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Searching for up to 100 curated homologs for SMa0218 FitnessBrowser__Smeli:SMa0218 (316 a.a.)

Found high-coverage hits (≥70%) to 37 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

PGA1_c07300 Inositol transport system sugar-binding protein from Phaeobacter inhibens BS107
    31% identity, 97% coverage of query (110 bits)

4ru1A / A0LVW8 Crystal structure of carbohydrate transporter acei_1806 from acidothermus cellulolyticus 11b, target efi-510965, in complex with myo-inositol
    30% identity, 88% coverage of query (91.3 bits)

Build an alignment

Build an alignment for SMa0218 and 2 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

XYLF_SULAC / Q4J710 Xylose/arabinose-binding protein XylF; D-xylose/L-arabinose substrate binding protein; SBP from Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) (see paper)
Q4J710 ABC-type D-xylose/L-arabinose transporter (subunit 1/2) (EC 7.5.2.13) from Sulfolobus acidocaldarius (see paper)
    29% identity, 84% coverage of query (85.5 bits)

2h3hA / Q9WXW9 Crystal structure of the liganded form of thermotoga maritima glucose binding protein (see paper)
    29% identity, 79% coverage of query (82.0 bits)

3c6qC Apo and ligand-bound form of a thermophilic glucose/xylose binding protein
    30% identity, 79% coverage of query (81.3 bits)

5dteB / A6VKG5 Crystal structure of an abc transporter periplasmic solute binding protein (ipr025997) from actinobacillus succinogenes 130z(asuc_0081, target efi-511065) with bound d-allose
    30% identity, 79% coverage of query (68.9 bits)

TC 3.A.1.2.13 / A6VKT0 RbsB, component of The probable autoinducer-2 (AI-2;, a furanosyl borate diester: 3aS,6S,6aR)-2,2,6,6a-tetrahydroxy-3a-methyltetrahydrofuro[3,2-d][1,3,2]dioxaborolan-2-uide) uptake porter (Shao et al., 2007) (50-70% identical to RbsABC of E. coli; TC# 3.A.1.2.1) from Actinobacillus succinogenes (strain ATCC 55618 / 130Z)
    28% identity, 85% coverage of query (67.4 bits)

RbsB / b3751 ribose ABC transporter periplasmic binding protein from Escherichia coli K-12 substr. MG1655 (see 25 papers)
RbsB / P02925 ribose ABC transporter periplasmic binding protein from Escherichia coli (strain K12) (see 25 papers)
RBSB_ECOLI / P02925 Ribose import binding protein RbsB from Escherichia coli (strain K12) (see 5 papers)
TC 3.A.1.2.1 / P02925 RbsB aka RBSP aka PRLB aka B3751, component of Ribose porter from Escherichia coli (see 11 papers)
rbsB / GB|AAC76774.1 D-ribose-binding periplasmic protein; EC 3.6.3.17 from Escherichia coli K12 (see 11 papers)
    27% identity, 85% coverage of query (67.4 bits)

AlsB / b4088 D-allose ABC transporter periplasmic binding protein (EC 7.5.2.8) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
AlsB / P39265 D-allose ABC transporter periplasmic binding protein (EC 7.5.2.8) from Escherichia coli (strain K12) (see 5 papers)
ALSB_ECOLI / P39265 D-allose-binding periplasmic protein; ALBP from Escherichia coli (strain K12) (see paper)
P39265 ABC-type D-allose transporter (EC 7.5.2.8) from Escherichia coli (see paper)
TC 3.A.1.2.6 / P39265 AlsB aka B4088, component of D-allose porter from Escherichia coli (see 6 papers)
alsB / GB|AAC77049.1 D-allose-binding periplasmic protein; EC 3.6.3.17 from Escherichia coli K12 (see 6 papers)
    29% identity, 79% coverage of query (64.7 bits)

4zjpA / A6VKT0 Structure of an abc-transporter solute binding protein (sbp_ipr025997) from actinobacillus succinogenes (asuc_0197, target efi-511067) with bound beta-d-ribopyranose
    28% identity, 73% coverage of query (63.5 bits)

7x0hA / A3DCF2 Crystal structure of sugar binding protein cbpa complexed wtih glucose from clostridium thermocellum (see paper)
    26% identity, 84% coverage of query (63.5 bits)

1gudA / P39265 Hinge-bending motion of d-allose binding protein from escherichia coli: three open conformations (see paper)
    28% identity, 79% coverage of query (61.6 bits)

1rpjA Crystal structure of d-allose binding protein from escherichia coli
    28% identity, 79% coverage of query (61.6 bits)

1dbpA / P02925 Identical mutations at corresponding positions in two homologous proteins with non-identical effects (see paper)
    28% identity, 72% coverage of query (61.2 bits)

TC 3.A.1.2.21 / B8H228 Inositol ABC transporter, periplasmic inositol-binding protein IbpA, component of The myoinositol (high affinity)/ D-ribose (low affinity) transporter IatP/IatA/IbpA. The structure of IbpA with myoinositol bound has been solved from Caulobacter crescentus (strain NA1000 / CB15N)
    25% identity, 88% coverage of query (60.8 bits)

5hqjA / B1G1H7 Crystal structure of abc transporter solute binding protein b1g1h7 from burkholderia graminis c4d1m, target efi-511179, in complex with d-arabinose
    27% identity, 81% coverage of query (60.5 bits)

4irxA / A0A0H3C834 Crystal structure of caulobacter myo-inositol binding protein bound to myo-inositol (see paper)
    25% identity, 88% coverage of query (58.5 bits)

8wlbA X-ray structure of enterobacter cloacae allose-binding protein in complex with d-psicose
    28% identity, 72% coverage of query (58.5 bits)

8wl9A X-ray structure of enterobacter cloacae allose-binding protein in complex with d-ribose
    28% identity, 72% coverage of query (58.5 bits)

7e7mC / Q8E283 Crystal structure analysis of the streptococcus agalactiae ribose binding protein rbsb
    25% identity, 74% coverage of query (57.0 bits)

6gt9A / W8QN64 Crystal structure of ganp, a glucose-galactose binding protein from geobacillus stearothermophilus, in complex with galactose
    26% identity, 76% coverage of query (55.8 bits)

6guqA Crystal structure of ganp, a glucose-galactose binding protein from geobacillus stearothermophilus, in complex with glucose
    26% identity, 76% coverage of query (55.8 bits)

2ioyA / Q8RD41 Crystal structure of thermoanaerobacter tengcongensis ribose binding protein (see paper)
    27% identity, 77% coverage of query (55.1 bits)

RBSB_BACSU / P36949 Ribose import binding protein RbsB from Bacillus subtilis (strain 168) (see 2 papers)
    25% identity, 73% coverage of query (55.1 bits)

RALBP_PSEAE / Q9I2F8 D-ribose/D-allose-binding protein from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
    27% identity, 71% coverage of query (53.1 bits)

MglB / b2150 D-galactose/methyl-galactoside ABC transporter periplasmic binding protein from Escherichia coli K-12 substr. MG1655 (see 43 papers)
MglB / P0AEE5 D-galactose/methyl-galactoside ABC transporter periplasmic binding protein from Escherichia coli (strain K12) (see 42 papers)
MGLB_ECOLI / P0AEE5 D-galactose/methyl-galactoside binding periplasmic protein MglB; D-galactose-binding periplasmic protein; GBP; D-galactose/D-glucose-binding protein; GGBP from Escherichia coli (strain K12) (see 3 papers)
TC 3.A.1.2.3 / P0AEE5 D-galactose-binding periplasmic protein DGAL aka MglB aka B2150, component of Galactose/glucose (methyl galactoside) porter from Escherichia coli (see 10 papers)
    28% identity, 82% coverage of query (52.0 bits)

HSERO_RS11480 D-ribose ABC transporter, substrate-binding component RbsB from Herbaspirillum seropedicae SmR1
    26% identity, 87% coverage of query (51.6 bits)

TC 3.A.1.2.9 / Q7BSH5 RhaS, component of Rhamnose porter (Richardson et al., 2004) (Transport activity is dependent on rhamnokinase (RhaK; AAQ92412) activity (Richardson and Oresnik, 2007) This could be an example of group translocation!) from Rhizobium leguminosarum (biovar trifolii) (see paper)
    25% identity, 98% coverage of query (50.8 bits)

2gbpA / P0AEE5 Sugar and signal-transducer binding sites of the escherichia coli galactose chemoreceptor protein (see paper)
    28% identity, 70% coverage of query (48.5 bits)

2qw1A Glucose/galactose binding protein bound to 3-o-methyl d-glucose
    28% identity, 70% coverage of query (48.5 bits)

8fxtA Escherichia coli periplasmic glucose-binding protein glucose complex: acrylodan conjugate attached at w183c
    28% identity, 70% coverage of query (48.1 bits)

P23905 D-galactose/methyl-galactoside binding periplasmic protein MglB; D-galactose-binding periplasmic protein; GBP; D-galactose/D-glucose-binding protein; GGBP from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
    27% identity, 82% coverage of query (47.4 bits)

APIBP_PARG4 / B1G898 D-apiose import binding protein; D-apiose binding SBP from Paraburkholderia graminis (strain ATCC 700544 / DSM 17151 / LMG 18924 / NCIMB 13744 / C4D1M) (see paper)
    28% identity, 90% coverage of query (46.6 bits)

TC 3.A.1.2.20 / G4FGN5 LacI family transcriptional regulator, component of Glucose porter. Also bind xylose (Boucher and Noll 2011). Induced by glucose (Frock et al. 2012). Directly regulated by glucose-responsive regulator GluR from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    24% identity, 78% coverage of query (45.8 bits)

2fn8A / Q9X053 Thermotoga maritima ribose binding protein ribose bound form (see paper)
    25% identity, 72% coverage of query (44.3 bits)

3ga5A X-ray structure of glucose/galactose receptor from salmonella typhimurium in complex with (2r)-glyceryl-beta-d-galactopyranoside
    26% identity, 70% coverage of query (42.7 bits)

1gcaA The 1.7 angstroms refined x-ray structure of the periplasmic glucose(slash)galactose receptor from salmonella typhimurium
    26% identity, 70% coverage of query (42.7 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory