Searching for up to 100 curated homologs for SMc00232 FitnessBrowser__Smeli:SMc00232 (456 a.a.)
Found high-coverage hits (≥70%) to 55 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
GLMU_HAEIN / P43889 Bifunctional protein GlmU; EC 2.7.7.23; EC 2.3.1.157 from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (see 2 papers)
P43889 glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157) from Haemophilus influenzae (see paper)
40% identity, 95% coverage of query (325 bits)
4e1kA / P43889 Glmu in complex with a quinazoline compound (see paper)
40% identity, 95% coverage of query (324 bits)
4kqlA Hin glmu bound to wg578
40% identity, 95% coverage of query (324 bits)
4kpzA Hin glmu bound to a small molecule fragment
40% identity, 95% coverage of query (324 bits)
4kpxA Hin glmu bound to wg766
40% identity, 95% coverage of query (324 bits)
4knxA Hin glmu bound to wg176
40% identity, 95% coverage of query (324 bits)
4knrA Hin glmu bound to wg188
40% identity, 95% coverage of query (324 bits)
2w0wA Crystal structure of glmu from haemophilus influenzae in complex with quinazoline inhibitor 2
40% identity, 95% coverage of query (324 bits)
2w0vA Crystal structure of glmu from haemophilus influenzae in complex with quinazoline inhibitor 1
40% identity, 95% coverage of query (324 bits)
2vd4A Structure of small-molecule inhibitor of glmu from haemophilus influenzae reveals an allosteric binding site
40% identity, 95% coverage of query (324 bits)
2v0lA Characterization of substrate binding and catalysis of the potential antibacterial target n-acetylglucosamine-1-phosphate uridyltransferase (glmu)
40% identity, 95% coverage of query (324 bits)
2v0kA Characterization of substrate binding and catalysis of the potential antibacterial target n-acetylglucosamine-1- phosphate uridyltransferase (glmu)
40% identity, 95% coverage of query (324 bits)
2v0iA Characterization of substrate binding and catalysis of the potential antibacterial target n-acetylglucosamine-1-phosphate uridyltransferase (glmu)
40% identity, 95% coverage of query (324 bits)
2v0jA Characterization of substrate binding and catalysis of the potential antibacterial target n-acetylglucosamine-1-phosphate uridyltransferase (glmu)
41% identity, 93% coverage of query (323 bits)
YieA / b3730 fused N-acetylglucosamine-1-phosphate uridyltransferase and glucosamine-1-phosphate acetyltransferase (EC 2.7.7.23; EC 2.3.1.157) from Escherichia coli K-12 substr. MG1655 (see 15 papers)
glmU / P0ACC7 fused N-acetylglucosamine-1-phosphate uridyltransferase and glucosamine-1-phosphate acetyltransferase (EC 2.7.7.23; EC 2.3.1.157) from Escherichia coli (strain K12) (see 13 papers)
GLMU_ECOLI / P0ACC7 Bifunctional protein GlmU; EC 2.7.7.23; EC 2.3.1.157 from Escherichia coli (strain K12) (see 8 papers)
P0ACC7 glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157); UDP-N-acetylglucosamine diphosphorylase (EC 2.7.7.23) from Escherichia coli (see 8 papers)
glmU / GB|AAC76753.1 bifunctional protein glmU; EC 2.3.1.157; EC 2.7.7.23 from Escherichia coli (see 10 papers)
40% identity, 95% coverage of query (322 bits)
2oi6B / P0ACC7 E. Coli glmu- complex with udp-glcnac, coa and glcn-1-po4 (see paper)
41% identity, 94% coverage of query (322 bits)
Q8Z9S7 Bifunctional protein GlmU; EC 2.7.7.23; EC 2.3.1.157 from Yersinia pestis
40% identity, 92% coverage of query (320 bits)
1hv9B Structure of e. Coli glmu: analysis of pyrophosphorylase and acetyltransferase active sites
41% identity, 94% coverage of query (320 bits)
2oi7A E. Coli glmu- complex with udp-glcnac, desulpho-coa and glcnac-1-po4
41% identity, 94% coverage of query (320 bits)
2oi5A E. Coli glmu- complex with udp-glcnac and acetyl-coa
41% identity, 94% coverage of query (320 bits)
4fceA / Q8Z9S7 Crystal structure of yersinia pestis glmu in complex with alpha-d- glucosamine 1-phosphate (gp1)
40% identity, 92% coverage of query (317 bits)
1hm8A / Q97R46 Crystal structure of s.Pneumoniae n-acetylglucosamine-1-phosphate uridyltransferase, glmu, bound to acetyl coenzyme a (see paper)
42% identity, 93% coverage of query (310 bits)
1hm9A Crystal structure of s.Pneumoniae n-acetylglucosamine-1-phosphate uridyltransferase, glmu, bound to acetyl coenzyme a and udp-n- acetylglucosamine
42% identity, 93% coverage of query (310 bits)
GLMU_STRPN / Q97R46 Bifunctional protein GlmU; EC 2.7.7.23; EC 2.3.1.157 from Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) (see 2 papers)
42% identity, 93% coverage of query (308 bits)
1g97A S.Pneumoniae glmu complexed with udp-n-acetylglucosamine and mg2+
42% identity, 93% coverage of query (308 bits)
7kr9A Bifunctional enzyme glmu bound to zn(ii)
42% identity, 93% coverage of query (308 bits)
4ac3A S.Pneumoniae glmu in complex with an antibacterial inhibitor
42% identity, 93% coverage of query (304 bits)
4aawA S.Pneumoniae glmu in complex with an antibacterial inhibitor
42% identity, 93% coverage of query (303 bits)
Q2P7P9 UDP-N-acetylglucosamine diphosphorylase (EC 2.7.7.23) from Xanthomonas oryzae pv. oryzae (see paper)
42% identity, 93% coverage of query (300 bits)
Q50986 UDP-N-acetylglucosamine diphosphorylase (EC 2.7.7.23) from Neisseria gonorrhoeae (see paper)
40% identity, 95% coverage of query (282 bits)
GLMU_MYCTU / P9WMN3 Bifunctional protein GlmU; EC 2.7.7.23; EC 2.3.1.157 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 4 papers)
A5U161 glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157); UDP-N-acetylglucosamine diphosphorylase (EC 2.7.7.23) from Mycobacterium tuberculosis (see 2 papers)
P9WMN3 glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157); UDP-N-acetylglucosamine diphosphorylase (EC 2.7.7.23) from Mycobacterium tuberculosis (see 13 papers)
38% identity, 92% coverage of query (256 bits)
3sptA Crystal structure of glmu from mycobacterium tuberculosis in complex with acetyl coenzyme a and uridine-diphosphate-n-acetylglucosamine
38% identity, 92% coverage of query (256 bits)
4k6rA Crystal structure of glmu in complex with atp
38% identity, 92% coverage of query (256 bits)
3st8A Crystal structure of glmu from mycobacterium tuberculosis in complex with coenzyme a, glucosamine 1-phosphate and uridine-diphosphate-n- acetylglucosamine
38% identity, 92% coverage of query (256 bits)
6ge9A Structure of mycobacterium tuberculosis glmu bound to glc-1p and ac- coa
38% identity, 92% coverage of query (256 bits)
3d8vA / P9WMN3 Crystal structure of glmu from mycobacterium tuberculosis in complex with uridine-diphosphate-n-acetylglucosamine (see paper)
38% identity, 92% coverage of query (249 bits)
glmU / Q9PPA2 GDP-glucosamine N-acetyltransferase from Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168) (see paper)
36% identity, 92% coverage of query (241 bits)
4g3pA Crystal structure of glmu from mycobacterium tuberculosis snapshot 3
37% identity, 92% coverage of query (240 bits)
3dj4A Crystal structure of glmu from mycobacterium tuberculosis in complex with uridine-diphosphate-n-acetylglucosamine.
37% identity, 92% coverage of query (240 bits)
2qkxA N-acetyl glucosamine 1-phosphate uridyltransferase from mycobacterium tuberculosis complex with n-acetyl glucosamine 1-phosphate
37% identity, 78% coverage of query (200 bits)
3foqA / P9WMN3 Crystal structure of n-acetylglucosamine-1-phosphate uridyltransferase (glmu) from mycobacterium tuberculosis in a cubic space group. (see paper)
35% identity, 92% coverage of query (195 bits)
Build an alignment for SMc00232 and 41 homologs with ≥ 30% identity
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GLMU_METJA / Q58501 Bifunctional protein GlmU; EC 2.7.7.23; EC 2.3.1.157 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see 2 papers)
25% identity, 92% coverage of query (113 bits)
ST0452 / Q975F9 multifunctional glucose-1-phosphate thymidylyltransferase/hexosamine-1-phosphate N-acetyltransferase/UDP-N-acetylhexosamine diphosphorylase (EC 2.7.7.24; EC 2.7.7.23; EC 2.7.7.83; EC 2.3.1.157; EC 2.3.1.276) from Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (see 2 papers)
S1PNA_SULTO / Q975F9 Bifunctional sugar-1-phosphate nucleotidylyltransferase/acetyltransferase; EC 2.7.7.24; EC 2.7.7.9; EC 2.7.7.83; EC 2.7.7.23; EC 2.3.1.276; EC 2.3.1.157 from Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (Sulfolobus tokodaii) (see 5 papers)
Q975F9 glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157); galactosamine-1-phosphate N-acetyltransferase (EC 2.3.1.276); UDP-N-acetylglucosamine diphosphorylase (EC 2.7.7.23); glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24); aldose-1-phosphate nucleotidyltransferase (EC 2.7.7.37); UDP-N-acetylgalactosamine diphosphorylase (EC 2.7.7.83); UTP-glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) from Sulfurisphaera tokodaii (see 7 papers)
2ggqA / Q975F9 Complex of hypothetical glucose-1-phosphate thymidylyltransferase from sulfolobus tokodaii
25% identity, 90% coverage of query (94.4 bits)
5z09A St0452(y97n)-utp binding form
25% identity, 90% coverage of query (91.7 bits)
MPG1_YEAST / P41940 Mannose-1-phosphate guanyltransferase; ATP-mannose-1-phosphate guanylyltransferase; GDP-mannose pyrophosphorylase; NDP-hexose pyrophosphorylase; EC 2.7.7.13 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
P41940 mannose-1-phosphate guanylyltransferase (EC 2.7.7.13) from Saccharomyces cerevisiae (see 3 papers)
MPG1 / GI|1431053 mannose-1-phosphate guanylyltransferase; EC 2.7.7.13 from Saccharomyces cerevisiae (see 5 papers)
26% identity, 74% coverage of query (72.0 bits)
MPG1_CANAL / O93827 Mannose-1-phosphate guanyltransferase; ATP-mannose-1-phosphate guanylyltransferase; CASRB1; GDP-mannose pyrophosphorylase; EC 2.7.7.13 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see paper)
O93827 mannose-1-phosphate guanylyltransferase (EC 2.7.7.13) from Candida albicans (see paper)
SRB1 / GB|BAA34807.1 mannose-1-phosphate guanyltransferase; EC 2.7.7.13 from Candida albicans (see 5 papers)
27% identity, 74% coverage of query (70.9 bits)
MPG1_SCHPO / O74484 Mannose-1-phosphate guanyltransferase; GDP-mannose pyrophosphorylase; GTP-mannose-1-phosphate guanylyltransferase; EC 2.7.7.13 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
mpg1 / RF|NP_588405.1 mannose-1-phosphate guanyltransferase Mpg1; EC 2.7.7.13 from Schizosaccharomyces pombe (see 2 papers)
25% identity, 80% coverage of query (69.3 bits)
MPG1_KLULA / Q70SJ2 Mannose-1-phosphate guanyltransferase; GDP-mannose pyrophosphorylase; GTP-mannose-1-phosphate guanylyltransferase; EC 2.7.7.13 from Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) (see paper)
26% identity, 74% coverage of query (67.8 bits)
MPG1_PICAN / Q9P8N0 Mannose-1-phosphate guanyltransferase; GDP-mannose pyrophosphorylase; GTP-mannose-1-phosphate guanylyltransferase; EC 2.7.7.13 from Pichia angusta (Yeast) (Hansenula polymorpha) (see paper)
25% identity, 71% coverage of query (66.6 bits)
Q4U3E8 mannose-1-phosphate guanylyltransferase (EC 2.7.7.13) from Aspergillus fumigatus (see paper)
24% identity, 80% coverage of query (62.0 bits)
Q9M2S0 mannose-1-phosphate guanylyltransferase (EC 2.7.7.13) from Arabidopsis thaliana (see paper)
22% identity, 73% coverage of query (59.3 bits)
CYT1 / O22287 GDP-D-mannose pyrophosphorylase (EC 2.7.7.13) from Arabidopsis thaliana (see paper)
GMPP1_ARATH / O22287 Mannose-1-phosphate guanylyltransferase 1; GDP-mannose pyrophosphorylase 1; Protein CYTOKINESIS DEFECTIVE 1; Protein EMBRYO DEFECTIVE 101; Protein HYPERSENSITIVE TO AMMONIUM ION 1; Protein SENSITIVE TO OZONE 1; Protein VITAMIN C DEFECTIVE 1; EC 2.7.7.13 from Arabidopsis thaliana (Mouse-ear cress) (see 16 papers)
O22287 mannose-1-phosphate guanylyltransferase (EC 2.7.7.13) from Arabidopsis thaliana (see 2 papers)
21% identity, 73% coverage of query (55.8 bits)
7x8kB / O22287 Arabidopsis gdp-d-mannose pyrophosphorylase (vtc1) structure (product- bound) (see paper)
21% identity, 73% coverage of query (55.8 bits)
Q84JH5 mannose-1-phosphate guanylyltransferase (EC 2.7.7.13) from Oryza sativa Japonica Group (see paper)
21% identity, 73% coverage of query (55.5 bits)
7x8kA Arabidopsis gdp-d-mannose pyrophosphorylase (vtc1) structure (product- bound)
21% identity, 73% coverage of query (54.7 bits)
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Lawrence Berkeley National Laboratory