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Searching for up to 100 curated homologs for Synpcc7942_1857 FitnessBrowser__SynE:Synpcc7942_1857 (288 a.a.)

Found high-coverage hits (≥70%) to 76 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

A0A1C8M593 glyoxylate reductase (NADP+) (EC 1.1.1.79) from Malus domestica (see paper)
    31% identity, 99% coverage of query (163 bits)

A0A1C8M582 glyoxylate reductase (NADP+) (EC 1.1.1.79) from Malus domestica (see paper)
    32% identity, 99% coverage of query (158 bits)

3pefA / Q39R98 Crystal structure of gamma-hydroxybutyrate dehydrogenase from geobacter metallireducens in complex with NADP+ (see paper)
    31% identity, 97% coverage of query (155 bits)

GLYR1 / Q9LSV0 succinate semialdehyde reductase (NADPH) from Arabidopsis thaliana (see paper)
GLYR1_ARATH / Q9LSV0 Glyoxylate/succinic semialdehyde reductase 1; AtGLYR1; AtGR1; SSA reductase 1; Gamma-hydroxybutyrate dehydrogenase; AtGHBDH; EC 1.1.1.79; EC 1.1.1.n11 from Arabidopsis thaliana (Mouse-ear cress) (see 5 papers)
Q9LSV0 glyoxylate reductase (EC 1.1.1.26); 4-hydroxybutyrate dehydrogenase (EC 1.1.1.61); glyoxylate reductase (NADP+) (EC 1.1.1.79) from Arabidopsis thaliana (see 6 papers)
    31% identity, 99% coverage of query (152 bits)

SSR1 / B1Q3F6 NAD-dependent succinate semialdehyde dehydrogenase (EC 1.2.1.24) from Solanum lycopersicum (see paper)
    31% identity, 98% coverage of query (152 bits)

3pduA / Q74DE4 Crystal structure of gamma-hydroxybutyrate dehydrogenase from geobacter sulfurreducens in complex with NADP+ (see paper)
    31% identity, 97% coverage of query (145 bits)

Build an alignment

Build an alignment for Synpcc7942_1857 and 6 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

GLYR2_ARATH / F4I907 Glyoxylate/succinic semialdehyde reductase 2, chloroplastic; AtGLYR2; AtGR2; SSA reductase 2; EC 1.1.1.79; EC 1.1.1.n11 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
F4I907 glyoxylate reductase (NADP+) (EC 1.1.1.79) from Arabidopsis thaliana (see 3 papers)
    29% identity, 98% coverage of query (141 bits)

2uyyA / Q49A26 Structure of the cytokine-like nuclear factor n-pac
    29% identity, 98% coverage of query (136 bits)

GLYR1_HUMAN / Q49A26 Cytokine-like nuclear factor N-PAC; NPAC; 3-hydroxyisobutyrate dehydrogenase-like protein; Glyoxylate reductase 1 homolog; Nuclear protein NP60; Nuclear protein of 60 kDa; Nucleosome-destabilizing factor; hNDF; Putative oxidoreductase GLYR1 from Homo sapiens (Human) (see 7 papers)
    29% identity, 98% coverage of query (133 bits)

GLYR1_MOUSE / Q922P9 Cytokine-like nuclear factor N-PAC; NPAC; Glyoxylate reductase 1 homolog; Nuclear protein NP60; Putative oxidoreductase GLYR1 from Mus musculus (Mouse) (see 2 papers)
    29% identity, 98% coverage of query (129 bits)

GLYR1_DROME / Q8T079 Cytokine-like nuclear factor N-PAC; NPAC; Glyoxylate reductase 1 homolog; Nuclear protein NP60 homolog; Nucleosome-destabilizing factor; Putative oxidoreductase GLYR1 homolog from Drosophila melanogaster (Fruit fly) (see 2 papers)
    27% identity, 96% coverage of query (128 bits)

3w6zA / A3MU08 Crystal structure of NADP bound l-serine 3-dehydrogenase (k170m) from hyperthermophilic archaeon pyrobaculum calidifontis (see paper)
    30% identity, 97% coverage of query (123 bits)

A0A1I9LPQ6 hydroxypyruvate reductase (EC 1.1.1.81) from Arabidopsis thaliana (see paper)
    32% identity, 70% coverage of query (120 bits)

3ws7A The 1.18 a resolution structure of l-serine 3-dehydrogenase complexed with NADP+ and sulfate ion from the hyperthermophilic archaeon pyrobaculum calidifontis
    32% identity, 97% coverage of query (120 bits)

Q8ZLV8 2-hydroxy-3-oxopropionate reductase (EC 1.1.1.60) from Salmonella enterica subsp. enterica serovar Typhimurium (see paper)
    30% identity, 98% coverage of query (119 bits)

YhaE / b3125 tartronate semialdehyde reductase (EC 1.1.1.60) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
garR / P0ABQ2 tartronate semialdehyde reductase (EC 1.1.1.60) from Escherichia coli (strain K12) (see 2 papers)
GARR_ECOLI / P0ABQ2 2-hydroxy-3-oxopropionate reductase; Tartronate semialdehyde reductase; TSAR; EC 1.1.1.60 from Escherichia coli (strain K12) (see 2 papers)
    30% identity, 97% coverage of query (113 bits)

YbbQ / b0509 tartronate semialdehyde reductase 2 from Escherichia coli K-12 substr. MG1655 (see 5 papers)
glxR / P77161 tartronate semialdehyde reductase 2 (EC 1.1.1.60) from Escherichia coli (strain K12) (see 3 papers)
    31% identity, 100% coverage of query (108 bits)

YKWC_BACSU / O34948 Uncharacterized oxidoreductase YkwC; EC 1.1.-.- from Bacillus subtilis (strain 168) (see paper)
    25% identity, 97% coverage of query (90.5 bits)

8bk1A / M2QI47 Mutant imine reductase ir007-143 from amycolatopsis azurea, e120a, m197w, m206s, a213p, d238g, i240l
    30% identity, 98% coverage of query (89.4 bits)

8a3xA / A0A0L8BGL4 Imine reductase from ensifer adhaerens in complex with NADP+ (see paper)
    28% identity, 96% coverage of query (85.9 bits)

7og3A / A0A5P2XKZ4 Ired-88
    25% identity, 97% coverage of query (84.7 bits)

5je8B / Q81DR6 The crystal structure of bacillus cereus 3-hydroxyisobutyrate dehydrogenase in complex with NAD (see paper)
    25% identity, 98% coverage of query (84.7 bits)

8ozvA Imine reductase from ajellomyces dermatitidis in complex with 2,2- difluoroacetophenone
    26% identity, 97% coverage of query (82.4 bits)

8p2jC / A0A179UH34 Imine reductase from ajellomyces dermatitidis in space group c21 (see paper)
    26% identity, 97% coverage of query (82.0 bits)

6jizB Apo structure of an imine reductase at 1.76 angstrom resolution
    27% identity, 97% coverage of query (81.6 bits)

6jizC / D3Q3R0 Apo structure of an imine reductase at 1.76 angstrom resolution
    27% identity, 97% coverage of query (81.3 bits)

8qheA / A0A0S7DXU4 Crystal structure ir-09 (see paper)
    26% identity, 97% coverage of query (81.3 bits)

6sleA Structure of reductive aminase from neosartorya fumigata in complex with NADP+
    25% identity, 97% coverage of query (81.3 bits)

8ozwA Imine reductase from ajellomyces dermatitidis in complex nadph4
    26% identity, 97% coverage of query (80.5 bits)

3zhbD / Q1EQE0 R-imine reductase from streptomyces kanamyceticus in complex with NADP. (see paper)
    27% identity, 96% coverage of query (79.3 bits)

6jitB Complex structure of an imine reductase at 2.05 angstrom resolution
    28% identity, 97% coverage of query (79.3 bits)

M4ZRJ3 2-methyl-1-pyrroline reductase (EC 1.5.1.48) from Streptomyces sp. GF3587 (see paper)
    27% identity, 98% coverage of query (76.3 bits)

6smtB / A0R5X0 S-enantioselective imine reductase from mycobacterium smegmatis (see paper)
    26% identity, 95% coverage of query (75.9 bits)

P29266 3-hydroxyisobutyrate dehydrogenase, mitochondrial; HIBADH; EC 1.1.1.31 from Rattus norvegicus (Rat)
    24% identity, 97% coverage of query (74.3 bits)

6eoiB / Q0CCT3 Reductive aminase from aspergillus terreus in complex with NADPH and ethyl-5-oxohexanoate
    26% identity, 96% coverage of query (73.9 bits)

7osnB / A0A1S8Y2S4 Ired361 from micromonospora sp. In complex with NADP+ (see paper)
    23% identity, 96% coverage of query (73.6 bits)

2i9pB / P31937 Crystal structure of human hydroxyisobutyrate dehydrogenase complexed with NAD+
    24% identity, 98% coverage of query (73.6 bits)

6to4A Coenzyme F420-dependent NADP oxidoreductase
    25% identity, 95% coverage of query (73.2 bits)

6eohA Reductive aminase from aspergillus terreus in complex with NADPH and ethyl levulinate
    27% identity, 96% coverage of query (73.2 bits)

6h7pB Reductive aminase from aspergillus terreus in complex with nadph4, cyclohexanone and allyl amine
    27% identity, 96% coverage of query (73.2 bits)

B9J8U1 L-threonate 2-dehydrogenase (EC 1.1.1.411) from Agrobacterium tumefaciens (see paper)
    28% identity, 97% coverage of query (72.8 bits)

8jytC Ancestral imine reducatase n560
    28% identity, 97% coverage of query (72.4 bits)

3HIDH_HUMAN / P31937 3-hydroxyisobutyrate dehydrogenase, mitochondrial; HIBADH; EC 1.1.1.31 from Homo sapiens (Human) (see paper)
    24% identity, 97% coverage of query (72.4 bits)

5ojlA Imine reductase from aspergillus terreus in complex with nadph4 and dibenz[c,e]azepine
    26% identity, 96% coverage of query (72.0 bits)

REDAM_ASPOR / Q2TW47 NADPH-dependent reductive aminase; RedAm; EC 1.1.1.- from Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
    24% identity, 100% coverage of query (71.2 bits)

5g6rB / Q2TW47 Imine reductase from aspergillus oryzae (see paper)
    24% identity, 97% coverage of query (70.1 bits)

4oqyA / M4ZS15 Streptomyces sp. Gf3546 imine reductase
    25% identity, 97% coverage of query (70.1 bits)

5g6sA Imine reductase from aspergillus oryzae in complex with NADP(h) and (r)-rasagiline
    24% identity, 97% coverage of query (70.1 bits)

Psest_2438 3-hydroxyisobutyrate dehydrogenase (EC 1.1.1.31) from Pseudomonas stutzeri RCH2
    27% identity, 100% coverage of query (69.3 bits)

6h7pA Reductive aminase from aspergillus terreus in complex with nadph4, cyclohexanone and allyl amine
    27% identity, 96% coverage of query (68.9 bits)

SquU / b3882 3-sulfolactaldehyde reductase (EC 1.1.1.373; EC 1.1.1.61) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
yihU / P0A9V8 3-sulfolactaldehyde reductase (EC 1.1.1.373; EC 1.1.1.61) from Escherichia coli (strain K12) (see 3 papers)
SQUU_ECOLI / P0A9V8 3-sulfolactaldehyde reductase; SLA reductase; 4-hydroxybutyrate dehydrogenase; Gamma-hydroxybutyrate dehydrogenase; GHBDH; Succinic semialdehyde reductase; SSA reductase; EC 1.1.1.373; EC 1.1.1.61 from Escherichia coli (strain K12) (see 2 papers)
P0A9V8 sulfolactaldehyde 3-reductase (EC 1.1.1.373); 4-hydroxybutyrate dehydrogenase (EC 1.1.1.61) from Escherichia coli (see 2 papers)
    26% identity, 97% coverage of query (68.2 bits)

6smzC / P0A9V8 Crystal structure of sla reductase yihu from e. Coli in complex with nadh
    26% identity, 97% coverage of query (68.2 bits)

6smyA Crystal structure of sla reductase yihu from e. Coli with nadh and product dhps
    26% identity, 97% coverage of query (68.2 bits)

6toeB / L7U9F5 Imine reductase from myxococcus stipitatus v8 variant in complex with NAD+
    25% identity, 95% coverage of query (66.6 bits)

5a9tA / R4SNK4 Imine reductase from amycolatopsis orientalis in complex with (r)-methyltetrahydroisoquinoline
    25% identity, 95% coverage of query (63.5 bits)

mmsB / Q76KL5 3-hydroxyisobutyrate dehydrogenase subunit (EC 1.1.1.31) from Pseudomonas putida (see 5 papers)
Q76KL5 3-hydroxyisobutyrate dehydrogenase (EC 1.1.1.31) from Pseudomonas putida (see paper)
    25% identity, 98% coverage of query (62.8 bits)

6sleB / Q4WDZ8 Structure of reductive aminase from neosartorya fumigata in complex with NADP+ (see paper)
    27% identity, 97% coverage of query (62.8 bits)

Q9SUC0 3-hydroxyisobutyrate dehydrogenase (EC 1.1.1.31) from Arabidopsis thaliana (see paper)
    22% identity, 97% coverage of query (60.8 bits)

MMSB_PSEAE / P28811 3-hydroxyisobutyrate dehydrogenase; HIBADH; EC 1.1.1.31 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
mmsB / AAA25892.1 3-hydroxyisobutyrate dehydrogenase from Pseudomonas aeruginosa (see paper)
    28% identity, 72% coverage of query (60.5 bits)

3q3cA Crystal structure of a serine dehydrogenase from pseudomonas aeruginosa pao1 in complex with NAD
    26% identity, 98% coverage of query (59.3 bits)

3obbA / Q9I5I6 Crystal structure of a possible 3-hydroxyisobutyrate dehydrogenase from pseudomonas aeruginosa pao1 (see paper)
    26% identity, 98% coverage of query (58.9 bits)

SERDH_PSEAE / Q9I5I6 NAD-dependent L-serine dehydrogenase; L-serine 3-dehydrogenase (NAD(+)); EC 1.1.1.387 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
Q9I5I6 L-serine 3-dehydrogenase (NAD+) (EC 1.1.1.387) from Pseudomonas aeruginosa (see paper)
    26% identity, 98% coverage of query (58.5 bits)

7y8mB / E2PUR9 Structure of scired-r2-v3 from streptomyces clavuligerus in complex with 5-(3-fluorophenyl)-3,4-dihydro-2h-pyrrole
    28% identity, 96% coverage of query (57.8 bits)

LTND_ECOL6 / A0A0H2VA68 L-threonate dehydrogenase; EC 1.1.1.411 from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) (see paper)
    24% identity, 98% coverage of query (57.8 bits)

7y8lC Structure of scired-r2-v3 from streptomyces clavuligerus in complex with 5-(2,5-difluorophenyl)-3,4-dihydro-2h-pyrrole
    28% identity, 96% coverage of query (57.8 bits)

7y8lA Structure of scired-r2-v3 from streptomyces clavuligerus in complex with 5-(2,5-difluorophenyl)-3,4-dihydro-2h-pyrrole
    28% identity, 96% coverage of query (57.8 bits)

5a9sA NADPH complex of imine reductase from amycolatopsis orientalis
    25% identity, 95% coverage of query (57.0 bits)

7puaFM / C9ZJW2 7puaFM (see paper)
    23% identity, 85% coverage of query (56.6 bits)

Q1QSN6 L-threonate 2-dehydrogenase (EC 1.1.1.411) from Chromohalobacter salexigens (see paper)
    25% identity, 98% coverage of query (55.5 bits)

8jkuA Ancestal imine reductase
    26% identity, 97% coverage of query (55.5 bits)

YgbJ / b2736 putative L-threonate dehydrogenase from Escherichia coli K-12 substr. MG1655 (see 2 papers)
    24% identity, 98% coverage of query (53.5 bits)

Q5SLQ6 3-hydroxypropionate dehydrogenase (NADP+) (EC 1.1.1.298) from Thermus thermophilus (see paper)
2cvzC / Q5SLQ6 Structure of hydroxyisobutyrate dehydrogenase from thermus thermophilus hb8 (see paper)
    26% identity, 83% coverage of query (53.1 bits)

1wp4A Structure of tt368 protein from thermus thermophilus hb8
    26% identity, 83% coverage of query (53.1 bits)

PfGW456L13_5145 3-hydroxyisobutyrate dehydrogenase (EC 1.1.1.31) from Pseudomonas fluorescens GW456-L13
    26% identity, 97% coverage of query (52.8 bits)

AO353_05985 3-hydroxyisobutyrate dehydrogenase (EC 1.1.1.31) from Pseudomonas fluorescens FW300-N2E3
    25% identity, 98% coverage of query (50.1 bits)

ltnD / P44979 L-threonate 2-dehydrogenase (EC 1.1.1.411) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (see paper)
LTND_HAEIN / P44979 L-threonate dehydrogenase; EC 1.1.1.411 from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (see paper)
    23% identity, 78% coverage of query (48.5 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory