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Searching for up to 100 curated homologs for SMc03206 FitnessBrowser__Smeli:SMc03206 (217 a.a.)

Found high-coverage hits (≥70%) to 80 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Psest_3511 Maleylacetoacetate isomerase (EC 5.2.1.2) from Pseudomonas stutzeri RCH2
    47% identity, 96% coverage of query (174 bits)

Ac3H11_2306 Maleylacetoacetate isomerase (EC 5.2.1.2) from Acidovorax sp. GW101-3H11
    45% identity, 94% coverage of query (171 bits)

SO1671 Maleylacetoacetate isomerase (EC 5.2.1.2) from Shewanella oneidensis MR-1
    45% identity, 94% coverage of query (169 bits)

1fw1A / O43708 Glutathione transferase zeta/maleylacetoacetate isomerase (see paper)
    46% identity, 94% coverage of query (166 bits)

GSTZ1 / O43708 maleylacetoacetate isomerase/glutathione transferase ζ monomer (EC 2.5.1.18; EC 5.2.1.2) from Homo sapiens (see 11 papers)
MAAI_HUMAN / O43708 Maleylacetoacetate isomerase; MAAI; GSTZ1-1; Glutathione S-transferase zeta 1; EC 5.2.1.2; EC 2.5.1.18 from Homo sapiens (Human) (see 3 papers)
O43708 glutathione transferase (EC 2.5.1.18); maleylacetoacetate isomerase (EC 5.2.1.2) from Homo sapiens (see 8 papers)
    45% identity, 96% coverage of query (164 bits)

Q9WVL0 Maleylacetoacetate isomerase; MAAI; GSTZ1-1; Glutathione S-transferase zeta 1; EC 5.2.1.2; EC 2.5.1.18 from Mus musculus (Mouse)
    43% identity, 96% coverage of query (163 bits)

2cz2A / Q9WVL0 Crystal structure of glutathione transferase zeta 1-1 (maleylacetoacetate isomerase) from mus musculus (form-1 crystal)
    43% identity, 94% coverage of query (162 bits)

2v6kA / O86043 Structure of maleyl pyruvate isomerase, a bacterial glutathione-s- transferase in zeta class, in complex with substrate analogue dicarboxyethyl glutathione (see paper)
    46% identity, 93% coverage of query (159 bits)

nagL / O86043 glutathion-dependent maleylpyruvate isomerase (EC 5.2.1.4) from Ralstonia sp. (see paper)
NAGL_RALSP / O86043 Maleylpyruvate isomerase; MPI; Naphthalene degradation protein L; EC 5.2.1.4 from Ralstonia sp. (see 2 papers)
    46% identity, 93% coverage of query (159 bits)

2jl4A Holo structure of maleyl pyruvate isomerase, a bacterial glutathione- s-transferase in zeta class
    46% identity, 93% coverage of query (159 bits)

MAAI_RAT / P57113 Maleylacetoacetate isomerase; MAAI; GSTZ1-1; Glutathione S-transferase zeta 1; EC 5.2.1.2; EC 2.5.1.18 from Rattus norvegicus (Rat) (see paper)
    44% identity, 96% coverage of query (158 bits)

MAAI2_DROME / Q9VHD2 Probable maleylacetoacetate isomerase 2; MAAI 2; Glutathione S-transferase zeta 2; EC 5.2.1.2; EC 2.5.1.18 from Drosophila melanogaster (Fruit fly) (see paper)
    42% identity, 95% coverage of query (153 bits)

MAAI1_DROME / Q9VHD3 Probable maleylacetoacetate isomerase 1; MAAI 1; Glutathione S-transferase zeta 1; EC 5.2.1.2; EC 2.5.1.18 from Drosophila melanogaster (Fruit fly) (see paper)
    38% identity, 96% coverage of query (147 bits)

Pf6N2E2_5292 Maleylacetoacetate isomerase (EC 5.2.1.2) from Pseudomonas fluorescens FW300-N2E2
    43% identity, 93% coverage of query (144 bits)

4kdyA / B8J605 Crystal structure of maleylacetoacetate isomerase from anaeromyxobacter dehalogenans 2cp-1, target efi-507175, with bound gsh in the active site
    45% identity, 94% coverage of query (142 bits)

4kaeA Crystal structure of maleylacetoacetate isomerase from anaeromyxobacter dehalogenans 2cp-1, target efi-507175, with bound dicarboxyethyl glutathione and citrate in the active site
    45% identity, 94% coverage of query (141 bits)

Q5K5T6 glutathione transferase subunit (EC 2.5.1.18) from Escherichia coli (see 8 papers)
    39% identity, 95% coverage of query (140 bits)

4pxoA / C5ATQ9 Crystal structure of maleylacetoacetate isomerase from methylobacteriu extorquens am1 with bound malonate and gsh (target efi-507068)
    44% identity, 94% coverage of query (139 bits)

AO356_16835 Maleylacetoacetate isomerase (EC 5.2.1.2) from Pseudomonas fluorescens FW300-N2C3
    42% identity, 94% coverage of query (139 bits)

MAIA_ASPFU / Q4WHT7 Maleylacetoacetate isomerase maiA; EC 5.2.1.2 from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata) (see 3 papers)
    38% identity, 97% coverage of query (129 bits)

AO353_15560 Maleylacetoacetate isomerase (EC 5.2.1.2) from Pseudomonas fluorescens FW300-N2E3
    38% identity, 93% coverage of query (128 bits)

3n5oA / D2YW48 Crystal structure of putative glutathione transferase from coccidioides immitis bound to glutathione (see paper)
    36% identity, 93% coverage of query (114 bits)

maiA / O43123 maleylacetoacetate isomerase (EC 5.2.1.2) from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (see paper)
MAAI_EMENI / O43123 Maleylacetoacetate isomerase; MAAI; EC 5.2.1.2 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see paper)
O43123 maleylacetoacetate isomerase (EC 5.2.1.2) from Aspergillus nidulans (see paper)
GI|2832725 maleylacetoacetate isomerase; EC 5.2.1.2 from Emericella nidulans (see paper)
maiA / CAA05041.1 maleylacetoacetate isomerase from Aspergillus nidulans (see paper)
maiA / CAA05044.1 maleylacetoacetate isomerase from Aspergillus nidulans (see paper)
    36% identity, 97% coverage of query (114 bits)

D2YW48 Probable glutathione S-transferase; EC 2.5.1.18 from Coccidioides immitis (strain RS) (Valley fever fungus)
    36% identity, 93% coverage of query (114 bits)

GSTZ1_ARATH / Q9ZVQ3 Glutathione S-transferase Z1; AtGSTZ1; GST class-zeta member 1; Glutathione S-transferase 18; Maleylacetone isomerase; MAI; EC 2.5.1.18; EC 5.2.1.- from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    35% identity, 94% coverage of query (97.1 bits)

O04437 glutathione transferase (EC 2.5.1.18) from Triticum aestivum (see paper)
    32% identity, 94% coverage of query (87.4 bits)

Q9FQE8 glutathione transferase (EC 2.5.1.18) from Glycine max (see paper)
    30% identity, 98% coverage of query (75.1 bits)

4chsA Crystal structure of a tau class glutathione transferase 10 from glycine max
    30% identity, 97% coverage of query (74.7 bits)

Build an alignment

Build an alignment for SMc03206 and 28 homologs with ≥ 30% identity

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Change minimum %identity:

Additional hits (identity < 30%)

3m3mA / Q4K8I0 Crystal structure of glutathione s-transferase from pseudomonas fluorescens [pf-5]
    28% identity, 88% coverage of query (71.6 bits)

O49235 glutathione transferase (EC 2.5.1.18) from Glycine max (see paper)
    28% identity, 98% coverage of query (70.9 bits)

5agyA / I1MJ34 Crystal structure of a tau class gst mutant from glycine (see paper)
    29% identity, 98% coverage of query (70.9 bits)

4topA Glycine max glutathione transferase
    28% identity, 97% coverage of query (70.5 bits)

Q9FUT0 glutathione transferase (EC 2.5.1.18) from Arabidopsis thaliana (see paper)
    28% identity, 89% coverage of query (60.1 bits)

D2WL48 glutathione transferase (EC 2.5.1.18) from Populus trichocarpa (see paper)
    26% identity, 98% coverage of query (58.5 bits)

5j4uA / B9I0G5 Crystal structure of a glutathione s-transferase ptgstu30 from populus trichocarpa in complex with gsh
    27% identity, 97% coverage of query (57.8 bits)

GSTF3_MAIZE / P04907 Glutathione S-transferase 3; GST class-phi member 3; GST-III; EC 2.5.1.18 from Zea mays (Maize) (see 2 papers)
    32% identity, 79% coverage of query (57.0 bits)

5f06A / U5GTL0 Crystal structure of glutathione transferase f7 from populus trichocarpa (see paper)
    27% identity, 78% coverage of query (57.0 bits)

3zmkB / G0XSZ1 Anopheles funestus glutathione-s-transferase epsilon 2 (gste2) protein structure from different alelles: a single amino acid change confers high level of ddt resistance and cross resistance to permethrin in a major malaria vector in africa (see paper)
    28% identity, 78% coverage of query (57.0 bits)

4ielB / Q0B681 Crystal structure of a glutathione s-transferase family protein from burkholderia ambifaria, target efi-507141, with bound glutathione
    32% identity, 76% coverage of query (57.0 bits)

2gdrA / Q59721 Crystal structure of a bacterial glutathione transferase (see paper)
    28% identity, 86% coverage of query (56.6 bits)

Q59721 4-chlorobenzoate dehalogenase (EC 3.8.1.6) from Burkholderia sp. (see paper)
bphK / CAA54033.1 glutathione S-transferase from Paraburkholderia xenovorans LB400 (see paper)
    28% identity, 86% coverage of query (56.6 bits)

GSTFA_ARATH / P42761 Glutathione S-transferase F10; AtGSTF10; AtGSTF4; GST class-phi member 10; Protein EARLY RESPONSE TO DEHYDRATION 13; EC 2.5.1.18 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
    30% identity, 73% coverage of query (56.6 bits)

2dsaA Ternary complex of bphk, a bacterial gst
    28% identity, 86% coverage of query (56.6 bits)

Q9SHH7 glutathione transferase (EC 2.5.1.18) from Arabidopsis thaliana (see paper)
    26% identity, 98% coverage of query (56.2 bits)

5g5aA / Q9SHH7 Glutathione transferase u25 from arabidopsis thaliana in complex with glutathione disulfide
    26% identity, 97% coverage of query (56.2 bits)

A1YW90 glutathione transferase (EC 2.5.1.18) from Vitis vinifera (see paper)
    29% identity, 98% coverage of query (55.8 bits)

6ezyB / O80852 Arabidopsis thaliana gstf9, gsh and gsoh bound (see paper)
    30% identity, 71% coverage of query (55.8 bits)

GSTF9_ARATH / O80852 Glutathione S-transferase F9; AtGSTF9; AtGSTF7; GST class-phi member 9; EC 2.5.1.18 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
    30% identity, 71% coverage of query (55.8 bits)

6f01B Arabidopsis thaliana gstf9, gso3 and gsoh bound
    30% identity, 71% coverage of query (55.8 bits)

A0A4Y5QZX3 glutathione transferase (EC 2.5.1.18) from Salix babylonica (see paper)
    28% identity, 97% coverage of query (55.5 bits)

GSTF1_ARATH / P42769 Glutathione S-transferase PM239X14; GST class-phi; EC 2.5.1.18 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    30% identity, 76% coverage of query (55.1 bits)

gst3b / CAB38119.1 Glutathione transferase III(b) from Zea mays (see paper)
    32% identity, 74% coverage of query (55.1 bits)

3pr8A / Q88RE7 Structure of glutathione s-transferase(pp0183) from pseudomonas putida in complex with gsh
    26% identity, 90% coverage of query (54.3 bits)

4nhwD Crystal structure of glutathione transferase smc00097 from sinorhizobium meliloti, target efi-507275, with one glutathione bound per one protein subunit
    31% identity, 95% coverage of query (54.3 bits)

4hz2B / A7ILT8 Crystal structure of glutathione s-transferase xaut_3756 (target efi- 507152) from xanthobacter autotrophicus py2
    29% identity, 87% coverage of query (54.3 bits)

GSTUG_ARATH / Q9XIF8 Glutathione S-transferase U16; AtGSTU16; GST class-tau member 16; EC 2.5.1.18 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    28% identity, 79% coverage of query (54.3 bits)

A0A4Y5QZX0 glutathione transferase (EC 2.5.1.18) from Salix babylonica (see paper)
    26% identity, 98% coverage of query (53.5 bits)

1f2eA / O33705 Structure of sphingomonad, glutathione s-transferase complexed with glutathione
GST / AAC46031.1 glutathione S-transferase from Sphingomonas paucimobilis (see paper)
    32% identity, 82% coverage of query (53.1 bits)

2on5A / D3U1A6 Structure of nagst-2 (see paper)
    30% identity, 70% coverage of query (53.1 bits)

GSTE_PSEP1 / P82998 Glutathione S-transferase; EC 2.5.1.18 from Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1) (see paper)
    26% identity, 90% coverage of query (53.1 bits)

gst3a / CAB38118.1 Glutathione transferase III(a) from Zea mays (see paper)
    32% identity, 74% coverage of query (52.8 bits)

A0A4Y5QZW9 glutathione transferase (EC 2.5.1.18) from Salix babylonica (see paper)
    29% identity, 98% coverage of query (52.8 bits)

GSTF8 / Q96266 glutathione S-transferase F8 monomer (EC 2.5.1.18) from Arabidopsis thaliana (see 6 papers)
GSTF8_ARATH / Q96266 Glutathione S-transferase F8, chloroplastic; AtGSTF8; AtGSTF5; GST class-phi member 8; Glutathione S-transferase 6; EC 2.5.1.18 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
    31% identity, 75% coverage of query (52.8 bits)

4gsnB / Q9GPL8 Crystal structure of gste2 zan/u variant from anopheles gambiae (see paper)
    27% identity, 78% coverage of query (51.2 bits)

2imkA Structures of an insect epsilon-class glutathione s-transferase from the malaria vector anopheles gambiae: evidence for high ddt- detoxifying activity
    26% identity, 78% coverage of query (50.1 bits)

7dw4A / A0A4Y5R032 Crystal structure of a glutathione s-transferase mutant sbgstu6(i55t) from salix babylonica in complex with glutathione
    30% identity, 74% coverage of query (48.9 bits)

7rkaA / A0A1P8PEY0 Crystal structure analysis of colorado potato beetle glutathione-s transferase ldgstu1 (see paper)
    27% identity, 95% coverage of query (48.9 bits)

4hojA / O33374 Crystal structure of glutathione transferase homolog from neisseria gonorrhoeae, target efi-501841, with bound glutathione
    29% identity, 93% coverage of query (48.5 bits)

6tk8AAA f122t variant from alopecurus myosuroides
    27% identity, 73% coverage of query (48.1 bits)

3uarA / Q60CN1 Crystal structure of glutathione transferase (target efi-501774) from methylococcus capsulatus str. Bath with gsh bound
    27% identity, 91% coverage of query (48.1 bits)

7oboAAA Glutathione transferase
    27% identity, 73% coverage of query (48.1 bits)

6rivA Crystal structure of alopecurus myosuroides gstf
    27% identity, 73% coverage of query (48.1 bits)

4kdxA / B1FZ96 Crystal structure of a glutathione transferase family member from burkholderia graminis, target efi-507264, bound gsh, ordered domains, space group p21, form(1)
    29% identity, 76% coverage of query (47.0 bits)

5ft3B / Q5PY77 Aedes aegypti gste2
    27% identity, 71% coverage of query (46.2 bits)

6ep7B / Q9M9F1 Arabidopsis thaliana gstu23, gsh bound (see paper)
    25% identity, 96% coverage of query (46.2 bits)

6zb6D Crystal structure of lolium rigidum gstf in complex with s-(p- nitrobenzyl) glutathione
    28% identity, 75% coverage of query (45.4 bits)

6zb6C / M5BPX4 Crystal structure of lolium rigidum gstf in complex with s-(p- nitrobenzyl) glutathione (see paper)
    28% identity, 75% coverage of query (45.4 bits)

3ibhA Crystal structure of saccharomyces cerevisiae gtt2 in complex with glutathione
    26% identity, 76% coverage of query (44.7 bits)

3ergA / Q12390 Crystal structure of gtt2 from saccharomyces cerevisiae in complex with glutathione sulfnate (see paper)
    26% identity, 76% coverage of query (44.7 bits)

3lszA / Q3IZT6 Crystal structure of glutathione s-transferase from rhodobacter sphaeroides
    28% identity, 91% coverage of query (42.7 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory