Sites on a Tree

 

Searching for up to 100 curated homologs for Synpcc7942_0950 FitnessBrowser__SynE:Synpcc7942_0950 (438 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

6dtqA / G4XU73 Maltose bound t. Maritima male3 (see paper)
    37% identity, 85% coverage of query (241 bits)

TC 3.A.1.1.41 / G4FGN8 Extracellular solute-binding protein family 1, component of Trehalose porter. Also binds sucrose (Boucher and Noll, 2011). Induced by glucose and trehalose. Directly regulated by trehalose-responsive regulator TreR from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    37% identity, 85% coverage of query (241 bits)

TC 3.A.1.1.7 / O51923 MalE aka PF1739, component of Maltose/trehalose porter (see paper)
    33% identity, 92% coverage of query (214 bits)

MALE_THELN / Q7LYW7 Trehalose/maltose-binding protein MalE; TMBP from Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C) (see 4 papers)
    33% identity, 92% coverage of query (212 bits)

1eu8A / Q7LYW7 Structure of trehalose maltose binding protein from thermococcus litoralis (see paper)
    34% identity, 85% coverage of query (211 bits)

SM_b20325 ABC transporter for D-trehalose/D-maltose/sucrose, substrate-binding component (ThuE) from Sinorhizobium meliloti 1021
TC 3.A.1.1.17 / Q9R9Q7 ThuE aka RB0311 aka SMB20325, component of Trehalose/maltose/sucrose porter (trehalose inducible) from Rhizobium meliloti (Sinorhizobium meliloti) (see 3 papers)
    32% identity, 79% coverage of query (172 bits)

Pf1N1B4_5112 sucrose ABC transporter, substrate-binding component from Pseudomonas fluorescens FW300-N1B4
    32% identity, 80% coverage of query (169 bits)

6jaiA Crystal structure of abc transporter alpha-glycoside-binding mutant protein d118a in complex with maltose
    31% identity, 82% coverage of query (168 bits)

TC 3.A.1.1.25 / Q72H68 Trehalose/maltose-binding protein aka TT_C1627, component of The trehalose/maltose/sucrose/palatinose porter (TTC1627-9) plus MalK1 (ABC protein, shared with 3.A.1.1.24) (Silva et al. 2005; Chevance et al., 2006). The receptor (TTC1627) binds disaccharide alpha-glycosides, namely trehalose (alpha-1,1), sucrose (alpha-1,2), maltose (alpha-1,4), palatinose (alpha-1,6) and glucose from Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) (see paper)
    31% identity, 81% coverage of query (166 bits)

6jahA Crystal structure of abc transporter alpha-glycoside-binding protein in complex with glucose
    30% identity, 82% coverage of query (166 bits)

6jagA Crystal structure of abc transporter alpha-glycoside-binding protein in complex with sucrose
    30% identity, 82% coverage of query (166 bits)

6jadA Crystal structure of abc transporter alpha-glycoside-binding protein in complex with palatinose
    30% identity, 82% coverage of query (166 bits)

6j9yA Crystal structure of abc transporter alpha-glycoside-binding protein in complex with maltose
    30% identity, 82% coverage of query (166 bits)

6jamA / Q5SLD7 Crystal structure of abc transporter alpha-glycoside-binding mutant protein r356a in complex with trehalose (see paper)
    30% identity, 82% coverage of query (163 bits)

6jb0A Crystal structure of abc transporter alpha-glycoside-binding mutant protein w287a in complex with trehalose
    30% identity, 82% coverage of query (160 bits)

Build an alignment

Build an alignment for Synpcc7942_0950 and 15 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

TC 3.A.1.1.19 / Q8L126 PalE, component of Platinose (isomaltulose) (6-O-α-D-glucopyranosyl-D-fructofuranose) porter from Agrobacterium tumefaciens (see 3 papers)
palE / BAB96538.1 PalE from Agrobacterium tumefaciens (see 3 papers)
    29% identity, 92% coverage of query (157 bits)

TC 3.A.1.1.12 / Q9AI68 PalE, component of Palatinose (isomaltulose; 6-O-α-D-glucopyranosyl-D-fructose) uptake porter from Erwinia rhapontici (see paper)
    34% identity, 72% coverage of query (154 bits)

SM_b21221 ABC transporter for D-Glucosamine, periplasmic substrate-binding protein from Sinorhizobium meliloti 1021
    27% identity, 90% coverage of query (147 bits)

smoF / A9CEY9 3-(6-sulfo-α-D-quinovosyl)-sn-glycerol binding protein from Agrobacterium fabrum (strain C58 / ATCC 33970) (see paper)
SMOF_AGRFC / A9CEY9 Sulfoquinovosyl glycerol-binding protein SmoF; SQGro-binding protein SmoF; SQ monooxygenase cluster protein F from Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58)) (see 2 papers)
    26% identity, 84% coverage of query (144 bits)

7yzuA Crystal structure of the sulfoquinovosyl binding protein smof complexed with sqme
    26% identity, 84% coverage of query (144 bits)

7ofyA Crystal structure of sq binding protein from agrobacterium tumefaciens in complex with sulfoquinovosyl glycerol (sqgro)
    26% identity, 84% coverage of query (143 bits)

7yzsAAA Sulfoquinovosyl binding protein
    26% identity, 84% coverage of query (143 bits)

7qhvAAA / A9CEY9 7qhvAAA (see paper)
    26% identity, 84% coverage of query (141 bits)

8s5bA Sulfoquinovosyl glycerol-binding protein SmoF
    26% identity, 85% coverage of query (141 bits)

TC 3.A.1.1.16 / P58300 MalE aka PF1938, component of Maltooligosaccharide porter (Maltose is not a substrate, but maltotriose is.) from Pyrococcus furiosus (see paper)
    25% identity, 75% coverage of query (92.0 bits)

1eljA / P58300 The crystal structure of liganded maltodextrin-binding protein from pyrococcus furiosus (see paper)
    26% identity, 74% coverage of query (90.9 bits)

5iaiA / B9JM84 Crystal structure of abc transporter solute binding protein arad_9887 from agrobacterium radiobacter k84, target efi-510945 in complex with ribitol
    24% identity, 77% coverage of query (90.1 bits)

TC 3.A.1.1.5 / O30831 SmoE, component of Hexitol (glucitol; mannitol) porter from Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides)
    25% identity, 80% coverage of query (87.4 bits)

Pf6N2E2_1963 ABC transporter for D-sorbitol, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N2E2
    26% identity, 83% coverage of query (83.6 bits)

AO356_00025 ABC transporter for D-Sorbitol, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N2C3
    26% identity, 83% coverage of query (83.2 bits)

PS417_12715 ABC transporter for D-Mannitol and D-Sorbitol, periplasmic substrate-binding protein from Pseudomonas simiae WCS417
    24% identity, 81% coverage of query (80.5 bits)

4ryaA / B9JRF8 Crystal structure of abc transporter solute binding protein avi_3567 from agrobacterium vitis s4, target efi-510645, with bound d-mannitol
    24% identity, 83% coverage of query (80.1 bits)

TC 3.A.1.1.49 / O30491 MtlE, component of The polyol (mannitol, glucitol (sorbitol), arabitol (arabinitol; lyxitol)) uptake porter, MtlEFGK from Pseudomonas fluorescens
    24% identity, 90% coverage of query (80.1 bits)

mtlE / Q4KC57 polyol ABC-type transporter periplasmic substrate-binding protein from Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) (see paper)
    25% identity, 93% coverage of query (77.4 bits)

BPHYT_RS16115 ABC transporter for D-Sorbitol, periplasmic substrate-binding component from Burkholderia phytofirmans PsJN
    23% identity, 92% coverage of query (77.0 bits)

HSERO_RS17000 ABC transporter for D-sorbitol/xylitol, substrate-binding component from Herbaspirillum seropedicae SmR1
    25% identity, 75% coverage of query (76.3 bits)

MANBP_PSEAE / Q9I1E0 Mannitol-binding protein from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
    25% identity, 84% coverage of query (73.2 bits)

3jzjA / B0B0V1 Crystal structures of the gach receptor of streptomyces glaucescens gla.O in the unliganded form and in complex with acarbose and an acarbose homolog. Comparison with acarbose-loaded maltose binding protein of salmonella typhimurium. (see paper)
    23% identity, 84% coverage of query (73.2 bits)

3k02A Crystal structures of the gach receptor of streptomyces glaucescens gla.O in the unliganded form and in complex with acarbose and an acarbose homolog. Comparison with acarbose-loaded maltose binding protein of salmonella typhimurium.
    23% identity, 84% coverage of query (73.2 bits)

Ac3H11_2944 ABC transporter for D-Sorbitol, periplasmic substrate-binding component from Acidovorax sp. GW101-3H11
    24% identity, 84% coverage of query (72.4 bits)

5ci5A / A8F7X5 Crystal structure of an abc transporter solute binding protein from thermotoga lettingae tmo (tlet_1705, target efi-510544) bound with alpha-d-tagatose
    22% identity, 78% coverage of query (67.8 bits)

8artB / C9ZHD5 Abc transporter binding protein male from streptomyces scabiei in complex with maltose
    26% identity, 82% coverage of query (64.3 bits)

4qrzA / A9CGI0 Crystal structure of sugar transporter atu4361 from agrobacterium fabrum c58, target efi-510558, with bound maltotriose
    23% identity, 84% coverage of query (64.3 bits)

4qsdA Crystal structure of atu4361 sugar transporter from agrobacterium fabrum c58, target efi-510558, with bound sucrose
    23% identity, 84% coverage of query (63.9 bits)

Dshi_0547 ABC transporter for Xylitol, periplasmic substrate-binding component from Dinoroseobacter shibae DFL-12
    22% identity, 96% coverage of query (60.1 bits)

Q92AS8 ABC-type beta-glucan transporter (EC 7.5.2.3) from Listeria innocua (see paper)
    21% identity, 84% coverage of query (57.4 bits)

PGA1_c13210 ABC transporter for D-Sorbitol, periplasmic substrate-binding component from Phaeobacter inhibens BS107
    22% identity, 73% coverage of query (55.1 bits)

TC 3.A.1.1.40 / Q9WZR7 Predicted chitobiose porter. Regulated by chitobiose-responsive regulator ChiR from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    20% identity, 96% coverage of query (53.9 bits)

5ysdB / Q92AS8 Crystal structure of beta-1,2-glucooligosaccharide binding protein in complex with sophorotriose (see paper)
    22% identity, 77% coverage of query (53.9 bits)

5ysdA Crystal structure of beta-1,2-glucooligosaccharide binding protein in complex with sophorotriose
    21% identity, 79% coverage of query (53.9 bits)

5ysbA Crystal structure of beta-1,2-glucooligosaccharide binding protein in ligand-free form
    22% identity, 77% coverage of query (53.9 bits)

6r1bB / P71619 Crystal structure of ugpb from mycobacterium tuberculosis in complex with glycerophosphocholine (see paper)
    24% identity, 71% coverage of query (50.1 bits)

TC 3.A.1.1.44 / Q7AKP1 Putative maltose-binding protein, component of MalEFG (K unknown), involved in maltose and maltodextrin uptake from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
    23% identity, 82% coverage of query (48.1 bits)

1a7lA Dominant b-cell epitope from the pres2 region of hepatitis b virus in the form of an inserted peptide segment in maltodextrin-binding protein
    24% identity, 75% coverage of query (47.4 bits)

1zjlA Crystal structure of zinc-bound engineered maltose binding protein
    24% identity, 74% coverage of query (47.0 bits)

5az7A / P0AEX9,Q62760 Crystal structure of mbp-tom20 fusion protein with a 4-residue spacer in the connector helix (see paper)
    24% identity, 76% coverage of query (46.6 bits)

5jonA / O88703,P0AEY0 Crystal structure of the unliganded form of hcn2 cnbd (see paper)
    24% identity, 75% coverage of query (46.6 bits)

5fsgA / P05133,P0AEX9 Structure of the hantavirus nucleoprotein provides insights into the mechanism of RNA encapsidation and a template for drug design (see paper)
    24% identity, 76% coverage of query (46.2 bits)

4nufA / P0AEX9,Q62227 Crystal structure of shp/eid1 (see paper)
    24% identity, 74% coverage of query (46.2 bits)

2vgqA / P0AEX9,Q7Z434 Crystal structure of human ips-1 card (see paper)
    24% identity, 75% coverage of query (46.2 bits)

3c4mA Structure of human parathyroid hormone in complex with the extracellular domain of its g-protein-coupled receptor (pth1r)
    24% identity, 76% coverage of query (46.2 bits)

3l2jA / P0AEX9,Q03431 Dimeric structure of the ligand-free extracellular domain of the human parathyroid hormone receptor (pth1r) (see paper)
    24% identity, 76% coverage of query (46.2 bits)

5z0rB / P0AEX9,Q32ZE1 Structural insight into the zika virus capsid encapsulating the viral genome (see paper)
    24% identity, 74% coverage of query (45.8 bits)

1y4cA / P0AEX9 Designed helical protein fusion mbp (see paper)
    24% identity, 75% coverage of query (45.8 bits)

7uajB / P03126,P0AEX9 Crystal structure of apo hpv16 e6
    24% identity, 75% coverage of query (45.8 bits)

3a3cA / P0AEX9,P36046 Crystal structure of tim40/mia40 fusing mbp, c296s and c298s mutant (see paper)
    24% identity, 75% coverage of query (45.8 bits)

4b3nA / P0AEX9,Q0PF16 Crystal structure of rhesus trim5alpha pry/spry domain (see paper)
    24% identity, 76% coverage of query (45.8 bits)

5cfvA / P0AEX9 Fusion of maltose-binding protein and pila from acinetobacter nosocomialis m2 (see paper)
    24% identity, 74% coverage of query (45.4 bits)

2v93A Equillibrium mixture of open and partially-closed species in the apo state of maltodextrin-binding protein by paramagnetic relaxation enhancement nmr
    24% identity, 74% coverage of query (45.4 bits)

3hpiA Crystal structure of maltose-binding protein mutant with bound sucrose
    24% identity, 74% coverage of query (45.4 bits)

4xaiA / P0AEY0,Q9NCL0 Crystal structure of red flour beetle nr2e1/tlx (see paper)
    24% identity, 74% coverage of query (45.4 bits)

3n96A / P0AEX9,Q13324 Crystal structure of human crfr2 alpha extracellular domain in complex with urocortin 1
    24% identity, 74% coverage of query (45.4 bits)

4my2A / P0AEX9,Q00604 Crystal structure of norrin in fusion with maltose binding protein (see paper)
    24% identity, 74% coverage of query (45.4 bits)

8qsoA Crystal structure of human mcl-1 in complex with compound 1
    24% identity, 74% coverage of query (45.4 bits)

8g3xA Mbp-mcl1 in complex with ligand 32
    24% identity, 74% coverage of query (45.4 bits)

8g3wA Mbp-mcl1 in complex with ligand 28
    24% identity, 74% coverage of query (45.4 bits)

8g3uA Mbp-mcl1 in complex with ligand 21
    24% identity, 74% coverage of query (45.4 bits)

8g3tA Mbp-mcl1 in complex with ligand 12
    24% identity, 74% coverage of query (45.4 bits)

8g3sA / Q07820 Mbp-mcl1 in complex with ligand 11 (see paper)
    24% identity, 74% coverage of query (45.4 bits)

1llsA Crystal structure of unliganded maltose binding protein with xenon
    24% identity, 74% coverage of query (45.4 bits)

1ez9B Structure of maltotetraitol bound to open-form maltodextrin binding protein in p1 crystal form
    24% identity, 74% coverage of query (45.4 bits)

3n94A / P0AEX9,P41586 Crystal structure of human pituitary adenylate cyclase 1 receptor- short n-terminal extracellular domain (see paper)
    24% identity, 74% coverage of query (45.4 bits)

8el0A Structure of mbp-mcl-1 in complex with a macrocyclic compound
    24% identity, 74% coverage of query (45.4 bits)

1ytvA Maltose-binding protein fusion to a c-terminal fragment of the v1a vasopressin receptor
    24% identity, 74% coverage of query (45.1 bits)

7omtA / P0AEX9 Crystal structure of promacrobody 21 with bound maltose (see paper)
    24% identity, 81% coverage of query (45.1 bits)

5w1cA Crystal structure of mbp fused activation-induced cytidine deaminase (aid) in complex with cytidine
    24% identity, 74% coverage of query (45.1 bits)

6ybkA Structure of mbp-mcl-1 in complex with compound 4d
    24% identity, 74% coverage of query (45.1 bits)

8el1A Structure of mbp-mcl-1 in complex with abbv-467
    24% identity, 74% coverage of query (45.1 bits)

6zhoA / O60894,P0AEX9,Q16602 Crystal structure of a cgrp receptor ectodomain heterodimer with bound high affinity inhibitor (see paper)
    24% identity, 74% coverage of query (45.1 bits)

3woaA / P03034,P0AEX9 Crystal structure of lambda repressor (1-45) fused with maltose- binding protein (see paper)
    24% identity, 74% coverage of query (45.1 bits)

8ax5A Crystal structure of a cgrp receptor ectodomain heterodimer bound to macrocyclic inhibitor htl0029881
    24% identity, 74% coverage of query (45.1 bits)

3rumA New strategy to analyze structures of glycopeptide antibiotic-target complexes
    24% identity, 74% coverage of query (45.1 bits)

4wthB Ataxin-3 carboxy terminal region - crystal c2 (triclinic)
    24% identity, 74% coverage of query (45.1 bits)

7p0iA Crystal structure of a cgrp receptor ectodomain heterodimer bound to macrocyclic inhibitor compound 13
    24% identity, 74% coverage of query (44.7 bits)

4rwgA Crystal structure of the clr:ramp1 extracellular domain heterodimer with bound high affinity cgrp analog
    24% identity, 74% coverage of query (44.7 bits)

8ax7A Crystal structure of a cgrp receptor ectodomain heterodimer bound to macrocyclic inhibitor htl0031448
    24% identity, 74% coverage of query (44.7 bits)

6pfoA / P30988 Crystal structure of n-glycosylated human calcitonin receptor extracellular domain in complex with salmon calcitonin (16-32) (see paper)
    24% identity, 74% coverage of query (44.7 bits)

7p0fA Crystal structure of a cgrp receptor ectodomain heterodimer bound to macrocyclic inhibitor htl0028125
    24% identity, 74% coverage of query (44.7 bits)

6qynA Structure of mbp-mcl-1 in complex with compound 10d
    24% identity, 74% coverage of query (44.7 bits)

4rwgB Crystal structure of the clr:ramp1 extracellular domain heterodimer with bound high affinity cgrp analog
    24% identity, 74% coverage of query (44.7 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory