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Searching for up to 100 curated homologs for SM_b20325 FitnessBrowser__Smeli:SM_b20325 (423 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

Removed hits that are identical to the query, leaving 99

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

TC 3.A.1.1.19 / Q8L126 PalE, component of Platinose (isomaltulose) (6-O-α-D-glucopyranosyl-D-fructofuranose) porter from Agrobacterium tumefaciens (see 3 papers)
palE / BAB96538.1 PalE from Agrobacterium tumefaciens (see 3 papers)
    77% identity, 100% coverage of query (651 bits)

TC 3.A.1.1.25 / Q72H68 Trehalose/maltose-binding protein aka TT_C1627, component of The trehalose/maltose/sucrose/palatinose porter (TTC1627-9) plus MalK1 (ABC protein, shared with 3.A.1.1.24) (Silva et al. 2005; Chevance et al., 2006). The receptor (TTC1627) binds disaccharide alpha-glycosides, namely trehalose (alpha-1,1), sucrose (alpha-1,2), maltose (alpha-1,4), palatinose (alpha-1,6) and glucose from Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) (see paper)
    48% identity, 92% coverage of query (383 bits)

6jahA Crystal structure of abc transporter alpha-glycoside-binding protein in complex with glucose
    48% identity, 92% coverage of query (382 bits)

6jagA Crystal structure of abc transporter alpha-glycoside-binding protein in complex with sucrose
    48% identity, 92% coverage of query (382 bits)

6jadA Crystal structure of abc transporter alpha-glycoside-binding protein in complex with palatinose
    48% identity, 92% coverage of query (382 bits)

6j9yA Crystal structure of abc transporter alpha-glycoside-binding protein in complex with maltose
    48% identity, 92% coverage of query (382 bits)

6jamA / Q5SLD7 Crystal structure of abc transporter alpha-glycoside-binding mutant protein r356a in complex with trehalose (see paper)
    48% identity, 92% coverage of query (379 bits)

6jaiA Crystal structure of abc transporter alpha-glycoside-binding mutant protein d118a in complex with maltose
    48% identity, 92% coverage of query (379 bits)

6jb0A Crystal structure of abc transporter alpha-glycoside-binding mutant protein w287a in complex with trehalose
    48% identity, 92% coverage of query (377 bits)

Pf1N1B4_5112 sucrose ABC transporter, substrate-binding component from Pseudomonas fluorescens FW300-N1B4
    44% identity, 92% coverage of query (350 bits)

TC 3.A.1.1.12 / Q9AI68 PalE, component of Palatinose (isomaltulose; 6-O-α-D-glucopyranosyl-D-fructose) uptake porter from Erwinia rhapontici (see paper)
    42% identity, 95% coverage of query (339 bits)

TC 3.A.1.1.41 / G4FGN8 Extracellular solute-binding protein family 1, component of Trehalose porter. Also binds sucrose (Boucher and Noll, 2011). Induced by glucose and trehalose. Directly regulated by trehalose-responsive regulator TreR from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    41% identity, 94% coverage of query (282 bits)

6dtqA / G4XU73 Maltose bound t. Maritima male3 (see paper)
    41% identity, 93% coverage of query (281 bits)

1eu8A / Q7LYW7 Structure of trehalose maltose binding protein from thermococcus litoralis (see paper)
    35% identity, 93% coverage of query (218 bits)

TC 3.A.1.1.7 / O51923 MalE aka PF1739, component of Maltose/trehalose porter (see paper)
    35% identity, 93% coverage of query (218 bits)

MALE_THELN / Q7LYW7 Trehalose/maltose-binding protein MalE; TMBP from Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C) (see 4 papers)
    35% identity, 93% coverage of query (215 bits)

smoF / A9CEY9 3-(6-sulfo-α-D-quinovosyl)-sn-glycerol binding protein from Agrobacterium fabrum (strain C58 / ATCC 33970) (see paper)
SMOF_AGRFC / A9CEY9 Sulfoquinovosyl glycerol-binding protein SmoF; SQGro-binding protein SmoF; SQ monooxygenase cluster protein F from Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58)) (see 2 papers)
    35% identity, 89% coverage of query (194 bits)

7yzsAAA Sulfoquinovosyl binding protein
    35% identity, 89% coverage of query (193 bits)

7ofyA Crystal structure of sq binding protein from agrobacterium tumefaciens in complex with sulfoquinovosyl glycerol (sqgro)
    35% identity, 89% coverage of query (193 bits)

7qhvAAA / A9CEY9 7qhvAAA (see paper)
    35% identity, 89% coverage of query (192 bits)

7yzuA Crystal structure of the sulfoquinovosyl binding protein smof complexed with sqme
    35% identity, 89% coverage of query (191 bits)

Build an alignment

Build an alignment for SM_b20325 and 21 homologs with ≥ 30% identity

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Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

SM_b21221 ABC transporter for D-Glucosamine, periplasmic substrate-binding protein from Sinorhizobium meliloti 1021
    29% identity, 77% coverage of query (106 bits)

3jzjA / B0B0V1 Crystal structures of the gach receptor of streptomyces glaucescens gla.O in the unliganded form and in complex with acarbose and an acarbose homolog. Comparison with acarbose-loaded maltose binding protein of salmonella typhimurium. (see paper)
    29% identity, 77% coverage of query (101 bits)

3k02A Crystal structures of the gach receptor of streptomyces glaucescens gla.O in the unliganded form and in complex with acarbose and an acarbose homolog. Comparison with acarbose-loaded maltose binding protein of salmonella typhimurium.
    29% identity, 77% coverage of query (101 bits)

LPQY_MYCT3 / G7CES0 Trehalose-binding lipoprotein LpqY; Extracellular solute-binding protein; SugABC transporter substrate-binding protein LpqY; SugABC transporter SBP LpqY from Mycolicibacterium thermoresistibile (strain ATCC 19527 / DSM 44167 / CIP 105390 / JCM 6362 / NCTC 10409 / 316) (Mycobacterium thermoresistibile) (see paper)
    26% identity, 84% coverage of query (100 bits)

7apeA / G7CES0 Crystal structure of lpqy from mycobacterium thermoresistible in complex with trehalose (see paper)
    26% identity, 82% coverage of query (99.8 bits)

5iaiA / B9JM84 Crystal structure of abc transporter solute binding protein arad_9887 from agrobacterium radiobacter k84, target efi-510945 in complex with ribitol
    26% identity, 88% coverage of query (91.7 bits)

8ja7E / P9WGU9 Cryo-em structure of mycobacterium tuberculosis lpqy-sugabc in complex with trehalose
    26% identity, 78% coverage of query (91.3 bits)

lpqY / P9WGU9 trehalose-binding lipoprotein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
LPQY_MYCTU / P9WGU9 Trehalose-binding lipoprotein LpqY; SugABC transporter substrate-binding protein LpqY; SugABC transporter SBP LpqY from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
TC 3.A.1.1.31 / Q7D8J9 PROBABLE SUGAR-BINDING LIPOPROTEIN LPQY, component of The trehalose-recycling ABC transporter, LpqY-SugA-SugB-SugC (essential for virulence) from Mycobacterium tuberculosis (see 2 papers)
    26% identity, 78% coverage of query (91.3 bits)

8jadA Crystal structure of mycobacterium tuberculosis lpqy in complex with trehalose analogue yb-17
    26% identity, 78% coverage of query (90.9 bits)

8jacA Crystal structure of mycobacterium tuberculosis lpqy in complex with trehalose analogue yb-16
    26% identity, 78% coverage of query (90.9 bits)

8ja9A Crystal structure of mycobacterium tuberculosis lpqy in complex with trehalose analogue yb-03
    26% identity, 78% coverage of query (90.9 bits)

8jabA Crystal structure of mycobacterium tuberculosis lpqy in complex with trehalose analogue yb-06
    26% identity, 78% coverage of query (90.9 bits)

8artB / C9ZHD5 Abc transporter binding protein male from streptomyces scabiei in complex with maltose
    30% identity, 77% coverage of query (90.5 bits)

TC 3.A.1.1.44 / Q7AKP1 Putative maltose-binding protein, component of MalEFG (K unknown), involved in maltose and maltodextrin uptake from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
    30% identity, 76% coverage of query (90.5 bits)

7cafE / A0R2C3 Mycobacterium smegmatis lpqy-sugabc complex in the pre-translocation state (see paper)
    25% identity, 84% coverage of query (90.5 bits)

5ysdB / Q92AS8 Crystal structure of beta-1,2-glucooligosaccharide binding protein in complex with sophorotriose (see paper)
    24% identity, 84% coverage of query (89.4 bits)

Q92AS8 ABC-type beta-glucan transporter (EC 7.5.2.3) from Listeria innocua (see paper)
    24% identity, 84% coverage of query (89.0 bits)

5ysdA Crystal structure of beta-1,2-glucooligosaccharide binding protein in complex with sophorotriose
    24% identity, 84% coverage of query (89.0 bits)

5ysbA Crystal structure of beta-1,2-glucooligosaccharide binding protein in ligand-free form
    24% identity, 84% coverage of query (89.0 bits)

TC 3.A.1.1.5 / O30831 SmoE, component of Hexitol (glucitol; mannitol) porter from Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides)
    26% identity, 89% coverage of query (76.6 bits)

SM_b21103 ABC transporter for L-Fucose, periplasmic substrate-binding protein from Sinorhizobium meliloti 1021
    25% identity, 91% coverage of query (76.3 bits)

AO356_00025 ABC transporter for D-Sorbitol, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N2C3
    26% identity, 87% coverage of query (75.9 bits)

5ci5A / A8F7X5 Crystal structure of an abc transporter solute binding protein from thermotoga lettingae tmo (tlet_1705, target efi-510544) bound with alpha-d-tagatose
    23% identity, 78% coverage of query (75.1 bits)

Pf6N2E2_1963 ABC transporter for D-sorbitol, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N2E2
    26% identity, 87% coverage of query (73.9 bits)

GANS_BACSU / O07009 Galactooligosaccharide-binding protein; Cyclodextrin-binding protein from Bacillus subtilis (strain 168) (see 2 papers)
TC 3.A.1.1.2 / O07009 Cyclodextrin-binding protein, component of The galactooligosaccharide (transports the di, tri and tetrasaccharides) uptake porter GanOPQ (GanSPQ; MalEFG) functioning with the energizing ATPase MsmX (see 3.A.1.1.26) from Bacillus subtilis (see 2 papers)
    27% identity, 75% coverage of query (72.0 bits)

4qrzA / A9CGI0 Crystal structure of sugar transporter atu4361 from agrobacterium fabrum c58, target efi-510558, with bound maltotriose
    26% identity, 74% coverage of query (70.9 bits)

4qsdA Crystal structure of atu4361 sugar transporter from agrobacterium fabrum c58, target efi-510558, with bound sucrose
    26% identity, 74% coverage of query (70.9 bits)

4ryaA / B9JRF8 Crystal structure of abc transporter solute binding protein avi_3567 from agrobacterium vitis s4, target efi-510645, with bound d-mannitol
    25% identity, 86% coverage of query (70.1 bits)

2gh9A / Q72I44 Thermus thermophilus maltotriose binding protein bound with maltotriose (see paper)
    24% identity, 78% coverage of query (66.6 bits)

6h0hA / B8DWA9 The abc transporter associated binding protein from b. Animalis subsp. Lactis bl-04 in complex with beta-1,6-galactobiose (see paper)
    25% identity, 71% coverage of query (65.1 bits)

MDXE_BACSU / O06989 Maltodextrin-binding protein MdxE from Bacillus subtilis (strain 168) (see paper)
TC 3.A.1.1.26 / O06989 MalE aka yvdG, component of The maltose porter, MdxEFG and MsmX from Bacillus subtilis (see 2 papers)
    26% identity, 71% coverage of query (63.2 bits)

7x0lA / A3DE73 Crystal structure of sugar binding protein cbpb complexed wtih cellotetraose from clostridium thermocellum (see paper)
    25% identity, 73% coverage of query (58.2 bits)

5z0rB / P0AEX9,Q32ZE1 Structural insight into the zika virus capsid encapsulating the viral genome (see paper)
    25% identity, 87% coverage of query (56.6 bits)

4b3nA / P0AEX9,Q0PF16 Crystal structure of rhesus trim5alpha pry/spry domain (see paper)
    25% identity, 87% coverage of query (56.2 bits)

5jonA / O88703,P0AEY0 Crystal structure of the unliganded form of hcn2 cnbd (see paper)
    25% identity, 88% coverage of query (56.2 bits)

HSERO_RS17000 ABC transporter for D-sorbitol/xylitol, substrate-binding component from Herbaspirillum seropedicae SmR1
    24% identity, 77% coverage of query (55.8 bits)

6gfjA / O43353 Structure of rip2 card domain fused to crystallisable mbp tag (see paper)
    26% identity, 75% coverage of query (55.8 bits)

6yblA Structure of mbp-mcl-1 in complex with compound 9m
    27% identity, 75% coverage of query (54.7 bits)

6qylA Structure of mbp-mcl-1 in complex with compound 8a
    27% identity, 75% coverage of query (54.7 bits)

6qxjA Structure of mbp-mcl-1 in complex with compound 6a
    27% identity, 75% coverage of query (54.7 bits)

4kegA / P0AEX9,Q9NP55 Crystal structure of mbp fused human splunc1
    26% identity, 75% coverage of query (54.3 bits)

6qgdA Structure of human mcl-1 in complex with thienopyrimidine inhibitor
    27% identity, 75% coverage of query (54.3 bits)

7cy4A Crystal structure of cmd1 in apo form
    25% identity, 75% coverage of query (54.3 bits)

6ob5B Computationally-designed, modular sense/response system (s3-2d)
    25% identity, 87% coverage of query (54.3 bits)

3py7A / P06931,P0AEX9 Crystal structure of full-length bovine papillomavirus oncoprotein e6 in complex with ld1 motif of paxillin at 2.3a resolution (see paper)
    26% identity, 75% coverage of query (53.9 bits)

5w0rA / P0AEX9,Q9GZX7 Crystal structure of mbp fused activation-induced cytidine deaminase (aid) in complex with cacodylic acid (see paper)
    26% identity, 75% coverage of query (53.5 bits)

TC 3.A.1.1.49 / O30491 MtlE, component of The polyol (mannitol, glucitol (sorbitol), arabitol (arabinitol; lyxitol)) uptake porter, MtlEFGK from Pseudomonas fluorescens
    24% identity, 83% coverage of query (53.5 bits)

6smvA / P0AEX9,P36813,Q92585 Structure of hpv49 e6 protein in complex with maml1 lxxll motif
    26% identity, 75% coverage of query (53.5 bits)

5w0uB Crystal structure of mbp fused activation-induced cytidine deaminase (aid) in complex with dcmp
    26% identity, 75% coverage of query (53.5 bits)

5w0uA Crystal structure of mbp fused activation-induced cytidine deaminase (aid) in complex with dcmp
    26% identity, 75% coverage of query (53.5 bits)

5hz7A / P0AEX9 High-resolution crystal structure of the minor DNA-binding pilin comp from neisseria meningitidis in fusion with mbp (see paper)
    26% identity, 75% coverage of query (53.1 bits)

3dm0A / O24456,P0AEX9 Maltose binding protein fusion with rack1 from a. Thaliana (see paper)
    26% identity, 75% coverage of query (53.1 bits)

6slmA / P0AEX9,P17386,Q05086 Crystal structure of full-length hpv31 e6 oncoprotein in complex with lxxll peptide of ubiquitin ligase e6ap (see paper)
    26% identity, 75% coverage of query (53.1 bits)

5t05B / P0AEX9 Crystal structure of heparan sulfate 6-o-sulfotransferase with bound pap and idoa2s containing hexasaccharide substrate (see paper)
    26% identity, 75% coverage of query (53.1 bits)

5h7nB / P0AEX9,P59046 Crystal structure of human nlrp12-pyd with a mbp tag (see paper)
    26% identity, 75% coverage of query (53.1 bits)

6sjvA / A0A376KDN7,P06463,Q05086 Structure of hpv18 e6 oncoprotein in complex with mutant e6ap lxxll motif
    26% identity, 75% coverage of query (53.1 bits)

7vn2C / P0AEX9,Q8S307 Crystal structure of mbp-fused bil1/bzr1 (21-90) in complex with double-stranded DNA contaning atcacgtgat (see paper)
    26% identity, 75% coverage of query (53.1 bits)

5jstB / A6ZQL5,P0AEX9 Mbp fused mdv1 coiled coil (see paper)
    26% identity, 75% coverage of query (53.1 bits)

6ki0A / P0AEX9,Q9ULZ3 Crystal structure of human asc-card (see paper)
    26% identity, 75% coverage of query (53.1 bits)

6apxA Crystal structure of human dual specificity phosphatase 1 catalytic domain (c258s) as a maltose binding protein fusion in complex with the monobody ysx1
    26% identity, 75% coverage of query (53.1 bits)

5ygsD / P0AEX9,Q93038 Human tnfrsf25 death domain (see paper)
    26% identity, 75% coverage of query (53.1 bits)

6i4yA / O43715,P0AEX9 X-ray structure of the human mitochondrial prelid3b-triap1 complex (see paper)
    26% identity, 75% coverage of query (53.1 bits)

8iiyA / C3SHQ8,O95619 Crystal structure of mbp fused gas41 yeats domain in complex with h3k14ac peptide (see paper)
    25% identity, 75% coverage of query (52.8 bits)

7cy6A / A0A2K3D5Z7,P0AEX9 Crystal structure of cmd1 in complex with 5mc-DNA (see paper)
    26% identity, 75% coverage of query (52.8 bits)

6d67A / P0AEX9,P28562 Crystal structure of the human dual specificity phosphatase 1 catalytic domain (c258s) as a maltose binding protein fusion (maltose bound form) in complex with the designed ar protein mbp3_16 (see paper)
    26% identity, 75% coverage of query (52.8 bits)

5gpqA / P0AEX9,Q9I9N6 Crystal structure of zebrafish asc card domain (see paper)
    26% identity, 75% coverage of query (52.8 bits)

4xa2A / P0AEX9 Structure of the major type iv pilin of acinetobacter baumannii
    26% identity, 75% coverage of query (52.8 bits)

4exkA / A0A0F6B1U8,P0AEX9 A chimera protein containing mbp fused to thE C-terminal domain of the uncharacterized protein stm14_2015 from salmonella enterica
    26% identity, 75% coverage of query (52.8 bits)

7cy5A Crystal structure of cmd1 in complex with vitamin c
    26% identity, 75% coverage of query (52.8 bits)

8c5lB / P0AEX9,P10588 Nr2f6 ligand binding domain in complex with nsd1 peptide
    26% identity, 75% coverage of query (52.8 bits)

6xdjC Crystal structure analysis of mbp-sin3
    26% identity, 75% coverage of query (52.8 bits)

4irlB / B0V1H4,P0AEX9 X-ray structure of the card domain of zebrafish gbp-nlrp1 like protein (see paper)
    26% identity, 75% coverage of query (52.8 bits)

6m4wA Crystal structure of mbp fused split fkbp-frb t2098l mutant in complex with rapamycin
    26% identity, 75% coverage of query (52.4 bits)

5h7qA / P0AEX9,P41218 Crystal structure of human mnda pyd domain with mbp tag (see paper)
    26% identity, 75% coverage of query (52.4 bits)

5gppB / P0AEX9,Q9I9N6 Crystal structure of zebrafish asc pyd domain (see paper)
    26% identity, 75% coverage of query (52.4 bits)

4ikmA / P0AEX9,Q9Y2G2 X-ray structure of card8 card domain (see paper)
    26% identity, 75% coverage of query (52.4 bits)

5tj4E / Q8TAX9 Gasdermin-b c-terminal domain containing the polymorphism residues gly299:pro306 fused to maltose binding protein (see paper)
    26% identity, 75% coverage of query (52.0 bits)

3vd8A / O14862,P0AEY0 Crystal structure of human aim2 pyd domain with mbp fusion (see paper)
    26% identity, 75% coverage of query (52.0 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory