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Searching for up to 100 curated homologs for SM_b21461 FitnessBrowser__Smeli:SM_b21461 (420 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Pf1N1B4_5112 sucrose ABC transporter, substrate-binding component from Pseudomonas fluorescens FW300-N1B4
    46% identity, 91% coverage of query (394 bits)

SM_b20325 ABC transporter for D-trehalose/D-maltose/sucrose, substrate-binding component (ThuE) from Sinorhizobium meliloti 1021
TC 3.A.1.1.17 / Q9R9Q7 ThuE aka RB0311 aka SMB20325, component of Trehalose/maltose/sucrose porter (trehalose inducible) from Rhizobium meliloti (Sinorhizobium meliloti) (see 3 papers)
    46% identity, 86% coverage of query (340 bits)

TC 3.A.1.1.19 / Q8L126 PalE, component of Platinose (isomaltulose) (6-O-α-D-glucopyranosyl-D-fructofuranose) porter from Agrobacterium tumefaciens (see 3 papers)
palE / BAB96538.1 PalE from Agrobacterium tumefaciens (see 3 papers)
    43% identity, 96% coverage of query (337 bits)

6jb0A Crystal structure of abc transporter alpha-glycoside-binding mutant protein w287a in complex with trehalose
    43% identity, 90% coverage of query (333 bits)

TC 3.A.1.1.25 / Q72H68 Trehalose/maltose-binding protein aka TT_C1627, component of The trehalose/maltose/sucrose/palatinose porter (TTC1627-9) plus MalK1 (ABC protein, shared with 3.A.1.1.24) (Silva et al. 2005; Chevance et al., 2006). The receptor (TTC1627) binds disaccharide alpha-glycosides, namely trehalose (alpha-1,1), sucrose (alpha-1,2), maltose (alpha-1,4), palatinose (alpha-1,6) and glucose from Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) (see paper)
    42% identity, 90% coverage of query (331 bits)

6jahA Crystal structure of abc transporter alpha-glycoside-binding protein in complex with glucose
    42% identity, 90% coverage of query (330 bits)

6jagA Crystal structure of abc transporter alpha-glycoside-binding protein in complex with sucrose
    42% identity, 90% coverage of query (330 bits)

6jadA Crystal structure of abc transporter alpha-glycoside-binding protein in complex with palatinose
    42% identity, 90% coverage of query (330 bits)

6j9yA Crystal structure of abc transporter alpha-glycoside-binding protein in complex with maltose
    42% identity, 90% coverage of query (330 bits)

6jamA / Q5SLD7 Crystal structure of abc transporter alpha-glycoside-binding mutant protein r356a in complex with trehalose (see paper)
    42% identity, 90% coverage of query (328 bits)

6jaiA Crystal structure of abc transporter alpha-glycoside-binding mutant protein d118a in complex with maltose
    42% identity, 90% coverage of query (327 bits)

TC 3.A.1.1.12 / Q9AI68 PalE, component of Palatinose (isomaltulose; 6-O-α-D-glucopyranosyl-D-fructose) uptake porter from Erwinia rhapontici (see paper)
    39% identity, 100% coverage of query (307 bits)

TC 3.A.1.1.41 / G4FGN8 Extracellular solute-binding protein family 1, component of Trehalose porter. Also binds sucrose (Boucher and Noll, 2011). Induced by glucose and trehalose. Directly regulated by trehalose-responsive regulator TreR from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    37% identity, 85% coverage of query (231 bits)

6dtqA / G4XU73 Maltose bound t. Maritima male3 (see paper)
    37% identity, 85% coverage of query (231 bits)

TC 3.A.1.1.7 / O51923 MalE aka PF1739, component of Maltose/trehalose porter (see paper)
    39% identity, 82% coverage of query (221 bits)

1eu8A / Q7LYW7 Structure of trehalose maltose binding protein from thermococcus litoralis (see paper)
    39% identity, 82% coverage of query (221 bits)

MALE_THELN / Q7LYW7 Trehalose/maltose-binding protein MalE; TMBP from Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C) (see 4 papers)
    39% identity, 81% coverage of query (219 bits)

smoF / A9CEY9 3-(6-sulfo-α-D-quinovosyl)-sn-glycerol binding protein from Agrobacterium fabrum (strain C58 / ATCC 33970) (see paper)
SMOF_AGRFC / A9CEY9 Sulfoquinovosyl glycerol-binding protein SmoF; SQGro-binding protein SmoF; SQ monooxygenase cluster protein F from Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58)) (see 2 papers)
    32% identity, 82% coverage of query (176 bits)

7ofyA Crystal structure of sq binding protein from agrobacterium tumefaciens in complex with sulfoquinovosyl glycerol (sqgro)
    32% identity, 82% coverage of query (175 bits)

7yzsAAA Sulfoquinovosyl binding protein
    32% identity, 82% coverage of query (174 bits)

7qhvAAA / A9CEY9 7qhvAAA (see paper)
    32% identity, 82% coverage of query (173 bits)

7yzuA Crystal structure of the sulfoquinovosyl binding protein smof complexed with sqme
    32% identity, 82% coverage of query (173 bits)

SM_b21221 ABC transporter for D-Glucosamine, periplasmic substrate-binding protein from Sinorhizobium meliloti 1021
    30% identity, 76% coverage of query (113 bits)

Build an alignment

Build an alignment for SM_b21461 and 23 homologs with ≥ 30% identity

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Change minimum %identity:

Additional hits (identity < 30%)

5iaiA / B9JM84 Crystal structure of abc transporter solute binding protein arad_9887 from agrobacterium radiobacter k84, target efi-510945 in complex with ribitol
    24% identity, 86% coverage of query (92.4 bits)

7apeA / G7CES0 Crystal structure of lpqy from mycobacterium thermoresistible in complex with trehalose (see paper)
    23% identity, 83% coverage of query (91.7 bits)

LPQY_MYCT3 / G7CES0 Trehalose-binding lipoprotein LpqY; Extracellular solute-binding protein; SugABC transporter substrate-binding protein LpqY; SugABC transporter SBP LpqY from Mycolicibacterium thermoresistibile (strain ATCC 19527 / DSM 44167 / CIP 105390 / JCM 6362 / NCTC 10409 / 316) (Mycobacterium thermoresistibile) (see paper)
    23% identity, 83% coverage of query (91.7 bits)

8jadA Crystal structure of mycobacterium tuberculosis lpqy in complex with trehalose analogue yb-17
    25% identity, 83% coverage of query (84.3 bits)

8jacA Crystal structure of mycobacterium tuberculosis lpqy in complex with trehalose analogue yb-16
    25% identity, 83% coverage of query (84.3 bits)

8ja9A Crystal structure of mycobacterium tuberculosis lpqy in complex with trehalose analogue yb-03
    25% identity, 83% coverage of query (84.3 bits)

8jabA Crystal structure of mycobacterium tuberculosis lpqy in complex with trehalose analogue yb-06
    25% identity, 83% coverage of query (84.3 bits)

lpqY / P9WGU9 trehalose-binding lipoprotein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
LPQY_MYCTU / P9WGU9 Trehalose-binding lipoprotein LpqY; SugABC transporter substrate-binding protein LpqY; SugABC transporter SBP LpqY from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
TC 3.A.1.1.31 / Q7D8J9 PROBABLE SUGAR-BINDING LIPOPROTEIN LPQY, component of The trehalose-recycling ABC transporter, LpqY-SugA-SugB-SugC (essential for virulence) from Mycobacterium tuberculosis (see 2 papers)
    24% identity, 83% coverage of query (84.0 bits)

8ja7E / P9WGU9 Cryo-em structure of mycobacterium tuberculosis lpqy-sugabc in complex with trehalose
    24% identity, 83% coverage of query (84.0 bits)

7cafE / A0R2C3 Mycobacterium smegmatis lpqy-sugabc complex in the pre-translocation state (see paper)
    24% identity, 77% coverage of query (83.6 bits)

5ysdB / Q92AS8 Crystal structure of beta-1,2-glucooligosaccharide binding protein in complex with sophorotriose (see paper)
    25% identity, 88% coverage of query (80.5 bits)

5ysbA Crystal structure of beta-1,2-glucooligosaccharide binding protein in ligand-free form
    25% identity, 89% coverage of query (80.5 bits)

5ysdA Crystal structure of beta-1,2-glucooligosaccharide binding protein in complex with sophorotriose
    25% identity, 89% coverage of query (80.5 bits)

Q92AS8 ABC-type beta-glucan transporter (EC 7.5.2.3) from Listeria innocua (see paper)
    24% identity, 88% coverage of query (80.1 bits)

3jzjA / B0B0V1 Crystal structures of the gach receptor of streptomyces glaucescens gla.O in the unliganded form and in complex with acarbose and an acarbose homolog. Comparison with acarbose-loaded maltose binding protein of salmonella typhimurium. (see paper)
    25% identity, 83% coverage of query (73.6 bits)

3k02A Crystal structures of the gach receptor of streptomyces glaucescens gla.O in the unliganded form and in complex with acarbose and an acarbose homolog. Comparison with acarbose-loaded maltose binding protein of salmonella typhimurium.
    25% identity, 83% coverage of query (73.6 bits)

4b3nA / P0AEX9,Q0PF16 Crystal structure of rhesus trim5alpha pry/spry domain (see paper)
    25% identity, 89% coverage of query (65.1 bits)

1zjlA Crystal structure of zinc-bound engineered maltose binding protein
    25% identity, 89% coverage of query (62.8 bits)

7bvtA / D2YYD8 Crystal structure of cyclic alpha-maltosyl-1,6-maltose binding protein from arthrobacter globiformis (see paper)
    24% identity, 83% coverage of query (62.4 bits)

MalE / b4034 maltose ABC transporter periplasmic binding protein (EC 7.5.2.1) from Escherichia coli K-12 substr. MG1655 (see 50 papers)
MalE / P0AEX9 maltose ABC transporter periplasmic binding protein (EC 7.5.2.1) from Escherichia coli (strain K12) (see 74 papers)
MALE_ECOLI / P0AEX9 Maltose/maltodextrin-binding periplasmic protein; MMBP; Maltodextrin-binding protein; Maltose-binding protein; MBP from Escherichia coli (strain K12) (see 5 papers)
P0AEX9 ABC-type maltose transporter (subunit 1/4) (EC 7.5.2.1) from Escherichia coli (see paper)
P0AEY0 single-stranded DNA cytosine deaminase (EC 3.5.4.38) from Escherichia coli O157:H7 (see paper)
TC 3.A.1.1.1 / P0AEX9 Maltose-binding periplasmic protein MalE aka B4034, component of Maltooligosaccharide porter. The 3-D structure has been reported by Oldham et al. (2007). An altering access mechanism has been suggested for the maltose transporter resulting from rigid-body rotations (Khare et al., 2009). Bordignon et al. (2010) and Schneider et al. (2012) have reviewed the extensive knowledge available on MalEFGK2, its mode of action and its regulatory interactions from Escherichia coli (see 12 papers)
malE / RF|NP_418458 maltose-binding periplasmic protein from Escherichia coli K12 (see 14 papers)
    25% identity, 89% coverage of query (62.0 bits)

3csbA / P0AEX9 Crystal structure of monobody ysx1/maltose binding protein fusion complex (see paper)
    25% identity, 89% coverage of query (62.0 bits)

1llsA Crystal structure of unliganded maltose binding protein with xenon
    25% identity, 89% coverage of query (61.6 bits)

1ez9B Structure of maltotetraitol bound to open-form maltodextrin binding protein in p1 crystal form
    25% identity, 89% coverage of query (61.6 bits)

7x0lA / A3DE73 Crystal structure of sugar binding protein cbpb complexed wtih cellotetraose from clostridium thermocellum (see paper)
    25% identity, 82% coverage of query (61.2 bits)

5z0rB / P0AEX9,Q32ZE1 Structural insight into the zika virus capsid encapsulating the viral genome (see paper)
    25% identity, 88% coverage of query (60.8 bits)

AO356_00025 ABC transporter for D-Sorbitol, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N2C3
    23% identity, 82% coverage of query (60.8 bits)

3hpiA Crystal structure of maltose-binding protein mutant with bound sucrose
    25% identity, 89% coverage of query (60.8 bits)

2v93A Equillibrium mixture of open and partially-closed species in the apo state of maltodextrin-binding protein by paramagnetic relaxation enhancement nmr
    24% identity, 89% coverage of query (60.8 bits)

4my2A / P0AEX9,Q00604 Crystal structure of norrin in fusion with maltose binding protein (see paper)
    25% identity, 87% coverage of query (60.5 bits)

7uajB / P03126,P0AEX9 Crystal structure of apo hpv16 e6
    25% identity, 87% coverage of query (60.5 bits)

6ob5B Computationally-designed, modular sense/response system (s3-2d)
    26% identity, 71% coverage of query (60.5 bits)

5cfvA / P0AEX9 Fusion of maltose-binding protein and pila from acinetobacter nosocomialis m2 (see paper)
    25% identity, 88% coverage of query (60.1 bits)

6k7fA / P0AEX9,P53220 Crystal structure of mbpholo-tim21 fusion protein with a 17-residue helical linker (see paper)
    24% identity, 88% coverage of query (60.1 bits)

5az7A / P0AEX9,Q62760 Crystal structure of mbp-tom20 fusion protein with a 4-residue spacer in the connector helix (see paper)
    24% identity, 89% coverage of query (60.1 bits)

5azaA / I6V0B8,P0AEX9 Crystal structure of mbp-saglb fusion protein with a 20-residue spacer in the connector helix (see paper)
    24% identity, 88% coverage of query (60.1 bits)

5jonA / O88703,P0AEY0 Crystal structure of the unliganded form of hcn2 cnbd (see paper)
    25% identity, 87% coverage of query (59.7 bits)

5ttdA / D2KPJ6,P0AEX9 Minor pilin fctb from s. Pyogenes with engineered intramolecular isopeptide bond (see paper)
    26% identity, 71% coverage of query (59.7 bits)

2vgqA / P0AEX9,Q7Z434 Crystal structure of human ips-1 card (see paper)
    25% identity, 87% coverage of query (59.7 bits)

6zhoA / O60894,P0AEX9,Q16602 Crystal structure of a cgrp receptor ectodomain heterodimer with bound high affinity inhibitor (see paper)
    25% identity, 87% coverage of query (59.7 bits)

8ax5A Crystal structure of a cgrp receptor ectodomain heterodimer bound to macrocyclic inhibitor htl0029881
    25% identity, 87% coverage of query (59.7 bits)

5w1cA Crystal structure of mbp fused activation-induced cytidine deaminase (aid) in complex with cytidine
    25% identity, 87% coverage of query (59.7 bits)

4rwgB Crystal structure of the clr:ramp1 extracellular domain heterodimer with bound high affinity cgrp analog
    25% identity, 87% coverage of query (59.7 bits)

4wgiA A single diastereomer of a macrolactam core binds specifically to myeloid cell leukemia 1 (mcl1)
    25% identity, 87% coverage of query (59.7 bits)

3oaiA / P0AEX9,P25189 Crystal structure of the extra-cellular domain of human myelin protein zero (see paper)
    25% identity, 88% coverage of query (59.3 bits)

3a3cA / P0AEX9,P36046 Crystal structure of tim40/mia40 fusing mbp, c296s and c298s mutant (see paper)
    25% identity, 87% coverage of query (59.3 bits)

3ehuA / P0AEX9,P34998 Crystal structure of the extracellular domain of human corticotropin releasing factor receptor type 1 (crfr1) in complex with crf (see paper)
    26% identity, 75% coverage of query (59.3 bits)

6pfoA / P30988 Crystal structure of n-glycosylated human calcitonin receptor extracellular domain in complex with salmon calcitonin (16-32) (see paper)
    25% identity, 87% coverage of query (59.3 bits)

Pf6N2E2_1963 ABC transporter for D-sorbitol, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N2E2
    23% identity, 82% coverage of query (59.3 bits)

3n94A / P0AEX9,P41586 Crystal structure of human pituitary adenylate cyclase 1 receptor- short n-terminal extracellular domain (see paper)
    25% identity, 87% coverage of query (59.3 bits)

4rwfA / O60895,P0AEX9,Q16602 Crystal structure of the clr:ramp2 extracellular domain heterodimer with bound adrenomedullin (see paper)
    25% identity, 87% coverage of query (59.3 bits)

3l2jA / P0AEX9,Q03431 Dimeric structure of the ligand-free extracellular domain of the human parathyroid hormone receptor (pth1r) (see paper)
    25% identity, 87% coverage of query (59.3 bits)

4rwgA Crystal structure of the clr:ramp1 extracellular domain heterodimer with bound high affinity cgrp analog
    25% identity, 87% coverage of query (59.3 bits)

3c4mA Structure of human parathyroid hormone in complex with the extracellular domain of its g-protein-coupled receptor (pth1r)
    25% identity, 87% coverage of query (59.3 bits)

7p0fA Crystal structure of a cgrp receptor ectodomain heterodimer bound to macrocyclic inhibitor htl0028125
    25% identity, 87% coverage of query (59.3 bits)

7p0iA Crystal structure of a cgrp receptor ectodomain heterodimer bound to macrocyclic inhibitor compound 13
    25% identity, 87% coverage of query (59.3 bits)

8ax6A Crystal structure of a cgrp receptor ectodomain heterodimer bound to macrocyclic inhibitor htl0029882
    25% identity, 87% coverage of query (59.3 bits)

8ax7A Crystal structure of a cgrp receptor ectodomain heterodimer bound to macrocyclic inhibitor htl0031448
    25% identity, 87% coverage of query (59.3 bits)

5f7vA / Q8YAE9 Abc substrate-binding protein lmo0181 from listeria monocytogenes in complex with cycloalternan (see paper)
    25% identity, 76% coverage of query (58.9 bits)

8g3sA / Q07820 Mbp-mcl1 in complex with ligand 11 (see paper)
    25% identity, 87% coverage of query (58.9 bits)

3n96A / P0AEX9,Q13324 Crystal structure of human crfr2 alpha extracellular domain in complex with urocortin 1
    25% identity, 87% coverage of query (58.9 bits)

4nufA / P0AEX9,Q62227 Crystal structure of shp/eid1 (see paper)
    25% identity, 87% coverage of query (58.9 bits)

7omtA / P0AEX9 Crystal structure of promacrobody 21 with bound maltose (see paper)
    25% identity, 87% coverage of query (58.9 bits)

1a7lA Dominant b-cell epitope from the pres2 region of hepatitis b virus in the form of an inserted peptide segment in maltodextrin-binding protein
    25% identity, 87% coverage of query (58.9 bits)

4wmwA The structure of mbp-mcl1 bound to ligand 5 at 1.9a
    25% identity, 87% coverage of query (58.9 bits)

4wmvA Structure of mbp-mcl1 bound to ligand 4 at 2.4a
    25% identity, 87% coverage of query (58.9 bits)

8qsoA Crystal structure of human mcl-1 in complex with compound 1
    25% identity, 87% coverage of query (58.9 bits)

8g3xA Mbp-mcl1 in complex with ligand 32
    25% identity, 87% coverage of query (58.9 bits)

8g3wA Mbp-mcl1 in complex with ligand 28
    25% identity, 87% coverage of query (58.9 bits)

8g3uA Mbp-mcl1 in complex with ligand 21
    25% identity, 87% coverage of query (58.9 bits)

8g3tA Mbp-mcl1 in complex with ligand 12
    25% identity, 87% coverage of query (58.9 bits)

8el1A Structure of mbp-mcl-1 in complex with abbv-467
    25% identity, 87% coverage of query (58.9 bits)

8el0A Structure of mbp-mcl-1 in complex with a macrocyclic compound
    25% identity, 87% coverage of query (58.9 bits)

4wthB Ataxin-3 carboxy terminal region - crystal c2 (triclinic)
    25% identity, 87% coverage of query (58.9 bits)

4xaiA / P0AEY0,Q9NCL0 Crystal structure of red flour beetle nr2e1/tlx (see paper)
    25% identity, 87% coverage of query (58.5 bits)

6anvA / L7P7M1,P0AEX9 Crystal structure of anti-crispr protein acrf1 (see paper)
    25% identity, 87% coverage of query (58.5 bits)

8h68A / P0AEX9,Q8MNT9 Crystal structure of caenorhabditis elegans nmad-1 in complex with nog and mg(ii) (see paper)
    25% identity, 87% coverage of query (58.5 bits)

4xajB / P0AEX9,Q9Y466 Crystal structure of human nr2e1/tlx (see paper)
    25% identity, 87% coverage of query (58.5 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory