Aldehyde oxidase homolog 3; Azaheterocycle hydroxylase 2; EC 1.2.3.1; EC 1.17.3.- from Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) (see paper)
    25% identity, 87% coverage of query (55.5 bits)

AOXA_RAT / Q9Z0U5 Aldehyde oxidase 1; Azaheterocycle hydroxylase 1; EC 1.2.3.1; EC 1.17.3.- from Rattus norvegicus (Rat) (see 5 papers)
Q9Z0U5 aldehyde oxidase (EC 1.2.3.1) from Rattus norvegicus (see 4 papers)
    25% identity, 82% coverage of query (55.1 bits)

AOXB_CAVPO / H9TB19 Aldehyde oxidase 2; Aldehyde oxidase homolog 3; Azaheterocycle hydroxylase 2; EC 1.2.3.1; EC 1.17.3.- from Cavia porcellus (Guinea pig) (see paper)
    25% identity, 87% coverage of query (54.7 bits)

Q2QB48 aldehyde oxidase (EC 1.2.3.1) from Canis lupus familiaris (see 2 papers)
    24% identity, 86% coverage of query (53.9 bits)

hcrB / Q5P3F4 4-hydroxybenzoyl-CoA reductase, β subunit (EC 1.1.7.1) from Aromatoleum aromaticum (strain EbN1) (see 3 papers)
    23% identity, 98% coverage of query (52.8 bits)

AOXA_CAVPO / H9TB17 Aldehyde oxidase 1; Azaheterocycle hydroxylase 1; EC 1.2.3.1; EC 1.17.3.- from Cavia porcellus (Guinea pig) (see 2 papers)
    25% identity, 93% coverage of query (52.4 bits)

1rm6B / O33820 Structure of 4-hydroxybenzoyl-coa reductase from thauera aromatica (see paper)
    23% identity, 97% coverage of query (52.0 bits)

hcrB / O33820 4-hydroxybenzoyl-CoA reductase β subunit (EC 1.1.7.1) from Thauera aromatica (see paper)
HCRB_THAAR / O33820 4-hydroxybenzoyl-CoA reductase subunit beta; 4-HBCR subunit beta; EC 1.1.7.1 from Thauera aromatica (see 2 papers)
hcrB / CAA05039.1 4-Hydroxybenzoyl-CoA reductase beta-subunit from Thauera aromatica (see paper)
    23% identity, 97% coverage of query (51.6 bits)

Q6V956 aldehyde oxidase (EC 1.2.3.1) from Mus musculus (see paper)
    24% identity, 80% coverage of query (51.6 bits)

AOXC_MOUSE / G3X982 Aldehyde oxidase 3; Aldehyde oxidase homolog 1; Azaheterocycle hydroxylase 3; EC 1.2.3.1; EC 1.17.3.- from Mus musculus (Mouse) (see 5 papers)
G3X982 aldehyde oxidase (EC 1.2.3.1) from Mus musculus (see 4 papers)
    24% identity, 80% coverage of query (51.2 bits)

Q2QB47 aldehyde oxidase (EC 1.2.3.1) from Canis lupus familiaris (see 2 papers)
    24% identity, 87% coverage of query (50.1 bits)

AAO1 / Q7G193 AO1 (EC 1.2.3.1; EC 1.2.3.9; EC 1.2.3.7) from Arabidopsis thaliana (see paper)
ALDO1_ARATH / Q7G193 Indole-3-acetaldehyde oxidase; IAA oxidase; Aldehyde oxidase 1; AO-1; AtAO-1; AtAO1; EC 1.2.3.7 from Arabidopsis thaliana (Mouse-ear cress) (see 7 papers)
Q7G193 aldehyde oxidase (EC 1.2.3.1); indole-3-acetaldehyde oxidase (EC 1.2.3.7) from Arabidopsis thaliana (see 2 papers)
    23% identity, 89% coverage of query (46.6 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory