Searching for up to 100 curated homologs for SMc02546 FitnessBrowser__Smeli:SMc02546 (538 a.a.)
Found high-coverage hits (≥70%) to 26 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
cimA / Q74C76 (R)-citramalate synthase (EC 2.3.3.21) from Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) (see paper)
CIMA_GEOSL / Q74C76 (R)-citramalate synthase; Citramalate synthase; EC 2.3.3.21 from Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) (see paper)
Q74C76 (R)-citramalate synthase (EC 2.3.3.21) from Geobacter sulfurreducens (see paper)
48% identity, 98% coverage of query (468 bits)
DVU1914 (R)-citramalate synthase (EC 2.3.3.21) from Desulfovibrio vulgaris Hildenborough JW710
46% identity, 98% coverage of query (425 bits)
B0K6M2 (R)-citramalate synthase (EC 2.3.3.21) from Thermoanaerobacter sp. (see paper)
44% identity, 97% coverage of query (421 bits)
CIMA_SULAC / Q4J6H1 (R)-citramalate synthase; Citramalate synthase; CMS; EC 2.3.3.21 from Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) (see paper)
43% identity, 98% coverage of query (404 bits)
LEU1_METJA / Q58595 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
Q58595 2-isopropylmalate synthase (EC 2.3.3.13) from Methanocaldococcus jannaschii (see paper)
31% identity, 98% coverage of query (209 bits)
cimA / Q58787 (R)-citratemalate synthase subunit (EC 2.3.3.21) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (see paper)
CIMA_METJA / Q58787 (R)-citramalate synthase CimA; EC 2.3.3.21 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
Q58787 (R)-citramalate synthase (EC 2.3.3.21) from Methanocaldococcus jannaschii (see 2 papers)
31% identity, 96% coverage of query (200 bits)
LEU1_SULAC / Q4JA78 2-isopropylmalate synthase; IPMS; Alpha-isopropylmalate synthase; Alpha-IPM synthase; EC 2.3.3.13 from Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) (see paper)
32% identity, 71% coverage of query (183 bits)
Build an alignment for SMc02546 and 7 homologs with ≥ 30% identity
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BT1861 2-isopropylmalate synthase (EC 2.3.3.13) from Bacteroides thetaiotaomicron VPI-5482
28% identity, 96% coverage of query (175 bits)
HOSA_SULAC / Q4J989 Homocitrate synthase; HCS; EC 2.3.3.14 from Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) (see paper)
Q4J989 homocitrate synthase (EC 2.3.3.14) from Sulfolobus acidocaldarius (see paper)
28% identity, 79% coverage of query (170 bits)
Q72JC9 2-isopropylmalate synthase (EC 2.3.3.13) from Thermus thermophilus (see 2 papers)
30% identity, 97% coverage of query (168 bits)
LEU11_LEPIN / Q8F445 2-isopropylmalate synthase 1; Alpha-IPM synthase 1; Alpha-isopropylmalate synthase 1; EC 2.3.3.13 from Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601) (see paper)
28% identity, 96% coverage of query (167 bits)
LEU1_SALTY / P15875 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 3 papers)
29% identity, 96% coverage of query (164 bits)
LeuA / b0074 2-isopropylmalate synthase (EC 2.3.3.13) from Escherichia coli K-12 substr. MG1655 (see 7 papers)
leuA / P09151 2-isopropylmalate synthase (EC 2.3.3.13) from Escherichia coli (strain K12) (see 15 papers)
28% identity, 96% coverage of query (163 bits)
LEU1_NEIMB / Q9JZG1 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Neisseria meningitidis serogroup B (strain MC58) (see 2 papers)
Q9JZG1 2-isopropylmalate synthase (EC 2.3.3.13) from Neisseria meningitidis (see 2 papers)
29% identity, 89% coverage of query (147 bits)
frbC / Q0ZQ46 2-phosphonomethylmalate synthase (EC 2.3.3.19) from Streptomyces rubellomurinus (strain ATCC 31215) (see 2 papers)
FRBC_STRR3 / Q0ZQ46 2-phosphonomethylmalate synthase; EC 2.3.3.19 from Streptomyces rubellomurinus (strain ATCC 31215) (see paper)
Q0ZQ46 2-phosphonomethylmalate synthase (EC 2.3.3.19) from Streptomyces rubellomurinus (see paper)
31% identity, 71% coverage of query (146 bits)
LEU11_ARATH / Q9LPR4 2-isopropylmalate synthase 1, chloroplastic; Methylthioalkylmalate synthase-like 4; EC 2.3.3.13 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q9LPR4 2-isopropylmalate synthase (EC 2.3.3.13) from Arabidopsis thaliana (see 3 papers)
28% identity, 91% coverage of query (144 bits)
K4C627 2-isopropylmalate synthase (EC 2.3.3.13) from Solanum lycopersicum (see paper)
27% identity, 90% coverage of query (142 bits)
LEU12_ARATH / Q9C550 2-isopropylmalate synthase 2, chloroplastic; 2-isopropylmalate synthase 1; Methylthioalkylmalate synthase-like 3; EC 2.3.3.13 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
Q9C550 2-isopropylmalate synthase (EC 2.3.3.13) from Arabidopsis thaliana (see 2 papers)
28% identity, 90% coverage of query (142 bits)
Q30DX9 2-isopropylmalate synthase (EC 2.3.3.13) from Brassica insularis (see paper)
28% identity, 90% coverage of query (140 bits)
Q2RAP8 2-isopropylmalate synthase (EC 2.3.3.13) from Oryza sativa Japonica Group (see paper)
27% identity, 83% coverage of query (137 bits)
B0SN40 2-isopropylmalate synthase (EC 2.3.3.13) from Leptospira biflexa (see paper)
29% identity, 73% coverage of query (135 bits)
cimA / Q8F3Q1 (R)-citramalate synthase subunit (EC 2.3.3.21) from Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601) (see paper)
CIMA_LEPIN / Q8F3Q1 (R)-citramalate synthase CimA; LiCMS; EC 2.3.3.21 from Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601) (see 3 papers)
26% identity, 91% coverage of query (130 bits)
D0VY45 homocitrate synthase (EC 2.3.3.14) from Lotus japonicus (see paper)
27% identity, 83% coverage of query (129 bits)
BT1858 (R)-citramalate synthase (EC 2.3.1.182) from Bacteroides thetaiotaomicron VPI-5482
27% identity, 90% coverage of query (118 bits)
CIRSY_SYNAS / Q2LTE1 Citrate (Re)-synthase; Re-citrate synthase; EC 2.3.3.3 from Syntrophus aciditrophicus (strain SB) (see paper)
26% identity, 83% coverage of query (99.8 bits)
CIRSY_CLOK5 / A5N6T4 Citrate (Re)-synthase; Re-citrate synthase; EC 2.3.3.3 from Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680) (see paper)
25% identity, 73% coverage of query (87.8 bits)
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Lawrence Berkeley National Laboratory