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Searching for up to 100 curated homologs for SM_b21163 FitnessBrowser__Smeli:SM_b21163 (557 a.a.)

Found high-coverage hits (≥70%) to 23 curated proteins.

Removed hits that are identical to the query, leaving 22

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

PGA1_c36320 Urocanate hydratase (EC 4.2.1.49) from Phaeobacter inhibens BS107
    84% identity, 100% coverage of query (959 bits)

Ga0059261_3961 Urocanate hydratase (EC 4.2.1.49) from Sphingomonas koreensis DSMZ 15582
    81% identity, 100% coverage of query (936 bits)

AO356_09630 Urocanate hydratase (EC 4.2.1.49) from Pseudomonas fluorescens FW300-N2C3
    79% identity, 98% coverage of query (927 bits)

Pf6N2E2_3805 Urocanate hydratase (EC 4.2.1.49) from Pseudomonas fluorescens FW300-N2E2
    79% identity, 98% coverage of query (927 bits)

AO353_12250 Urocanate hydratase (EC 4.2.1.49) from Pseudomonas fluorescens FW300-N2E3
    78% identity, 99% coverage of query (923 bits)

Pf1N1B4_1587 Urocanate hydratase (EC 4.2.1.49) from Pseudomonas fluorescens FW300-N1B4
    78% identity, 98% coverage of query (919 bits)

BWI76_RS08735 Urocanate hydratase (EC 4.2.1.49) from Klebsiella michiganensis M5al
    78% identity, 99% coverage of query (918 bits)

PfGW456L13_326 Urocanate hydratase (EC 4.2.1.49) from Pseudomonas fluorescens GW456-L13
    77% identity, 100% coverage of query (916 bits)

PS417_01720 Urocanate hydratase (EC 4.2.1.49) from Pseudomonas simiae WCS417
    79% identity, 98% coverage of query (915 bits)

hutU / P25080 urocanase subunit (EC 4.2.1.49) from Pseudomonas putida (see 4 papers)
HUTU_PSEPU / P25080 Urocanate hydratase; Urocanase; Imidazolonepropionate hydrolase; EC 4.2.1.49 from Pseudomonas putida (Arthrobacter siderocapsulatus) (see 3 papers)
    76% identity, 100% coverage of query (904 bits)

1uwkA / P25080 The high resolution structure of urocanate hydratase from pseudomonas putida in complex with urocanate (see paper)
    77% identity, 99% coverage of query (901 bits)

Ac3H11_2557 Urocanate hydratase (EC 4.2.1.49) from Acidovorax sp. GW101-3H11
    71% identity, 99% coverage of query (847 bits)

7jfzA / Q5ZVR1 Structure of urocanate hydratase from legionella pneumophila bound to NAD
    70% identity, 98% coverage of query (805 bits)

hutU / P25503 HutU (EC 4.2.1.49) from Bacillus subtilis (strain 168) (see 2 papers)
HUTU_BACSU / P25503 Urocanate hydratase; Urocanase; Imidazolonepropionate hydrolase; EC 4.2.1.49 from Bacillus subtilis (strain 168) (see paper)
    64% identity, 98% coverage of query (731 bits)

2fknB / P25503 Crystal structure of urocanase from bacillus subtilis
    65% identity, 97% coverage of query (730 bits)

HUTU_GEOKA / Q5L084 Urocanate hydratase; Urocanase; Imidazolonepropionate hydrolase; EC 4.2.1.49 from Geobacillus kaustophilus (strain HTA426)
    65% identity, 98% coverage of query (717 bits)

1x87A / Q5L084 2.4a x-ray structure of urocanase protein complexed with NAD
    57% identity, 97% coverage of query (593 bits)

7nedA / A0A0Q9KFZ4 Thiourocanate hydratase from paenibacillus sp. Soil724d2 in complex with cofactor NAD+ and urocanate (see paper)
    51% identity, 97% coverage of query (558 bits)

6uekA / Q4D9S6 Structure of urocanate hydratase from trypanosoma cruzi in complex with NAD+ (see paper)
    37% identity, 99% coverage of query (327 bits)

HUTU_HUMAN / Q96N76 Urocanate hydratase; Urocanase; Imidazolonepropionate hydrolase; EC 4.2.1.49 from Homo sapiens (Human) (see paper)
    33% identity, 97% coverage of query (304 bits)

6uekD / Q4D9S6 Structure of urocanate hydratase from trypanosoma cruzi in complex with NAD+ (see paper)
    38% identity, 99% coverage of query (303 bits)

Sama_1632 Urocanate hydratase (EC 4.2.1.49) from Shewanella amazonensis SB2B
    33% identity, 96% coverage of query (300 bits)

Build an alignment

Build an alignment for SM_b21163 and 22 homologs with ≥ 30% identity

Select sequences

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory