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Searching for up to 100 curated homologs for SM_b21103 FitnessBrowser__Smeli:SM_b21103 (439 a.a.)

Found high-coverage hits (≥70%) to 32 curated proteins.

Removed hits that are identical to the query, leaving 31

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

6dtqA / G4XU73 Maltose bound t. Maritima male3 (see paper)
    31% identity, 77% coverage of query (127 bits)

TC 3.A.1.1.41 / G4FGN8 Extracellular solute-binding protein family 1, component of Trehalose porter. Also binds sucrose (Boucher and Noll, 2011). Induced by glucose and trehalose. Directly regulated by trehalose-responsive regulator TreR from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    31% identity, 77% coverage of query (127 bits)

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Build an alignment for SM_b21103 and 2 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

SM_b21221 ABC transporter for D-Glucosamine, periplasmic substrate-binding protein from Sinorhizobium meliloti 1021
    26% identity, 74% coverage of query (101 bits)

4qrzA / A9CGI0 Crystal structure of sugar transporter atu4361 from agrobacterium fabrum c58, target efi-510558, with bound maltotriose
    29% identity, 76% coverage of query (84.7 bits)

4qsdA Crystal structure of atu4361 sugar transporter from agrobacterium fabrum c58, target efi-510558, with bound sucrose
    29% identity, 76% coverage of query (84.7 bits)

1eu8A / Q7LYW7 Structure of trehalose maltose binding protein from thermococcus litoralis (see paper)
    26% identity, 72% coverage of query (77.4 bits)

MALE_THELN / Q7LYW7 Trehalose/maltose-binding protein MalE; TMBP from Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C) (see 4 papers)
    27% identity, 72% coverage of query (77.4 bits)

TC 3.A.1.1.7 / O51923 MalE aka PF1739, component of Maltose/trehalose porter (see paper)
    27% identity, 72% coverage of query (77.0 bits)

Dshi_0547 ABC transporter for Xylitol, periplasmic substrate-binding component from Dinoroseobacter shibae DFL-12
    22% identity, 100% coverage of query (76.3 bits)

7qhvAAA / A9CEY9 7qhvAAA (see paper)
    25% identity, 73% coverage of query (75.9 bits)

7ofyA Crystal structure of sq binding protein from agrobacterium tumefaciens in complex with sulfoquinovosyl glycerol (sqgro)
    25% identity, 72% coverage of query (74.7 bits)

TC 3.A.1.1.25 / Q72H68 Trehalose/maltose-binding protein aka TT_C1627, component of The trehalose/maltose/sucrose/palatinose porter (TTC1627-9) plus MalK1 (ABC protein, shared with 3.A.1.1.24) (Silva et al. 2005; Chevance et al., 2006). The receptor (TTC1627) binds disaccharide alpha-glycosides, namely trehalose (alpha-1,1), sucrose (alpha-1,2), maltose (alpha-1,4), palatinose (alpha-1,6) and glucose from Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) (see paper)
    25% identity, 74% coverage of query (73.9 bits)

6jahA Crystal structure of abc transporter alpha-glycoside-binding protein in complex with glucose
    25% identity, 74% coverage of query (73.9 bits)

6jagA Crystal structure of abc transporter alpha-glycoside-binding protein in complex with sucrose
    25% identity, 74% coverage of query (73.9 bits)

6jadA Crystal structure of abc transporter alpha-glycoside-binding protein in complex with palatinose
    25% identity, 74% coverage of query (73.9 bits)

6j9yA Crystal structure of abc transporter alpha-glycoside-binding protein in complex with maltose
    25% identity, 74% coverage of query (73.9 bits)

6jb0A Crystal structure of abc transporter alpha-glycoside-binding mutant protein w287a in complex with trehalose
    25% identity, 74% coverage of query (73.9 bits)

SM_b20325 ABC transporter for D-trehalose/D-maltose/sucrose, substrate-binding component (ThuE) from Sinorhizobium meliloti 1021
TC 3.A.1.1.17 / Q9R9Q7 ThuE aka RB0311 aka SMB20325, component of Trehalose/maltose/sucrose porter (trehalose inducible) from Rhizobium meliloti (Sinorhizobium meliloti) (see 3 papers)
    26% identity, 73% coverage of query (73.2 bits)

6jamA / Q5SLD7 Crystal structure of abc transporter alpha-glycoside-binding mutant protein r356a in complex with trehalose (see paper)
    25% identity, 74% coverage of query (73.2 bits)

6jaiA Crystal structure of abc transporter alpha-glycoside-binding mutant protein d118a in complex with maltose
    25% identity, 74% coverage of query (72.4 bits)

TC 3.A.1.1.19 / Q8L126 PalE, component of Platinose (isomaltulose) (6-O-α-D-glucopyranosyl-D-fructofuranose) porter from Agrobacterium tumefaciens (see 3 papers)
palE / BAB96538.1 PalE from Agrobacterium tumefaciens (see 3 papers)
    26% identity, 74% coverage of query (71.2 bits)

4ryaA / B9JRF8 Crystal structure of abc transporter solute binding protein avi_3567 from agrobacterium vitis s4, target efi-510645, with bound d-mannitol
    25% identity, 83% coverage of query (67.4 bits)

PGA1_c13210 ABC transporter for D-Sorbitol, periplasmic substrate-binding component from Phaeobacter inhibens BS107
    25% identity, 73% coverage of query (66.2 bits)

MANBP_PSEAE / Q9I1E0 Mannitol-binding protein from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
    25% identity, 75% coverage of query (62.4 bits)

7bvtA / D2YYD8 Crystal structure of cyclic alpha-maltosyl-1,6-maltose binding protein from arthrobacter globiformis (see paper)
    27% identity, 81% coverage of query (59.3 bits)

mtlE / Q4KC57 polyol ABC-type transporter periplasmic substrate-binding protein from Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) (see paper)
    25% identity, 74% coverage of query (58.9 bits)

TC 3.A.1.1.44 / Q7AKP1 Putative maltose-binding protein, component of MalEFG (K unknown), involved in maltose and maltodextrin uptake from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
    24% identity, 73% coverage of query (58.5 bits)

Pf6N2E2_1963 ABC transporter for D-sorbitol, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N2E2
    24% identity, 83% coverage of query (55.5 bits)

AO356_00025 ABC transporter for D-Sorbitol, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N2C3
    23% identity, 91% coverage of query (55.1 bits)

BPHYT_RS16115 ABC transporter for D-Sorbitol, periplasmic substrate-binding component from Burkholderia phytofirmans PsJN
    24% identity, 100% coverage of query (50.1 bits)

GANS_BACSU / O07009 Galactooligosaccharide-binding protein; Cyclodextrin-binding protein from Bacillus subtilis (strain 168) (see 2 papers)
TC 3.A.1.1.2 / O07009 Cyclodextrin-binding protein, component of The galactooligosaccharide (transports the di, tri and tetrasaccharides) uptake porter GanOPQ (GanSPQ; MalEFG) functioning with the energizing ATPase MsmX (see 3.A.1.1.26) from Bacillus subtilis (see 2 papers)
    25% identity, 71% coverage of query (49.7 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory