Searching for up to 100 curated homologs for SMc02739 FitnessBrowser__Smeli:SMc02739 (349 a.a.)
Found high-coverage hits (≥70%) to 52 curated proteins.
Removed hits that are identical to the query, leaving 51
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
TC 3.A.1.12.13 / A9CI32 ABC transporter, nucleotide binding/ATPase protein (Proline/glycine betaine), component of High affinity (2mμM) choline uptake porter. The choline binding receptor exhibits a venus fly trap mechanism of substrate binding. (ChoX binds acetyl choline and betaine with low affinity (80μM and 470μM, respectively) (Aktas et al., 2011) (most similar to 3.A.1.12.7) from Agrobacterium tumefaciens (strain C58 / ATCC 33970) (see 2 papers)
76% identity, 100% coverage of query (553 bits)
AO353_07790 ABC transporter for Carnitine, ATPase component from Pseudomonas fluorescens FW300-N2E3
57% identity, 81% coverage of query (332 bits)
AO356_13805 ABC transporter for Carnitine, ATPase component from Pseudomonas fluorescens FW300-N2C3
56% identity, 81% coverage of query (327 bits)
Pf6N2E2_4681 ABC transporter for Carnitine, ATPase component from Pseudomonas fluorescens FW300-N2E2
56% identity, 81% coverage of query (327 bits)
TC 3.A.1.12.12 / Q9HTI8 Probable ATP-binding component of ABC transporter, component of The CbcWV/CbcX (choline)/CaiX (carnitine)/BetX (betaine) transporter with 3 binding receptors for distinct quaternary ammonium compounds. Only the ligand-bound receptor binds to the transporter with high affinity from Pseudomonas aeruginosa (see paper)
57% identity, 81% coverage of query (327 bits)
A0A077T7Z1 ABC-type quaternary amine transporter (subunit 1/3) (EC 7.6.2.9) from Vibrio anguillarum serotype O1 (see paper)
51% identity, 81% coverage of query (280 bits)
ProU / b2677 glycine betaine ABC transporter ATP binding subunit ProV (EC 7.6.2.9) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
proV / P14175 glycine betaine ABC transporter ATP binding subunit ProV (EC 7.6.2.9) from Escherichia coli (strain K12) (see 6 papers)
PROV_ECOLI / P14175 Glycine betaine/proline betaine transport system ATP-binding protein ProV from Escherichia coli (strain K12) (see 4 papers)
TC 3.A.1.12.1 / P14175 ProV aka B2677, component of Glycine betaine/proline porter, ProU or ProVWX (also transports proline betaine, carnitine, dimethyl proline, homobetaine, γ-butyrobetaine and choline with low affinity) from Escherichia coli (see 6 papers)
proV / GB|AAC75724.1 glycine betaine/l-proline transport atp-binding protein prov from Escherichia coli K12 (see 6 papers)
50% identity, 81% coverage of query (276 bits)
PROV_SALTY / P17328 Glycine betaine/proline betaine transport system ATP-binding protein ProV from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
51% identity, 79% coverage of query (276 bits)
OUSV_DICD3 / E0SCY1 Glycine betaine/choline transport system ATP-binding protein OusV from Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937)) (see paper)
52% identity, 78% coverage of query (273 bits)
TC 3.A.1.12.9 / Q8U4S5 OtaA, component of The salt-induced glycine betaine OtaABC transporter from Methanosarcina mazei (see 2 papers)
50% identity, 80% coverage of query (273 bits)
TC 3.A.1.12.5 / Q9RQ06 BusAA, component of Uptake system for glycine-betaine (high affinity) and proline (low affinity) (OpuAA-OpuABC) or BusAA-ABC of Lactococcus lactis). BusAA, the ATPase subunit, has a C-terminal tandem cystathionine β-synthase (CBS) domain which is the cytoplasmic K+ sensor for osmotic stress (osmotic strength)while the BusABC subunit has the membrane and receptor domains fused to each other (Biemans-Oldehinkel et al., 2006; Mahmood et al., 2006; Gul et al. 2012). An N-terminal amphipathic α-helix of OpuA is necessary for high activity but is not critical for biogenesis or the ionic regulation of transport from Lactococcus lactis (see paper)
51% identity, 78% coverage of query (269 bits)
7aheC / Q9KIF7 Opua inhibited inward facing (see paper)
51% identity, 78% coverage of query (263 bits)
OPUAA_BACSU / P46920 Glycine betaine transport ATP-binding protein OpuAA; Quaternary-amine-transporting ATPase; EC 7.6.2.9 from Bacillus subtilis (strain 168) (see 2 papers)
P46920 ABC-type quaternary amine transporter (EC 7.6.2.9) from Bacillus subtilis (see paper)
TC 3.A.1.12.2 / P46920 OPAA aka OpuAA, component of Glycine betaine OpuAA/AB/AC porter (also transports dimethylsulfonioacetate and dimethylsulfoniopropionate) from Bacillus subtilis (see 4 papers)
49% identity, 80% coverage of query (263 bits)
7ahhC Opua inhibited inward-facing, sbd docked
51% identity, 78% coverage of query (263 bits)
GBUA_LISM4 / Q9RR46 Glycine betaine/carnitine transport ATP-binding protein GbuA; EC 7.6.2.9 from Listeria monocytogenes serotype 1/2a (strain 10403S) (see 4 papers)
49% identity, 78% coverage of query (262 bits)
AO356_09610 ABC transporter for L-Histidine, ATPase component from Pseudomonas fluorescens FW300-N2C3
50% identity, 77% coverage of query (258 bits)
7ahdC Opua (e190q) occluded
53% identity, 72% coverage of query (256 bits)
TC 3.A.1.12.6 / Q9KKE1 HutV aka HISV aka R02702 aka SMC00670, component of Uptake system for hisitidine, proline, proline-betaine and glycine-betaine from Rhizobium meliloti (Sinorhizobium meliloti) (see 2 papers)
49% identity, 79% coverage of query (243 bits)
TMOW_RUEPO / Q5LT65 Trimethylamine N-oxide transport system ATP-binding protein TmoW; TMAO transport system ATP-binding protein TmoW; EC 7.6.2.9 from Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi) (see paper)
42% identity, 98% coverage of query (237 bits)
TMOW_PELUB / Q4FL37 Trimethylamine N-oxide transport system ATP-binding protein TmoW; TMAO transport system ATP-binding protein TmoW; EC 7.6.2.9 from Pelagibacter ubique (strain HTCC1062) (see paper)
37% identity, 100% coverage of query (218 bits)
TC 3.A.1.12.8 / Q93A35 BilEA aka OpuBA protein, component of A proline/glycine betaine uptake system. Also reported to be a bile exclusion system that exports oxgall and other bile compounds, BilEA/EB or OpuBA/BB (required for normal virulence) from Listeria monocytogenes (see 2 papers)
36% identity, 87% coverage of query (197 bits)
TC 3.A.1.12.11 / Q8Q041 Glycine betaine transporter, ATP-binding protein, component of The glycine betaine uptake porter, GbpABCD from Methanosarcina mazei (see paper)
38% identity, 90% coverage of query (194 bits)
OSMV_SALTY / Q8ZPK4 Osmoprotectant import ATP-binding protein OsmV; EC 7.6.2.- from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
TC 3.A.1.12.14 / Q8ZPK4 ABC-type proline/glycine betaine transport system, component of OsmU (OsmVWXY) transporter for glycine betaine and choline-O-sulfate uptake. Induced by osmotic stress (0.3M NaCl) (Frossard et al., 2012). Also called OpuCA/CB1/CB2/CC from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
38% identity, 81% coverage of query (186 bits)
TC 3.A.1.10.4 / Q82VN5 Putative iron transport system ATP-binding protein, component of The Fe-hydroxamate-type siderophore uptake porter (transports Fe+3 bound to ferrioxamine, ferrichrome or pyoverdine siderophores) from Nitrosomonas europaea (see paper)
39% identity, 75% coverage of query (177 bits)
OPUCA_LISM4 / G2JZ44 Carnitine transport ATP-binding protein OpuCA; EC 7.6.2.9 from Listeria monocytogenes serotype 1/2a (strain 10403S) (see 4 papers)
OPUCA_LISMN / Q9KHT9 Carnitine transport ATP-binding protein OpuCA; EC 7.6.2.9 from Listeria monocytogenes (see paper)
36% identity, 85% coverage of query (171 bits)
1g291 / Q9YGA6 Malk (see paper)
39% identity, 72% coverage of query (167 bits)
3fvqB / Q5FA19 Crystal structure of the nucleotide binding domain fbpc complexed with atp (see paper)
35% identity, 74% coverage of query (130 bits)
3c4jA Abc protein artp in complex with atp-gamma-s
35% identity, 71% coverage of query (124 bits)
3c41J / D0VWX4 Abc protein artp in complex with amp-pnp/mg2+
35% identity, 71% coverage of query (124 bits)
2olkA Abc protein artp in complex with adp-beta-s
35% identity, 71% coverage of query (124 bits)
2oljA Abc protein artp in complex with adp/mg2+
35% identity, 71% coverage of query (124 bits)
Build an alignment for SMc02739 and 31 homologs with ≥ 30% identity
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7e7qA / P78363 Cryo-em structure of human abca4 in atp-bound state (see paper)
29% identity, 76% coverage of query (104 bits)
ABCA3_MOUSE / Q8R420 Phospholipid-transporting ATPase ABCA3; ATP-binding cassette sub-family A member 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Mus musculus (Mouse) (see 7 papers)
27% identity, 84% coverage of query (100 bits)
ABCA3_HUMAN / Q99758 Phospholipid-transporting ATPase ABCA3; ABC-C transporter; ATP-binding cassette sub-family A member 3; ATP-binding cassette transporter 3; ATP-binding cassette 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Homo sapiens (Human) (see 18 papers)
TC 3.A.1.211.5 / Q99758 The surfactant-secreting porter, ABCA3 (exports lipids and proteins into lamellar bodies). Fatal surfactant deficiency (FSD) can result from mutations in ABCA3, causing abnormal intracellular localization (type I) or decreased ATP hydrolysis (type II). Other mutations cause pediatric interstitial lung disease (pILD) from Homo sapiens (Human) (see 7 papers)
ABCA3 / RF|NP_001080.2 ATP-binding cassette sub-family A member 3 from Homo sapiens (see paper)
29% identity, 82% coverage of query (100 bits)
ABCA4_BOVIN / F1MWM0 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM protein; RmP; Retinal-specific ATP-binding cassette transporter; EC 7.6.2.1 from Bos taurus (Bovine) (see 11 papers)
30% identity, 74% coverage of query (98.6 bits)
7w02A / Q99758 Cryo-em structure of atp-bound abca3 (see paper)
28% identity, 82% coverage of query (98.2 bits)
8bmpB / Q1GBI9 Cryo-em structure of the folate-specific ecf transporter complex in msp2n2 lipid nanodiscs bound to atp and adp (see paper)
29% identity, 73% coverage of query (92.0 bits)
5d3mB Folate ecf transporter: amppnp bound state
29% identity, 73% coverage of query (92.0 bits)
8bmsB Cryo-em structure of the mutant solitary ecf module 2eq in msp2n2 lipid nanodiscs in the atpase closed and atp-bound conformation
29% identity, 73% coverage of query (90.5 bits)
ABCAC_MOUSE / E9Q876 Glucosylceramide transporter ABCA12; ATP-binding cassette sub-family A member 12; EC 7.6.2.1 from Mus musculus (Mouse) (see 9 papers)
26% identity, 70% coverage of query (85.1 bits)
ABC1_MYCTU / O65934 ABC transporter ATP-binding/permease protein Rv1747; EC 7.-.-.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 4 papers)
28% identity, 73% coverage of query (78.6 bits)
ABCA2_HUMAN / Q9BZC7 ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2; ATP-binding cassette 2; EC 7.6.2.- from Homo sapiens (Human) (see 10 papers)
25% identity, 85% coverage of query (77.4 bits)
4f4cA / P34712 The crystal structure of the multi-drug transporter (see paper)
27% identity, 73% coverage of query (75.5 bits)
7y1jA / Q63563 Structure of sur2a in complex with mg-atp and repaglinide in the inward-facing conformation. (see paper)
28% identity, 72% coverage of query (75.1 bits)
7vlsA Structure of sur2b in complex with mgatp/adp and p1075
26% identity, 72% coverage of query (74.3 bits)
7vltA Structure of sur2b in complex with mg-atp/adp and levcromakalim
26% identity, 72% coverage of query (73.9 bits)
7vlrA Structure of sur2b in complex with mg-atp/adp
26% identity, 72% coverage of query (73.9 bits)
7y1lA Structure of sur2b in complex with mg-atp and repaglinide in the inward-facing conformation
27% identity, 72% coverage of query (73.6 bits)
IRTA_MYCS2 / A0R6H8 Mycobactin import ATP-binding/permease protein IrtA; EC 7.2.2.- from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see paper)
27% identity, 73% coverage of query (66.6 bits)
MRP1_RAT / Q8CG09 Multidrug resistance-associated protein 1; ATP-binding cassette sub-family C member 1; Glutathione-S-conjugate-translocating ATPase ABCC1; Leukotriene C(4) transporter; LTC4 transporter; EC 7.6.2.2; EC 7.6.2.3 from Rattus norvegicus (Rat) (see 3 papers)
27% identity, 78% coverage of query (66.6 bits)
MRP2_HUMAN / Q92887 ATP-binding cassette sub-family C member 2; Canalicular multidrug resistance protein; Canalicular multispecific organic anion transporter 1; Multidrug resistance-associated protein 2; EC 7.6.2.-; EC 7.6.2.2; EC 7.6.2.3 from Homo sapiens (Human) (see 14 papers)
Q92887 ABC-type xenobiotic transporter (EC 7.6.2.2); ABC-type glutathione-S-conjugate transporter (EC 7.6.2.3) from Homo sapiens (see 12 papers)
26% identity, 75% coverage of query (65.5 bits)
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Lawrence Berkeley National Laboratory