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Searching for up to 100 curated homologs for SM_b21149 FitnessBrowser__Smeli:SM_b21149 (294 a.a.)

Found high-coverage hits (≥70%) to 48 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Q6MNM0 ABC-type maltose transporter (EC 7.5.2.1) from Bdellovibrio bacteriovorus (see paper)
TC 3.A.1.1.51 / Q6MNM0 Maltose - maltoheptose transporter, MalEFGK from Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIB 9529 / HD100)
    34% identity, 97% coverage of query (171 bits)

TC 3.A.1.1.41 / G4FGN7 ABC-type transporter, integral membrane subunit, component of Trehalose porter. Also binds sucrose (Boucher and Noll, 2011). Induced by glucose and trehalose. Directly regulated by trehalose-responsive regulator TreR from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    32% identity, 92% coverage of query (154 bits)

SM_b20326 ABC transporter for D-trehalose/D-maltose/sucrose, permease component 1 (ThuF) from Sinorhizobium meliloti 1021
TC 3.A.1.1.17 / Q9R9Q6 ThuF aka RB0312 aka SMB20326, component of Trehalose/maltose/sucrose porter (trehalose inducible) from Rhizobium meliloti (Sinorhizobium meliloti) (see 3 papers)
    31% identity, 97% coverage of query (152 bits)

SM_b21220 ABC transporter for D-Glucosamine, permease component 2 from Sinorhizobium meliloti 1021
    38% identity, 90% coverage of query (150 bits)

TC 3.A.1.1.19 / Q8L125 PalF, component of Platinose (isomaltulose) (6-O-α-D-glucopyranosyl-D-fructofuranose) porter from Agrobacterium tumefaciens (see 3 papers)
    30% identity, 97% coverage of query (148 bits)

MALF_THELN / O51924 Trehalose/maltose transport system permease protein MalF from Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C) (see 3 papers)
    37% identity, 93% coverage of query (143 bits)

TC 3.A.1.1.25 / Q72H67 Maltose transport system permease protein malF aka TT_C1628, component of The trehalose/maltose/sucrose/palatinose porter (TTC1627-9) plus MalK1 (ABC protein, shared with 3.A.1.1.24) (Silva et al. 2005; Chevance et al., 2006). The receptor (TTC1627) binds disaccharide alpha-glycosides, namely trehalose (alpha-1,1), sucrose (alpha-1,2), maltose (alpha-1,4), palatinose (alpha-1,6) and glucose from Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) (see paper)
    32% identity, 95% coverage of query (143 bits)

Pf1N1B4_5113 sucrose ABC transporter, permease component 1 from Pseudomonas fluorescens FW300-N1B4
    32% identity, 94% coverage of query (130 bits)

TC 3.A.1.1.7 / O51924 MalF, component of Maltose/trehalose porter from Thermococcus litoralis (see paper)
    37% identity, 93% coverage of query (129 bits)

Build an alignment

Build an alignment for SM_b21149 and 9 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

TC 3.A.1.1.6 / Q48396 CymF, component of Cyclodextrin porter from Klebsiella oxytoca (see paper)
    29% identity, 93% coverage of query (127 bits)

TC 3.A.1.1.44 / Q9KZ07 Putative maltose permease, component of MalEFG (K unknown), involved in maltose and maltodextrin uptake from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
    31% identity, 95% coverage of query (119 bits)

SM_b21104 ABC transporter for L-Fucose, permease component 1 from Sinorhizobium meliloti 1021
    33% identity, 92% coverage of query (118 bits)

GANP_BACSU / O32261 Galactooligosaccharides transport system permease protein GanP from Bacillus subtilis (strain 168) (see 2 papers)
TC 3.A.1.1.2 / O32261 Putative arabinogalactan oligomer transport system permease protein ganP, component of The galactooligosaccharide (transports the di, tri and tetrasaccharides) uptake porter GanOPQ (GanSPQ; MalEFG) functioning with the energizing ATPase MsmX (see 3.A.1.1.26) from Bacillus subtilis (see 2 papers)
    29% identity, 94% coverage of query (115 bits)

DASB_STRCO / Q9K490 Diacetylchitobiose uptake system permease protein DasB from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) (see paper)
    29% identity, 90% coverage of query (112 bits)

TC 3.A.1.1.22 / Q9X0T0 MalF1; aka Maltose ABC transporter, permease protein, component of The maltose, maltotriose, mannotetraose (MalE1)/maltose, maltotriose, trehalose (MalE2) porter (Nanavati et al., 2005). For MalG1 (823aas) and MalG2 (833aas), the C-terminal transmembrane domain with 6 putative TMSs is preceded by a single N-terminal TMS and a large (600 residue) hydrophilic region showing sequence similarity to MLP1 and 2 (9.A.14; e-12 & e-7) as well as other proteins from Thermotoga maritima (see paper)
    32% identity, 85% coverage of query (112 bits)

MELD_BACSU / O34706 Melibiose/raffinose/stachyose import permease protein MelD from Bacillus subtilis (strain 168) (see paper)
    29% identity, 93% coverage of query (111 bits)

MalF / b4033 maltose ABC transporter membrane subunit MalF (EC 7.5.2.1) from Escherichia coli K-12 substr. MG1655 (see 14 papers)
MalF / P02916 maltose ABC transporter membrane subunit MalF (EC 7.5.2.1) from Escherichia coli (strain K12) (see 13 papers)
MALF_ECOLI / P02916 Maltose/maltodextrin transport system permease protein MalF from Escherichia coli (strain K12) (see 4 papers)
P02916 ABC-type maltose transporter (subunit 1/3) (EC 7.5.2.1) from Escherichia coli (see paper)
TC 3.A.1.1.1 / P02916 MalF aka B4033, component of Maltooligosaccharide porter. The 3-D structure has been reported by Oldham et al. (2007). An altering access mechanism has been suggested for the maltose transporter resulting from rigid-body rotations (Khare et al., 2009). Bordignon et al. (2010) and Schneider et al. (2012) have reviewed the extensive knowledge available on MalEFGK2, its mode of action and its regulatory interactions from Escherichia coli (see 14 papers)
    32% identity, 82% coverage of query (110 bits)

BWI76_RS01825 maltose ABC transporter, permease component 1 (MalF) from Klebsiella michiganensis M5al
    30% identity, 81% coverage of query (110 bits)

TC 3.A.1.1.20 / Q7WWQ9 Transmembrane permease MsmF, component of The fructooligosaccharide porter, MsmEFGK from Lactobacillus acidophilus (see 2 papers)
msmF / GI|33149339 transmembrane permease MsmF from Lactobacillus acidophilus (see paper)
    29% identity, 91% coverage of query (110 bits)

4ki0F / P02916 Crystal structure of the maltose-binding protein/maltose transporter complex in an outward-facing conformation bound to maltohexaose (see paper)
    32% identity, 80% coverage of query (108 bits)

TC 3.A.1.1.37 / Q9WYB4 Predicted arabinoside porter. Regulated by arabinose-responsive regulator AraR from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    29% identity, 95% coverage of query (105 bits)

TC 3.A.1.1.12 / Q9AI67 PalF, component of Palatinose (isomaltulose; 6-O-α-D-glucopyranosyl-D-fructose) uptake porter from Erwinia rhapontici (see paper)
    31% identity, 71% coverage of query (105 bits)

P0A4N1 4-alpha-glucanotransferase (EC 2.4.1.25) from Streptococcus pneumoniae (see paper)
    29% identity, 77% coverage of query (104 bits)

TC 3.A.1.1.50 / Q5SLB6 Sugar ABC transporter, permease protein, component of Probable glycerophosphocholine (GPC) uptake porter (Chandravanshi et al. 2016). The system may include a receptor and three membrane proteins (of 378 aas and 6 TMSs, 299 aas and 7 TMSs, and 113 aas and 3 TMSs (?). The ATPase has not been identified from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
    30% identity, 89% coverage of query (104 bits)

TC 3.A.1.1.26 / O06990 MalF aka yvdH, component of The maltose porter, MdxEFG and MsmX from Bacillus subtilis (see 2 papers)
    29% identity, 77% coverage of query (103 bits)

TC 3.A.1.1.16 / Q8TZP9 MalF, component of Maltooligosaccharide porter (Maltose is not a substrate, but maltotriose is.) from Pyrococcus furiosus
    27% identity, 99% coverage of query (103 bits)

TC 3.A.1.1.33 / Q8KN18 Putative sugar transporter integral membrane protein, component of The N,N'-diacetylchitobiose uptake transporter, DasABC/MsiK (MsiK energizes several ABC transporters (see 3.A.1.1.23)) from Streptomyces sp. 139 (see 2 papers)
    27% identity, 89% coverage of query (101 bits)

TC 3.A.1.1.11 / Q93KC0 TogM, component of Saturated and unsaturated oligogalacturonide transporter, TogMNAB (transports di- to tetrasaccharide pectin degradation products which consist of D-galacuronate, sometimes with 4-deoxy-L-threo-5-hexosulose uronate at the reducing end of the oligosaccharide) (Hugouvieux-Cotte-Pattat et al. 2001). Regulated by pectin utilization regulator KdgR from Erwinia chrysanthemi (see paper)
    28% identity, 92% coverage of query (99.0 bits)

TC 3.A.1.1.38 / Q9WYQ0 ABC-type transporter, integral membrane subunit, component of Inositol phosphate porter (Rodionova et al. 2013). Binds inositol phosphate with low Kd and inositol with a lower affinity from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    29% identity, 93% coverage of query (98.6 bits)

TC 3.A.1.1.27 / Q8DT27 MalF, component of Maltose/Maltotriose/maltodextrin (up to 7 glucose units) transporters MalXFGK (MsmK (3.A.1.1.28) can probably substitute for MalK; Webb et al., 2008) from Streptococcus mutans (see paper)
    25% identity, 90% coverage of query (97.4 bits)

TC 3.A.1.1.18 / Q8RJU9 NgcF, component of N-Acetylglucosamine/N,N'-diacetyl chitobiose porter (NgcK (C) not identified) from Streptomyces olivaceoviridis (Streptomyces corchorusii) (see paper)
    29% identity, 91% coverage of query (97.1 bits)

Psest_0864 maltose ABC transporter, permease component 1 (MalF) from Pseudomonas stutzeri RCH2
    29% identity, 80% coverage of query (96.7 bits)

TC 3.A.1.1.21 / Q9L026 BxlF, component of The xylobiose porter; BxlEFG(K) from Streptomyces coelicolor (see paper)
    29% identity, 94% coverage of query (92.4 bits)

UgpA / b3452 sn-glycerol 3-phosphate ABC transporter membrane subunit UgpA (EC 7.6.2.10) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
UgpA / P10905 sn-glycerol 3-phosphate ABC transporter membrane subunit UgpA (EC 7.6.2.10) from Escherichia coli (strain K12) (see 20 papers)
UGPA_ECOLI / P10905 sn-glycerol-3-phosphate transport system permease protein UgpA from Escherichia coli (strain K12) (see 5 papers)
P10905 ABC-type glycerol 3-phosphate transporter (EC 7.6.2.10) from Escherichia coli (see paper)
TC 3.A.1.1.3 / P10905 UgpA aka B3452, component of Glycerol-phosphate porter. Transports both glycerol-3-P and glycerol-3-P diesters including glycerophosphocholine but not glycerol-2-P from Escherichia coli (see 5 papers)
    27% identity, 81% coverage of query (91.3 bits)

NGCF_STRCO / O50500 Diacetylchitobiose uptake system permease protein NgcF from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) (see paper)
    26% identity, 100% coverage of query (89.0 bits)

TC 3.A.1.1.28 / Q00750 MsmF aka SMU.879, component of The raffinose/stachyose transporter, MsmEFGK (MalK (3.A.1.1.27) can probably substitute for MsmK; Webb et al., 2008). This system may also transport melibiose, isomaltotriose and sucrose as well as isomaltosaccharides from Streptococcus mutans (see 2 papers)
    27% identity, 89% coverage of query (88.2 bits)

PGA1_c27940 N-Acetyl-D-glucosamine ABC transport system, permease component 1 from Phaeobacter inhibens BS107
    29% identity, 94% coverage of query (86.7 bits)

ARAP_BACSU / P94529 Arabinooligosaccharides transport system permease protein AraP from Bacillus subtilis (strain 168) (see 3 papers)
TC 3.A.1.1.34 / P94529 L-arabinose transport system permease protein AraP, component of The arabinosaccharide transporter AraNPQMsmX. Transports α-1,5-arabinooligosaccharides, at least up to four L-arabinosyl units; the key transporter for α-1,5-arabinotriose and α-1,5-arabinotetraose, but not for α-1,5-arabinobiose which is transported by AraE. MsmX is also used by the MdxEFG-MsmX system (3.A.1.1.36) (Ferreira and Sá-Nogueira, 2010). Involved in the uptake of pectin oligosaccharides with either MsmX or YurJ as the ATPase from Bacillus subtilis (see 4 papers)
araP / GB|CAB14834.1 L-arabinose transport system permease protein AraP from Bacillus subtilis (see 4 papers)
    26% identity, 85% coverage of query (86.7 bits)

smoG / Q7CS30 ABC-type 3-(6-sulfo-α-D-quinovosyl)-sn-glycerol transporter permease subunit from Agrobacterium fabrum (strain C58 / ATCC 33970) (see paper)
    29% identity, 88% coverage of query (86.3 bits)

PfGW456L13_1895 ABC transporter for D-Galactose and D-Glucose, permease component 1 from Pseudomonas fluorescens GW456-L13
    25% identity, 88% coverage of query (85.5 bits)

PS417_22140 glucose/xylose ABC transporter, permease component 2 from Pseudomonas simiae WCS417
    25% identity, 88% coverage of query (84.0 bits)

SMc02872 ABC transporter for N-Acetyl-D-glucosamine, permease protein 1 from Sinorhizobium meliloti 1021
    28% identity, 94% coverage of query (83.6 bits)

HSERO_RS17005 ABC transporter for D-sorbitol/xylitol, permease component 1 from Herbaspirillum seropedicae SmR1
    27% identity, 96% coverage of query (83.2 bits)

7cagA / A0R2C2 Mycobacterium smegmatis lpqy-sugabc complex in the catalytic intermediate state (see paper)
    26% identity, 98% coverage of query (83.2 bits)

SM_b21653 ABC transporter for Lactose, permease component 1 from Sinorhizobium meliloti 1021
    28% identity, 82% coverage of query (81.6 bits)

TC 3.A.1.1.4 / P29823 LacF, component of Lactose porter from Agrobacterium radiobacter (see paper)
    26% identity, 85% coverage of query (81.3 bits)

PGA1_c13200 ABC transporter for D-Sorbitol, permease component 2 from Phaeobacter inhibens BS107
    28% identity, 94% coverage of query (80.9 bits)

YcjO / b1311 putative ABC transporter membrane subunit YcjO from Escherichia coli K-12 substr. MG1655 (see 2 papers)
TC 3.A.1.1.46 / P0AFR7 Inner membrane ABC transporter permease protein YcjO, component of Probable glucoside uptake porter, YcjNOPV from Escherichia coli (strain K12)
    28% identity, 86% coverage of query (80.9 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory