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Searching for up to 100 curated homologs for SMc04013 FitnessBrowser__Smeli:SMc04013 (385 a.a.)

Found high-coverage hits (≥70%) to 31 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

para-aminobenzoate synthase component I / b1812 aminodeoxychorismate synthase subunit 1 (EC 2.6.1.85) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
pabB / P05041 aminodeoxychorismate synthase subunit 1 (EC 2.6.1.85) from Escherichia coli (strain K12) (see 17 papers)
PABB_ECOLI / P05041 Aminodeoxychorismate synthase component 1; ADC synthase; ADCS; 4-amino-4-deoxychorismate synthase component 1; EC 2.6.1.85 from Escherichia coli (strain K12) (see 8 papers)
pabB / RF|NP_416326.1 para-aminobenzoate synthase, component 1; EC 2.6.1.85 from Escherichia coli K12 (see 8 papers)
    36% identity, 94% coverage of query (216 bits)

cmlB / F2RB79 4-amino-4-deoxychorismate synthase (EC 2.6.1.85) from Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745) (see 2 papers)
ADCS_STRVP / F2RB79 Aminodeoxychorismate synthase; ADC synthase; 4-amino-4-deoxychorismate synthase; p-aminobenzoate synthase; EC 2.6.1.85 from Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745) (see paper)
    42% identity, 78% coverage of query (212 bits)

papA / BAD21140.1 4-amino-4-deoxychorismate synthase from Streptomyces venezuelae (see paper)
    42% identity, 78% coverage of query (210 bits)

8hx9A / Q6L8Q5 Crystal structure of 4-amino-4-deoxychorismate synthase from streptomyces venezuelae with chorismate (see paper)
    41% identity, 81% coverage of query (210 bits)

1k0eA / P05041 The crystal structure of aminodeoxychorismate synthase from formate grown crystals (see paper)
    36% identity, 94% coverage of query (206 bits)

ADCS / Q8LPN3 aminodeoxychorismate synthase (EC 2.6.1.85) from Arabidopsis thaliana (see 2 papers)
ADCS_ARATH / Q8LPN3 Aminodeoxychorismate synthase, chloroplastic; ADC synthase; P-aminobenzoic acid synthase; PABA synthase; Para-aminobenzoate synthase; Protein EMBRYO DEFFECTIVE 1997; EC 2.6.1.85 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
    38% identity, 81% coverage of query (201 bits)

1k0gB / P05041 The crystal structure of aminodeoxychorismate synthase from phosphate grown crystals (see paper)
    33% identity, 94% coverage of query (176 bits)

1k0gA The crystal structure of aminodeoxychorismate synthase from phosphate grown crystals
    33% identity, 94% coverage of query (176 bits)

7pi1DDD / P28820 7pi1DDD
    33% identity, 83% coverage of query (171 bits)

trpE / Q08653 anthranilate synthase component I (EC 4.1.3.27) from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
    35% identity, 78% coverage of query (167 bits)

O94582 Probable anthranilate synthase component 1; Anthranilate synthase component I; EC 4.1.3.27 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    33% identity, 79% coverage of query (159 bits)

A0QX93 Anthranilate synthase component 1; AS; ASI; EC 4.1.3.27 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
    35% identity, 77% coverage of query (146 bits)

Build an alignment

Build an alignment for SMc04013 and 12 homologs with ≥ 30% identity

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Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

TRPE_PSEPU / P20579 Anthranilate synthase component 1; AS; ASI; EC 4.1.3.27 from Pseudomonas putida (Arthrobacter siderocapsulatus) (see paper)
    29% identity, 87% coverage of query (142 bits)

7bvdA / A0QX93 Anthranilate synthase component i (trpe)[mycolicibacterium smegmatis]
    34% identity, 77% coverage of query (137 bits)

pabaA para-aminobenzoic acid synthase from Emericella nidulans (see 2 papers)
    29% identity, 74% coverage of query (110 bits)

8qc4A Salicylate synthase
    25% identity, 79% coverage of query (70.9 bits)

3st6A Structure of a m. Tuberculosis synthase, mbti, in complex with an isochorismate analogue inhibitor
    25% identity, 79% coverage of query (70.9 bits)

MBTI_MYCTU / P9WFX1 Salicylate synthase; Chorismate mutase; CM; Isochorismate synthase/isochorismate lyase; Mycobactin synthase protein; EC 5.4.99.5; EC 4.2.99.21; EC 5.4.4.2 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 8 papers)
P9WFX1 isochorismate lyase (EC 4.2.99.21); isochorismate synthase (EC 5.4.4.2) from Mycobacterium tuberculosis (see 2 papers)
    25% identity, 79% coverage of query (70.9 bits)

6za5B M. Tuberculosis salicylate synthase mbti in complex with salicylate and mg2+
    25% identity, 79% coverage of query (70.9 bits)

3vehB / P9WFX1 Structure of a m. Tuberculosis salicylate synthase, mbti, in complex with an inhibitor methylamt (see paper)
    25% identity, 79% coverage of query (70.9 bits)

3logB Crystal structure of mbti from mycobacterium tuberculosis
    25% identity, 79% coverage of query (70.9 bits)

2g5fA The structure of mbti from mycobacterium tuberculosis, the first enzyme in the synthesis of mycobactin, reveals it to be a salicylate synthase
    25% identity, 79% coverage of query (70.9 bits)

3rv8C Structure of a m. Tuberculosis salicylate synthase, mbti, in complex with an inhibitor with cyclopropyl r-group
    25% identity, 79% coverage of query (66.2 bits)

6za4A M. Tuberculosis salicylate synthase mbti in complex with 5-(3- cyanophenyl)furan-2-carboxylate
    25% identity, 79% coverage of query (63.2 bits)

3rv7A Structure of a m. Tuberculosis salicylate synthase, mbti, in complex with an inhibitor with isopropyl r-group
    25% identity, 79% coverage of query (60.8 bits)

3rv8A Structure of a m. Tuberculosis salicylate synthase, mbti, in complex with an inhibitor with cyclopropyl r-group
    25% identity, 79% coverage of query (60.1 bits)

3rv9A Structure of a m. Tuberculosis salicylate synthase, mbti, in complex with an inhibitor with ethyl r-group
    25% identity, 79% coverage of query (59.7 bits)

3rv6A Structure of a m. Tuberculosis salicylate synthase, mbti, in complex with an inhibitor with phenyl r-group
    24% identity, 79% coverage of query (57.0 bits)

3rv6B Structure of a m. Tuberculosis salicylate synthase, mbti, in complex with an inhibitor with phenyl r-group
    24% identity, 79% coverage of query (54.7 bits)

3rv9C Structure of a m. Tuberculosis salicylate synthase, mbti, in complex with an inhibitor with ethyl r-group
    24% identity, 79% coverage of query (53.5 bits)

6za4B / P9WFX1 M. Tuberculosis salicylate synthase mbti in complex with 5-(3- cyanophenyl)furan-2-carboxylate (see paper)
    24% identity, 79% coverage of query (51.2 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory