Searching for up to 100 curated homologs for SMc00962 FitnessBrowser__Smeli:SMc00962 (226 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
BIOM_RHIEC / Q2KBP5 Biotin transport ATP-binding protein BioM; Biotin ECF transporter A component BioM; EC 7.6.2.- from Rhizobium etli (strain CFN 42 / ATCC 51251) (see paper)
66% identity, 99% coverage of query (287 bits)
TC 3.A.1.25.1 / Q6GUB2 ATP-binding protein BioM, component of The biotin uptake porter (binding receptor lacking) (see also the VUT or ECF family; BioY; 2.A.88.1.1) (Rodionov et al., 2006; Hebbeln et al., 2007). BioN (the EcfT component of the biotin transporter) appears to be required for intramolecular signaling and subunit assembly (Neubauer et al., 2009). The Ala-Arg-Ser and Ala-Arg-Gly signatures in BioN are coupling sites to the BioM ATPases from Rhizobium etli (see paper)
60% identity, 99% coverage of query (252 bits)
BIOM_RHOCB / D5ARH0 Biotin transport ATP-binding protein BioM; ECF transporter A component BioM; EC 7.6.2.- from Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003) (see paper)
TC 3.A.1.25.7 / D5ARH0 Biotin transport ATP-binding protein BioM, component of The riboflavin uptake system, BioMNY from Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)
43% identity, 88% coverage of query (155 bits)
TC 3.A.1.26.10 / TC 3.A.1.26.7 / Q839D5 Cobalt import ATP-binding protein CbiO 1, component of ATP-dependent folic acid uptake porter, FolT/EcfT/EcfA1/EcfA2 from Enterococcus faecalis (see paper)
40% identity, 88% coverage of query (140 bits)
ECFA1_LACP3 / Q035B2 Energy-coupling factor transporter ATP-binding protein EcfA1; ECF transporter A component EcfA; EC 7.-.-.- from Lacticaseibacillus paracasei (strain ATCC 334 / BCRC 17002 / CCUG 31169 / CIP 107868 / KCTC 3260 / NRRL B-441) (Lactobacillus paracasei) (see paper)
41% identity, 82% coverage of query (140 bits)
TC 3.A.1.26.9 / TC 3.A.1.28.2 / Q03PY5 Energy-coupling factor transporter ATP-binding protein EcfA1, component of The folate transporter, FolT/EcfAA''T (The 3-d structure is known to 3.0Å resolution (Xu et al. 2013; 4HUQ) from Lactobacillus brevis (strain ATCC 367 / JCM 1170)
41% identity, 84% coverage of query (139 bits)
ECFA1_LEUMM / Q03ZL6 Energy-coupling factor transporter ATP-binding protein EcfA1; ECF transporter A component EcfA1; EC 7.-.-.- from Leuconostoc mesenteroides subsp. mesenteroides (strain ATCC 8293 / DSM 20343 / BCRC 11652 / CCM 1803 / JCM 6124 / NCDO 523 / NBRC 100496 / NCIMB 8023 / NCTC 12954 / NRRL B-1118 / 37Y) (see 2 papers)
37% identity, 96% coverage of query (135 bits)
cbiO1 / Q18CJ0 energy-coupling factor transporter ATP-bindind protein 1 from Clostridioides difficile (strain 630) (see 10 papers)
37% identity, 88% coverage of query (135 bits)
8bmsA Cryo-em structure of the mutant solitary ecf module 2eq in msp2n2 lipid nanodiscs in the atpase closed and atp-bound conformation
36% identity, 96% coverage of query (133 bits)
5d3mA / Q1GBJ0 Folate ecf transporter: amppnp bound state (see paper)
36% identity, 96% coverage of query (132 bits)
8bmpA Cryo-em structure of the folate-specific ecf transporter complex in msp2n2 lipid nanodiscs bound to atp and adp
38% identity, 91% coverage of query (132 bits)
ECFA1_STRT2 / Q5M243 Energy-coupling factor transporter ATP-binding protein EcfA1; ECF transporter A component EcfA1; EC 7.-.-.- from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311) (see paper)
TC 3.A.1.25.6 / Q5M243 Energy-coupling factor transporter ATP-binding protein EcfA 2, component of Riboflavin ECF transport system, EcfAA'T/RibU from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
37% identity, 86% coverage of query (131 bits)
ECFA1_LACLM / A2RI01 Energy-coupling factor transporter ATP-binding protein EcfA1; ECF transporter A component EcfA; EC 7.-.-.- from Lactococcus lactis subsp. cremoris (strain MG1363) (see paper)
TC 3.A.1.25.4 / A2RI01 Energy-coupling factor transporter ATP-binding protein EcfA 1, component of The biotin uptake system, BioMNY. The 3-d structure of the EcfS subunit, BioY, at 2.1Å resolution is known (Berntsson et al., 2012). BioY and ThiT from L. lactis from Lactococcus lactis subsp. cremoris (strain MG1363)
39% identity, 82% coverage of query (129 bits)
NIKO_RHOCB / D5AQY6 Nickel import ATP-binding protein NikO; Energy-coupling factor transporter ATP-binding protein NikO; ECF transporter A component NikO; EC 3.6.3.- from Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003) (see paper)
TC 3.A.1.23.7 / D5AQY6 Nickel import ATP-binding protein NikO, component of Ni2+, Co2+ uptake transporter, NikMNOQ (subunit sizes: NikMN, 347 aas, 9 TMSs; NikQ, 284 aas, 4 TMSs; NikO, 254 aas, 0 TMS from Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)
38% identity, 90% coverage of query (126 bits)
TC 3.A.1.26.9 / TC 3.A.1.28.2 / Q03PY6 Energy-coupling factor transporter ATP-binding protein EcfA2, component of The folate transporter, FolT/EcfAA''T (The 3-d structure is known to 3.0Å resolution (Xu et al. 2013; 4HUQ) from Lactobacillus brevis (strain ATCC 367 / JCM 1170)
34% identity, 94% coverage of query (116 bits)
GlnQ / b0809 L-glutamine ABC transporter ATP binding subunit (EC 7.4.2.1) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
GlnQ / P10346 L-glutamine ABC transporter ATP binding subunit (EC 7.4.2.1) from Escherichia coli (strain K12) (see paper)
GLNQ_ECOLI / P10346 Glutamine transport ATP-binding protein GlnQ from Escherichia coli (strain K12) (see paper)
TC 3.A.1.3.2 / P10346 GlnQ aka B0809, component of Three component ABC L-glutamine porter. The basal ATPase activity (ATP hydrolysis in the absence of substrate) is mainly caused by the docking of the closed-unliganded state of GlnH onto the transporter domain of GlnPQ. Unlike glutamine, arginine binds both GlnH domains, but does not trigger their closing. Comparison of the ATPase activity in nanodiscs with glutamine transport in proteoliposomes suggested that the stoichiometry of ATP per substrate is close to two from Escherichia coli (see 5 papers)
glnQ / GB|ABB65374.1 glutamine ABC transporter, ATP-binding protein GlnQ from Escherichia coli K12 (see 5 papers)
35% identity, 96% coverage of query (113 bits)
CBIO_RHOCB / O68106 Cobalt import ATP-binding protein CbiO; Energy-coupling factor transporter ATP-binding protein CbiO; ECF transporter A component CbiO; EC 7.2.2.- from Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003) (see 2 papers)
TC 3.A.1.23.8 / O68106 Cobalt import ATP-binding protein CbiO, component of Ni2+/Co2+ uptake porter, CbiMNOQ (CbiM, 222 aas, 5 TMSs; CbiN, 103 aas, 2 TMSs; CbiO, 280 aas, 0 TMSs; CbiQ, 244 aas, 5 TMSs) from Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)
38% identity, 87% coverage of query (112 bits)
cbiO2 / Q18CI9 energy-coupling factor transporter ATP-bindind protein 2 from Clostridioides difficile (strain 630) (see 10 papers)
36% identity, 89% coverage of query (111 bits)
5x40A / O68106 Structure of a cbio dimer bound with amppcp (see paper)
35% identity, 89% coverage of query (110 bits)
ECFA2_STRT2 / Q5M244 Energy-coupling factor transporter ATP-binding protein EcfA2; ECF transporter A component EcfA2; EC 3.6.3.- from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311) (see paper)
TC 3.A.1.25.6 / Q5M244 Energy-coupling factor transporter ATP-binding protein EcfA 1, component of Riboflavin ECF transport system, EcfAA'T/RibU from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
33% identity, 96% coverage of query (109 bits)
ECFA2_LEUMM / Q03ZL5 Energy-coupling factor transporter ATP-binding protein EcfA2; ECF transporter A component EcfA2; ECF transporter A component EcfA'; EC 3.6.3.- from Leuconostoc mesenteroides subsp. mesenteroides (strain ATCC 8293 / DSM 20343 / BCRC 11652 / CCM 1803 / JCM 6124 / NCDO 523 / NBRC 100496 / NCIMB 8023 / NCTC 12954 / NRRL B-1118 / 37Y) (see 2 papers)
30% identity, 97% coverage of query (108 bits)
TC 3.A.1.1.38 / Q9WYQ2 Glycerol-3-phosphate-transporting ATPase, component of Inositol phosphate porter (Rodionova et al. 2013). Binds inositol phosphate with low Kd and inositol with a lower affinity from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
32% identity, 94% coverage of query (107 bits)
TC 3.A.1.26.10 / TC 3.A.1.26.7 / Q839D4 Cobalt import ATP-binding protein CbiO 2, component of ATP-dependent folic acid uptake porter, FolT/EcfT/EcfA1/EcfA2 from Enterococcus faecalis (see paper)
32% identity, 96% coverage of query (107 bits)
CysA / b2422 sulfate/thiosulfate ABC transporter ATP binding subunit (EC 7.3.2.3; EC 7.3.2.5) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
CysA / P16676 sulfate/thiosulfate ABC transporter ATP binding subunit (EC 7.3.2.3; EC 7.3.2.5) from Escherichia coli (strain K12) (see 2 papers)
TC 3.A.1.6.1 / P16676 CysA aka B2422, component of Sulfate/thiosulfate porter from Escherichia coli (see 5 papers)
35% identity, 96% coverage of query (106 bits)
PotG / b0855 putrescine ABC transporter ATP binding subunit (EC 7.6.2.11; EC 7.6.2.16) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
PotG / P31134 putrescine ABC transporter ATP binding subunit (EC 7.6.2.11) from Escherichia coli (strain K12) (see 2 papers)
POTG_ECOLI / P31134 Putrescine transport ATP-binding protein PotG; EC 7.6.2.16 from Escherichia coli (strain K12) (see 2 papers)
TC 3.A.1.11.2 / P31134 PotG aka B0855, component of Putrescine porter from Escherichia coli (see 4 papers)
32% identity, 95% coverage of query (106 bits)
TC 3.A.1.26.5 / A7NRG0 ABC transporter related, component of ThiW/CbiQ/CbiO homologues (ThiW: 174 aas; 5 putative TMSs) from Roseiflexus castenholzii (strain DSM 13941 / HLO8)
38% identity, 88% coverage of query (105 bits)
2d62A / O57933 Crystal structure of multiple sugar binding transport atp- binding protein
33% identity, 96% coverage of query (105 bits)
TC 3.A.1.20.2 / Q9KLQ5 Fe(3+) ions import ATP-binding protein FbpC, component of Hexose-phosphate transporter from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
32% identity, 92% coverage of query (105 bits)
TC 3.A.1.6.3 / P0A4W2 Sulfate/thiosulfate import ATP-binding protein CysA aka RV2397C aka MT2468 aka MTCY253.24, component of Sulfate porter from Mycobacterium tuberculosis (see 3 papers)
32% identity, 94% coverage of query (104 bits)
1g291 / Q9YGA6 Malk (see paper)
33% identity, 95% coverage of query (104 bits)
MALK_THELN / Q9YGA6 Trehalose/maltose import ATP-binding protein MalK; EC 7.5.2.1 from Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C) (see 5 papers)
33% identity, 95% coverage of query (103 bits)
natA / P46903 Na+ ABC efflux transporter ATP-binding protein (EC 7.2.2.4) from Bacillus subtilis (strain 168) (see paper)
NATA_BACSU / P46903 ABC transporter ATP-binding protein NatA; ABC-type Na(+) transporter; EC 7.2.2.4 from Bacillus subtilis (strain 168) (see 2 papers)
P46903 ABC-type Na+ transporter (EC 7.2.2.4) from Bacillus subtilis (see 2 papers)
TC 3.A.1.115.1 / P46903 NatA; ATP-binding transport protein (Na(+) ABC transporter), component of Na+ efflux pump NatAB from Bacillus subtilis (see 3 papers)
natA / GB|BAA22236.1 sodium extrusion ABC transporter, ATP-binding protein NatA from Bacillus subtilis (see paper)
31% identity, 93% coverage of query (103 bits)
ECFA2_LACLM / A2RI02 Energy-coupling factor transporter ATP-binding protein EcfA2; ECF transporter A component EcfA2; ECF transporter A component EcfA'; EC 3.6.3.- from Lactococcus lactis subsp. cremoris (strain MG1363) (see paper)
31% identity, 84% coverage of query (102 bits)
LolD / b1117 lipoprotein release complex - ATP binding subunit from Escherichia coli K-12 substr. MG1655 (see 2 papers)
LolD / P75957 lipoprotein release complex - ATP binding subunit from Escherichia coli (strain K12) (see paper)
LOLD_ECOLI / P75957 Lipoprotein-releasing system ATP-binding protein LolD; EC 7.6.2.- from Escherichia coli (strain K12) (see paper)
TC 3.A.1.125.1 / P75957 LolD aka B1117, component of Lipoprotein translocation system (translocates lipoproteins from the inner membrane to periplasmic chaperone, LolA, which transfers the lipoproteins to an outer membrane receptor, LolB, which anchors the lipoprotein to the outer membrane of the Gram-negative bacterial cell envelope) (see 1.B.46; Narita et al., 2003; Ito et al., 2006; Watanabe et al., 2007). The structure of ligand-bound LolCDE has been solved (Ito et al., 2006). LolC and LolE each have 4 TMSs (1+3). Unlike most ATP binding cassette transporters mediating the transmembrane flux of substrates, the LolCDE complex catalyzes the extrusion of lipoproteins anchored to the outer leaflet of the inner membrane. The LolCDE complex is unusual in that it can be purified as a liganded form, which is an intermediate of the lipoprotein release reaction (Taniguchi and Tokuda, 2008). LolCDE has been reconstituted from separated subunits from Escherichia coli (see 5 papers)
lolD / GB|BAA35937.2 lipoprotein releasing system, ATP-binding protein; EC 3.6.3.- from Escherichia coli K12 (see 5 papers)
35% identity, 92% coverage of query (101 bits)
7mdyC Lolcde nucleotide-bound
35% identity, 92% coverage of query (101 bits)
7v8iD / P75957 Lolcd(e171q)e with bound amppnp in nanodiscs (see paper)
35% identity, 92% coverage of query (100 bits)
7arlD Lolcde in complex with lipoprotein and adp
35% identity, 91% coverage of query (100 bits)
Build an alignment for SMc00962 and 37 homologs with ≥ 30% identity
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ECFA1_THEMA / Q9X1Z1 Energy-coupling factor transporter ATP-binding protein EcfA1; ECF transporter A component EcfA1; EC 7.-.-.- from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
TC 3.A.1.25.5 / Q9X1Z1 Energy-coupling factor transporter ATP-binding protein EcfA, component of Biotin/Riboflavin ECF transport system, EcfAA'T/RibU/BioY (Karpowich and Wang 2013). RibU binds riboflavin with high affinity, and the protein-substrate complex is exceptionally stable in solution. The crystal structure of riboflavin-bound RibU reveals an electronegative binding pocket at the extracellular surface in which the substrate is completely buried from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
29% identity, 97% coverage of query (99.8 bits)
CBIO_SALTY / Q05596 Cobalt import ATP-binding protein CbiO; Energy-coupling factor transporter ATP-binding protein CbiO; ECF transporter A component CbiO; EC 7.-.-.- from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
TC 3.A.1.23.6 / Q05596 CbiO aka STM2020, component of Cobalt (Co2+) porter from Salmonella typhimurium (see 2 papers)
32% identity, 83% coverage of query (99.8 bits)
TC 3.A.1.23.1 / Q79CI9 Nickel transport ATP-binding protein UreO, component of Nickel (Ni2+) porter from Streptococcus salivarius (see paper)
33% identity, 79% coverage of query (99.4 bits)
PVDT_PSEAE / Q9I190 Pyoverdine export ATP-binding/permease protein PvdT; EC 7.6.2.- from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 4 papers)
34% identity, 87% coverage of query (99.4 bits)
4hluC / Q9X1Z1 Structure of the ecfa-a' heterodimer bound to adp (see paper)
32% identity, 83% coverage of query (99.4 bits)
TC 3.A.1.1.16 / Q8TZQ3 MalK aka PF1933, component of Maltooligosaccharide porter (Maltose is not a substrate, but maltotriose is.) from Pyrococcus furiosus
30% identity, 96% coverage of query (99.4 bits)
PHNT_SALTY / P96063 Putative 2-aminoethylphosphonate import ATP-binding protein PhnT from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
TC 3.A.1.11.5 / P96063 PhnT aka STM0428, component of 2-aminoethyl phosphonate porter from Salmonella typhimurium (see 2 papers)
33% identity, 89% coverage of query (99.0 bits)
4u00A / Q5SJ55 Crystal structure of ttha1159 in complex with adp (see paper)
35% identity, 89% coverage of query (98.6 bits)
PotA / b1126 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11; EC 7.6.2.16) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
PotA / P69874 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11) from Escherichia coli (strain K12) (see 5 papers)
POTA_ECOLI / P69874 Spermidine/putrescine import ATP-binding protein PotA; EC 7.6.2.11 from Escherichia coli (strain K12) (see 6 papers)
TC 3.A.1.11.1 / P69874 Spermidine/putrescine import ATP-binding protein PotA aka B1126, component of Polyamine (putrescine/spermidine) uptake porter from Escherichia coli (see 9 papers)
potA / MB|P69874 spermidine/putrescine ABC transporter, ATP-binding protein PotA; EC 3.6.3.31 from Escherichia coli K12 (see 10 papers)
32% identity, 81% coverage of query (96.7 bits)
4zirA Crystal structure of ecfaa' heterodimer bound to amppnp
33% identity, 92% coverage of query (96.7 bits)
1oxvD Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus
34% identity, 90% coverage of query (96.3 bits)
1oxvA Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus
34% identity, 90% coverage of query (96.3 bits)
GLCV_SACS2 / Q97UY8 Glucose import ATP-binding protein GlcV; EC 7.5.2.- from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see 3 papers)
TC 3.A.1.1.13 / Q97UY8 GlcV, component of Glucose, mannose, galactose porter from Sulfolobus solfataricus (see 3 papers)
1oxuA / Q97UY8 Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus (see paper)
34% identity, 90% coverage of query (96.3 bits)
1vciA / O57758 Crystal structure of the atp-binding cassette of multisugar transporter from pyrococcus horikoshii ot3 complexed with atp (see paper)
31% identity, 99% coverage of query (95.1 bits)
4hluA / Q9WY65 Structure of the ecfa-a' heterodimer bound to adp (see paper)
32% identity, 92% coverage of query (93.6 bits)
4zirB Crystal structure of ecfaa' heterodimer bound to amppnp
31% identity, 83% coverage of query (92.8 bits)
8i6rB / Q9I6C0 Cryo-em structure of pseudomonas aeruginosa ftse(e163q)x/envc complex with atp in peptidisc (see paper)
33% identity, 92% coverage of query (91.7 bits)
2pclA / O66646 Crystal structure of abc transporter with complex (aq_297) from aquifex aeolicus vf5
32% identity, 80% coverage of query (89.7 bits)
2ixfA / P36370 Crystal structure of the atpase domain of tap1 with atp (d645q, q678h mutant) (see paper)
30% identity, 99% coverage of query (89.4 bits)
3fvqB / Q5FA19 Crystal structure of the nucleotide binding domain fbpc complexed with atp (see paper)
32% identity, 93% coverage of query (88.2 bits)
5lilA / Q2EHL8 Structure of aggregatibacter actinomycetemcomitans macb bound to atpys (p21) (see paper)
30% identity, 88% coverage of query (87.4 bits)
5lj7A / Q2EHL8 Structure of aggregatibacter actinomycetemcomitans macb bound to atp (p21) (see paper)
30% identity, 88% coverage of query (87.4 bits)
3c4jA Abc protein artp in complex with atp-gamma-s
30% identity, 94% coverage of query (86.7 bits)
3c41J / D0VWX4 Abc protein artp in complex with amp-pnp/mg2+
30% identity, 94% coverage of query (86.7 bits)
2olkA Abc protein artp in complex with adp-beta-s
30% identity, 94% coverage of query (86.7 bits)
2oljA Abc protein artp in complex with adp/mg2+
30% identity, 94% coverage of query (86.7 bits)
7w79A Heme exporter hrtba in complex with mn-amppnp
31% identity, 79% coverage of query (86.3 bits)
7w78A / Q6NEF2 Heme exporter hrtba in complex with mg-amppnp (see paper)
31% identity, 79% coverage of query (86.3 bits)
TAP1_RAT / P36370 Antigen peptide transporter 1; APT1; ATP-binding cassette sub-family B member 2; Peptide transporter TAP1; EC 7.4.2.14 from Rattus norvegicus (Rat) (see 2 papers)
P36370 ABC-type antigen peptide transporter (subunit 2/2) (EC 7.4.2.14) from Rattus norvegicus (see 6 papers)
30% identity, 99% coverage of query (85.9 bits)
Q8TTZ3 ABC-type molybdate transporter (EC 7.3.2.5) from Methanosarcina acetivorans (see paper)
3d31A / Q8TTZ3 Modbc from methanosarcina acetivorans (see paper)
33% identity, 90% coverage of query (85.1 bits)
8bmpB / Q1GBI9 Cryo-em structure of the folate-specific ecf transporter complex in msp2n2 lipid nanodiscs bound to atp and adp (see paper)
26% identity, 96% coverage of query (84.7 bits)
5d3mB Folate ecf transporter: amppnp bound state
26% identity, 96% coverage of query (84.7 bits)
7e7oA / P78363 Cryo-em structure of human abca4 in nrpe-bound state (see paper)
29% identity, 88% coverage of query (84.3 bits)
4ymuJ / Q8RCC2 Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
29% identity, 96% coverage of query (84.3 bits)
1f3oA / Q58206 Crystal structure of mj0796 atp-binding cassette (see paper)
31% identity, 88% coverage of query (84.0 bits)
8tzjA / A0A085R4L6 Cryo-em structure of vibrio cholerae ftse/ftsx complex (see paper)
31% identity, 85% coverage of query (84.0 bits)
8pm6A / O95342 Human bile salt export pump (bsep) in complex with inhibitor gbm in nanodiscs (see paper)
28% identity, 95% coverage of query (84.0 bits)
3vx4D / Q8DW05 Crystal structure of the nucleotide-binding domain of s. Mutans coma, a bifunctional atp-binding cassette transporter involved in the quorum-sensing pathway (see paper)
27% identity, 96% coverage of query (83.6 bits)
8f5bA / P78363 Human abca4 structure in complex with amp-pnp
30% identity, 88% coverage of query (83.6 bits)
ABCA4_HUMAN / P78363 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM proteinv; RmP; Retinal-specific ATP-binding cassette transporter; Stargardt disease protein; EC 7.6.2.1 from Homo sapiens (Human) (see 38 papers)
TC 3.A.1.211.2 / P78363 The retinal-specific ABC transporter (RIM protein, ABCR or ABCA4) (Stargardt's disease protein, involved in retinal/macular degeneration) in the rod outer segment. Changes in the oligomeric state of the nucleotide binding domains of ABCR are coupled to ATP hydrolysis and might represent a signal for the TMDs of ABCR to export the bound substrate (Biswas-Fiss 2006). The ABCA4 porter flips N-retinylidene-phosphatidylethanolamine, a product generated from the photobleaching of rhodopsin, from the lumen to the cytoplasmic side of disc membranes following the photobleaching of rhodopsin, insuring that retinoids do not accumulate in disc membranes (Molday, 2007; Molday et al. 2009; Tsybovsky et al. 2013). It also transports several vitamin A derivatives (Sun, 2011) and phosphatidylethanolamine in the same direction. Mutations, known to cause Stargardt disease, decrease N-retinylidene-phosphatidylethanolamine and phosphatidylethanolamine transport activities (Quazi et al. 2012). It functions as an inwardly directed retinoid flippase in the visual cycle from Homo sapiens (Human) (see 28 papers)
30% identity, 88% coverage of query (83.6 bits)
8bmsB Cryo-em structure of the mutant solitary ecf module 2eq in msp2n2 lipid nanodiscs in the atpase closed and atp-bound conformation
25% identity, 96% coverage of query (83.6 bits)
6tejB / A0A100XE85 Structure of apo irtab devoid sid in complex with sybody syb_nl5 (see paper)
32% identity, 96% coverage of query (83.2 bits)
7dv5U / O95342 Human bile salt exporter abcb11 in complex with taurocholate (see paper)
28% identity, 95% coverage of query (83.2 bits)
8pmjA / O95342 Vanadate-trapped bsep in nanodiscs (see paper)
28% identity, 95% coverage of query (83.2 bits)
1l2tA Dimeric structure of mj0796, a bacterial abc transporter cassette
30% identity, 88% coverage of query (82.8 bits)
ABCBB_HUMAN / O95342 Bile salt export pump; ATP-binding cassette sub-family B member 11; EC 7.6.2.- from Homo sapiens (Human) (see 21 papers)
TC 3.A.1.201.2 / O95342 Bile salt export pump, BSEP, ABCB11 or SPGP in the canalicular membrane of liver cells, is associated with progressive familial intrahepatic cholestasis-2 and benign recurrent intrahepatic cholestasis (Kagawa et al., 2008; Stindt et al. 2013; Park et al. 2016). It exports unconjugaged bile salts and glycine conjugates > taurine conjugates as well as the statin, pravastatin (Nigam 2015). BSEP mediates biliary excretion of bile acids from hepatocytes. Compounds based on GW4064 (Q96RI1), a representative farnesoid X receptor (RXR) agonist, enhance E297G BSEP transport activity from Homo sapiens (Human) (see 11 papers)
28% identity, 95% coverage of query (82.8 bits)
8hf7B Cryo-em structure of coma bound to its mature substrate csp peptide
26% identity, 93% coverage of query (82.8 bits)
7sgrE / Q8FDZ8 Structure of hemolysin a secretion system hlyb/d complex (see paper)
27% identity, 89% coverage of query (82.4 bits)
7m1qA / P78363 Human abca4 structure in complex with n-ret-pe (see paper)
29% identity, 89% coverage of query (82.4 bits)
7lkzA Structure of atp-bound human abca4
29% identity, 88% coverage of query (82.4 bits)
7e7qA / P78363 Cryo-em structure of human abca4 in atp-bound state (see paper)
29% identity, 88% coverage of query (82.4 bits)
5ws4A / A0A0D8G707 Crystal structure of tripartite-type abc transporter macb from acinetobacter baumannii (see paper)
28% identity, 83% coverage of query (82.4 bits)
7lkpA Structure of atp-free human abca4
29% identity, 88% coverage of query (82.4 bits)
ABCA3_HUMAN / Q99758 Phospholipid-transporting ATPase ABCA3; ABC-C transporter; ATP-binding cassette sub-family A member 3; ATP-binding cassette transporter 3; ATP-binding cassette 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Homo sapiens (Human) (see 18 papers)
TC 3.A.1.211.5 / Q99758 The surfactant-secreting porter, ABCA3 (exports lipids and proteins into lamellar bodies). Fatal surfactant deficiency (FSD) can result from mutations in ABCA3, causing abnormal intracellular localization (type I) or decreased ATP hydrolysis (type II). Other mutations cause pediatric interstitial lung disease (pILD) from Homo sapiens (Human) (see 7 papers)
ABCA3 / RF|NP_001080.2 ATP-binding cassette sub-family A member 3 from Homo sapiens (see paper)
29% identity, 88% coverage of query (82.4 bits)
8hf4A / A0A0H2ZPI8 Cryo-em structure of nucleotide-bound coma at outward-facing state with ec gate closed conformation (see paper)
25% identity, 93% coverage of query (81.6 bits)
Q00748 Multidrug resistance protein homolog 65; P-glycoprotein 65; EC 7.6.2.2 from Drosophila melanogaster (Fruit fly)
28% identity, 82% coverage of query (81.6 bits)
ABCA4_BOVIN / F1MWM0 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM protein; RmP; Retinal-specific ATP-binding cassette transporter; EC 7.6.2.1 from Bos taurus (Bovine) (see 11 papers)
29% identity, 88% coverage of query (81.3 bits)
8dckA Structure of hemolysin a secretion system hlyb/d complex, atp-bound
27% identity, 89% coverage of query (81.3 bits)
7w02A / Q99758 Cryo-em structure of atp-bound abca3 (see paper)
29% identity, 88% coverage of query (81.3 bits)
8hplC / A0R2C0 Lpqy-sugabc in state 1 (see paper)
31% identity, 89% coverage of query (80.9 bits)
8hprC Lpqy-sugabc in state 4
31% identity, 89% coverage of query (80.9 bits)
8hprD Lpqy-sugabc in state 4
31% identity, 89% coverage of query (80.9 bits)
6z67B Ftse structure of streptococcus pneumoniae in complex with amppnp at 2.4 a resolution
32% identity, 90% coverage of query (80.9 bits)
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Lawrence Berkeley National Laboratory