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Searching for up to 100 curated homologs for SM_b21016 FitnessBrowser__Smeli:SM_b21016 (343 a.a.)

Found high-coverage hits (≥70%) to 17 curated proteins.

Removed hits that are identical to the query, leaving 16

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

LsrB / b1516 Autoinducer-2 ABC transporter periplasmic binding protein (EC 7.6.2.13) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
LsrB / P76142 Autoinducer-2 ABC transporter periplasmic binding protein (EC 7.6.2.13) from Escherichia coli (strain K12) (see 5 papers)
LSRB_ECOLI / P76142 Autoinducer 2-binding protein LsrB; AI-2-binding protein LsrB from Escherichia coli (strain K12) (see 2 papers)
TC 3.A.1.2.8 / P76142 LsrB(R), component of Autoinducer-2 (AI-2, a furanosyl borate diester: (3aS,6S,6aR)-2,2,6,6a-tetrahydroxy-3a-methyltetrahydrofuro[3,2-d][1,3,2]dioxaborolan-2-uide) uptake porter (Taga et al., 2001, 2003) from Escherichia coli (see 4 papers)
lsrB autoinducer 2 ABC transporter, periplasmic substrate-binding protein LsrB from Escherichia coli K12 (see paper)
    77% identity, 99% coverage of query (512 bits)

LSRB_SALTY / Q8ZKQ1 Autoinducer 2-binding protein LsrB; AI-2-binding protein LsrB from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
    72% identity, 99% coverage of query (491 bits)

3t95A / Q74PW2 Crystal structure of lsrb from yersinia pestis complexed with autoinducer-2 (see paper)
    77% identity, 91% coverage of query (490 bits)

1tjyA / Q8ZKQ1 Crystal structure of salmonella typhimurium ai-2 receptor lsrb in complex with r-thmf (see paper)
    76% identity, 91% coverage of query (483 bits)

4pz0A / A0A6H3AKG3 The crystal structure of a solute binding protein from bacillus anthracis str. Ames in complex with quorum-sensing signal autoinducer-2 (ai-2)
    61% identity, 91% coverage of query (417 bits)

6dspA / U5MRH9 Lsrb from clostridium saccharobutylicum in complex with ai-2 (see paper)
    44% identity, 91% coverage of query (259 bits)

TC 3.A.1.2.9 / Q7BSH5 RhaS, component of Rhamnose porter (Richardson et al., 2004) (Transport activity is dependent on rhamnokinase (RhaK; AAQ92412) activity (Richardson and Oresnik, 2007) This could be an example of group translocation!) from Rhizobium leguminosarum (biovar trifolii) (see paper)
    33% identity, 84% coverage of query (167 bits)

Build an alignment

Build an alignment for SM_b21016 and 7 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

4wzzA / A9KIX1 Crystal structure of an abc transporter solute binding protein (ipr025997) from clostridium phytofermentas (cphy_0583, target efi- 511148) with bound l-rhamnose
    26% identity, 76% coverage of query (92.8 bits)

HSERO_RS05260 ABC transporter for L-fucose, substrate-binding component from Herbaspirillum seropedicae SmR1
    29% identity, 76% coverage of query (80.9 bits)

H281DRAFT_01114 deoxynucleoside transporter, substrate-binding component from Paraburkholderia bryophila 376MFSha3.1
    26% identity, 84% coverage of query (75.1 bits)

RALBP_PSEAE / Q9I2F8 D-ribose/D-allose-binding protein from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
    25% identity, 76% coverage of query (68.6 bits)

HSERO_RS11480 D-ribose ABC transporter, substrate-binding component RbsB from Herbaspirillum seropedicae SmR1
    24% identity, 74% coverage of query (59.3 bits)

APIBP_RHIEC / Q2JZQ5 D-apiose import binding protein; D-apiose binding SBP from Rhizobium etli (strain CFN 42 / ATCC 51251) (see paper)
    24% identity, 77% coverage of query (50.1 bits)

5ibqA / Q2JZQ5 Crystal structure of an abc solute binding protein from rhizobium etli cfn 42 (rhe_pf00037,target efi-511357) in complex with alpha-d-apiose
    24% identity, 72% coverage of query (49.3 bits)

4ry0A Crystal structure of ribose transporter solute binding protein rhe_pf00037 from rhizobium etli cfn 42, target efi-511357, in complex with d-ribose
    24% identity, 72% coverage of query (49.3 bits)

APIBP_PARG4 / B1G898 D-apiose import binding protein; D-apiose binding SBP from Paraburkholderia graminis (strain ATCC 700544 / DSM 17151 / LMG 18924 / NCIMB 13744 / C4D1M) (see paper)
    24% identity, 85% coverage of query (48.5 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory