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Searching for up to 100 curated homologs for SMa0056 FitnessBrowser__Smeli:SMa0056 (377 a.a.)

Found high-coverage hits (≥70%) to 56 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

4it1D / Q3KB33 Crystal structure of enolase pfl01_3283 (target efi-502286) from pseudomonas fluorescens pf0-1 with bound magnesium, potassium and tartrate
    34% identity, 81% coverage of query (181 bits)

3vc6A / D6Y7Y6 Crystal structure of enolase tbis_1083(target efi-502310) from thermobispora bispora dsm 43833 complexed with magnesium and formate
    39% identity, 74% coverage of query (173 bits)

3va8A Crystal structure of enolase fg03645.1 (target efi-502278) from gibberella zeae ph-1 complexed with magnesium, formate and sulfate
    32% identity, 95% coverage of query (152 bits)

3pfrA Crystal structure of d-glucarate dehydratase related protein from actinobacillus succinogenes complexed with d-glucarate
    33% identity, 74% coverage of query (119 bits)

3n6hB / A6VQF6 Crystal structure of mandelate racemase/muconate lactonizing protein from actinobacillus succinogenes 130z complexed with magnesium/sulfate
    33% identity, 74% coverage of query (115 bits)

GudX / b2788 glucarate dehydratase-related protein from Escherichia coli K-12 substr. MG1655 (see 2 papers)
GUDX_ECOLI / Q46915 Glucarate dehydratase-related protein; GDH-RP; GlucDRP; EC 4.2.1.- from Escherichia coli (strain K12) (see paper)
gudX / RF|NP_417268 glucarate dehydratase-related protein from Escherichia coli K12
    30% identity, 74% coverage of query (110 bits)

Build an alignment

Build an alignment for SMa0056 and 6 homologs with ≥ 30% identity

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Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Additional hits (identity < 30%)

1ec9D / P0AES2 E. Coli glucarate dehydratase bound to xylarohydroxamate (see paper)
    29% identity, 74% coverage of query (108 bits)

YgcX / b2787 D-glucarate dehydratase (EC 4.2.1.40) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
gudD / P0AES2 D-glucarate dehydratase (EC 4.2.1.40) from Escherichia coli (strain K12) (see 5 papers)
GUDD_ECOLI / P0AES2 Glucarate dehydratase; GDH; GlucD; D-glucarate dehydratase; EC 4.2.1.40 from Escherichia coli (strain K12) (see 3 papers)
gudD / RF|NP_417267 glucarate dehydratase; EC 4.2.1.40 from Escherichia coli K12 (see 8 papers)
    29% identity, 74% coverage of query (108 bits)

1ecqA E. Coli glucarate dehydratase bound to 4-deoxyglucarate
    29% identity, 74% coverage of query (108 bits)

1jctA Glucarate dehydratase, n341l mutant orthorhombic form
    29% identity, 74% coverage of query (108 bits)

1ec8A E. Coli glucarate dehydratase bound to product 2,3-dihydroxy-5-oxo- hexanedioate
    29% identity, 74% coverage of query (108 bits)

gudD / Q6FFQ2 D-glucarate dehydratase subunit (EC 4.2.1.40) from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) (see paper)
GUDD_ACIAD / Q6FFQ2 Glucarate dehydratase; GDH; GlucD; EC 4.2.1.40 from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) (see paper)
Q6FFQ2 glucarate dehydratase (EC 4.2.1.40) from Acinetobacter baylyi (see paper)
    30% identity, 74% coverage of query (103 bits)

3p0wB / B2UIZ1 Crystal structure of d-glucarate dehydratase from ralstonia solanacearum complexed with mg and d-glucarate
    30% identity, 74% coverage of query (94.7 bits)

3nfuA / Q1QUN0 Crystal structure of probable glucarate dehydratase from chromohalobacter salexigens dsm 3043 complexed with magnesium
    27% identity, 74% coverage of query (90.1 bits)

gudD / P42206 D-glucarate dehydratase subunit (EC 4.2.1.40) from Pseudomonas putida (see paper)
GUDD_PSEPU / P42206 Glucarate dehydratase; GDH; GlucD; EC 4.2.1.40 from Pseudomonas putida (Arthrobacter siderocapsulatus) (see paper)
    28% identity, 74% coverage of query (84.7 bits)

gci / A9CEQ8 D-galactarolactone cycloisomerase monomer (EC 5.5.1.27) from Agrobacterium fabrum (strain C58 / ATCC 33970) (see paper)
GCI_AGRFC / A9CEQ8 D-galactarolactone cycloisomerase; EC 5.5.1.27 from Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58)) (see 2 papers)
A9CEQ8 D-galactarolactone cycloisomerase (EC 5.5.1.27) from Agrobacterium tumefaciens (see paper)
4hpnA / A9CEQ8 Crystal structure of a proposed galactarolactone cycloisomerase from agrobacterium tumefaciens, target efi-500704, with bound ca, ordered loops (see paper)
    28% identity, 74% coverage of query (84.3 bits)

C3HPD_STAND / D7A0Y2 Cis-3-hydroxy-L-proline dehydratase; c3LHyp dehydratase; c3LHypD; EC 4.2.1.171 from Starkeya novella (strain ATCC 8093 / DSM 506 / JCM 20403 / CCM 1077 / IAM 12100 / NBRC 12443 / NCIMB 10456) (see paper)
    29% identity, 74% coverage of query (75.1 bits)

3sjnA / A8H9D1 Crystal structure of enolase spea_3858 (target efi-500646) from shewanella pealeana with magnesium bound
    27% identity, 74% coverage of query (73.9 bits)

xacD / D4GP40 D-xylonate dehydratase subunit (EC 4.2.1.25; EC 4.2.1.82) from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (see 3 papers)
XAD_HALVD / D4GP40 D-xylonate dehydratase; XAD; EC 4.2.1.82 from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) (see 2 papers)
D4GP40 xylonate dehydratase (EC 4.2.1.82) from Haloferax volcanii (see paper)
    27% identity, 75% coverage of query (71.6 bits)

4mggA / A0NXQ8 Crystal structure of an enolase (mandelate racemase subgroup) from labrenzia aggregata iam 12614 (target nysgrc-012903) with bound mg, space group p212121
    25% identity, 79% coverage of query (69.7 bits)

C3HPD_ROSAI / A0NXQ8 Cis-3-hydroxy-L-proline dehydratase; c3LHyp dehydratase; c3LHypD; EC 4.2.1.171 from Roseibium aggregatum (strain ATCC 25650 / DSM 13394 / JCM 20685 / NBRC 16684 / NCIMB 2208 / IAM 12614 / B1) (Stappia aggregata) (see paper)
A0NXQ8 cis-L-3-hydroxyproline dehydratase (EC 4.2.1.171) from Roseibium aggregatum (see paper)
    25% identity, 79% coverage of query (69.3 bits)

2ps2A / Q2U1E8 Crystal structure of putative mandelate racemase/muconate lactonizing enzyme from aspergillus oryzae
    24% identity, 73% coverage of query (68.6 bits)

tfdDI / P05404 chloromuconate cycloisomerase subunit (EC 5.5.1.7; EC 5.5.1.11) from Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (see 5 papers)
2chrA / P05404 A re-evaluation of the crystal structure of chloromuconate cycloisomerase (see paper)
    27% identity, 87% coverage of query (66.6 bits)

3op2A Crystal structure of putative mandelate racemase from bordetella bronchiseptica rb50 complexed with 2-oxoglutarate/phosphate
    26% identity, 74% coverage of query (65.1 bits)

clcB / AAC38249.1 chloromuconate cycloisomerase from Rhodococcus opacus (see paper)
    28% identity, 88% coverage of query (63.9 bits)

D4GYD4 gluconate dehydratase (EC 4.2.1.39) from Haloferax volcanii (see paper)
    26% identity, 74% coverage of query (63.5 bits)

araD / Q97U96 D-arabinonate dehydratase subunit (EC 4.2.1.5) from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (see paper)
ARAD_SACS2 / Q97U96 Arabinonate dehydratase; EC 4.2.1.5 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see paper)
Q97U96 Arabinonate dehydratase (EC 4.2.1.5) from Saccharolobus solfataricus (see paper)
    24% identity, 84% coverage of query (63.5 bits)

3ozmA / A0A0H3LT39 Crystal structure of enolase superfamily member from bordetella bronchiseptica complexed with mg, m-xylarate and l-lyxarate
    26% identity, 74% coverage of query (63.2 bits)

1nu5A / P27099 Crystal structure of pseudomonas sp. P51 chloromuconate lactonizing enzyme (see paper)
    25% identity, 87% coverage of query (63.2 bits)

tcbD / P27099 chloromuconate cycloisomerase subunit (EC 5.5.1.11; EC 5.5.1.7) from Pseudomonas sp. (strain P51) (see 2 papers)
TCBD_PSESQ / P27099 Chloromuconate cycloisomerase; Muconate cycloisomerase II; EC 5.5.1.7 from Pseudomonas sp. (strain P51) (see paper)
    25% identity, 87% coverage of query (63.2 bits)

3ozmD Crystal structure of enolase superfamily member from bordetella bronchiseptica complexed with mg, m-xylarate and l-lyxarate
    26% identity, 74% coverage of query (62.8 bits)

TFDD_DELAC / Q9RNZ9 Chloromuconate cycloisomerase; EC 5.5.1.7 from Delftia acidovorans (Pseudomonas acidovorans) (Comamonas acidovorans) (see paper)
    26% identity, 87% coverage of query (62.4 bits)

catB / AAA66202.1 muconate lactonizing enzyme from Pseudomonas putida (see paper)
    28% identity, 75% coverage of query (60.8 bits)

4h83F / A4AFX2 Crystal structure of mandelate racemase/muconate lactonizing enzyme (efi target:502127)
    26% identity, 71% coverage of query (59.7 bits)

AEEP_CLOAB / Q97MK4 L-Ala-D/L-Glu epimerase; AE epimerase; AEE; EC 5.1.1.20 from Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) (see paper)
    26% identity, 74% coverage of query (59.7 bits)

catB / BAD11152.1 cis,cis-muconate cycloisomerase from Arthrobacter sp. BA-5-17 (see paper)
    23% identity, 74% coverage of query (59.7 bits)

3no1A Crystal structure of mandelate racemase/muconate lactonizing enzyme from a marine actinobacterium in complex with magnesium
    25% identity, 71% coverage of query (57.8 bits)

IMAND_VIBBS / A5KUH4 D-galactonate dehydratase family member VSWAT3_13707 from Vibrionales bacterium (strain SWAT-3) (see paper)
    24% identity, 75% coverage of query (57.4 bits)

3dg6A / A0QTN8 Crystal structure of muconate lactonizing enzyme from mucobacterium smegmatis complexed with muconolactone (see paper)
    26% identity, 74% coverage of query (57.0 bits)

salC / Q4KPK2 muconate cycloisomerase I (EC 5.5.1.1; EC 5.5.1.7) from Pseudomonas reinekei (see paper)
Q4KPK2 Muconate cycloisomerase (EC 5.5.1.1) from Pseudomonas reinekei (see paper)
    27% identity, 75% coverage of query (57.0 bits)

2pmqB / Q0FPQ4 Crystal structure of a mandelate racemase/muconate lactonizing enzyme from roseovarius sp. Htcc2601 (see paper)
    24% identity, 72% coverage of query (56.6 bits)

DGD_SALEP / B5R541 D-galactonate dehydratase family member SEN1436; D-gluconate dehydratase; EC 4.2.1.-; EC 4.2.1.39 from Salmonella enteritidis PT4 (strain P125109) (see paper)
    23% identity, 74% coverage of query (56.6 bits)

hpbD / Q0FPQ4 hydroxyproline betaine 2-epimerase (EC 5.1.1.22) from Salipiger bermudensis (strain DSM 26914 / JCM 13377 / KCTC 12554 / HTCC2601) (see paper)
HPBD_SALBH / Q0FPQ4 4-hydroxyproline betaine 2-epimerase; Hyp-B 2-epimerase; (4R)-4-hydroxyproline betaine 2-epimerase; EC 5.1.1.22 from Salipiger bermudensis (strain DSM 26914 / JCM 13377 / KCTC 12554 / HTCC2601) (Pelagibaca bermudensis) (see paper)
Q0FPQ4 4-hydroxyproline betaine 2-epimerase (EC 5.1.1.22) from Salipiger bermudensis (see paper)
    24% identity, 72% coverage of query (56.6 bits)

4ihcB / C6CBG9 Crystal structure of probable mannonate dehydratase dd703_0947 (target efi-502222) from dickeya dadantii ech703
    25% identity, 73% coverage of query (56.6 bits)

3es7A / Q8EMJ9 Crystal structure of divergent enolase from oceanobacillus iheyensis complexed with mg and l-malate. (see paper)
    25% identity, 74% coverage of query (56.2 bits)

4h2hA Crystal structure of an enolase (mandalate racemase subgroup, target efi-502101) from pelagibaca bermudensis htcc2601, with bound mg and l-4-hydroxyproline betaine (betonicine)
    24% identity, 72% coverage of query (56.2 bits)

Ob2843 / Q8EMJ9 galactarate dehydratase (D-threo-forming) (EC 4.2.1.158) from Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831) (see paper)
GALRD_OCEIH / Q8EMJ9 Galactarate dehydratase (D-threo-forming); GalrD; GalrD-II; EC 4.2.1.158 from Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831) (see paper)
Q8EMJ9 galactarate dehydratase (D-threo-forming) (EC 4.2.1.158) from Oceanobacillus iheyensis (see paper)
    25% identity, 74% coverage of query (55.8 bits)

3twbC / B5R541 Crystal structure of gluconate dehydratase (target efi-501679) from salmonella enterica subsp. Enterica serovar enteritidis str. P125109 complexed with magnesium and gluconic acid
    23% identity, 74% coverage of query (55.5 bits)

IMAND_ENTCS / C9CN91 D-galactonate dehydratase family member ECAG_02205 from Enterococcus casseliflavus (strain EC10) (see paper)
    25% identity, 74% coverage of query (55.5 bits)

catB / BAE46388.1 cis,cis-muconate cycloisomerase from Rhodococcus sp. AN-22 (see paper)
    26% identity, 74% coverage of query (55.1 bits)

DGD_SALVI / B5QBD4 D-galactonate dehydratase family member SeV_A0456; D-gluconate dehydratase; EC 4.2.1.-; EC 4.2.1.39 from Salmonella virchow (see paper)
    23% identity, 74% coverage of query (54.7 bits)

3hpfA Crystal structure of the mutant y90f of divergent galactarate dehydratase from oceanobacillus iheyensis complexed with mg and galactarate
    25% identity, 74% coverage of query (54.3 bits)

DMGD_MUSP7 / C6CBG9 D-galactonate dehydratase family member Dd703_0947; D-gluconate dehydratase; D-mannonate dehydratase; EC 4.2.1.-; EC 4.2.1.39; EC 4.2.1.8 from Musicola paradisiaca (strain Ech703) (Dickeya paradisiaca) (Dickeya dadantii) (see paper)
    23% identity, 74% coverage of query (54.3 bits)

IMND1_ENTGE / C8ZZN2 D-galactonate dehydratase family member EGBG_01401 from Enterococcus gallinarum (strain EG2) (see paper)
    25% identity, 74% coverage of query (49.7 bits)

4hnlA / C8ZZN2 Crystal structure of enolase egbg_01401 (target efi-502226) from enterococcus gallinarum eg2
    25% identity, 74% coverage of query (49.7 bits)

4k1wA Crystal structure of the a314p mutant of mannonate dehydratase from novosphingobium aromaticivorans complexed with mg and d-mannonate
    25% identity, 72% coverage of query (47.4 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory