Searching for up to 100 curated homologs for SMc00476 FitnessBrowser__Smeli:SMc00476 (551 a.a.)
Found high-coverage hits (≥70%) to 61 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
TC 2.A.53.3.9 / A1JRS3 SulP homologue. The low resolution structure is available from Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081) (see paper)
40% identity, 93% coverage of query (290 bits)
DauA / b1206 aerobic C4-dicarboxylate transporter DauA from Escherichia coli K-12 substr. MG1655 (see 9 papers)
DauA / P0AFR2 aerobic C4-dicarboxylate transporter DauA from Escherichia coli (strain K12) (see 9 papers)
DAUA_ECOLI / P0AFR2 C4-dicarboxylic acid transporter DauA; Dicarboxylic acid uptake system A from Escherichia coli (strain K12) (see 3 papers)
TC 2.A.53.3.11 / P0AFR2 Bicarbonate transporter, DauA (YchM). Also transports dicarboxylic acids including fumarate, aspartate and succinate, and is therefore designated the dicarboxylic acid uptake system A (DauA) (Karinou et al. 2013) It is the only succinate uptake porter at acidic pHs. The STAS domain forms a complex with the acyl carrier protein, ACP and malonyl-ACP, and the complex has been determined by x-ray crystallography (PDB# 3NY7) from Escherichia coli (strain K12)
37% identity, 93% coverage of query (275 bits)
BICA_SYNY3 / Q55415 Bicarbonate transporter BicA from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
32% identity, 92% coverage of query (201 bits)
BICA_SYNP2 / Q14SY0 Bicarbonate transporter BicA from Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum) (see 2 papers)
TC 2.A.53.3.3 / Q14SY0 12 TMS Na+:bicarbonate symporter, BicA (Price et al., 2004; Shelden et al., 2010) (low affinity but high efficiency) from Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (see paper)
30% identity, 93% coverage of query (188 bits)
TC 2.A.53.3.13 / Q1J2S8 Fumarate (Na+-independent anion) transporter, SLC26dg of 499 aas and 14 TMSs from Deinococcus geothermalis (strain DSM 11300)
30% identity, 88% coverage of query (186 bits)
5da0A / Q1J2S8 Structure of the the slc26 transporter slc26dg in complex with a nanobody (see paper)
31% identity, 88% coverage of query (185 bits)
Build an alignment for SMc00476 and 6 homologs with ≥ 30% identity
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TC 2.A.53.3.1 / O07488 Sulfate permease from Yersinia enterocolitica (see paper)
26% identity, 93% coverage of query (172 bits)
TC 2.A.53.3.2 / Q7U617 Bicarbonate:Na+ symporter, BicA (see paper)
30% identity, 91% coverage of query (161 bits)
Y1739_MYCTU / P9WGF7 Probable sulfate transporter Rv1739c from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
TC 2.A.53.4.2 / P71997 Sulfate transporter, Rv1739c from Mycobacterium tuberculosis
29% identity, 92% coverage of query (155 bits)
P96878 carbonic anhydrase (EC 4.2.1.1) from Mycobacterium tuberculosis (see paper)
TC 2.A.53.3.12 / P96878 A bicarbonate transporter fused to a carbonic anhydrase, Rv3273 from Mycobacterium tuberculosis
31% identity, 93% coverage of query (152 bits)
S2611_HUMAN / Q86WA9 Sodium-independent sulfate anion transporter; Solute carrier family 26 member 11 from Homo sapiens (Human) (see 3 papers)
29% identity, 92% coverage of query (137 bits)
S2611_CAVPO / G3C7W6 Sodium-independent sulfate anion transporter; Solute carrier family 26 member 11 from Cavia porcellus (Guinea pig) (see paper)
TC 2.A.53.1.9 / G3C7W6 Slc26a11 Cl-/oxalate or sulfate (but not bicarbonate) exchanger from Cavia porcellus (see paper)
27% identity, 92% coverage of query (133 bits)
TC 2.A.53.3.8 / Q8F8H7 SulP homologue with fused C-terminal carbonic anhydrase domain, probable bicarbonate uptake transporter from Leptospira interrogans (see paper)
25% identity, 91% coverage of query (132 bits)
7v74A Thermostabilized human prestin in complex with sulfate
26% identity, 91% coverage of query (126 bits)
TC 2.A.53.4.1 / P72770 Sulfate transporter (see paper)
26% identity, 92% coverage of query (124 bits)
7v75A Thermostabilized human prestin in complex with salicylate (see paper)
26% identity, 91% coverage of query (123 bits)
SUT41_ARATH / Q9FY46 Sulfate transporter 4.1, chloroplastic; AST82 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
25% identity, 91% coverage of query (121 bits)
7lhvA / Q9FY46 Structure of arabidopsis thaliana sulfate transporter atsultr4;1 (see paper)
25% identity, 91% coverage of query (120 bits)
ST1 / CAA65291.1 high affinity sulphate transporter from Hordeum vulgare (see paper)
23% identity, 90% coverage of query (114 bits)
TC 2.A.53.1.12 / Q0P7I2 Symbiotic sulfate transporter-1, SST1 of 645 aas from Lotus japonicus
23% identity, 91% coverage of query (113 bits)
SUT33_ARATH / Q9SXS2 Probable sulfate transporter 3.3; AST91 from Arabidopsis thaliana (Mouse-ear cress)
25% identity, 79% coverage of query (109 bits)
bst3.1 / CAE46442.1 sulphate transporter from Brassica napus (see paper)
22% identity, 92% coverage of query (105 bits)
SUT11_ARATH / Q9SAY1 Sulfate transporter 1.1; AST101; High-affinity sulfate transporter 1; Hst1At from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
TC 2.A.53.1.7 / Q9SAY1 High affinity sulfate transporter, Sultr1.1 regulated differently from Sultr1.2 (2.A.53.1.6) from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
22% identity, 93% coverage of query (103 bits)
SUT21_ARATH / O04722 Sulfate transporter 2.1; AST68 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
23% identity, 93% coverage of query (98.2 bits)
SUT22_ARATH / P92946 Sulfate transporter 2.2; AST56; AtH14 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
25% identity, 97% coverage of query (97.4 bits)
SULT2_CHLRE / A8J6J0 Proton/sulfate cotransporter 2 from Chlamydomonas reinhardtii (Chlamydomonas smithii) (see 2 papers)
TC 2.A.53.1.8 / A8J6J0 The proton:sulfate symporter, SulP from Chlamydomonas reinhardtii (see paper)
21% identity, 91% coverage of query (96.7 bits)
sB sulfate permease from Emericella nidulans (see 3 papers)
26% identity, 73% coverage of query (96.3 bits)
TC 2.A.53.1.4 / P53393 Low-affinity sulfate:H+ symporter, Sut3 from Stylosanthes hamata (see paper)
24% identity, 97% coverage of query (96.3 bits)
sutA / AAF14540.1 SutA from Penicillium chrysogenum (see paper)
25% identity, 73% coverage of query (95.5 bits)
S26A1_MOUSE / P58735 Sulfate anion transporter 1; SAT-1; Solute carrier family 26 member 1 from Mus musculus (Mouse) (see 4 papers)
24% identity, 79% coverage of query (92.4 bits)
S26A5_CHICK / A0FKN5 Prestin; Solute carrier family 26 member 5 from Gallus gallus (Chicken) (see 5 papers)
TC 2.A.53.2.9 / A0FKN5 The electrogenic divalent anion: chloride exchanger (1:1 stoichiometry) (transports sulfate, chloride, and oxalate) from Gallus gallus (Chicken) (see paper)
24% identity, 72% coverage of query (90.5 bits)
S26A1_RAT / P45380 Sulfate anion transporter 1; SAT-1; Canalicular sulfate transporter; Solute carrier family 26 member 1; Sulfate/carbonate antiporter from Rattus norvegicus (Rat) (see 7 papers)
TC 2.A.53.2.2 / P45380 Canicular sulfate:HCO3- antiporter (Slc26a1) from Rattus norvegicus (Rat) (see paper)
24% identity, 79% coverage of query (90.1 bits)
Q9URY8 Probable sulfate permease C869.05c from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
24% identity, 83% coverage of query (88.2 bits)
TC 2.A.53.1.2 / P23622 Sulfate permease II from Neurospora crassa (see 4 papers)
26% identity, 73% coverage of query (86.7 bits)
S26A6_MOUSE / Q8CIW6 Solute carrier family 26 member 6; Anion exchange transporter; Chloride-formate exchanger; Pendrin-L1; Pendrin-like protein 1; Putative anion transporter-1; Pat-1 from Mus musculus (Mouse) (see 22 papers)
25% identity, 81% coverage of query (85.5 bits)
S26A6_HUMAN / Q9BXS9 Solute carrier family 26 member 6; Anion exchange transporter; Pendrin-like protein 1; Pendrin-L1 from Homo sapiens (Human) (see 7 papers)
TC 2.A.53.2.7 / Q9BXS9 The human Slc26a6 anion exchanger (transports sulfate, formate, oxalate, chloride and bicarbonate in antiport with any one of these anions) (Jiang et al., 2002). However, Cl- and HSO4- are transported slowly; Cl-/HCO3-, Cl-/OH- and Cl-:oxalate exchange reactions are electroneutral (Chernova et al., 2005). (The oxalate nephrolithiasis gene; Clark et al., 2008). Catalyzes 1Cl-/2HCO3- antiport from Homo sapiens (Human) (see 4 papers)
25% identity, 78% coverage of query (85.5 bits)
SUT13_ARATH / Q9FEP7 Sulfate transporter 1.3 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
23% identity, 93% coverage of query (85.5 bits)
TC 2.A.53.2.8 / Q8K142 The mouse Slc26a6 anion exchanger (same substrate specificity as its human orthologue (2.A.53.2.7)), but Cl- and HSO4- are transported rapidly. Moreover, although Cl-/HCO3- and Cl-/OH- exchange reactions are electroneutral, Cl-:oxalate exchange is electrogenic (Chernova et al., 2005). Also catalyzes Cl-:formate exchange (see paper)
Slc26a6 / RF|NP_599252.2 solute carrier family 26, member 6 from Mus musculus
25% identity, 81% coverage of query (85.1 bits)
7lguA / P58743 Structure of human prestin in the presence of nacl (see paper)
21% identity, 91% coverage of query (82.4 bits)
S26A2_RAT / O70531 Sulfate transporter; Diastrophic dysplasia protein homolog; Solute carrier family 26 member 2 from Rattus norvegicus (Rat) (see 2 papers)
25% identity, 71% coverage of query (81.3 bits)
8sgwC / A0A8D0Z6H8 Pendrin in complex with chloride
23% identity, 91% coverage of query (80.9 bits)
8sieC Pendrin in complex with bicarbonate
23% identity, 91% coverage of query (80.9 bits)
8shcC Pendrin in complex with niflumic acid
23% identity, 91% coverage of query (80.9 bits)
S26A2_MOUSE / Q62273 Sulfate transporter; Diastrophic dysplasia protein homolog; ST-OB; Solute carrier family 26 member 2 from Mus musculus (Mouse) (see 4 papers)
24% identity, 71% coverage of query (80.1 bits)
S26A1_HUMAN / Q9H2B4 Sulfate anion transporter 1; SAT-1; Solute carrier family 26 member 1 from Homo sapiens (Human) (see 3 papers)
TC 2.A.53.2.16 / Q9H2B4 Sulfate anion transporter 1 (SAT-1 or SAT1) (Solute carrier family 26 member 1); anion exchanger. Transports chloride, sulfate, bicarbonate and oxalate (Regeer et al. 2003; Lee et al. 2003). The mouse and rat orthologues have the same specificities and functions. Loss in mice is associated with hyperoxalurea and calcium oxalate kidney stones, and specific mutations when heterozygous in humans cause urolithiasis (Dawson et al. 2013). When homozygous, they can cause severe nephrocalcinosis from Homo sapiens (see 5 papers)
23% identity, 79% coverage of query (79.7 bits)
SULX_YEAST / P53394 Putative sulfate transporter YPR003C from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
23% identity, 92% coverage of query (79.3 bits)
S26A5_TURTR / D7PC76 Prestin; Solute carrier family 26 member 5 from Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus) (see paper)
23% identity, 83% coverage of query (78.2 bits)
SUT12_ARATH / Q9MAX3 Sulfate transporter 1.2 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
TC 2.A.53.1.6 / Q9MAX3 The sulfate transporter, Sultr1.2 with C-terminal STAS domain that is required both for activity and biogenesis/stability (Shibagaki and Grossman, 2006). It physically interacts with 0-acetylserine (thiol)lyase (cysteine synthetase) via its STAS domain. This interaction stimulates the activity of from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
SULTR1;2 / RF|NP_849899.1 sulfate transporter 1.2 from Arabidopsis thaliana (see paper)
21% identity, 93% coverage of query (75.5 bits)
S26A2_HUMAN / P50443 Sulfate transporter; Diastrophic dysplasia protein; Solute carrier family 26 member 2 from Homo sapiens (Human) (see 9 papers)
TC 2.A.53.2.1 / P50443 Sulfate/anion transporter (diastrophic dysplasia protein) (SLC26A2). It catalyzes electroneutral SO4-, OH- from Homo sapiens (Human) (see 12 papers)
22% identity, 90% coverage of query (74.7 bits)
TC 2.A.53.1.1 / P38359 High-affinity sulfate permease from Saccharomyces cerevisiae (Baker's yeast) (see 5 papers)
SUL1 / RF|NP_009853.1 sulfate permease 1 from Saccharomyces cerevisiae
23% identity, 71% coverage of query (72.8 bits)
S26A7_HUMAN / Q8TE54 Anion exchange transporter; Solute carrier family 26 member 7 from Homo sapiens (Human) (see 11 papers)
TC 2.A.53.2.6 / Q8TE54 Basolateral kidney cortical collecting duct and parietal cell chloride/sulfate/oxalate permease or channel, SLC26A7 [substrate preference: NO3- >> Cl- = Br- = I- > SO42- = Glucarate-] (minimal OH- and HCO3- transport; regulated by cytoplasmic pH) (see 7 papers)
SLC26A7 / RF|NP_439897.1 anion exchange transporter from Homo sapiens (see paper)
20% identity, 96% coverage of query (70.9 bits)
S26A7_MOUSE / Q8R2Z3 Anion exchange transporter; Solute carrier family 26 member 7 from Mus musculus (Mouse) (see 9 papers)
21% identity, 96% coverage of query (69.3 bits)
S26A5_DANRE / Q7T2C4 Prestin; Solute carrier family 26 member 5 from Danio rerio (Zebrafish) (Brachydanio rerio) (see 3 papers)
25% identity, 72% coverage of query (69.3 bits)
SULH3_SCHPO / O59782 Probable sulfate permease C320.05 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
22% identity, 79% coverage of query (63.2 bits)
7xujA Human slc26a3 in complex with uk5099
23% identity, 71% coverage of query (62.4 bits)
7xulA Human slc26a3 in complex with tenidap
23% identity, 71% coverage of query (60.5 bits)
7xuhA / P40879 Down-regulated in adenoma in complex with tqr1122
23% identity, 71% coverage of query (59.3 bits)
S26A3_HUMAN / P40879 Chloride anion exchanger; Down-regulated in adenoma; Protein DRA; Solute carrier family 26 member 3 from Homo sapiens (Human) (see 16 papers)
TC 2.A.53.2.18 / P40879 Chloride anion exchanger (Down-regulated in adenoma) (Protein DRA) (Solute carrier family 26 member 3) from Homo sapiens (see 12 papers)
22% identity, 71% coverage of query (56.2 bits)
S26A9_MOUSE / Q8BU91 Solute carrier family 26 member 9; Anion transporter/exchanger protein 9 from Mus musculus (Mouse) (see 3 papers)
TC 2.A.53.2.10 / Q8BU91 The anion exchanger, channel and Na+-transporter, SLC26a9 from Mus musculus (see 3 papers)
23% identity, 70% coverage of query (55.5 bits)
7ch1A / Q7LBE3 The overall structure of slc26a9 (see paper)
23% identity, 70% coverage of query (53.5 bits)
S26A9_HUMAN / Q7LBE3 Solute carrier family 26 member 9; Anion transporter/exchanger protein 9 from Homo sapiens (Human) (see 5 papers)
TC 2.A.53.2.15 / Q7LBE3 Solute carrier family 26 member 9 (Anion transporter/exchanger protein 9) from Homo sapiens (see 4 papers)
23% identity, 70% coverage of query (53.1 bits)
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Lawrence Berkeley National Laboratory