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Searching for up to 100 curated homologs for SMa1403 FitnessBrowser__Smeli:SMa1403 (338 a.a.)

Found high-coverage hits (≥70%) to 69 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

BPHYT_RS34225 L-fucose dehydrogenase (EC 1.1.1.122) from Burkholderia phytofirmans PsJN
    50% identity, 99% coverage of query (342 bits)

PLD_MICLT / Q76KC2 Pyridoxal 4-dehydrogenase; EC 1.1.1.107 from Microbacterium luteolum (Aureobacterium luteolum) (see paper)
    45% identity, 98% coverage of query (295 bits)

SMc02775 D-arabinose 1-dehydrogenase from Sinorhizobium meliloti 1021
    46% identity, 92% coverage of query (288 bits)

FCDH_PSESP / Q52472 D-threo-aldose 1-dehydrogenase; L-fucose dehydrogenase; EC 1.1.1.122 from Pseudomonas sp.
Q52472 D-threo-aldose 1-dehydrogenase (EC 1.1.1.122) from Pseudomonas sp. (see paper)
    39% identity, 92% coverage of query (225 bits)

Build an alignment

Build an alignment for SMa1403 and 4 homologs with ≥ 30% identity

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Change minimum %identity:

Additional hits (identity < 30%)

7svqA / Q6BDJ2 Crystal structure of l-galactose dehydrogenase from spinacia oleracea in complex with NAD+ (see paper)
    28% identity, 90% coverage of query (122 bits)

Q6BDJ2 L-galactose 1-dehydrogenase (EC 1.1.1.316) from Spinacia oleracea (see paper)
GDH / BAD32687.1 L-galactose dehydrogenase from Spinacia oleracea (see paper)
    28% identity, 90% coverage of query (122 bits)

LGALDH / O81884 L-galactose dehydrogenase (EC 1.1.1.316) from Arabidopsis thaliana (see paper)
GALDH_ARATH / O81884 L-galactose dehydrogenase; At-GalDH; L-GalDH; EC 1.1.1.316 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
O81884 L-galactose 1-dehydrogenase (EC 1.1.1.316) from Arabidopsis thaliana (see paper)
L-GalDH / CAD10386.1 L-galactose dehydrogenase from Arabidopsis thaliana (see paper)
    27% identity, 97% coverage of query (114 bits)

Q84L20 L-galactose 1-dehydrogenase (EC 1.1.1.316) from Malus domestica (see paper)
    27% identity, 91% coverage of query (111 bits)

C0LVA5 L-galactose 1-dehydrogenase (EC 1.1.1.316) from Actinidia eriantha (see paper)
    25% identity, 90% coverage of query (109 bits)

7ezlA Rice l-galactose dehydrogenase (holo form)
    26% identity, 91% coverage of query (108 bits)

7eziA / Q2QQV2 Rice l-galactose dehydrogenase (apo form)
    26% identity, 95% coverage of query (107 bits)

E9M5S4 L-galactose 1-dehydrogenase (EC 1.1.1.316) from Citrus unshiu (see paper)
    26% identity, 92% coverage of query (106 bits)

lgaA / A6KWY2 L-galactose dehydrogenase from Phocaeicola vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / CCUG 4940 / NBRC 14291 / NCTC 11154) (see paper)
    23% identity, 94% coverage of query (104 bits)

1ynpB / Q9KE47 Aldo-keto reductase akr11c1 from bacillus halodurans (apo form) (see paper)
    28% identity, 91% coverage of query (102 bits)

1ynqB Aldo-keto reductase akr11c1 from bacillus halodurans (holo form)
    28% identity, 91% coverage of query (102 bits)

1pz0A / P46336 Structure of NADPH-dependent family 11 aldo-keto reductase akr11a(holo) (see paper)
    26% identity, 91% coverage of query (101 bits)

IOLS_BACSU / P46336 Aldo-keto reductase IolS; AKR11A; Vegetative protein 147; VEG147; EC 1.1.1.- from Bacillus subtilis (strain 168) (see 4 papers)
    26% identity, 91% coverage of query (101 bits)

1ynpA Aldo-keto reductase akr11c1 from bacillus halodurans (apo form)
    27% identity, 91% coverage of query (97.8 bits)

YdjG / b1771 NADH-dependent methylglyoxal reductase from Escherichia coli K-12 substr. MG1655 (see 5 papers)
ydjG / P77256 NADH-dependent methylglyoxal reductase from Escherichia coli (strain K12) (see 4 papers)
AKRMG_ECOLI / P77256 NADH-specific methylglyoxal reductase; AKR11B2; EC 1.1.1.- from Escherichia coli (strain K12) (see 3 papers)
ydjG / RF|NP_416285 uncharacterized oxidoreductase ydjG from Escherichia coli K12 (see paper)
    24% identity, 91% coverage of query (88.6 bits)

8hw0A / A0A6B8QIS5 The structure of akr6d1
    24% identity, 92% coverage of query (78.6 bits)

YajO / b0419 1-deoxyxylulose-5-phosphate synthase YajO from Escherichia coli K-12 substr. MG1655 (see 7 papers)
yajO / P77735 1-deoxyxylulose-5-phosphate synthase YajO from Escherichia coli (strain K12) (see 6 papers)
YAJO_ECOLI / P77735 1-deoxyxylulose-5-phosphate synthase YajO; EC 1.1.-.- from Escherichia coli (strain K12) (see 2 papers)
P77735 1-deoxy-D-xylulose-5-phosphate synthase (EC 2.2.1.7) from Escherichia coli (see paper)
    26% identity, 89% coverage of query (77.8 bits)

AKR1_SOYBN / C6TBN2 Probable aldo-keto reductase 1; GmAKR1; EC 1.1.1.- from Glycine max (Soybean) (Glycine hispida) (see paper)
    26% identity, 89% coverage of query (77.8 bits)

GME68_PESMI / A0A5B8YXI2 Aryl-alcohol dehydrogenase GME11368; Dibenzodioxocinones biosynthesis cluster protein GME11368; EC 1.1.1.- from Pestalotiopsis microspora (see 2 papers)
    25% identity, 88% coverage of query (76.6 bits)

KCAB_SCHPO / O59826 Putative voltage-gated potassium channel subunit beta; K(+) channel subunit beta; EC 1.1.1.- from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    27% identity, 90% coverage of query (75.9 bits)

KCAB_ARATH / O23016 Probable voltage-gated potassium channel subunit beta; K(+) channel subunit beta; Potassium voltage beta 1; KV-beta1; EC 1.1.1.- from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    23% identity, 90% coverage of query (72.4 bits)

AFTS1_ALTAL / Q75ZG3 Aldo-keto reductase AFTS1; AF-toxin biosynthesis protein S1; EC 1.1.1.- from Alternaria alternata (Alternaria rot fungus) (Torula alternata) (see 3 papers)
    24% identity, 90% coverage of query (72.0 bits)

PR / Q3L181 perakine reductase (EC 1.1.1.317) from Rauvolfia serpentina (see 2 papers)
PERR_RAUSE / Q3L181 Perakine reductase; EC 1.1.1.317 from Rauvolfia serpentina (Serpentine wood) (Ophioxylon serpentinum) (see 2 papers)
Q3L181 perakine reductase (EC 1.1.1.317) from Rauvolfia serpentina (see 3 papers)
    24% identity, 89% coverage of query (70.5 bits)

3v0sA / Q3L181 Crystal structure of perakine reductase, founder member of a novel akr subfamily with unique conformational changes during NADPH binding (see paper)
    23% identity, 89% coverage of query (65.9 bits)

Q9X265 carbonyl reductase (NADPH) (EC 1.1.1.184) from Thermotoga maritima (see 2 papers)
    24% identity, 90% coverage of query (65.5 bits)

6kikA / Q9X265 Crystal structure of a thermostable aldo-keto reductase tm1743 in complex with inhibitor tolrestat (see paper)
    24% identity, 90% coverage of query (65.5 bits)

5danA Crystal structure of a novel aldo keto reductase tm1743 from thermotoga maritima in complex with NADP+
    24% identity, 90% coverage of query (65.5 bits)

6kiyA Crystal structure of a thermostable aldo-keto reductase tm1743 in complex with inhibitor epalrestat
    24% identity, 90% coverage of query (65.5 bits)

KCAB_ORYSJ / Q40648 Probable voltage-gated potassium channel subunit beta; K(+) channel subunit beta; EC 1.1.1.- from Oryza sativa subsp. japonica (Rice) (see paper)
    24% identity, 90% coverage of query (65.1 bits)

5t79A / Q8ZNA1 X-ray crystal structure of a novel aldo-keto reductases for the biocatalytic conversion of 3-hydroxybutanal to 1,3-butanediol (see paper)
    26% identity, 90% coverage of query (64.7 bits)

3erpA Structure of idp01002, a putative oxidoreductase from and essential gene of salmonella typhimurium
    27% identity, 90% coverage of query (64.7 bits)

ALKR4_ARATH / Q93ZN2 Probable aldo-keto reductase 4; EC 1.1.1.- from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    23% identity, 95% coverage of query (64.3 bits)

AFLE_ASPPU / Q00258 Norsolorinic acid reductase A; Aflatoxin biosynthesis protein E; EC 1.1.1.- from Aspergillus parasiticus (strain ATCC 56775 / NRRL 5862 / SRRC 143 / SU-1) (see 2 papers)
nor / AAC49166.1 norsolorinic acid reductase from Aspergillus parasiticus (see paper)
    25% identity, 87% coverage of query (62.8 bits)

eryBII / A4F7P4 dTDP-(2R,6S)-6-hydroxy-2-methyl-3-oxo-3,6-dihydro-2H-pyran-4-olate 3-ketoreductase (dTDP-4-dehydro-2,6-dideoxy-α-D-allose-forming) from Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338) (see 2 papers)
    25% identity, 89% coverage of query (60.8 bits)

AMT2_ALTAL / Q75ZG2 Aldo-keto reductase AMT2; AM-toxin biosynthesis protein 2; EC 1.1.1.- from Alternaria alternata (Alternaria rot fungus) (Torula alternata) (see 3 papers)
    23% identity, 82% coverage of query (60.5 bits)

6ow0A / Q194Q1 Crystal structure of mithramycin 3-side chain keto-reductase mtmw in complex with NAD+ and peg (see paper)
    25% identity, 90% coverage of query (60.5 bits)

SAN2_FUSV7 / C7ZBE5 Aldo-keto reductase NECHADRAFT_45914; Sansalvamide biosynthesis cluster protein NECHADRAFT_45914; EC 1.1.1.- from Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4) (Fusarium solani subsp. pisi) (see paper)
    22% identity, 90% coverage of query (60.1 bits)

mtmW / Q194Q1 mithramycin dehydrogenase from Streptomyces argillaceus (see 2 papers)
    26% identity, 90% coverage of query (59.7 bits)

megBIIb / Q9F833 MegBIIb from Micromonospora megalomicea subsp. nigra (see paper)
    25% identity, 89% coverage of query (59.3 bits)

6ow0B / Q194Q1 Crystal structure of mithramycin 3-side chain keto-reductase mtmw in complex with NAD+ and peg (see paper)
    25% identity, 90% coverage of query (58.9 bits)

KCAB2_MOUSE / P62482 Voltage-gated potassium channel subunit beta-2; K(+) channel subunit beta-2; Kv-beta-2; Neuroimmune protein F5; EC 1.1.1.- from Mus musculus (Mouse) (see 8 papers)
KCAB2_RAT / P62483 Voltage-gated potassium channel subunit beta-2; K(+) channel subunit beta-2; Kv-beta-2; EC 1.1.1.- from Rattus norvegicus (Rat) (see 19 papers)
    24% identity, 90% coverage of query (58.5 bits)

PLR1 / Q56Y42 pyridoxal reductase (EC 1.1.1.65) from Arabidopsis thaliana (see paper)
PLR1_ARATH / Q56Y42 Pyridoxal reductase, chloroplastic; EC 1.1.1.65 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    25% identity, 91% coverage of query (58.5 bits)

KCAB2_BOVIN / Q27955 Voltage-gated potassium channel subunit beta-2; K(+) channel subunit beta-2; Kv-beta-2; EC 1.1.1.- from Bos taurus (Bovine) (see paper)
    23% identity, 90% coverage of query (58.2 bits)

1exbA Structure of the cytoplasmic beta subunit-t1 assembly of voltage- dependent k channels
    24% identity, 90% coverage of query (58.2 bits)

3eauA Voltage-dependent k+ channel beta subunit in complex with cortisone
    24% identity, 90% coverage of query (58.2 bits)

KCAB2_HUMAN / Q13303 Voltage-gated potassium channel subunit beta-2; K(+) channel subunit beta-2; Kv-beta-2; hKvbeta2; EC 1.1.1.- from Homo sapiens (Human) (see 4 papers)
    23% identity, 90% coverage of query (57.4 bits)

NORB_DOTSN / M2YJQ2 Norsolorinic acid reductase B; Dothistromin biosynthesis protein norB; EC 1.1.1.- from Dothistroma septosporum (strain NZE10 / CBS 128990) (Red band needle blight fungus) (Mycosphaerella pini) (see 3 papers)
    24% identity, 88% coverage of query (57.0 bits)

7wf3C / Q13303 Composite map of human kv1.3 channel in apo state with beta subunits (see paper)
    23% identity, 90% coverage of query (57.0 bits)

STCV_EMENI / Q00727 Norsolorinic acid reductase stcV; Sterigmatocystin biosynthesis cluster protein V; EC 1.1.1.- from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see 8 papers)
stcV putative sterigmatocystin biosynthesis dehydrogenase stcV; EC 1.1.1.- from Emericella nidulans (see paper)
    25% identity, 88% coverage of query (56.6 bits)

KCAB1_MUSPU / Q28528 Voltage-gated potassium channel subunit beta-1; K(+) channel subunit beta-1; Kv-beta-1; EC 1.1.1.- from Mustela putorius (European polecat) (see paper)
    24% identity, 90% coverage of query (55.5 bits)

VRDA_ASPPA / B9WYE6 Versiconal hemiacetal acetate reductase; VHA reductase; EC 1.1.1.353 from Aspergillus parasiticus (see paper)
B9WYE6 versiconal hemiacetal acetate reductase (EC 1.1.1.353) from Aspergillus parasiticus (see paper)
    22% identity, 77% coverage of query (55.5 bits)

KCAB1_RABIT / Q9XT31 Voltage-gated potassium channel subunit beta-1; K(+) channel subunit beta-1; Kv-beta-1; EC 1.1.1.- from Oryctolagus cuniculus (Rabbit) (see paper)
    24% identity, 90% coverage of query (55.1 bits)

KCAB1_HUMAN / Q14722 Voltage-gated potassium channel subunit beta-1; K(+) channel subunit beta-1; Kv-beta-1; EC 1.1.1.- from Homo sapiens (Human) (see 13 papers)
    24% identity, 90% coverage of query (55.1 bits)

KCAB1_RAT / P63144 Voltage-gated potassium channel subunit beta-1; K(+) channel subunit beta-1; Kv-beta-1; EC 1.1.1.- from Rattus norvegicus (Rat) (see 9 papers)
    25% identity, 90% coverage of query (54.7 bits)

KCAB1_MOUSE / P63143 Voltage-gated potassium channel subunit beta-1; K(+) channel subunit beta-1; Kv-beta-1; EC 1.1.1.- from Mus musculus (Mouse) (see 5 papers)
    25% identity, 90% coverage of query (54.7 bits)

YI7E_SCHPO / Q9P7U2 Putative aryl-alcohol dehydrogenase C977.14c; EC 1.1.1.- from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    22% identity, 82% coverage of query (54.7 bits)

8hnqA / A0A6B8QJ47 The structure of a alcohol dehydrogenase akr13b2 with NADP
    26% identity, 93% coverage of query (53.9 bits)

KCAB2_XENLA / Q9PTM5 Voltage-gated potassium channel subunit beta-2; K(+) channel subunit beta-2; Kv-beta-2; EC 1.1.1.- from Xenopus laevis (African clawed frog) (see paper)
    23% identity, 90% coverage of query (53.9 bits)

4g5dA / P22045 X-ray crystal structure of prostaglandin f synthase from leishmania major friedlin bound to NADPH (see paper)
    25% identity, 78% coverage of query (53.5 bits)

PGFS_LEIMA / P22045 9,11-endoperoxide prostaglandin H2 reductase; Prostaglandin F2-alpha synthase; EC 1.1.1.- from Leishmania major (see paper)
P22045 prostaglandin-F synthase (EC 1.1.1.188) from Leishmania major (see paper)
    25% identity, 78% coverage of query (53.5 bits)

YAKC_SCHPO / Q09923 Aldo-keto reductase yakc [NADP(+)]; EC 1.1.1.- from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
yak3 aldose reductase YakC from Schizosaccharomyces pombe (see 3 papers)
    23% identity, 90% coverage of query (52.8 bits)

smoB / A9CEY6 6-dehydroglucose reductase monomer (EC 1.1.1.432) from Agrobacterium fabrum (strain C58 / ATCC 33970) (see paper)
DHGRD_AGRFC / A9CEY6 6-dehydroglucose reductase; SQ monooxygenase cluster protein B; EC 1.1.1.432 from Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58)) (see paper)
    25% identity, 89% coverage of query (50.1 bits)

7bc1A / A9CEY6 Crystal structure of aldo-keto reductase from agrobacterium tumefaciens in a ternary complex with NADPH and glucose (see paper)
    25% identity, 89% coverage of query (48.1 bits)

4aubB / Q46851 The complex structure of the bacterial aldo-keto reductase akr14a1 with NADP and citrate (see paper)
    22% identity, 90% coverage of query (47.8 bits)

3n6qD Crystal structure of yghz from e. Coli
    23% identity, 90% coverage of query (47.8 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory