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Searching for up to 100 curated homologs for Synpcc7942_0282 FitnessBrowser__SynE:Synpcc7942_0282 (427 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

I7H6W6 glycine hydroxymethyltransferase (EC 2.1.2.1) from Aphanothece halophytica (see paper)
    78% identity, 99% coverage of query (706 bits)

6ymdA / I7H6W6 Crystal structure of serine hydroxymethyltransferase from aphanothece halophytica in the covalent complex with malonate (see paper)
    79% identity, 98% coverage of query (701 bits)

6ymfA Crystal structure of serine hydroxymethyltransferase from aphanothece halophytica in the plp-serine external aldimine state
    79% identity, 98% coverage of query (701 bits)

glyA / P77962 glycine hydroxymethyltransferase (EC 2.1.2.1) from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
    78% identity, 100% coverage of query (699 bits)

GLYA_BACSU / P39148 Serine hydroxymethyltransferase; SHMT; Serine methylase; EC 2.1.2.1 from Bacillus subtilis (strain 168) (see 2 papers)
    66% identity, 95% coverage of query (555 bits)

GLYA_STAAC / Q5HE87 Serine hydroxymethyltransferase; SHMT; Serine methylase; EC 2.1.2.1 from Staphylococcus aureus (strain COL)
Q5HE87 glycine hydroxymethyltransferase (EC 2.1.2.1) from Staphylococcus aureus (see paper)
    64% identity, 96% coverage of query (545 bits)

1kkjA / Q7SIB6 Crystal structure of serine hydroxymethyltransferase from b.Stearothermophilus (see paper)
    65% identity, 94% coverage of query (528 bits)

1kl2A Crystal structure of serine hydroxymethyltransferase complexed with glycine and 5-formyl tetrahydrofolate
    65% identity, 94% coverage of query (528 bits)

1kl1A Crystal structure of serine hydroxymethyltransferase complexed with glycine
    65% identity, 94% coverage of query (528 bits)

1kkpA Crystal structure of serine hydroxymethyltransferase complexed with serine
    65% identity, 94% coverage of query (528 bits)

GLYA_HYDTT / D3DKC4 Serine hydroxymethyltransferase; SHMT; Serine methylase; L-threonine/L-allo-threonine aldolase; EC 2.1.2.1; EC 4.1.2.48 from Hydrogenobacter thermophilus (strain DSM 6534 / IAM 12695 / TK-6) (see paper)
    62% identity, 96% coverage of query (526 bits)

7x5oB / I3U4H4 Crystal structure of e. Faecium shmt in complex with me-thf and plp- gly (see paper)
    63% identity, 95% coverage of query (526 bits)

7x5nA Crystal structure of e. Faecium shmt in complex with (+)-shin-1 and plp-ser
    64% identity, 94% coverage of query (525 bits)

7v3dA Complex structure of serine hydroxymethyltransferase from enterococcus faecium and its inhibitor
    64% identity, 94% coverage of query (525 bits)

2vmyA Crystal structure of f351gbsshmt in complex with gly and fthf
    65% identity, 94% coverage of query (524 bits)

2vmxA Crystal structure of f351gbsshmt in complex with l-allo-thr
    65% identity, 94% coverage of query (524 bits)

R9YJZ9 glycine hydroxymethyltransferase (EC 2.1.2.1) from Shewanella algae (see paper)
    62% identity, 96% coverage of query (523 bits)

A8GTI9 glycine hydroxymethyltransferase (EC 2.1.2.1) from Rickettsia rickettsii (see paper)
    62% identity, 96% coverage of query (521 bits)

3pgyB / Q5HE87 Serine hydroxymethyltransferase from staphylococcus aureus, s95p mutant.
    62% identity, 96% coverage of query (520 bits)

A0A069BAT4 glycine hydroxymethyltransferase (EC 2.1.2.1) from Burkholderia pseudomallei (see paper)
    61% identity, 96% coverage of query (517 bits)

4n0wA / B4ECY9 X-ray crystal structure of a serine hydroxymethyltransferase from burkholderia cenocepacia with covalently attached pyridoxal phosphate
    62% identity, 96% coverage of query (516 bits)

B4ECY9 glycine hydroxymethyltransferase (EC 2.1.2.1) from Burkholderia cenocepacia (see paper)
    62% identity, 96% coverage of query (516 bits)

4otlA X-ray crystal structure of serine hydroxymethyl transferase from burkholderia cenocepacia bound to plp and glycine
    62% identity, 96% coverage of query (516 bits)

4ot8A X-ray crystal structure of serine hydroxymethyl transferase from burkholderia cenocepacia bound to plp and serine
    62% identity, 96% coverage of query (516 bits)

GLYA_METBF / Q46A52 Serine hydroxymethyltransferase; SHMT; Serine methylase; EC 2.1.2.1 from Methanosarcina barkeri (strain Fusaro / DSM 804) (see paper)
Q46A52 glycine hydroxymethyltransferase (EC 2.1.2.1) from Methanosarcina barkeri (see 2 papers)
    57% identity, 96% coverage of query (513 bits)

GLYA2_BURP1 / Q3JGP5 Serine hydroxymethyltransferase 2; SHMT 2; Serine methylase 2; EC 2.1.2.1 from Burkholderia pseudomallei (strain 1710b)
    62% identity, 96% coverage of query (513 bits)

GLYA_THET8 / Q5SI56 Serine hydroxymethyltransferase; SHMT; Serine methylase; EC 2.1.2.1 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
Q5SI56 glycine hydroxymethyltransferase (EC 2.1.2.1) from Thermus thermophilus (see paper)
    63% identity, 93% coverage of query (509 bits)

2dkjA / Q5SI56 Crystal structure of t.Th.Hb8 serine hydroxymethyltransferase
    63% identity, 93% coverage of query (508 bits)

8suiB Joint x-ray/neutron structure of thermus thermophilus serine hydroxymethyltransferase (tthshmt) in internal aldimine state with l- ser bound in a pre-michalis complex
    63% identity, 93% coverage of query (508 bits)

8ssyA Room-temperature x-ray structure of thermus thermophilus serine hydroxymethyltransferase (shmt) bound with d-ser in a pseudo- michaelis complex
    63% identity, 93% coverage of query (508 bits)

L7Y8B0 glycine hydroxymethyltransferase (EC 2.1.2.1) from Pseudomonas plecoglossicida (see paper)
    62% identity, 95% coverage of query (507 bits)

PfGW456L13_2685 Glycine hydroxymethyltransferase (EC 2.1.2.1) from Pseudomonas fluorescens GW456-L13
    61% identity, 95% coverage of query (504 bits)

U5TRK6 glycine hydroxymethyltransferase (EC 2.1.2.1) from Glutamicibacter nicotianae (see paper)
    59% identity, 96% coverage of query (495 bits)

GLYA_SALTY / P0A2E1 Serine hydroxymethyltransferase; SHMT; Serine methylase; EC 2.1.2.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
P0A2E1 glycine hydroxymethyltransferase (EC 2.1.2.1) from Salmonella enterica subsp. enterica serovar Typhimurium (see paper)
glyA serine hydroxymethyltransferase; EC 2.1.2.1 from Salmonella enterica subsp. enterica serovar Typhimurium (see 3 papers)
    60% identity, 96% coverage of query (491 bits)

GLYA_CAMJE / P24531 Serine hydroxymethyltransferase; SHMT; Serine methylase; EC 2.1.2.1 from Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
glyA serine hydroxymethyltransferase; EC 2.1.2.1 from Campylobacter jejuni (see 2 papers)
    58% identity, 95% coverage of query (488 bits)

A1SUU0 glycine hydroxymethyltransferase (EC 2.1.2.1) from Psychromonas ingrahamii (see 2 papers)
    59% identity, 96% coverage of query (488 bits)

GlyA / b2551 serine hydroxymethyltransferase (EC 2.1.2.1) from Escherichia coli K-12 substr. MG1655 (see 27 papers)
glyA / P0A825 serine hydroxymethyltransferase (EC 2.1.2.1) from Escherichia coli (strain K12) (see 25 papers)
GLYA_ECOLI / P0A825 Serine hydroxymethyltransferase; SHMT; Serine methylase; EC 2.1.2.1 from Escherichia coli (strain K12) (see 11 papers)
P0A825 low-specificity L-threonine aldolase (EC 4.1.2.48) from Escherichia coli (see paper)
1dfoB / P0A825 Crystal structure at 2.4 angstrom resolution of e. Coli serine hydroxymethyltransferase in complex with glycine and 5-formyl tetrahydrofolate (see paper)
glyA / RF|NP_417046 serine hydroxymethyltransferase; EC 2.1.2.1 from Escherichia coli K12 (see 12 papers)
    60% identity, 96% coverage of query (485 bits)

1eqbA X-ray crystal structure at 2.7 angstroms resolution of ternary complex between the y65f mutant of e-coli serine hydroxymethyltransferase, glycine and 5-formyl tetrahydrofolate
    60% identity, 96% coverage of query (483 bits)

4wxgA Crystal structure of l-serine hydroxymethyltransferase in complex with a mixture of l-threonine and glycine
    60% identity, 95% coverage of query (477 bits)

4wxfA Crystal structure of l-serine hydroxymethyltransferase in complex with glycine
    60% identity, 95% coverage of query (477 bits)

Q5M0B4 glycine hydroxymethyltransferase (EC 2.1.2.1) from Streptococcus thermophilus (see paper)
    60% identity, 95% coverage of query (476 bits)

6tghA / Q5M0B4 Shmt from streptococcus thermophilus tyr55thr variant in complex with d-serine both as external aldimine and as non-covalent complex
    60% identity, 95% coverage of query (473 bits)

P56089 glycine hydroxymethyltransferase (EC 2.1.2.1) from Helicobacter pylori (see paper)
    56% identity, 96% coverage of query (473 bits)

6ti4A Shmt from streptococcus thermophilus tyr55ser variant in complex with plp/d-serine/lys230 gem diamine complex
    60% identity, 95% coverage of query (473 bits)

6ti3A Apo-shmt from streptococcus thermophilus tyr55ser variant in complex with d-threonine
    60% identity, 95% coverage of query (473 bits)

6tghC Shmt from streptococcus thermophilus tyr55thr variant in complex with d-serine both as external aldimine and as non-covalent complex
    60% identity, 95% coverage of query (473 bits)

glyA / P34895 serine hydroxymethyltransferase subunit (EC 2.1.2.1) from Hyphomicrobium methylovorum (see paper)
    60% identity, 96% coverage of query (471 bits)

GLYA2_MYCTU / P9WGI7 Serine hydroxymethyltransferase 2; SHM2; SHMT 2; Serine methylase 2; EC 2.1.2.1 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
P9WGI7 glycine hydroxymethyltransferase (EC 2.1.2.1) from Mycobacterium tuberculosis (see paper)
    57% identity, 97% coverage of query (470 bits)

GLYA1_MYCTU / P9WGI9 Serine hydroxymethyltransferase 1; SHM1; SHMT 1; Serine methylase 1; EC 2.1.2.1 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
P9WGI9 glycine hydroxymethyltransferase (EC 2.1.2.1) from Mycobacterium tuberculosis (see 2 papers)
    57% identity, 96% coverage of query (451 bits)

6uldA Crystal structure of serine hydroxymethyltransferase from mycobacterium tuberculosis with bound plp forming a schiff base with substrate serine in one monomer and plp forming a schiff base with product glycine in the other monomer
    57% identity, 96% coverage of query (451 bits)

MSHMT_AMISX / B2DEU8 2-methylserine hydroxymethyltransferase; MSHMT; AHMT; Alpha-methylserine hydroxymethyltransferase; D-alanine 2-hydroxymethyltransferase; EC 2.1.2.7 from Aminobacter sp. (see paper)
B2DEU8 D-alanine 2-hydroxymethyltransferase (EC 2.1.2.7) from Aminobacter sp. AJ110403 (see paper)
    55% identity, 95% coverage of query (442 bits)

MSHMT_ENSSX / B2DEV1 2-methylserine hydroxymethyltransferase; MSHMT; Alpha-methylserine hydroxymethyltransferase; D-alanine 2-hydroxymethyltransferase; EHMT; EC 2.1.2.7 from Ensifer sp. (see paper)
B2DEV1 D-alanine 2-hydroxymethyltransferase (EC 2.1.2.7) from Ensifer sp. AJ110404 (see paper)
    53% identity, 95% coverage of query (434 bits)

MSHMT_PARSX / B2DEU7 2-methylserine hydroxymethyltransferase; MSHMT; Alpha-methylserine hydroxymethyltransferase; D-alanine 2-hydroxymethyltransferase; EC 2.1.2.7 from Paracoccus sp.
    52% identity, 95% coverage of query (430 bits)

GLYM_SCHPO / Q10104 Serine hydroxymethyltransferase, mitochondrial; SHMT; Glycine hydroxymethyltransferase; Serine methylase; EC 2.1.2.1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    49% identity, 89% coverage of query (375 bits)

SHMT / Q8W4V3 serine hydroxymethyltransferase (EC 2.1.2.1) from Chlamydomonas reinhardtii (see paper)
    51% identity, 90% coverage of query (375 bits)

GLYP3_ARATH / Q94JQ3 Serine hydroxymethyltransferase 3, chloroplastic; AtSHM3; AtSHMT3; Glycine hydroxymethyltransferase 3; Serine methylase 3; EC 2.1.2.1 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Q94JQ3 glycine hydroxymethyltransferase (EC 2.1.2.1) from Arabidopsis thaliana (see paper)
    50% identity, 89% coverage of query (374 bits)

6cczA Crystal structure of medicago truncatula serine hydroxymethyltransferase 3 (mtshmt3) soaked with selenourea
    51% identity, 89% coverage of query (370 bits)

6cd1A / G7ILW0 Crystal structure of medicago truncatula serine hydroxymethyltransferase 3 (mtshmt3), complexes with reaction intermediates (see paper)
    51% identity, 89% coverage of query (369 bits)

G7ILW0 glycine hydroxymethyltransferase (EC 2.1.2.1) from Medicago truncatula (see paper)
    51% identity, 89% coverage of query (369 bits)

Q7SXN1 glycine hydroxymethyltransferase (EC 2.1.2.1) from Danio rerio (see paper)
    49% identity, 89% coverage of query (369 bits)

6cd1E Crystal structure of medicago truncatula serine hydroxymethyltransferase 3 (mtshmt3), complexes with reaction intermediates
    51% identity, 89% coverage of query (369 bits)

SHM1 / P37292 serine hydroxymethyltransferase, mitochondrial (EC 2.1.2.1) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see paper)
GLYM_YEAST / P37292 Serine hydroxymethyltransferase, mitochondrial; SHMT; Glycine hydroxymethyltransferase; Serine methylase; EC 2.1.2.1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
    47% identity, 89% coverage of query (365 bits)

GLYM_EREGS / Q758F0 Serine hydroxymethyltransferase, mitochondrial; SHMT; Glycine hydroxymethyltransferase; Serine methylase; EC 2.1.2.1 from Eremothecium gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Ashbya gossypii) (see paper)
    47% identity, 88% coverage of query (362 bits)

6smrA / O23254 A. Thaliana serine hydroxymethyltransferase isoform 4 (atshmt4) in complex with methotrexate (see paper)
    48% identity, 89% coverage of query (361 bits)

GLYC4_ARATH / O23254 Serine hydroxymethyltransferase 4; AtSHMT4; Glycine hydroxymethyltransferase 4; Serine methylase 4; EC 2.1.2.1 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
    48% identity, 89% coverage of query (361 bits)

GLYC_SHEEP / P35623 Serine hydroxymethyltransferase, cytosolic; SHMT; Glycine hydroxymethyltransferase; Serine methylase; EC 2.1.2.1 from Ovis aries (Sheep) (see paper)
    48% identity, 89% coverage of query (360 bits)

8aqlA High-resolution crystal structure of human shmt2
    50% identity, 89% coverage of query (357 bits)

6qvlA Human shmt2 in complex with pemetrexed
    50% identity, 89% coverage of query (357 bits)

6qvgA Human shmt2 in complex with lometrexol
    50% identity, 89% coverage of query (357 bits)

8t4pA Human mitochondrial serine hydroxymethyltransferase (shmt2) in complex with plp, glycine and di-glutamate agf347 inhibitor
    50% identity, 89% coverage of query (357 bits)

SHMT2 / P34897 serine hydroxymethyltransferase (EC 2.1.2.1) from Homo sapiens (see 4 papers)
GLYM_HUMAN / P34897 Serine hydroxymethyltransferase, mitochondrial; SHMT; Glycine hydroxymethyltransferase; Serine methylase; EC 2.1.2.1 from Homo sapiens (Human) (see 9 papers)
P34897 glycine hydroxymethyltransferase (EC 2.1.2.1) from Homo sapiens (see 6 papers)
    49% identity, 90% coverage of query (356 bits)

8gksA Human mitochondrial serine hydroxymethyltransferase (shmt2) in complex with plp, glycine and agf291 inhibitor
    49% identity, 90% coverage of query (356 bits)

6m5oA Co-crystal structure of human serine hydroxymethyltransferase 2 in complex with pyridoxal 5'-phosphate (plp) and glycodeoxycholic acid
    49% identity, 90% coverage of query (356 bits)

5v7iA Crystal structure of homo sapiens serine hydroxymethyltransferase 2 (mitochondrial) (shmt2), in complex with glycine, plp and folate- competitive pyrazolopyran inhibitor: 6-amino-4-isopropyl-3-methyl-4- (3-(pyrrolidin-1-yl)-5-(trifluoromethyl)phenyl)-1,4-dihydropyrano[2, 3-c]pyrazole-5-carbonitrile
    49% identity, 90% coverage of query (356 bits)

GLYM_MOUSE / Q9CZN7 Serine hydroxymethyltransferase, mitochondrial; SHMT; Glycine hydroxymethyltransferase; Serine methylase; EC 2.1.2.1 from Mus musculus (Mouse) (see 2 papers)
    46% identity, 96% coverage of query (355 bits)

8gktA Human mitochondrial serine hydroxymethyltransferase (shmt2) in complex with plp, glycine and agf320 inhibitor
    50% identity, 90% coverage of query (355 bits)

8t4oA Human mitochondrial serine hydroxymethyltransferase (shmt2) in complex with plp, glycine and agf347 inhibitor with no glutamate
    49% identity, 90% coverage of query (355 bits)

P50432 Serine hydroxymethyltransferase; SHMT; Glycine hydroxymethyltransferase; Glycosylation-related protein 1; Maternal effect lethal protein 32; Serine methylase; EC 2.1.2.1 from Caenorhabditis elegans
    48% identity, 89% coverage of query (355 bits)

8gkwA Human mitochondrial serine hydroxymethyltransferase (shmt2) in complex with plp, glycine and agf359 inhibitor
    50% identity, 89% coverage of query (355 bits)

8dskA / A0A0R0IK90 Structure of the n358y variant of serine hydroxymethyltransferase 8 in complex with plp, glycine, and formyl tetrahydrofolate (see paper)
    47% identity, 89% coverage of query (354 bits)

8fjtA Human mitochondrial serine hydroxymethyltransferase (shmt2) in complex with plp, glycine and agf362 inhibitor
    49% identity, 90% coverage of query (354 bits)

8gkuA Human mitochondrial serine hydroxymethyltransferase (shmt2) in complex with plp, glycine and agf355 inhibitor
    49% identity, 90% coverage of query (354 bits)

GLYC_BOMMO / Q2F5L3 Serine hydroxymethyltransferase; SHMT; Glycine hydroxymethyltransferase; Serine methylase; bmSHMT; EC 2.1.2.1 from Bombyx mori (Silk moth) (see paper)
    47% identity, 90% coverage of query (353 bits)

7byiA / P34897 Structure of shmt2 in complex with cbx
    49% identity, 90% coverage of query (353 bits)

8tlcA Human mitochondrial serine hydroxymethyltransferase (shmt2) in complex with plp, glycine and tri-glutamate agf347 inhibitor
    50% identity, 89% coverage of query (353 bits)

8fjuA Human mitochondrial serine hydroxymethyltransferase (shmt2) in complex with plp, glycine and agf347 inhibitor
    49% identity, 89% coverage of query (353 bits)

A9LDD9 glycine hydroxymethyltransferase (EC 2.1.2.1) from Danio rerio (see paper)
    48% identity, 90% coverage of query (350 bits)

7e13A Caprylic acid targets a serine hydroxymethyltransferase to kill horseweed
    47% identity, 89% coverage of query (348 bits)

A0R2V7 Serine hydroxymethyltransferase; SHMT; Serine methylase; EC 2.1.2.1 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
    45% identity, 96% coverage of query (344 bits)

GLYM2_ARATH / Q94C74 Serine hydroxymethyltransferase 2, mitochondrial; AtSHMT2; Glycine hydroxymethyltransferase 2; Serine methylase 2; EC 2.1.2.1 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
    47% identity, 88% coverage of query (343 bits)

6smwC A. Thaliana serine hydroxymethyltransferase isoform 2 (atshmt2) in complex with pemetrexed
    47% identity, 88% coverage of query (343 bits)

6smwB A. Thaliana serine hydroxymethyltransferase isoform 2 (atshmt2) in complex with pemetrexed
    47% identity, 88% coverage of query (343 bits)

6smnD / Q94C74 A. Thaliana serine hydroxymethyltransferase isoform 2 (atshmt2) in complex with methotrexate (see paper)
    47% identity, 88% coverage of query (342 bits)

GLYC_CANAL / O13426 Serine hydroxymethyltransferase, cytosolic; SHMT; Glycine hydroxymethyltransferase; SHMII; Serine methylase; EC 2.1.2.1 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see paper)
SHM2 serine hydroxymethyltransferase; EC 2.1.2.1 from Candida albicans (see paper)
    45% identity, 89% coverage of query (342 bits)

GLYC_RABIT / P07511 Serine hydroxymethyltransferase, cytosolic; SHMT; Glycine hydroxymethyltransferase; Serine methylase; EC 2.1.2.1 from Oryctolagus cuniculus (Rabbit) (see 3 papers)
    49% identity, 89% coverage of query (339 bits)

1ls3A Crystal structure of the complex between rabbit cytosolic serine hydroxymethyltransferase and triglu-5-formyl-tetrahydrofolate
    49% identity, 89% coverage of query (339 bits)

5yg4A Plasmodium vivax shmt bound with plp-glycine and s-gs849
    45% identity, 89% coverage of query (338 bits)

5yg3A Plasmodium vivax shmt bound with plp-glycine and s-gs834
    45% identity, 89% coverage of query (338 bits)

5yg2A Plasmodium vivax shmt bound with plp-glycine and gs705
    45% identity, 89% coverage of query (338 bits)

5yg1A Plasmodium vivax shmt bound with plp-glycine and gs704
    45% identity, 89% coverage of query (338 bits)

Build an alignment

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory