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Searching for up to 100 curated homologs for SM_b21011 FitnessBrowser__Smeli:SM_b21011 (495 a.a.)

Found high-coverage hits (≥70%) to 83 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

AO356_02560 Xanthine dehydrogenase (EC 1.17.1.4) from Pseudomonas fluorescens FW300-N2C3
    49% identity, 96% coverage of query (447 bits)

PS417_20885 Xanthine dehydrogenase (EC 1.17.1.4) from Pseudomonas simiae WCS417
    47% identity, 96% coverage of query (433 bits)

Dshi_2958 Xanthine dehydrogenase (EC 1.17.1.4) from Dinoroseobacter shibae DFL-12
    50% identity, 97% coverage of query (431 bits)

O54050 xanthine dehydrogenase (subunit 2/2) (EC 1.17.1.4); xanthine oxidase (EC 1.17.3.2) from Rhodobacter capsulatus (see 2 papers)
xdhA / CAA04469.1 xanthine dehydrogenase from Rhodobacter capsulatus (see paper)
    46% identity, 97% coverage of query (383 bits)

1jroA / O54050 Crystal structure of xanthine dehydrogenase from rhodobacter capsulatus (see paper)
    46% identity, 97% coverage of query (378 bits)

2w54A Crystal structure of xanthine dehydrogenase from rhodobacter capsulatus in complex with bound inhibitor pterin-6-aldehyde
    46% identity, 97% coverage of query (378 bits)

A0A1S4F2J6 xanthine dehydrogenase (EC 1.17.1.4) from Aedes aegypti (see paper)
    35% identity, 88% coverage of query (264 bits)

A0A1S4G2F8 xanthine dehydrogenase (EC 1.17.1.4) from Aedes aegypti (see paper)
    33% identity, 88% coverage of query (262 bits)

XDH_EMENI / Q12553 Xanthine dehydrogenase; Purine hydroxylase I; EC 1.17.1.4 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see paper)
hxA xanthine dehydrogenase (purine hydroxylase I); EC 1.17.1.4 from Emericella nidulans (see 2 papers)
    33% identity, 96% coverage of query (246 bits)

Q17209 xanthine dehydrogenase (EC 1.17.1.4); aldehyde oxidase (EC 1.2.3.1) from Bombyx mori (see paper)
    31% identity, 95% coverage of query (239 bits)

XDH_DROME / P10351 Xanthine dehydrogenase; XD; Protein rosy locus; EC 1.17.1.4 from Drosophila melanogaster (Fruit fly) (see paper)
    31% identity, 95% coverage of query (231 bits)

AOXB_MACFA / C4NYZ3 Aldehyde oxidase 2; Aldehyde oxidase homolog 3; Azaheterocycle hydroxylase 2; EC 1.2.3.1; EC 1.17.3.- from Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) (see paper)
    30% identity, 100% coverage of query (223 bits)

Build an alignment

Build an alignment for SM_b21011 and 12 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

Q2QB47 aldehyde oxidase (EC 1.2.3.1) from Canis lupus familiaris (see 2 papers)
    29% identity, 98% coverage of query (219 bits)

XDH_CHICK / P47990 Xanthine dehydrogenase/oxidase; EC 1.17.1.4; EC 1.17.3.2 from Gallus gallus (Chicken) (see 2 papers)
    31% identity, 96% coverage of query (214 bits)

Q5QE78 aldehyde oxidase (EC 1.2.3.1) from Rattus norvegicus (see paper)
    30% identity, 88% coverage of query (213 bits)

2e3tA Crystal structure of rat xanthine oxidoreductase mutant (w335a and f336l)
    32% identity, 96% coverage of query (213 bits)

6a7xA Rat xanthine oxidoreductase, d428a variant, NAD bound form
    32% identity, 96% coverage of query (210 bits)

2e1qA / P47989 Crystal structure of human xanthine oxidoreductase mutant, glu803val (see paper)
    32% identity, 96% coverage of query (208 bits)

4yswA Structure of rat xanthine oxidoreductase, c-terminal deletion protein variant, nadh bound form
    32% identity, 96% coverage of query (208 bits)

6a7xB Rat xanthine oxidoreductase, d428a variant, NAD bound form
    32% identity, 96% coverage of query (207 bits)

1fo4A / P80457 Crystal structure of xanthine dehydrogenase isolated from bovine milk (see paper)
    31% identity, 89% coverage of query (206 bits)

3amzA Bovine xanthine oxidoreductase urate bound form
    31% identity, 89% coverage of query (206 bits)

3am9A Complex of bovine xanthine dehydrogenase and trihydroxy fyx-051
    31% identity, 89% coverage of query (206 bits)

1n5xA Xanthine dehydrogenase from bovine milk with inhibitor tei-6720 bound
    31% identity, 89% coverage of query (206 bits)

1vdvA Bovine milk xanthine dehydrogenase y-700 bound form
    31% identity, 89% coverage of query (206 bits)

AOXB_MOUSE / Q5SGK3 Aldehyde oxidase 2; Aldehyde oxidase homolog 3; Azaheterocycle hydroxylase 2; EC 1.2.3.1; EC 1.17.3.- from Mus musculus (Mouse) (see 2 papers)
Q5SGK3 aldehyde oxidase (EC 1.2.3.1) from Mus musculus (see 4 papers)
    28% identity, 100% coverage of query (205 bits)

1v97A Crystal structure of bovine milk xanthine dehydrogenase fyx-051 bound form
    31% identity, 89% coverage of query (205 bits)

3unaA Crystal structure of bovine milk xanthine dehydrogenase with NAD bound
    31% identity, 89% coverage of query (204 bits)

3bdjA Crystal structure of bovine milk xanthine dehydrogenase with a covalently bound oxipurinol inhibitor
    31% identity, 89% coverage of query (204 bits)

3zyvB / G3X982 Crystal structure of the mouse liver aldehyde oxidase 3 (maox3) (see paper)
    31% identity, 96% coverage of query (202 bits)

2ckjA / P47989 Human milk xanthine oxidoreductase
    31% identity, 99% coverage of query (202 bits)

3ax7A / P80457 Bovine xanthine oxidase, protease cleaved form (see paper)
    30% identity, 97% coverage of query (201 bits)

AOXD_MOUSE / Q3TYQ9 Aldehyde oxidase 4; Aldehyde oxidase homolog 2; Azaheterocycle hydroxylase 4; Retinal oxidase; EC 1.2.3.1; EC 1.17.3.- from Mus musculus (Mouse) (see 2 papers)
Q3TYQ9 aldehyde oxidase (EC 1.2.3.1) from Mus musculus (see 2 papers)
    28% identity, 96% coverage of query (201 bits)

Q148T8 aldehyde oxidase (EC 1.2.3.1) from Mus musculus (see paper)
    28% identity, 96% coverage of query (201 bits)

F1S3Y7 xanthine oxidase (EC 1.17.3.2) from Sus scrofa (see paper)
    31% identity, 97% coverage of query (199 bits)

AOXB_CAVPO / H9TB19 Aldehyde oxidase 2; Aldehyde oxidase homolog 3; Azaheterocycle hydroxylase 2; EC 1.2.3.1; EC 1.17.3.- from Cavia porcellus (Guinea pig) (see paper)
    29% identity, 98% coverage of query (199 bits)

AOXD_CAVPO / H9TB18 Aldehyde oxidase 4; Aldehyde oxidase homolog 2; Azaheterocycle hydroxylase 4; Retinal oxidase; EC 1.2.3.1; EC 1.17.3.- from Cavia porcellus (Guinea pig) (see paper)
    30% identity, 88% coverage of query (199 bits)

Xdh / P22985 xanthine oxidoreductase subunit (EC 1.17.1.4; EC 1.17.3.2) from Rattus norvegicus (see paper)
XDH_RAT / P22985 Xanthine dehydrogenase/oxidase; EC 1.17.1.4; EC 1.17.3.2 from Rattus norvegicus (Rat) (see 4 papers)
P22985 xanthine dehydrogenase (EC 1.17.1.4); xanthine oxidase (EC 1.17.3.2) from Rattus norvegicus (see 4 papers)
    30% identity, 96% coverage of query (198 bits)

XDH / P47989 xanthine dehydrogenase monomer (EC 1.17.1.4) from Homo sapiens (see 14 papers)
XDH_HUMAN / P47989 Xanthine dehydrogenase/oxidase; EC 1.17.1.4; EC 1.17.3.2 from Homo sapiens (Human) (see 6 papers)
P47989 xanthine oxidase (EC 1.17.3.2) from Homo sapiens (see paper)
    30% identity, 96% coverage of query (197 bits)

XDH_BOVIN / P80457 Xanthine dehydrogenase/oxidase; EC 1.17.1.4; EC 1.17.3.2 from Bos taurus (Bovine) (see 6 papers)
P80457 xanthine dehydrogenase (EC 1.17.1.4); xanthine oxidase (EC 1.17.3.2) from Bos taurus (see 15 papers)
    30% identity, 89% coverage of query (195 bits)

XDH2_ARATH / F4JLI5 Xanthine dehydrogenase 2; AtXDH2; EC 1.17.1.4 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    32% identity, 88% coverage of query (194 bits)

AOXC_RAT / Q5QE80 Aldehyde oxidase 3; Aldehyde oxidase homolog 1; Azaheterocycle hydroxylase 3; EC 1.2.3.1; EC 1.17.3.- from Rattus norvegicus (Rat) (see 2 papers)
Q5QE80 aldehyde oxidase (EC 1.2.3.1) from Rattus norvegicus (see paper)
    30% identity, 98% coverage of query (194 bits)

Q2QB49 aldehyde oxidase (EC 1.2.3.1) from Gallus gallus (see 2 papers)
    29% identity, 97% coverage of query (193 bits)

Q2QB48 aldehyde oxidase (EC 1.2.3.1) from Canis lupus familiaris (see 2 papers)
    30% identity, 96% coverage of query (193 bits)

AOXC_MOUSE / G3X982 Aldehyde oxidase 3; Aldehyde oxidase homolog 1; Azaheterocycle hydroxylase 3; EC 1.2.3.1; EC 1.17.3.- from Mus musculus (Mouse) (see 5 papers)
G3X982 aldehyde oxidase (EC 1.2.3.1) from Mus musculus (see 4 papers)
    31% identity, 90% coverage of query (193 bits)

Xdh / Q00519 xanthine oxidase monomer (EC 1.17.1.4; EC 1.17.3.2) from Mus musculus (see 4 papers)
XDH_MOUSE / Q00519 Xanthine dehydrogenase/oxidase; EC 1.17.1.4; EC 1.17.3.2 from Mus musculus (Mouse) (see paper)
    31% identity, 96% coverage of query (192 bits)

AOXA_RAT / Q9Z0U5 Aldehyde oxidase 1; Azaheterocycle hydroxylase 1; EC 1.2.3.1; EC 1.17.3.- from Rattus norvegicus (Rat) (see 5 papers)
Q9Z0U5 aldehyde oxidase (EC 1.2.3.1) from Rattus norvegicus (see 4 papers)
    33% identity, 88% coverage of query (191 bits)

Q6V956 aldehyde oxidase (EC 1.2.3.1) from Mus musculus (see paper)
    31% identity, 90% coverage of query (191 bits)

AOXA_RABIT / P80456 Aldehyde oxidase 1; Azaheterocycle hydroxylase 1; Retinal oxidase; Retinoic acid synthase; EC 1.2.3.1; EC 1.17.3.- from Oryctolagus cuniculus (Rabbit) (see 4 papers)
P80456 aldehyde oxidase (EC 1.2.3.1) from Oryctolagus cuniculus (see 3 papers)
    32% identity, 89% coverage of query (190 bits)

Q5QE79 aldehyde oxidase (EC 1.2.3.1) from Rattus norvegicus (see paper)
    28% identity, 97% coverage of query (190 bits)

Q2QB50 aldehyde oxidase (EC 1.2.3.1) from Gallus gallus (see 3 papers)
    31% identity, 97% coverage of query (190 bits)

7orcB / Q06278 Human aldehyde oxidase in complex with raloxifene (see paper)
    33% identity, 88% coverage of query (189 bits)

8emtA / Q06278 Cryo-em analysis of the human aldehyde oxidase from liver (see paper)
    32% identity, 88% coverage of query (188 bits)

8emtB / Q06278 Cryo-em analysis of the human aldehyde oxidase from liver (see paper)
    32% identity, 88% coverage of query (187 bits)

4uhxA Human aldehyde oxidase in complex with phthalazine and thioridazine
    32% identity, 88% coverage of query (187 bits)

AOXA_BOVIN / P48034 Aldehyde oxidase 1; Azaheterocycle hydroxylase 1; EC 1.2.3.1; EC 1.17.3.- from Bos taurus (Bovine) (see paper)
P48034 aldehyde oxidase (EC 1.2.3.1) from Bos taurus (see 3 papers)
    31% identity, 89% coverage of query (184 bits)

Q8R387 aldehyde oxidase (EC 1.2.3.1) from Mus musculus (see paper)
    32% identity, 88% coverage of query (182 bits)

AOXA_MACFA / Q5FB27 Aldehyde oxidase 1; Azaheterocycle hydroxylase 1; EC 1.2.3.1; EC 1.17.3.- from Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) (see paper)
Q5FB27 aldehyde oxidase (EC 1.2.3.1) from Macaca fascicularis (see 2 papers)
    31% identity, 90% coverage of query (182 bits)

AOXA_MOUSE / O54754 Aldehyde oxidase 1; Azaheterocycle hydroxylase 1; Retinal oxidase; EC 1.2.3.1; EC 1.17.3.- from Mus musculus (Mouse) (see 8 papers)
O54754 aldehyde oxidase (EC 1.2.3.1) from Oryctolagus cuniculus (see paper)
    32% identity, 88% coverage of query (181 bits)

AOX1 / Q06278 aldehyde oxidase monomer (EC 1.2.3.1) from Homo sapiens (see 5 papers)
AOXA_HUMAN / Q06278 Aldehyde oxidase; Aldehyde oxidase 1; Azaheterocycle hydroxylase; EC 1.2.3.1; EC 1.17.3.- from Homo sapiens (Human) (see 14 papers)
Q06278 aldehyde oxidase (EC 1.2.3.1) from Homo sapiens (see 5 papers)
    31% identity, 90% coverage of query (178 bits)

F6Y8K6 aldehyde oxidase (EC 1.2.3.1) from Callithrix jacchus (see paper)
    30% identity, 88% coverage of query (177 bits)

AOXA_CAVPO / H9TB17 Aldehyde oxidase 1; Azaheterocycle hydroxylase 1; EC 1.2.3.1; EC 1.17.3.- from Cavia porcellus (Guinea pig) (see 2 papers)
    31% identity, 89% coverage of query (166 bits)

AAO2 / Q7G192 aldehyde oxidase subunit (EC 1.2.3.9; EC 1.2.3.1) from Arabidopsis thaliana (see paper)
ALDO2_ARATH / Q7G192 Indole-3-acetaldehyde oxidase; IAA oxidase; Aldehyde oxidase 2; AO-2; AtAO-2; AtAO3; EC 1.2.3.7 from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
Q7G192 aldehyde oxidase (EC 1.2.3.1) from Arabidopsis thaliana (see paper)
    28% identity, 95% coverage of query (164 bits)

A8TUB4 aldehyde oxidase (EC 1.2.3.1) from Bombyx mori (see paper)
    26% identity, 97% coverage of query (149 bits)

7px0B / Q9VF53 Drosophila melanogaster aldehyde oxidase 1
    28% identity, 94% coverage of query (146 bits)

Q9VF53 aldehyde oxidase (EC 1.2.3.1); pyridoxal oxidase (EC 1.2.3.8) from Drosophila melanogaster (see 2 papers)
    27% identity, 94% coverage of query (141 bits)

A8TUC0 aldehyde oxidase (EC 1.2.3.1) from Bombyx mori (see paper)
    25% identity, 95% coverage of query (136 bits)

AAO1 / Q7G193 AO1 (EC 1.2.3.1; EC 1.2.3.9; EC 1.2.3.7) from Arabidopsis thaliana (see paper)
ALDO1_ARATH / Q7G193 Indole-3-acetaldehyde oxidase; IAA oxidase; Aldehyde oxidase 1; AO-1; AtAO-1; AtAO1; EC 1.2.3.7 from Arabidopsis thaliana (Mouse-ear cress) (see 7 papers)
Q7G193 aldehyde oxidase (EC 1.2.3.1); indole-3-acetaldehyde oxidase (EC 1.2.3.7) from Arabidopsis thaliana (see 2 papers)
    28% identity, 97% coverage of query (136 bits)

Q9NCL9 aldehyde oxidase (EC 1.2.3.1) from Culex quinquefasciatus (see paper)
    27% identity, 92% coverage of query (135 bits)

AO2 / B0LB00 aldehyde oxidase (EC 1.2.3.1) from Pisum sativum (see paper)
B0LB00 aldehyde oxidase (EC 1.2.3.1) from Pisum sativum (see paper)
    28% identity, 87% coverage of query (132 bits)

O61198 aldehyde oxidase (EC 1.2.3.1) from Caenorhabditis elegans (see paper)
    27% identity, 86% coverage of query (132 bits)

GAD3_CAEEL / Q960A1 Probable aldehyde oxidase gad-3; EC 1.2.3.1 from Caenorhabditis elegans (see paper)
Q960A1 aldehyde oxidase (EC 1.2.3.1) from Caenorhabditis elegans (see paper)
    27% identity, 86% coverage of query (131 bits)

ALDO2_MAIZE / O23888 Indole-3-acetaldehyde oxidase; IAA oxidase; Aldehyde oxidase-2; ZmAO-2; EC 1.2.3.7 from Zea mays (Maize) (see paper)
O23888 aldehyde oxidase (EC 1.2.3.1) from Zea mays (see paper)
    29% identity, 92% coverage of query (131 bits)

S5FPI8 aldehyde oxidase (EC 1.2.3.1) from Amyelois transitella (see paper)
    26% identity, 91% coverage of query (129 bits)

ALDO1_MAIZE / O23887 Indole-3-acetaldehyde oxidase; IAA oxidase; Aldehyde oxidase; ZmAO-1; EC 1.2.3.7 from Zea mays (Maize) (see 2 papers)
O23887 aldehyde oxidase (EC 1.2.3.1) from Zea mays (see paper)
    28% identity, 88% coverage of query (129 bits)

AO3 / B0LB01 aldehyde oxidase (EC 1.2.3.1) from Pisum sativum (see paper)
B0LB01 aldehyde oxidase (EC 1.2.3.1); abscisic-aldehyde oxidase (EC 1.2.3.14) from Pisum sativum (see 2 papers)
    26% identity, 97% coverage of query (128 bits)

A0A336UZ51 aldehyde oxidase (EC 1.2.3.1) from Penaeus japonicus (see paper)
    28% identity, 97% coverage of query (127 bits)

A0A1L8D6P5 aldehyde oxidase (EC 1.2.3.1) from Plutella xylostella (see paper)
    27% identity, 91% coverage of query (123 bits)

AO2 / Q9FV24 aldehyde oxidase (EC 1.2.3.1) from Solanum lycopersicum (see paper)
Q9FV24 aldehyde oxidase (EC 1.2.3.1) from Solanum lycopersicum (see paper)
    29% identity, 87% coverage of query (120 bits)

AO1 / B0LAZ9 aldehyde oxidase (EC 1.2.3.1) from Pisum sativum (see paper)
B0LAZ9 aldehyde oxidase (EC 1.2.3.1) from Pisum sativum (see paper)
    27% identity, 97% coverage of query (117 bits)

A0A1U9X1S0 aldehyde oxidase (EC 1.2.3.1) from Bombyx mori (see paper)
    26% identity, 91% coverage of query (114 bits)

Q9FV23 aldehyde oxidase (EC 1.2.3.1) from Solanum lycopersicum (see paper)
    28% identity, 87% coverage of query (113 bits)

AO1 / Q9FV25 aldehyde oxidase (EC 1.2.3.1) from Solanum lycopersicum (see paper)
Q9FV25 aldehyde oxidase (EC 1.2.3.1) from Solanum lycopersicum (see paper)
    27% identity, 87% coverage of query (110 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory