Searching for up to 100 curated homologs for SMc00375 FitnessBrowser__Smeli:SMc00375 (328 a.a.)
Found high-coverage hits (≥70%) to 33 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
XDH2_HALVD / D4GP30 D-xylose 1-dehydrogenase (NADP(+)) 2; XDH 2; EC 1.1.1.179 from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) (see paper)
D4GP30 D-xylose 1-dehydrogenase (NADP+, D-xylono-1,5-lactone-forming) (EC 1.1.1.179) from Haloferax volcanii (see paper)
36% identity, 98% coverage of query (166 bits)
slgS4 / CBA11563.1 NDP-hexose-3-ketoreductase from Streptomyces lydicus (see paper)
35% identity, 99% coverage of query (142 bits)
3rc1A / B3TMR8 Crystal structure of kijd10, a 3-ketoreductase from actinomadura kijaniata incomplex with NADP and tdp-benzene (see paper)
31% identity, 99% coverage of query (124 bits)
KIJDR_ACTKI / B3TMR8 dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose 3-reductase; 3-ketoreductase; NADPH-dependent C3-ketoreductase; EC 1.1.1.384 from Actinomadura kijaniata (see paper)
B3TMR8 dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose 3-reductase (EC 1.1.1.384) from Actinomadura kijaniata (see paper)
31% identity, 99% coverage of query (124 bits)
xacA / D4GP29 D-xylose dehydrogenase subunit (EC 1.1.1.424) from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (see 4 papers)
XDH1_HALVD / D4GP29 D-xylose 1-dehydrogenase [NADP(+)] 1; XDH 1; EC 1.1.1.424 from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) (see 3 papers)
D4GP29 D-xylose 1-dehydrogenase (NADP+, D-xylono-1,5-lactone-forming) (EC 1.1.1.179); D-xylose 1-dehydrogenase (NADP+, D-xylono-1,4-lactone-forming) (EC 1.1.1.424) from Haloferax volcanii (see 2 papers)
30% identity, 97% coverage of query (123 bits)
Build an alignment for SMc00375 and 5 homologs with ≥ 30% identity
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YgjR / b3087 putative oxidoreductase YgjR from Escherichia coli K-12 substr. MG1655
28% identity, 97% coverage of query (112 bits)
DHDH_HUMAN / Q9UQ10 Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; D-xylose 1-dehydrogenase; D-xylose-NADP dehydrogenase; Dimeric dihydrodiol dehydrogenase; Hum2DD; EC 1.3.1.20; EC 1.1.1.179 from Homo sapiens (Human) (see paper)
30% identity, 76% coverage of query (108 bits)
Q9DBB8 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (EC 1.3.1.20) from Mus musculus (see paper)
30% identity, 75% coverage of query (105 bits)
xdh / Q5UY95 D-xylose dehydrogenase subunit (EC 1.1.1.424) from Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (see paper)
GFO6_HALMA / Q5UY95 D-xylose 1-dehydrogenase [NADP(+)]; XDH; EC 1.1.1.424 from Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui) (see paper)
Q5UY95 D-xylose 1-dehydrogenase (NADP+, D-xylono-1,5-lactone-forming) (EC 1.1.1.179); D-xylose 1-dehydrogenase (NADP+, D-xylono-1,4-lactone-forming) (EC 1.1.1.424) from Haloarcula marismortui (see paper)
28% identity, 98% coverage of query (105 bits)
DHDH_PIG / Q9TV69 Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; D-xylose 1-dehydrogenase; D-xylose-NADP dehydrogenase; Dimeric dihydrodiol dehydrogenase; Sus2DD; EC 1.3.1.20; EC 1.1.1.179 from Sus scrofa (Pig) (see 3 papers)
31% identity, 76% coverage of query (103 bits)
Q5R5J5 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (EC 1.3.1.20) from Pongo abelii (see paper)
29% identity, 76% coverage of query (103 bits)
2o4uX / Q9TQS6 Crystal structure of mammalian dimeric dihydrodiol dehydrogenase (see paper)
31% identity, 76% coverage of query (103 bits)
DHDH_MACFU / Q7JK39 Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; D-xylose 1-dehydrogenase; D-xylose-NADP dehydrogenase; Dimeric dihydrodiol dehydrogenase; Jmo2DD; EC 1.3.1.20; EC 1.1.1.179 from Macaca fuscata fuscata (Japanese macaque) (see 3 papers)
DHDH_MACFA / Q9TQS6 Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Cmo2DD; D-xylose 1-dehydrogenase; D-xylose-NADP dehydrogenase; Dimeric dihydrodiol dehydrogenase; EC 1.3.1.20; EC 1.1.1.179 from Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) (see paper)
Q9TQS6 D-xylose 1-dehydrogenase (NADP+, D-xylono-1,5-lactone-forming) (EC 1.1.1.179); trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (EC 1.3.1.20) from Macaca fascicularis (see 2 papers)
31% identity, 76% coverage of query (103 bits)
2poqX Dimeric dihydrodiol dehydrogenase complexed with inhibitor, isoascorbic acid
31% identity, 76% coverage of query (103 bits)
Q148L6 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (EC 1.3.1.20) from Bos taurus (see paper)
31% identity, 76% coverage of query (102 bits)
DHDH_CANLF / Q9TV68 Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Can2DD; D-xylose 1-dehydrogenase; D-xylose-NADP dehydrogenase; Dimeric dihydrodiol dehydrogenase; EC 1.3.1.20; EC 1.1.1.179 from Canis lupus familiaris (Dog) (Canis familiaris) (see 3 papers)
30% identity, 76% coverage of query (102 bits)
5a03C / Q9A8X3 Crystal structure of aldose-aldose oxidoreductase from caulobacter crescentus complexed with xylose (see paper)
25% identity, 98% coverage of query (98.6 bits)
5a06A Crystal structure of aldose-aldose oxidoreductase from caulobacter crescentus complexed with sorbitol
25% identity, 98% coverage of query (98.6 bits)
5a05A Crystal structure of aldose-aldose oxidoreductase from caulobacter crescentus complexed with maltotriose
25% identity, 98% coverage of query (98.6 bits)
5a04A Crystal structure of aldose-aldose oxidoreductase from caulobacter crescentus complexed with glucose
25% identity, 98% coverage of query (98.6 bits)
5a03E Crystal structure of aldose-aldose oxidoreductase from caulobacter crescentus complexed with xylose
25% identity, 98% coverage of query (98.6 bits)
5a02A Crystal structure of aldose-aldose oxidoreductase from caulobacter crescentus complexed with glycerol
25% identity, 98% coverage of query (98.6 bits)
D4GR07 L-arabinose 1-dehydrogenase [NAD(P)+] (EC 1.1.1.376) from Haloferax volcanii (see paper)
28% identity, 98% coverage of query (95.9 bits)
1zh8A / Q9WYE8 Crystal structure of oxidoreductase (tm0312) from thermotoga maritima at 2.50 a resolution
27% identity, 97% coverage of query (94.0 bits)
DHDH_RABIT / Q9TV70 Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; D-xylose 1-dehydrogenase; D-xylose-NADP dehydrogenase; Dimeric dihydrodiol dehydrogenase; Ory2DD; EC 1.3.1.20; EC 1.1.1.179 from Oryctolagus cuniculus (Rabbit) (see 2 papers)
32% identity, 71% coverage of query (93.2 bits)
Echvi_3375 predicted 3-ketohexose reductase from Echinicola vietnamensis KMM 6221, DSM 17526
28% identity, 78% coverage of query (90.1 bits)
afr / Q2I8V6 1,5-anhydro-D-fructose reductase (EC 1.1.1.292) from Ensifer adhaerens (see 3 papers)
AFR_ENSAD / Q2I8V6 1,5-anhydro-D-fructose reductase; Anhydrofructose reductase; 1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming); EC 1.1.1.292 from Ensifer adhaerens (Sinorhizobium morelense) (see 2 papers)
Q2I8V6 1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming) (EC 1.1.1.292) from Ensifer adhaerens (see 2 papers)
30% identity, 93% coverage of query (89.7 bits)
2glxA / Q2I8V6 Crystal structure analysis of bacterial 1,5-af reductase (see paper)
30% identity, 93% coverage of query (86.7 bits)
3ceaA / F9ULF9 Crystal structure of myo-inositol 2-dehydrogenase (np_786804.1) from lactobacillus plantarum at 2.40 a resolution
26% identity, 75% coverage of query (80.9 bits)
YcjS / b1315 D-glucoside 3-dehydrogenase from Escherichia coli K-12 substr. MG1655 (see 3 papers)
ycjS / P77503 D-glucoside 3-dehydrogenase from Escherichia coli (strain K12) (see 3 papers)
YCJS_ECOLI / P77503 D-glucoside 3-dehydrogenase; EC 1.1.1.- from Escherichia coli (strain K12) (see paper)
ycjS / MB|P77503 uncharacterized oxidoreductase ycjS from Escherichia coli K12 (see paper)
22% identity, 98% coverage of query (62.4 bits)
YM94_YEAST / Q04869 Uncharacterized protein YMR315W from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
24% identity, 98% coverage of query (54.7 bits)
8qc8B Crystal structure of NAD-dependent glycoside hydrolase from flavobacterium sp. (Strain k172) in complex with co-factor NAD+ (see paper)
23% identity, 78% coverage of query (45.1 bits)
8qc2A Crystal structure of NAD-dependent glycoside hydrolase from flavobacterium sp. (Strain k172) in complex with co-factor NAD+ and sulfoquinovose (sq)
23% identity, 78% coverage of query (45.1 bits)
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Lawrence Berkeley National Laboratory