Searching for up to 100 curated homologs for SMc00833 FitnessBrowser__Smeli:SMc00833 (405 a.a.)
Found high-coverage hits (≥70%) to 22 curated proteins.
Removed hits that are identical to the query, leaving 21
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
PGA1_c29710 D-lactate dehydrogenase, FAD binding subunit GlcE (EC 1.1.99.6) from Phaeobacter inhibens BS107
47% identity, 97% coverage of query (297 bits)
Psest_3840 D-lactate/glycolate dehydrogenase, FAD binding subunit GlcE (EC 1.1.99.6; EC 1.1.99.14) from Pseudomonas stutzeri RCH2
38% identity, 94% coverage of query (201 bits)
Gox / b4468 glycolate dehydrogenase, putative FAD-binding subunit (EC 1.1.99.14) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
glcE / P52073 glycolate dehydrogenase, putative FAD-binding subunit (EC 1.1.99.14) from Escherichia coli (strain K12) (see 3 papers)
GLCE_ECOLI / P52073 Glycolate oxidase subunit GlcE; Glycolate dehydrogenase subunit GlcE; EC 1.1.99.14 from Escherichia coli (strain K12) (see 4 papers)
glcE / RF|YP_026191.1 glycolate oxidase, subunit glcE from Escherichia coli K12 (see paper)
glcE / AAB02531.1 glycolate oxidase subunit from Escherichia coli (see paper)
35% identity, 98% coverage of query (192 bits)
RR42_RS17310 D-lactate dehydrogenase, FAD binding subunit GlcE (EC 1.1.99.6) from Cupriavidus basilensis FW507-4G11
38% identity, 98% coverage of query (182 bits)
Build an alignment for SMc00833 and 4 homologs with ≥ 30% identity
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D2HDH_STUS1 / A4VGK4 D-2-hydroxyglutarate dehydrogenase; D-2-HG dehydrogenase; D2HGDH; D-malate dehydrogenase; EC 1.1.99.39; EC 1.1.99.- from Stutzerimonas stutzeri (strain A1501) (Pseudomonas stutzeri) (see 2 papers)
24% identity, 98% coverage of query (85.5 bits)
P9WIT1 Uncharacterized FAD-linked oxidoreductase Rv2280; EC 1.-.-.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
26% identity, 97% coverage of query (77.8 bits)
Q9I6H4 D-2-hydroxyglutarate dehydrogenase (EC 1.1.99.39) from Pseudomonas aeruginosa (see paper)
24% identity, 98% coverage of query (75.5 bits)
DLD2_YEAST / P46681 D-2-hydroxyglutarate--pyruvate transhydrogenase DLD2; D-2HG--pyruvate transhydrogenase DLD2; Actin-interacting protein 2; D-lactate dehydrogenase [cytochrome] 2, mitochondrial; D-lactate ferricytochrome C oxidoreductase; D-LCR; EC 1.1.99.40; EC 1.1.2.4 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 4 papers)
24% identity, 73% coverage of query (73.6 bits)
6lpnB / Q8N465 Crystal structure of human d-2-hydroxyglutarate dehydrogenase in apo form (see paper)
23% identity, 98% coverage of query (71.6 bits)
D2HGDH / Q8N465 D-2-hydroxyglutarate dehydrogenase, mitochondrial (EC 1.1.99.39) from Homo sapiens (see paper)
D2HDH_HUMAN / Q8N465 D-2-hydroxyglutarate dehydrogenase, mitochondrial; EC 1.1.99.39 from Homo sapiens (Human) (see 7 papers)
Q8N465 D-2-hydroxyglutarate dehydrogenase (EC 1.1.99.39) from Homo sapiens (see 3 papers)
24% identity, 97% coverage of query (71.2 bits)
6lpxA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with 2-oxoglutarate (2-og)
23% identity, 98% coverage of query (71.2 bits)
6lpuA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with l-2-hydroxyglutarate (l-2-hg)
23% identity, 98% coverage of query (71.2 bits)
6lpqA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with d-malate (d-mal)
23% identity, 98% coverage of query (71.2 bits)
6lppA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with d-2-hydroxyglutarate (d-2-hg)
23% identity, 98% coverage of query (71.2 bits)
D2HDH_RAT / P84850 D-2-hydroxyglutarate dehydrogenase, mitochondrial; EC 1.1.99.39 from Rattus norvegicus (Rat) (see paper)
23% identity, 98% coverage of query (69.3 bits)
DLD3_YEAST / P39976 D-2-hydroxyglutarate--pyruvate transhydrogenase DLD3; D-2HG--pyruvate transhydrogenase DLD3; (R)-2-hydroxyglutarate--pyruvate transhydrogenase; D-lactate dehydrogenase [cytochrome] 3; D-lactate ferricytochrome C oxidoreductase; D-LCR; EC 1.1.99.40; EC 1.1.2.4 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
P39976 (R)-2-hydroxyglutarate-pyruvate transhydrogenase (EC 1.1.99.40) from Saccharomyces cerevisiae (see paper)
25% identity, 74% coverage of query (67.0 bits)
Psest_3841 D-lactate/glycolate dehydrogenase, FAD-linked subunit GlcD (EC 1.1.99.6; EC 1.1.99.14) from Pseudomonas stutzeri RCH2
26% identity, 72% coverage of query (62.4 bits)
D2HDH_ARATH / O23240 D-2-hydroxyglutarate dehydrogenase, mitochondrial; AtD-2HGDH; EC 1.1.99.39 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
22% identity, 97% coverage of query (60.5 bits)
8jdeA Crystal structure of mldhd in complex with d-lactate
24% identity, 73% coverage of query (49.7 bits)
8jdvA Crystal structure of mldhd in complex with 2-ketohexanoic acid
25% identity, 73% coverage of query (48.9 bits)
8jdpA Crystal structure of h405a mldhd in complex with d-2-hydroxyisovaleric acid
25% identity, 73% coverage of query (48.5 bits)
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Lawrence Berkeley National Laboratory