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Searching for up to 100 curated homologs for VIMSS590795 5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase (344 a.a.)

Found high-coverage hits (≥70%) to 41 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

3rpdA The structure of a b12-independent methionine synthase from shewanella sp. W3-18-1 in complex with selenomethionine.
    86% identity, 99% coverage of query (613 bits)

Ga0059261_2929 oxygen-dependent methionine synthase, methyltransferase component MesD from Sphingomonas koreensis DSMZ 15582
    84% identity, 99% coverage of query (607 bits)

Build an alignment

Build an alignment for VIMSS590795 and 2 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

xecA / Q56837 2-hydroxypropyl-CoM lyase subunit (EC 4.4.1.23) from Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2) (see 3 papers)
XECA_XANP2 / Q56837 2-hydroxypropyl-CoM lyase; Aliphatic epoxide carboxylation component I; Epoxide carboxylase component I; Epoxyalkane:CoM transferase; EaCoMT; EC 4.4.1.23 from Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2) (see 4 papers)
    29% identity, 98% coverage of query (135 bits)

Q5U9J8 2-hydroxypropyl-CoM lyase (EC 4.4.1.23) from Nocardioides sp. JS614 (see paper)
    29% identity, 99% coverage of query (134 bits)

etnE / Q6XBI9 epoxyalkane:coenzyme M transferase monomer (EC 4.4.1.23) from Mycolicibacterium rhodesiae (see 2 papers)
etnE / AAO48573.1 epoxyalkane:coenzyme M transferase from Mycolicibacterium rhodesiae (see paper)
    29% identity, 99% coverage of query (130 bits)

B9VTP0 2-hydroxypropyl-CoM lyase (EC 4.4.1.23) from Mycobacterium sp. JS623 (see paper)
    29% identity, 98% coverage of query (130 bits)

B9VTP5 2-hydroxypropyl-CoM lyase (EC 4.4.1.23) from Mycobacterium sp. JS623 (see paper)
    29% identity, 98% coverage of query (130 bits)

MetE / b3829 cobalamin-independent homocysteine transmethylase (EC 2.1.1.14) from Escherichia coli K-12 substr. MG1655 (see 19 papers)
metE / P25665 cobalamin-independent homocysteine transmethylase (EC 2.1.1.14) from Escherichia coli (strain K12) (see 16 papers)
P25665 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase (EC 2.1.1.14) from Escherichia coli (see 2 papers)
metE 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; EC 2.1.1.14 from Escherichia coli K12 (see 9 papers)
    27% identity, 97% coverage of query (119 bits)

P25665 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Cobalamin-independent methionine synthase; Methionine synthase, vitamin-B12 independent isozyme; EC 2.1.1.14 from Escherichia coli (strain K12)
    27% identity, 97% coverage of query (119 bits)

ms2 / CAJ01714.1 methionine synthase 2 enzyme from Hordeum vulgare (see paper)
    25% identity, 99% coverage of query (110 bits)

METE3_ARATH / Q0WNZ5 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 3, chloroplastic; Cobalamin-independent methionine synthase 3; AtMS3; EC 2.1.1.14 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    24% identity, 98% coverage of query (106 bits)

ms1 / CAJ01713.1 methionine synthase 1 enzyme from Hordeum vulgare (see paper)
    25% identity, 98% coverage of query (105 bits)

metE / CAA58474.1 methionine synthase from Catharanthus roseus (see paper)
    25% identity, 99% coverage of query (105 bits)

METE1_ARATH / O50008 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1; Cobalamin-independent methionine synthase 1; AtMS1; Vitamin-B12-independent methionine synthase 1; EC 2.1.1.14 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
O50008 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase (EC 2.1.1.14) from Arabidopsis thaliana (see paper)
    24% identity, 99% coverage of query (103 bits)

AtMS2 / Q9SRV5 cobalamin-independent methionine synthase MS2 (EC 2.1.1.14) from Arabidopsis thaliana (see paper)
METE2_ARATH / Q9SRV5 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 2; Cobalamin-independent methionine synthase 2; AtMS2; EC 2.1.1.14 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    24% identity, 99% coverage of query (103 bits)

METE_KALTU / C1KEU0 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Cobalamin-independent methionine synthase; Pollen allergen Sal k 3; SkMetE; Vitamin-B12-independent methionine synthase; Allergen Sal k 3.0101; EC 2.1.1.14 from Kali turgidum (Prickly saltwort) (Salsola kali) (see paper)
    26% identity, 90% coverage of query (99.8 bits)

METE_THEMA / Q9X112 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Cobalamin-independent methionine synthase; Methionine synthase, vitamin-B12 independent isozyme; EC 2.1.1.14 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see 2 papers)
Q9X112 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase (EC 2.1.1.14) from Thermotoga maritima (see paper)
    23% identity, 99% coverage of query (98.6 bits)

1xpgA Crystal structure of t. Maritima cobalamin-independent methionine synthase complexed with zn2+ and methyltetrahydrofolate
    23% identity, 98% coverage of query (98.6 bits)

1xdjA Crystal structure of t. Maritima cobalamin-independent methionine synthase complexed with zn2+ and homocysteine
    23% identity, 98% coverage of query (98.6 bits)

1t7lA / Q9X112 Crystal structure of cobalamin-independent methionine synthase from t. Maritima (see paper)
    23% identity, 98% coverage of query (98.2 bits)

metH cobalamin-independent methionine synthase; EC 2.1.1.14 from Emericella nidulans (see 2 papers)
    24% identity, 98% coverage of query (97.4 bits)

1u1hA / O50008 A. Thaliana cobalamine independent methionine synthase (see paper)
    24% identity, 98% coverage of query (96.7 bits)

1u22A A. Thaliana cobalamine independent methionine synthase
    24% identity, 98% coverage of query (96.7 bits)

1u1jA A. Thaliana cobalamine independent methionine synthase
    24% identity, 98% coverage of query (96.7 bits)

3bq5A / Q9X112 Crystal structure of t. Maritima cobalamin-independent methionine synthase complexed with zn2+ and homocysteine (monoclinic) (see paper)
    24% identity, 97% coverage of query (95.9 bits)

metE / P80877 cobalamin-independent methionine synthase (EC 2.1.1.14) from Bacillus subtilis (strain 168) (see paper)
    23% identity, 97% coverage of query (95.9 bits)

P80877 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Cobalamin-independent methionine synthase; Methionine synthase, vitamin-B12 independent isozyme; Superoxide-inducible protein 9; SOI9; EC 2.1.1.14 from Bacillus subtilis (strain 168)
    23% identity, 97% coverage of query (95.9 bits)

4ztxA / Q8X1E4 Neurospora crassa cobalamin-independent methionine synthase complexed with zn2+ (see paper)
    23% identity, 98% coverage of query (90.9 bits)

METE_SCHPO / Q9UT19 Probable 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Cobalamin-independent methionine synthase; Methionine synthase, vitamin-B12 independent isozyme; EC 2.1.1.14 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
met26 / RF|NP_593352.1 homocysteine methyltransferase Met26; EC 2.1.1.14 from Schizosaccharomyces pombe (see 2 papers)
    23% identity, 90% coverage of query (89.7 bits)

METE_CANAL / P82610 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Cobalamin-independent methionine synthase; Methionine synthase, vitamin-B12 independent isozyme; EC 2.1.1.14 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see 3 papers)
P82610 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase (EC 2.1.1.14) from Candida albicans (see paper)
MET6 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; EC 2.1.1.14 from Candida albicans (see 10 papers)
    24% identity, 90% coverage of query (83.6 bits)

4qquA / P82610 Crystal structure of the cobalamin-independent methionine synthase enzyme in a closed conformation (see paper)
    24% identity, 90% coverage of query (83.2 bits)

METE_STRMU / Q8CWX6 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Cobalamin-independent methionine synthase; Methionine synthase, vitamin-B12 independent isozyme; EC 2.1.1.14 from Streptococcus mutans serotype c (strain ATCC 700610 / UA159) (see paper)
Q8CWX6 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase (EC 2.1.1.14) from Streptococcus mutans (see paper)
    23% identity, 98% coverage of query (82.0 bits)

4l61A Crystal structure of the candida albicans methionine synthase in complex with methionine
    24% identity, 90% coverage of query (80.9 bits)

mesA / P55299 MtrA-dependent methionine synthase from Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg) (see paper)
METE_METTM / P55299 Methionine synthase; Homocysteine methyltransferase; Methylcobalamin:homocysteine methyltransferase; EC 2.1.1.- from Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum) (see paper)
    27% identity, 85% coverage of query (80.5 bits)

3ppcB / P82610 Crystal structure of the candida albicans methionine synthase by surface entropy reduction, tyrosine variant with zinc (see paper)
    24% identity, 90% coverage of query (78.6 bits)

4l6hA Crystal structure of the candida albicans methionine synthase in complex with methotrexate and homocysteine
    23% identity, 90% coverage of query (76.6 bits)

metE / Q8NRB3 cobalamin-independent methionine synthase (EC 2.1.1.14) from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see paper)
    25% identity, 98% coverage of query (76.3 bits)

met6 / P05694 cobalamin-independent methionine synthase (EC 2.1.1.14) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 2 papers)
METE_YEAST / P05694 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Cobalamin-independent methionine synthase; Delta-P8 protein; Methionine synthase, vitamin-B12 independent isozyme; EC 2.1.1.14 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
P05694 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase (EC 2.1.1.14) from Saccharomyces cerevisiae (see paper)
    21% identity, 98% coverage of query (76.3 bits)

4l6oA Crystal structure of the candida albicans methionine synthase in complex with glutamine
    24% identity, 78% coverage of query (74.3 bits)

Q6GYJ7 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase (EC 2.1.1.14) from Komagataella pastoris (see paper)
    24% identity, 98% coverage of query (73.6 bits)

3t0cA / Q8CWX6 Crystal structure of streptococcus mutans mete complexed with zinc (see paper)
    23% identity, 97% coverage of query (71.6 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory