Searching for up to 100 curated homologs for SM_b20259 FitnessBrowser__Smeli:SM_b20259 (320 a.a.)
Found high-coverage hits (≥70%) to 48 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
A9CGZ4 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Agrobacterium tumefaciens (see paper)
88% identity, 100% coverage of query (571 bits)
2hmcA / A9CGZ4 The crystal structure of dihydrodipicolinate synthase dapa from agrobacterium tumefaciens
89% identity, 97% coverage of query (557 bits)
lhpC / Q88NF4 Δ1-pyrroline-4-hydroxy-2-carboxylate deaminase subunit (EC 3.5.4.22) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see 2 papers)
74% identity, 97% coverage of query (462 bits)
O67216 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Aquifex aeolicus (see paper)
30% identity, 93% coverage of query (96.7 bits)
DAPA_AGRFC / Q8UGL3 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; EC 4.3.3.7 from Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58)) (see paper)
Q8UGL3 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Agrobacterium tumefaciens (see 2 papers)
34% identity, 72% coverage of query (90.9 bits)
4i7wA / F0L8Z6 Agrobacterium tumefaciens dhdps with lysine and pyruvate
34% identity, 72% coverage of query (89.7 bits)
DAPA_RHIML / Q07607 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; Protein MosA; EC 4.3.3.7 from Rhizobium meliloti (Ensifer meliloti) (Sinorhizobium meliloti) (see 2 papers)
Q07607 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Sinorhizobium meliloti (see 2 papers)
32% identity, 75% coverage of query (87.4 bits)
Q8RBI5 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Caldanaerobacter subterraneus subsp. tengcongensis (see paper)
32% identity, 75% coverage of query (86.7 bits)
DAPA_NEIMB / Q9JZR4 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; EC 4.3.3.7 from Neisseria meningitidis serogroup B (strain MC58) (see paper)
Q9JZR4 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Neisseria meningitidis (see paper)
33% identity, 72% coverage of query (86.3 bits)
Q8NMD2 N-acetylneuraminate lyase (EC 4.1.3.3) from Corynebacterium glutamicum (see paper)
31% identity, 71% coverage of query (82.4 bits)
Build an alignment for SM_b20259 and 10 homologs with ≥ 30% identity
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DAPA_METJA / Q57695 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; EC 4.3.3.7 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
28% identity, 76% coverage of query (82.0 bits)
4pfmA / A9DKW4 Shewanella benthica dhdps with lysine and pyruvate
27% identity, 87% coverage of query (80.5 bits)
7lvlA / A0A0F4VK59 Dihydrodipicolinate synthase bound with allosteric inhibitor (s)- lysine from candidatus liberibacter solanacearum
30% identity, 78% coverage of query (80.1 bits)
7mjfA Crystal structure of candidatus liberibacter solanacearum dihydrodipicolinate synthase with pyruvate and succinic semi-aldehyde bound in active site
30% identity, 78% coverage of query (80.1 bits)
dhdps / CAC50571.1 dihydrodipicolinate synthetase from Yersinia enterocolitica (see paper)
30% identity, 75% coverage of query (77.0 bits)
Q3M723 4-hydroxy-tetrahydrodipicolinate reductase (EC 1.17.1.8) from Trichormus variabilis (see paper)
29% identity, 73% coverage of query (75.1 bits)
5ktlA / Q3M723 Dihydrodipicolinate synthase from the industrial and evolutionarily important cyanobacteria anabaena variabilis. (see paper)
29% identity, 73% coverage of query (74.7 bits)
DAPAL_RHIML / O69782 Uncharacterized DapA-like lyase; EC 4.-.-.- from Rhizobium meliloti (Ensifer meliloti) (Sinorhizobium meliloti) (see paper)
29% identity, 76% coverage of query (73.9 bits)
HOGA1 / Q86XE5 4-hydroxy-2-ketoglutarate aldolase subunit (EC 4.1.3.16) from Homo sapiens (see 6 papers)
HOGA1_HUMAN / Q86XE5 4-hydroxy-2-oxoglutarate aldolase, mitochondrial; Dihydrodipicolinate synthase-like; DHDPS-like protein; Probable 2-keto-4-hydroxyglutarate aldolase; Probable KHG-aldolase; Protein 569272; EC 4.1.3.16 from Homo sapiens (Human) (see 2 papers)
Q86XE5 4-Hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16) from Homo sapiens (see 5 papers)
27% identity, 78% coverage of query (71.6 bits)
YjhH / b4298 KpLE2 phage-like element; putative 2-dehydro-3-deoxy-D-pentonate aldolase (EC 4.1.2.28) from Escherichia coli K-12 substr. MG1655 (see 8 papers)
yjhH / P39359 KpLE2 phage-like element; putative 2-dehydro-3-deoxy-D-pentonate aldolase (EC 4.1.2.28) from Escherichia coli (strain K12) (see 7 papers)
YJHH_ECOLI / P39359 Probable 2-dehydro-3-deoxy-D-pentonate aldolase YjhH; EC 4.1.2.28 from Escherichia coli (strain K12) (see paper)
29% identity, 73% coverage of query (71.6 bits)
4dxvA / D0CFC3 Crystal structure of dihydrodipicolinate synthase from acinetobacter baumannii complexed with mg and cl ions at 1.80 a resolution
27% identity, 83% coverage of query (70.5 bits)
HOGA1_BOVIN / Q0P5I5 4-hydroxy-2-oxoglutarate aldolase, mitochondrial; Dihydrodipicolinate synthase-like; DHDPS-like protein; Probable 2-keto-4-hydroxyglutarate aldolase; Probable KHG-aldolase; EC 4.1.3.16 from Bos taurus (Bovine) (see 2 papers)
Q0P5I5 4-Hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16) from Bos taurus (see paper)
27% identity, 78% coverage of query (70.5 bits)
3u8gA Crystal structure of the complex of dihydrodipicolinate synthase from acinetobacter baumannii with oxalic acid at 1.80 a resolution
27% identity, 83% coverage of query (70.5 bits)
3tdfA Crystal structure of the complex of dihydrodipicolinate synthase from acinetobacter baumannii with 2-ketobutanoic acid at 1.99 a resolution
27% identity, 83% coverage of query (70.5 bits)
3tceA Crystal structure of the complex of dihydrodipicolinate synthase from acinetobacter baumannii with 5-hydroxylysine at 2.6 a resolution
27% identity, 83% coverage of query (70.5 bits)
3rk8A Crystal structure of the chloride inhibited dihydrodipicolinate synthase from acinetobacter baumannii complexed with pyruvate at 1.8 a resolution
27% identity, 83% coverage of query (70.5 bits)
3pueB Crystal structure of the complex of dhydrodipicolinate synthase from acinetobacter baumannii with lysine at 2.6a resolution
27% identity, 83% coverage of query (70.5 bits)
dapA2 dihydrodipicolinate synthase; EC 4.2.1.52 from Bacillus anthracis (see paper)
28% identity, 76% coverage of query (69.3 bits)
5t25A / B7M7I1 Kinetic, spectral and structural characterization of the slow binding inhibitor acetopyruvate with dihydrodipicolinate synthase from escherichia coli.
31% identity, 77% coverage of query (68.9 bits)
3l21B The crystal structure of a dimeric mutant of dihydrodipicolinate synthase (dapa, rv2753c) from mycobacterium tuberculosis - dhdps- a204r
30% identity, 71% coverage of query (67.0 bits)
1xxxA Crystal structure of dihydrodipicolinate synthase (dapa, rv2753c) from mycobacterium tuberculosis
30% identity, 71% coverage of query (66.2 bits)
5j5dA / P9WP25 Crystal structure of dihydrodipicolinate synthase from mycobacterium tuberculosis in complex with alpha-ketopimelic acid (see paper)
30% identity, 71% coverage of query (65.9 bits)
Q8A3Z0 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Bacteroides thetaiotaomicron (see paper)
26% identity, 74% coverage of query (65.9 bits)
5ud6C / M1V4H9 Crystal structure of dhdps from cyanidioschyzon merolae with lysine bound
29% identity, 78% coverage of query (65.9 bits)
DAPA_MYCTU / P9WP25 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; EC 4.3.3.7 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 3 papers)
30% identity, 71% coverage of query (65.9 bits)
A5F699 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Vibrio cholerae (see paper)
27% identity, 91% coverage of query (64.3 bits)
Q7D3Z9 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Agrobacterium tumefaciens (see paper)
24% identity, 74% coverage of query (55.1 bits)
C8P490 N-acetylneuraminate lyase (EC 4.1.3.3) from Limosilactobacillus antri (see paper)
27% identity, 74% coverage of query (54.7 bits)
CNSN_PENEN / A0A0A2JW93 Communesin biosynthesis cluster-specific transcription factor cnsN; Communesin biosynthesis cluster protein N from Penicillium expansum (Blue mold rot fungus) (see paper)
25% identity, 73% coverage of query (53.9 bits)
2wpbA / P0A6L4 Crystal structure of the e192n mutant of e. Coli n-acetylneuraminic acid lyase in complex with pyruvate and the inhibitor (2r,3r)-2,3,4- trihydroxy-n,n-dipropylbutanamide in space group p21 crystal form i (see paper)
26% identity, 74% coverage of query (50.4 bits)
Npl / b3225 N-acetylneuraminate lyase (EC 4.1.3.3) from Escherichia coli K-12 substr. MG1655 (see 21 papers)
nanA / P0A6L4 N-acetylneuraminate lyase (EC 4.1.3.3) from Escherichia coli (strain K12) (see 30 papers)
NANA_ECOLI / P0A6L4 N-acetylneuraminate lyase; NAL; Neu5Ac lyase; N-acetylneuraminate pyruvate-lyase; N-acetylneuraminic acid aldolase; NALase; Sialate lyase; Sialic acid aldolase; Sialic acid lyase; EC 4.1.3.3 from Escherichia coli (strain K12) (see 4 papers)
P0A6L4 N-acetylneuraminate lyase (EC 4.1.3.3) from Escherichia coli (see 4 papers)
nanA N-acetylneuraminate lyase; EC 4.1.3.3 from Escherichia coli K12 (see 6 papers)
26% identity, 74% coverage of query (50.4 bits)
3lbcD D-sialic acid aldolase complexed with l-arabinose
26% identity, 74% coverage of query (50.4 bits)
1fdzA N-acetylneuraminate lyase in complex with pyruvate via borohydride reduction
25% identity, 74% coverage of query (50.1 bits)
1fdyA N-acetylneuraminate lyase in complex with hydroxypyruvate
25% identity, 74% coverage of query (50.1 bits)
SSA_0078 / A3CK37 N-acetylneuraminate lyase subunit (EC 4.1.3.3) from Streptococcus sanguinis (strain SK36) (see 3 papers)
26% identity, 77% coverage of query (48.1 bits)
8u8wA / A0A0H3FJT8 Crystal structure of n-acetylneuraminate lyase (nana) from klebsiella aerogenes (pyruvate and halides bound)
25% identity, 74% coverage of query (48.1 bits)
4bwlA Structure of the y137a mutant of e. Coli n-acetylneuraminic acid lyase in complex with pyruvate, n-acetyl-d-mannosamine and n- acetylneuraminic acid
26% identity, 74% coverage of query (46.2 bits)
4bwlC Structure of the y137a mutant of e. Coli n-acetylneuraminic acid lyase in complex with pyruvate, n-acetyl-d-mannosamine and n- acetylneuraminic acid
26% identity, 74% coverage of query (46.2 bits)
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Lawrence Berkeley National Laboratory