Searching for up to 100 curated homologs for SMc04342 FitnessBrowser__Smeli:SMc04342 (320 a.a.)

Found high-coverage hits (≥70%) to 25 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

PGA1_c16040 Methionine synthase component, pterin-binding domain (EC:2.1.1.13) from Phaeobacter inhibens BS107
    62% identity, 89% coverage of query (400 bits)

DVU1585 Methionine synthase (cobalamin-dependent) (EC 2.1.1.13) from Desulfovibrio vulgaris Hildenborough JW710
    37% identity, 91% coverage of query (168 bits)

DvMF_0476 vitamin B12-dependent methionine synthase without a reactivation domain (EC 2.1.1.13) from Desulfovibrio vulgaris Miyazaki F
    36% identity, 91% coverage of query (165 bits)

3bofA / Q9WYA5 Cobalamin-dependent methionine synthase (1-566) from thermotoga maritima complexed with zn2+ and homocysteine (see paper)
    39% identity, 83% coverage of query (147 bits)

Q9WYA5 methionine synthase (EC 2.1.1.13) from Thermotoga maritima (see paper)
    39% identity, 83% coverage of query (147 bits)

1q8jA Cobalamin-dependent methionine synthase (1-566) from thermotoga maritima (cd2+, hcy, methyltetrahydrofolate complex)
    39% identity, 83% coverage of query (147 bits)

4o1eA / B8FW00 Structure of a methyltransferase component in complex with mthf involved in o-demethylation (see paper)
    37% identity, 83% coverage of query (141 bits)

mtvA1 / Q2RLH0 [methyl-Co(III) methoxylated-aromatic-compound-specific corrinoid protein]--tetrahydrofolate methyltransferase monomer (EC 2.1.1.385) from Moorella thermoacetica (strain ATCC 39073 / JCM 9320) (see 2 papers)
    33% identity, 82% coverage of query (140 bits)

4o1fA Structure of a methyltransferase component in complex with thf involved in o-demethylation
    37% identity, 83% coverage of query (136 bits)

2yckX / Q3ACR9 Methyltransferase bound with tetrahydrofolate (see paper)
    33% identity, 82% coverage of query (130 bits)

2ycjA Methyltransferase bound with methyltetrahydrofolate
    33% identity, 82% coverage of query (130 bits)

2yciX Methyltransferase native
    33% identity, 82% coverage of query (130 bits)

MTQA_EUBLI / P0DX08 Methylcorrinoid:tetrahydrofolate methyltransferase; Methylcorrinoid protein:THF methyltransferase; [methyl-Co(III) quarternary-amine-specific corrinoid protein]--tetrahydrofolate methyltransferase; EC 2.1.1.- from Eubacterium limosum (see 2 papers)
    34% identity, 83% coverage of query (127 bits)

acsE / Q46389 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase subunit (EC 2.1.1.258) from Moorella thermoacetica (see 4 papers)
ACSE_MOOTH / Q46389 5-methyltetrahydrofolate:corrinoid/iron-sulfur protein co-methyltransferase; 5-methyltetrahydrofolate corrinoid/iron sulfur protein methyltransferase; MeTr; EC 2.1.1.258 from Moorella thermoacetica (Clostridium thermoaceticum) (see 3 papers)
Q46389 5-methyltetrahydrofolate:corrinoid/iron-sulfur protein Co-methyltransferase (EC 2.1.1.258) from Moorella thermoacetica (see 3 papers)
4djdA / Q46389 Crystal structure of folate-free corrinoid iron-sulfur protein (cfesp) in complex with its methyltransferase (metr) (see paper)
    31% identity, 82% coverage of query (117 bits)

4djfA Crystal structure of folate-bound corrinoid iron-sulfur protein (cfesp) in complex with its methyltransferase (metr), co-crystallized with folate and ti(iii) citrate reductant
    31% identity, 82% coverage of query (117 bits)

4djeA Crystal structure of folate-bound corrinoid iron-sulfur protein (cfesp) in complex with its methyltransferase (metr), co-crystallized with folate
    31% identity, 82% coverage of query (117 bits)

2e7fA 5-methyltetrahydrofolate corrinoid/iron sulfur protein methyltransferase complexed with methyltetrahydrofolate to 2.2 angsrom resolution
    31% identity, 82% coverage of query (117 bits)

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Build an alignment for SMc04342 and 17 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

8g3hA / A0A0A2XCD7 Structure of cobalamin-dependent methionine synthase (meth) in a resting state (see paper)
    29% identity, 94% coverage of query (106 bits)

METH_RAT / Q9Z2Q4 Methionine synthase; MS; 5-methyltetrahydrofolate--homocysteine methyltransferase; Cobalamin-dependent methionine synthase; Vitamin-B12 dependent methionine synthase; EC 2.1.1.13 from Rattus norvegicus (Rat) (see 2 papers)
Q9Z2Q4 methionine synthase (EC 2.1.1.13) from Rattus norvegicus (see paper)
    33% identity, 73% coverage of query (105 bits)

metH / Q8NQD1 cobalamin-dependent methionine synthase (EC 2.1.1.13) from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see paper)
    31% identity, 78% coverage of query (102 bits)

4cczA / Q99707 Crystal structure of human 5-methyltetrahydrofolate-homocysteine methyltransferase, the homocysteine and folate binding domains
    31% identity, 73% coverage of query (98.6 bits)

MTR / Q99707 cobalamin-dependent methionine synthase (EC 2.1.1.13) from Homo sapiens (see 5 papers)
METH_HUMAN / Q99707 Methionine synthase; MS; 5-methyltetrahydrofolate--homocysteine methyltransferase; Cobalamin-dependent methionine synthase; Vitamin-B12 dependent methionine synthase; EC 2.1.1.13 from Homo sapiens (Human) (see 7 papers)
Q99707 methionine synthase (EC 2.1.1.13) from Homo sapiens (see paper)
    31% identity, 73% coverage of query (97.1 bits)

5vooA / Q5SKM5 Methionine synthase folate-binding domain with methyltetrahydrofolate from thermus thermophilus hb8 (see paper)
    29% identity, 73% coverage of query (94.4 bits)

3k13C / Q8ABD0 Structure of the pterin-binding domain metr of 5- methyltetrahydrofolate-homocysteine methyltransferase from bacteroides thetaiotaomicron
    31% identity, 73% coverage of query (87.0 bits)

MetH / b4019 cobalamin-dependent methionine synthase (EC 2.1.1.13) from Escherichia coli K-12 substr. MG1655 (see 60 papers)
metH / P13009 cobalamin-dependent methionine synthase (EC 2.1.1.13) from Escherichia coli (strain K12) (see 58 papers)
METH_ECOLI / P13009 Methionine synthase; 5-methyltetrahydrofolate--homocysteine methyltransferase; Methionine synthase, vitamin-B12-dependent; MS; EC 2.1.1.13 from Escherichia coli (strain K12) (see 4 papers)
metH methionine synthase; EC 2.1.1.13 from Escherichia coli K12 (see 15 papers)
    30% identity, 74% coverage of query (86.7 bits)

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