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Searching for up to 100 curated homologs for SMc02324 FitnessBrowser__Smeli:SMc02324 (329 a.a.)

Found high-coverage hits (≥70%) to 42 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

TC 3.A.1.2.9 / Q7BSH5 RhaS, component of Rhamnose porter (Richardson et al., 2004) (Transport activity is dependent on rhamnokinase (RhaK; AAQ92412) activity (Richardson and Oresnik, 2007) This could be an example of group translocation!) from Rhizobium leguminosarum (biovar trifolii) (see paper)
    67% identity, 100% coverage of query (455 bits)

4wzzA / A9KIX1 Crystal structure of an abc transporter solute binding protein (ipr025997) from clostridium phytofermentas (cphy_0583, target efi- 511148) with bound l-rhamnose
    37% identity, 93% coverage of query (191 bits)

LSRB_SALTY / Q8ZKQ1 Autoinducer 2-binding protein LsrB; AI-2-binding protein LsrB from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
    36% identity, 86% coverage of query (178 bits)

1tjyA / Q8ZKQ1 Crystal structure of salmonella typhimurium ai-2 receptor lsrb in complex with r-thmf (see paper)
    36% identity, 86% coverage of query (178 bits)

LsrB / b1516 Autoinducer-2 ABC transporter periplasmic binding protein (EC 7.6.2.13) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
LsrB / P76142 Autoinducer-2 ABC transporter periplasmic binding protein (EC 7.6.2.13) from Escherichia coli (strain K12) (see 5 papers)
LSRB_ECOLI / P76142 Autoinducer 2-binding protein LsrB; AI-2-binding protein LsrB from Escherichia coli (strain K12) (see 2 papers)
TC 3.A.1.2.8 / P76142 LsrB(R), component of Autoinducer-2 (AI-2, a furanosyl borate diester: (3aS,6S,6aR)-2,2,6,6a-tetrahydroxy-3a-methyltetrahydrofuro[3,2-d][1,3,2]dioxaborolan-2-uide) uptake porter (Taga et al., 2001, 2003) from Escherichia coli (see 4 papers)
lsrB autoinducer 2 ABC transporter, periplasmic substrate-binding protein LsrB from Escherichia coli K12 (see paper)
    34% identity, 92% coverage of query (174 bits)

3t95A / Q74PW2 Crystal structure of lsrb from yersinia pestis complexed with autoinducer-2 (see paper)
    34% identity, 85% coverage of query (174 bits)

4pz0A / A0A6H3AKG3 The crystal structure of a solute binding protein from bacillus anthracis str. Ames in complex with quorum-sensing signal autoinducer-2 (ai-2)
    30% identity, 88% coverage of query (167 bits)

3ejwA / Q926H7 Crystal structure of the sinorhizobium meliloti ai-2 receptor, smlsrb (see paper)
    32% identity, 85% coverage of query (150 bits)

H281DRAFT_01114 deoxynucleoside transporter, substrate-binding component from Paraburkholderia bryophila 376MFSha3.1
    33% identity, 85% coverage of query (132 bits)

Build an alignment

Build an alignment for SMc02324 and 9 homologs with ≥ 30% identity

Select sequences

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Change minimum %identity:

Additional hits (identity < 30%)

6dspA / U5MRH9 Lsrb from clostridium saccharobutylicum in complex with ai-2 (see paper)
    27% identity, 87% coverage of query (108 bits)

5hqjA / B1G1H7 Crystal structure of abc transporter solute binding protein b1g1h7 from burkholderia graminis c4d1m, target efi-511179, in complex with d-arabinose
    31% identity, 78% coverage of query (107 bits)

RALBP_PSEAE / Q9I2F8 D-ribose/D-allose-binding protein from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
    29% identity, 74% coverage of query (89.4 bits)

HSERO_RS05260 ABC transporter for L-fucose, substrate-binding component from Herbaspirillum seropedicae SmR1
    26% identity, 86% coverage of query (83.6 bits)

HSERO_RS11480 D-ribose ABC transporter, substrate-binding component RbsB from Herbaspirillum seropedicae SmR1
    30% identity, 74% coverage of query (77.8 bits)

3c6qC Apo and ligand-bound form of a thermophilic glucose/xylose binding protein
    24% identity, 81% coverage of query (75.5 bits)

2h3hA / Q9WXW9 Crystal structure of the liganded form of thermotoga maritima glucose binding protein (see paper)
    24% identity, 81% coverage of query (74.7 bits)

TC 3.A.1.2.20 / G4FGN5 LacI family transcriptional regulator, component of Glucose porter. Also bind xylose (Boucher and Noll 2011). Induced by glucose (Frock et al. 2012). Directly regulated by glucose-responsive regulator GluR from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    27% identity, 83% coverage of query (74.3 bits)

5dkvA / B9K0T2 Crystal structure of an abc transporter solute binding protein from agrobacterium vitis(avis_5339, target efi-511225) bound with alpha-d- tagatopyranose
    29% identity, 79% coverage of query (73.6 bits)

6gt9A / W8QN64 Crystal structure of ganp, a glucose-galactose binding protein from geobacillus stearothermophilus, in complex with galactose
    22% identity, 80% coverage of query (73.2 bits)

6guqA Crystal structure of ganp, a glucose-galactose binding protein from geobacillus stearothermophilus, in complex with glucose
    22% identity, 78% coverage of query (72.8 bits)

4wutA / B9K0B2 Crystal structure of an abc transporter solute binding protein (ipr025997) from agrobacterium vitis (avi_5133, target efi-511220) with bound d-fucose
    25% identity, 74% coverage of query (68.6 bits)

TC 3.A.1.2.19 / Q9X053 Periplasmic binding protein/LacI transcriptional regulator, component of D-ribose porter (Nanavati et al., 2006). Induced by ribose from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    23% identity, 73% coverage of query (67.0 bits)

8wlbA X-ray structure of enterobacter cloacae allose-binding protein in complex with d-psicose
    27% identity, 76% coverage of query (63.5 bits)

8wl9A X-ray structure of enterobacter cloacae allose-binding protein in complex with d-ribose
    27% identity, 76% coverage of query (63.5 bits)

2ioyA / Q8RD41 Crystal structure of thermoanaerobacter tengcongensis ribose binding protein (see paper)
    27% identity, 82% coverage of query (62.8 bits)

AlsB / b4088 D-allose ABC transporter periplasmic binding protein (EC 7.5.2.8) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
AlsB / P39265 D-allose ABC transporter periplasmic binding protein (EC 7.5.2.8) from Escherichia coli (strain K12) (see 5 papers)
ALSB_ECOLI / P39265 D-allose-binding periplasmic protein; ALBP from Escherichia coli (strain K12) (see paper)
P39265 ABC-type D-allose transporter (EC 7.5.2.8) from Escherichia coli (see paper)
TC 3.A.1.2.6 / P39265 AlsB aka B4088, component of D-allose porter from Escherichia coli (see 6 papers)
alsB / GB|AAC77049.1 D-allose-binding periplasmic protein; EC 3.6.3.17 from Escherichia coli K12 (see 6 papers)
    26% identity, 84% coverage of query (62.4 bits)

RBSB_BACSU / P36949 Ribose import binding protein RbsB from Bacillus subtilis (strain 168) (see 2 papers)
    27% identity, 84% coverage of query (61.6 bits)

1gudA / P39265 Hinge-bending motion of d-allose binding protein from escherichia coli: three open conformations (see paper)
    26% identity, 76% coverage of query (60.5 bits)

1rpjA Crystal structure of d-allose binding protein from escherichia coli
    26% identity, 76% coverage of query (60.5 bits)

7x0hA / A3DCF2 Crystal structure of sugar binding protein cbpa complexed wtih glucose from clostridium thermocellum (see paper)
    26% identity, 77% coverage of query (60.1 bits)

5xssA / A6LW07 Xylfii molecule (see paper)
    21% identity, 72% coverage of query (58.9 bits)

APIBP_RHIR8 / B9JK76 D-apiose import binding protein; D-apiose binding SBP from Rhizobium rhizogenes (strain K84 / ATCC BAA-868) (Agrobacterium radiobacter) (see paper)
    26% identity, 79% coverage of query (58.2 bits)

4rxtA / B9JKX8 Crystal structure of carbohydrate transporter solute binding protein arad_9553 from agrobacterium radiobacter, target efi-511541, in complex with d-arabinose
    25% identity, 74% coverage of query (57.4 bits)

YphF / b2548 putative ABC transporter periplasmic binding protein YphF from Escherichia coli K-12 substr. MG1655 (see 4 papers)
    26% identity, 78% coverage of query (56.6 bits)

3ksmA / Q2S7D2 Crystal structure of abc-type sugar transport system, periplasmic component from hahella chejuensis
    22% identity, 78% coverage of query (55.8 bits)

APIBP_ACTSZ / A6VKQ8 D-apiose import binding protein; D-apiose binding SBP from Actinobacillus succinogenes (strain ATCC 55618 / DSM 22257 / CCUG 43843 / 130Z) (see paper)
    23% identity, 71% coverage of query (55.5 bits)

APIBP_RHIEC / Q2JZQ5 D-apiose import binding protein; D-apiose binding SBP from Rhizobium etli (strain CFN 42 / ATCC 51251) (see paper)
    26% identity, 71% coverage of query (52.8 bits)

5ibqA / Q2JZQ5 Crystal structure of an abc solute binding protein from rhizobium etli cfn 42 (rhe_pf00037,target efi-511357) in complex with alpha-d-apiose
    26% identity, 71% coverage of query (52.8 bits)

4ry0A Crystal structure of ribose transporter solute binding protein rhe_pf00037 from rhizobium etli cfn 42, target efi-511357, in complex with d-ribose
    26% identity, 71% coverage of query (52.8 bits)

PGA1_262p00430 glucose transporter, periplasmic substrate-binding component from Phaeobacter inhibens BS107
    27% identity, 86% coverage of query (52.0 bits)

RbsB / b3751 ribose ABC transporter periplasmic binding protein from Escherichia coli K-12 substr. MG1655 (see 25 papers)
RbsB / P02925 ribose ABC transporter periplasmic binding protein from Escherichia coli (strain K12) (see 25 papers)
RBSB_ECOLI / P02925 Ribose import binding protein RbsB from Escherichia coli (strain K12) (see 5 papers)
TC 3.A.1.2.1 / P02925 RbsB aka RBSP aka PRLB aka B3751, component of Ribose porter from Escherichia coli (see 11 papers)
rbsB / GB|AAC76774.1 D-ribose-binding periplasmic protein; EC 3.6.3.17 from Escherichia coli K12 (see 11 papers)
    26% identity, 71% coverage of query (48.9 bits)

XYPA_MYCS2 / A0QYB3 Xylitol-binding protein from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see paper)
    23% identity, 72% coverage of query (43.9 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory