Sites on a Tree

 

Searching for up to 100 curated homologs for Synpcc7942_0931 Synpcc7942_0931 UDP-N-acetylglucosamine acyltransferase (268 a.a.)

Found high-coverage hits (≥70%) to 50 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

4eqyG / Q2SWY6 Crystal structure of acyl-[acyl-carrier-protein]--udp-n- acetylglucosamine o-acyltransferase from burkholderia thailandensis (see paper)
    42% identity, 94% coverage of query (218 bits)

LpxA / b0181 acyl-[acyl-carrier-protein]—UDP-N-acetylglucosamine O-acyltransferase (EC 2.3.1.129) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
lpxA / P0A722 acyl-[acyl-carrier-protein]—UDP-N-acetylglucosamine O-acyltransferase (EC 2.3.1.129) from Escherichia coli (strain K12) (see 19 papers)
LPXA_ECOLI / P0A722 Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase; UDP-N-acetylglucosamine acyltransferase; EC 2.3.1.129 from Escherichia coli (strain K12) (see 3 papers)
lpxA / MB|P0A722 acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase; EC 2.3.1.129 from Escherichia coli K12 (see 6 papers)
    45% identity, 90% coverage of query (211 bits)

7okcA / C3TPH2 Crystal structure of escherichia coli lpxa in complex with compound 1 (see paper)
    45% identity, 90% coverage of query (211 bits)

6p9tA E.Coli lpxa in complex with udp-3-o-(r-3-hydroxymyristoyl)-glcnac and compound 8
    45% identity, 90% coverage of query (211 bits)

6p9sA E.Coli lpxa in complex with udp-3-o-(r-3-hydroxymyristoyl)-glcnac and compound 7
    45% identity, 90% coverage of query (211 bits)

6p9rA E.Coli lpxa in complex with udp-3-o-(r-3-hydroxymyristoyl)-glcnac and compound 6
    45% identity, 90% coverage of query (211 bits)

6p9qA E.Coli lpxa in complex with udp-3-o-(r-3-hydroxymyristoyl)-glcnac and compound 2
    45% identity, 90% coverage of query (211 bits)

6p9pA E.Coli lpxa in complex with compound 1
    45% identity, 90% coverage of query (211 bits)

2qivX Structural basis for the acyl chain selectivity and mechanism of udp- n-acetylglucosamine acyltransferase
    45% identity, 90% coverage of query (211 bits)

2qiaA Structural basis for the acyl chain selectivity and mechanism of udp- n-acetylglucosamine acyltransferase
    45% identity, 90% coverage of query (211 bits)

2jf3A Nucleotide substrate binding by udp-n-acetylglucosamine acyltransferase
    45% identity, 90% coverage of query (211 bits)

2aq9A Structure of e. Coli lpxa with a bound peptide that is competitive with acyl-acp
    45% identity, 90% coverage of query (211 bits)

Q6QHI7 acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase (EC 2.3.1.129); acyl-[acyl-carrier protein]—UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose N-acyltransferase (EC 2.3.1.305) from Acidithiobacillus ferrooxidans (see paper)
    43% identity, 97% coverage of query (204 bits)

lpxA / Q8EZA6 acyl-[acyl-carrier protein]--UDP-3-acetamido-2-amino-2,3-dideoxy-α-D-glucopyranose N-acyltransferase (EC 2.3.1.305) from Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601) (see 4 papers)
Q8EZA6 acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase (EC 2.3.1.129); acyl-[acyl-carrier protein]—UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose N-acyltransferase (EC 2.3.1.305) from Leptospira interrogans (see 2 papers)
3i3aA / Q8EZA6 Structural basis for the sugar nucleotide and acyl chain selectivity of leptospira interrogans lpxa (see paper)
    40% identity, 94% coverage of query (188 bits)

Q3BDJ0 acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase (EC 2.3.1.129) from Moraxella catarrhalis (see paper)
    43% identity, 89% coverage of query (188 bits)

3i3xA Structural basis for the sugar nucleotide and acyl chain selectivity of leptospira interrogans lpxa
    40% identity, 94% coverage of query (188 bits)

A6V1E4 acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase (EC 2.3.1.129) from Pseudomonas aeruginosa (see 2 papers)
    40% identity, 83% coverage of query (173 bits)

7t61A P. Aeruginosa lpxa in complex with ligand l15
    40% identity, 83% coverage of query (173 bits)

7t60A P. Aeruginosa lpxa in complex with ligand l13
    40% identity, 83% coverage of query (173 bits)

7t5zA P. Aeruginosa lpxa in complex with ligand l8
    40% identity, 83% coverage of query (173 bits)

7t5xA P. Aeruginosa lpxa in complex with ligand l6
    40% identity, 83% coverage of query (173 bits)

7t5sA P. Aeruginosa lpxa in complex with ligand h16
    40% identity, 83% coverage of query (173 bits)

7t5rA P. Aeruginosa lpxa in complex with ligand h7
    40% identity, 83% coverage of query (173 bits)

7okbA Crystal structure of pseudomonas aeruginosa lpxa in complex with compound 45
    40% identity, 83% coverage of query (173 bits)

7okaa Crystal structure of pseudomonas aeruginosa lpxa in complex with compound 14
    40% identity, 83% coverage of query (173 bits)

7ok1A Crystal structure of pseudomonas aeruginosa lpxa in complex with compound 3
    40% identity, 83% coverage of query (173 bits)

7ojyA Crystal structure of pseudomonas aeruginosa lpxa in complex with compound 6
    40% identity, 83% coverage of query (173 bits)

6uegA Pseudomonas aeruginosa lpxa complex structure with ligand
    40% identity, 83% coverage of query (173 bits)

6ueeA Pseudomonas aeruginosa lpxa complex structure with ligand
    40% identity, 83% coverage of query (173 bits)

5depA Structure of pseudomonas aeruginosa lpxa in complex with udp-glcnac
    40% identity, 83% coverage of query (173 bits)

7ojpZ / Q9X6P4 Crystal structure of pseudomonas aeruginosa lpxa in complex with compound 1 (see paper)
    40% identity, 83% coverage of query (172 bits)

Q5LH16 acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase (EC 2.3.1.129) from Bacteroides fragilis (see paper)
4r37A / Q5LH16 Crystal structure analysis of lpxa, a udp-n-acetylglucosamine acyltransferase from bacteroides fragilis 9343 with udp-glcnac (see paper)
    37% identity, 94% coverage of query (172 bits)

5dg3A Structure of pseudomonas aeruginosa lpxa in complex with udp-3-o-(r-3- hydroxydecanoyl)-glcnac
    40% identity, 82% coverage of query (172 bits)

LPXA_ARATH / Q9SU91 Probable acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, mitochondrial; UDP-N-acetylglucosamine acyltransferase; Protein LIPID X A; AtLpxA; EC 2.3.1.129 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q9SU91 acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase (EC 2.3.1.129) from Arabidopsis thaliana (see 2 papers)
    36% identity, 97% coverage of query (167 bits)

7ojwA Crystal structure of pseudomonas aeruginosa lpxa in complex with compound 93
    39% identity, 83% coverage of query (166 bits)

7ojqA Crystal structure of pseudomonas aeruginosa lpxa in complex with compound 7
    39% identity, 83% coverage of query (166 bits)

lpxA / Q7MAX0 acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase monomer (EC 2.3.1.129) from Porphyromonas gingivalis (strain ATCC BAA-308 / W83) (see 5 papers)
    36% identity, 96% coverage of query (159 bits)

Q02RB8 UDP-3-O-(3-hydroxyacyl)glucosamine N-acyltransferase (EC 2.3.1.191) from Pseudomonas aeruginosa (see paper)
    30% identity, 72% coverage of query (75.5 bits)

Q9HXY6 UDP-3-O-(3-hydroxyacyl)glucosamine N-acyltransferase (EC 2.3.1.191) from Pseudomonas aeruginosa (see 2 papers)
    30% identity, 72% coverage of query (75.1 bits)

6uecA Pseudomonas aeruginosa lpxd complex structure with ligand
    30% identity, 72% coverage of query (75.1 bits)

8e62C / Q1QD55 Structure of pcryo_0615 from psychrobacter cryohalolentis, an n- acetyltransferase required to produce diacetamido-2,3-dideoxy-d- glucuronic acid (see paper)
    30% identity, 71% coverage of query (68.6 bits)

Build an alignment

Build an alignment for Synpcc7942_0931 and 41 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

LPXD_CHLTR / P0CD76 UDP-3-O-acylglucosamine N-acyltransferase; EC 2.3.1.191 from Chlamydia trachomatis (strain D/UW-3/Cx) (see paper)
    26% identity, 71% coverage of query (52.4 bits)

2iu8A / P0CD76 Chlamydia trachomatis lpxd with 25mm udpglcnac (complex i) (see paper)
    26% identity, 71% coverage of query (52.4 bits)

LPXD1_ARATH / F4JGP6 Probable UDP-3-O-acylglucosamine N-acyltransferase 1, mitochondrial; Protein LIPID X D1; AtLpxD1; EC 2.3.1.191 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
F4JGP6 UDP-3-O-(3-hydroxyacyl)glucosamine N-acyltransferase (EC 2.3.1.191) from Arabidopsis thaliana (see paper)
    27% identity, 71% coverage of query (49.7 bits)

3fsbA / Q6TFC6 Crystal structure of qdtc, the dtdp-3-amino-3,6-dideoxy-d-glucose n- acetyl transferase from thermoanaerobacterium thermosaccharolyticum in complex with coa and dtdp-3-amino-quinovose (see paper)
    25% identity, 70% coverage of query (48.5 bits)

3fscA Crystal structure of qdtc, the dtdp-3-amino-3,6-dideoxy-d-glucose n- acetyl transferase from thermoanaerobacterium thermosaccharolyticum in complex with coa and dtdp-3-amino-fucose
    25% identity, 70% coverage of query (48.5 bits)

3fs8A Crystal structure of qdtc, the dtdp-3-amino-3,6-dideoxy-d- glucose n-acetyl transferase from thermoanaerobacterium thermosaccharolyticum in complex with acetyl-coa
    25% identity, 70% coverage of query (48.5 bits)

qdtC / Q6TFC6 dTDP-3-amino-3,6-dideoxy-α-D-glucopyranose:acetyl-CoA acetyltransferase from Thermoanaerobacterium thermosaccharolyticum (see paper)
    25% identity, 70% coverage of query (48.1 bits)

CAG_GEOKA / Q5KW03 Carbonic anhydrase; Gamma-carbonic anhydrase; Cag; EC 4.2.1.1 from Geobacillus kaustophilus (strain HTA426) (see 2 papers)
    26% identity, 72% coverage of query (44.7 bits)

3vnpA / Q5KW03 Crystal structure of hypothetical protein (gk2848) from geobacillus kaustophilus
    26% identity, 72% coverage of query (44.3 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory