Sites on a Tree

 

Searching for up to 100 curated homologs for SMc00588 FitnessBrowser__Smeli:SMc00588 (308 a.a.)

Found high-coverage hits (≥70%) to 9 curated proteins.

Removed hits that are identical to the query, leaving 8

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

ARAA_AZOBR / Q53TZ2 L-arabinose 1-dehydrogenase (NAD(P)(+)); D-galactose 1-dehydrogenase; EC 1.1.1.376; EC 1.1.1.120; EC 1.1.1.48 from Azospirillum brasilense (see paper)
Q53TZ2 L-arabinose 1-dehydrogenase [NAD(P)+] (EC 1.1.1.376) from Azospirillum brasilense (see 3 papers)
    55% identity, 98% coverage of query (340 bits)

7cgqA / Q53TZ2 Crystal structure of azospirillum brasilense l-arabinose 1- dehydrogenase e147a mutant (NADP and l-arabinose bound form)
    55% identity, 98% coverage of query (338 bits)

gal / P11886 D-galactose dehydrogenase subunit (EC 1.1.1.48) from Pseudomonas fluorescens (see paper)
GAL_PSEFL / P11886 Galactose 1-dehydrogenase; EC 1.1.1.48 from Pseudomonas fluorescens (see paper)
    47% identity, 100% coverage of query (264 bits)

Build an alignment

Build an alignment for SMc00588 and 3 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

mtmU / Q194Q3 D-oliose 4-ketoreductase from Streptomyces argillaceus (see paper)
    23% identity, 90% coverage of query (56.6 bits)

1zh8A / Q9WYE8 Crystal structure of oxidoreductase (tm0312) from thermotoga maritima at 2.50 a resolution
    22% identity, 95% coverage of query (51.2 bits)

XDH2_HALVD / D4GP30 D-xylose 1-dehydrogenase (NADP(+)) 2; XDH 2; EC 1.1.1.179 from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) (see paper)
D4GP30 D-xylose 1-dehydrogenase (NADP+, D-xylono-1,5-lactone-forming) (EC 1.1.1.179) from Haloferax volcanii (see paper)
    26% identity, 76% coverage of query (47.0 bits)

3rc1A / B3TMR8 Crystal structure of kijd10, a 3-ketoreductase from actinomadura kijaniata incomplex with NADP and tdp-benzene (see paper)
    21% identity, 76% coverage of query (44.3 bits)

KIJDR_ACTKI / B3TMR8 dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose 3-reductase; 3-ketoreductase; NADPH-dependent C3-ketoreductase; EC 1.1.1.384 from Actinomadura kijaniata (see paper)
B3TMR8 dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose 3-reductase (EC 1.1.1.384) from Actinomadura kijaniata (see paper)
    21% identity, 76% coverage of query (43.9 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory