Searching for up to 100 curated homologs for SMc04325 FitnessBrowser__Smeli:SMc04325 (337 a.a.)
Found high-coverage hits (≥70%) to 24 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
PGA1_c13370 Methionine synthase component, methyltransferase domain (EC:2.1.1.13) from Phaeobacter inhibens BS107
54% identity, 95% coverage of query (341 bits)
Q9WYA5 methionine synthase (EC 2.1.1.13) from Thermotoga maritima (see paper)
32% identity, 88% coverage of query (149 bits)
3bofA / Q9WYA5 Cobalamin-dependent methionine synthase (1-566) from thermotoga maritima complexed with zn2+ and homocysteine (see paper)
32% identity, 88% coverage of query (149 bits)
DVU1585 Methionine synthase (cobalamin-dependent) (EC 2.1.1.13) from Desulfovibrio vulgaris Hildenborough JW710
39% identity, 83% coverage of query (149 bits)
DvMF_0476 vitamin B12-dependent methionine synthase without a reactivation domain (EC 2.1.1.13) from Desulfovibrio vulgaris Miyazaki F
35% identity, 85% coverage of query (149 bits)
1q8jA Cobalamin-dependent methionine synthase (1-566) from thermotoga maritima (cd2+, hcy, methyltetrahydrofolate complex)
32% identity, 88% coverage of query (149 bits)
8g3hA / A0A0A2XCD7 Structure of cobalamin-dependent methionine synthase (meth) in a resting state (see paper)
31% identity, 92% coverage of query (136 bits)
YITJ_BACSU / O06745 Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase; EC 2.1.1.10; EC 1.5.1.20 from Bacillus subtilis (strain 168) (see paper)
31% identity, 86% coverage of query (113 bits)
Build an alignment for SMc04325 and 8 homologs with ≥ 30% identity
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METH_RAT / Q9Z2Q4 Methionine synthase; MS; 5-methyltetrahydrofolate--homocysteine methyltransferase; Cobalamin-dependent methionine synthase; Vitamin-B12 dependent methionine synthase; EC 2.1.1.13 from Rattus norvegicus (Rat) (see 2 papers)
Q9Z2Q4 methionine synthase (EC 2.1.1.13) from Rattus norvegicus (see paper)
27% identity, 85% coverage of query (110 bits)
MTR / Q99707 cobalamin-dependent methionine synthase (EC 2.1.1.13) from Homo sapiens (see 5 papers)
METH_HUMAN / Q99707 Methionine synthase; MS; 5-methyltetrahydrofolate--homocysteine methyltransferase; Cobalamin-dependent methionine synthase; Vitamin-B12 dependent methionine synthase; EC 2.1.1.13 from Homo sapiens (Human) (see 7 papers)
Q99707 methionine synthase (EC 2.1.1.13) from Homo sapiens (see paper)
28% identity, 77% coverage of query (107 bits)
metH / Q8NQD1 cobalamin-dependent methionine synthase (EC 2.1.1.13) from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see paper)
29% identity, 91% coverage of query (105 bits)
MetH / b4019 cobalamin-dependent methionine synthase (EC 2.1.1.13) from Escherichia coli K-12 substr. MG1655 (see 60 papers)
metH / P13009 cobalamin-dependent methionine synthase (EC 2.1.1.13) from Escherichia coli (strain K12) (see 58 papers)
METH_ECOLI / P13009 Methionine synthase; 5-methyltetrahydrofolate--homocysteine methyltransferase; Methionine synthase, vitamin-B12-dependent; MS; EC 2.1.1.13 from Escherichia coli (strain K12) (see 4 papers)
metH methionine synthase; EC 2.1.1.13 from Escherichia coli K12 (see 15 papers)
29% identity, 88% coverage of query (84.7 bits)
4cczA / Q99707 Crystal structure of human 5-methyltetrahydrofolate-homocysteine methyltransferase, the homocysteine and folate binding domains
24% identity, 85% coverage of query (81.3 bits)
1lt8A Reduced homo sapiens betaine-homocysteine s-methyltransferase in complex with s-(delta-carboxybutyl)-l-homocysteine
25% identity, 73% coverage of query (70.5 bits)
Bhmt / O09171 betaine-homocysteine S-methyltransferase subunit (EC 2.1.1.5) from Rattus norvegicus (see paper)
BHMT1_RAT / O09171 Betaine--homocysteine S-methyltransferase 1; EC 2.1.1.5 from Rattus norvegicus (Rat) (see 3 papers)
O09171 homocysteine S-methyltransferase (EC 2.1.1.10); betaine-homocysteine S-methyltransferase (EC 2.1.1.5) from Rattus norvegicus (see 5 papers)
25% identity, 73% coverage of query (64.3 bits)
BHMT / Q93088 betaine--homocysteine S-methyltransferase 1 (EC 2.1.1.5) from Homo sapiens (see 7 papers)
BHMT1_HUMAN / Q93088 Betaine--homocysteine S-methyltransferase 1; EC 2.1.1.5 from Homo sapiens (Human) (see 5 papers)
Q93088 betaine-homocysteine S-methyltransferase (EC 2.1.1.5) from Homo sapiens (see 8 papers)
24% identity, 73% coverage of query (62.4 bits)
1umyD / O09171 Bhmt from rat liver (see paper)
26% identity, 73% coverage of query (62.0 bits)
O35490 betaine-homocysteine S-methyltransferase (EC 2.1.1.5) from Mus musculus (see paper)
25% identity, 73% coverage of query (62.0 bits)
YagD / b0261 CP4-6 prophage; homocysteine S-methyltransferase (EC 2.1.1.10) from Escherichia coli K-12 substr. MG1655 (see 8 papers)
mmuM / Q47690 CP4-6 prophage; homocysteine S-methyltransferase (EC 2.1.1.10) from Escherichia coli (strain K12) (see 5 papers)
MMUM_ECOLI / Q47690 Homocysteine S-methyltransferase; S-methylmethionine:homocysteine methyltransferase; EC 2.1.1.10 from Escherichia coli (strain K12) (see 2 papers)
Q47690 homocysteine S-methyltransferase (EC 2.1.1.10); selenocysteine Se-methyltransferase (EC 2.1.1.280) from Escherichia coli (see 3 papers)
27% identity, 85% coverage of query (59.7 bits)
4m3pA Betaine-homocysteine s-methyltransferase from homo sapiens complexed with homocysteine
23% identity, 73% coverage of query (58.2 bits)
5dmmA / Q47690 Crystal structure of the homocysteine methyltransferase mmum from escherichia coli, metallated form (see paper)
26% identity, 85% coverage of query (57.0 bits)
BHMT2 / Q9H2M3 S-methylmethionine--homocysteine S-methyltransferase (EC 2.1.1.10) from Homo sapiens (see 4 papers)
BHMT2_HUMAN / Q9H2M3 S-methylmethionine--homocysteine S-methyltransferase BHMT2; SMM-hcy methyltransferase; Betaine--homocysteine S-methyltransferase 2; EC 2.1.1.10 from Homo sapiens (Human) (see 2 papers)
23% identity, 73% coverage of query (53.1 bits)
HMT3 / Q8LAX0 homocysteine S-methyltransferase 3 (EC 2.1.1.10) from Arabidopsis thaliana (see 2 papers)
HMT3_ARATH / Q8LAX0 Homocysteine S-methyltransferase 3; S-methylmethionine:homocysteine methyltransferase 3; AtHMT-3; SMM:Hcy S-methyltransferase 3; EC 2.1.1.10 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Q8LAX0 homocysteine S-methyltransferase (EC 2.1.1.10) from Arabidopsis thaliana (see paper)
25% identity, 89% coverage of query (52.4 bits)
SMTA / P56707 selenocysteine methyltransferase (EC 2.1.1.280) from Astragalus bisulcatus (see 3 papers)
SMTA_ASTBI / P56707 Selenocysteine methyltransferase; SECYS-MT; SECYS-methyltransferase; EC 2.1.1.280 from Astragalus bisulcatus (Two-grooved milkvetch) (Phaca bisulcata) (see 2 papers)
P56707 selenocysteine Se-methyltransferase (EC 2.1.1.280) from Astragalus bisulcatus (see 4 papers)
smtA / CAA10368.1 selenocysteine methyltransferase from Astragalus bisulcatus (see paper)
24% identity, 89% coverage of query (48.9 bits)
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