Searching for up to 100 curated homologs for WP_001036146.1 NCBI__GCF_000382825.1:WP_001036146.1 (351 a.a.)

Found high-coverage hits (≥70%) to 25 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

6y9uA / A0A0H2UPF3 Crystal structure of pnra from s. Pneumoniae in complex with adenosine (see paper)
    94% identity, 89% coverage of query (565 bits)

6ya4A Crystal structure of pnra from s. Pneumoniae in complex with cytidine
    94% identity, 89% coverage of query (565 bits)

6ya3A Crystal structure of pnra from s. Pneumoniae in complex with guanosine
    94% identity, 89% coverage of query (565 bits)

6yabAAA Lipoprotein
    94% identity, 89% coverage of query (565 bits)

6yagA Crystal structure of pnra from s. Pneumoniae in complex with thymidine
    94% identity, 88% coverage of query (563 bits)

TC 3.A.1.2.12 / Q8DU36 RnsA, component of The (deoxy)ribonucleoside permease; probably takes up all deoxy- and ribonucleosides (cytidine, uridine, adenosine and toxic analogues, fluorocytidine and fluorouridine tested), but not ribose or nucleobases from Streptococcus mutans (see paper)
    71% identity, 100% coverage of query (443 bits)

TC 3.A.1.2.17 / D2BKA1 Basic membrane lipoprotein, component of General nucleoside uptake porter, NupABC/BmpA (transports all common nucleosides as well as 5-fluorocytidine, inosine, deoxyuridine and xanthosine) (Martinussen et al., 2010) (Most similar to 3.A.1.2.12). NupA is 506aas with two ABC (C) domains. NupB has 8 predicted TMSs, NupC has 9 or 10 predicted TMSs in a 4 + 1 (or 2) + 4 arrangement from Lactococcus lactis subsp. lactis (strain KF147) (see 2 papers)
    61% identity, 99% coverage of query (417 bits)

BMPA_LACLM / A2RK47 ABC transporter nucleoside-binding protein BmpA from Lactococcus lactis subsp. cremoris (strain MG1363) (see paper)
    60% identity, 99% coverage of query (410 bits)

NUPN_BACSU / O05252 ABC transporter guanosine-binding protein NupN from Bacillus subtilis (strain 168) (see 2 papers)
    46% identity, 99% coverage of query (296 bits)

TMPC_TREPA / P29724 Membrane lipoprotein TmpC; Membrane protein C; 35 kDa antigen; Lipoprotein TpN35; Purine nucleoside receptor A; PnrA from Treponema pallidum (strain Nichols) (see paper)
TC 3.A.1.2.10 / P29724 TmpC aka Membrane protein C aka 35 kDa antigen aka Lipoprotein TpN35, component of The purine nucleoside permease (probably transports guanosine, adenosine, 2'-deoxyguanosine, inosine and xanthosine with decreasing affinity in this order) from Treponema pallidum (see 2 papers)
    39% identity, 88% coverage of query (198 bits)

2fqwA / P29724 Pnra from treponema pallidum as purified from e. Coli (bound to inosine) (see paper)
    39% identity, 88% coverage of query (197 bits)

2fqyA Pnra from treponema pallidum complexed with adenosine.
    39% identity, 88% coverage of query (197 bits)

2fqxA Pnra from treponema pallidum complexed with guanosine
    39% identity, 88% coverage of query (197 bits)

7x0rB / A3DFS3 Crystal structure of substrate binding protein lbp complexed wtih guanosine from clostridium thermocellum (see paper)
    38% identity, 89% coverage of query (186 bits)

BMPD_BORBJ / E4S1L1 Basic membrane protein D; Probable substrate-binding protein BmpD from Borreliella burgdorferi (strain JD1) (Borrelia burgdorferi) (see paper)
BMPD_BORBU / P0CL55 Basic membrane protein D; Probable substrate-binding protein BmpD from Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31) (Borrelia burgdorferi) (see 2 papers)
    33% identity, 91% coverage of query (149 bits)

6shuA / P0CL55 Borrelia burgdorferi bmpd nucleoside binding protein bound to adenosine (see paper)
    33% identity, 90% coverage of query (149 bits)

BMPA_BORBU / Q45010 Basic membrane protein A; Immunodominant antigen P39; Probable substrate-binding protein BmpA from Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31) (Borrelia burgdorferi) (see paper)
    33% identity, 89% coverage of query (145 bits)

BMPA_BORAP / Q0SND0 Basic membrane protein A; Immunodominant antigen P39; Probable substrate-binding protein BmpA from Borreliella afzelii (strain PKo) (Borrelia afzelii) (see paper)
    31% identity, 99% coverage of query (144 bits)

BMPA_BORAF / P0C223 Basic membrane protein A; Immunodominant antigen P39; Probable substrate-binding protein BmpA from Borreliella afzelii (Borrelia afzelii) (see paper)
    33% identity, 89% coverage of query (143 bits)

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Build an alignment for WP_001036146.1 and 19 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

BMPA2_BORGP / O31357 Basic membrane protein A2; Immunodominant antigen P39; Probable substrate-binding protein BmpA2 from Borrelia garinii subsp. bavariensis (strain ATCC BAA-2496 / DSM 23469 / PBi) (Borreliella bavariensis) (see paper)
    29% identity, 99% coverage of query (139 bits)

BMPB_BORBU / Q45011 Basic membrane protein B; Probable substrate-binding protein BmpB from Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31) (Borrelia burgdorferi) (see paper)
    30% identity, 97% coverage of query (126 bits)

BMPC_BORBU / P0CL65 Basic membrane protein C; Probable substrate-binding protein BmpC from Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31) (Borrelia burgdorferi) (see paper)
    28% identity, 86% coverage of query (101 bits)

4pevA / Q9Y8P1 Crystal structure of abc transporter system solute-binding proteins from aeropyrum pernix k1
    26% identity, 87% coverage of query (85.5 bits)

3s99A / Q2YKI6 Crystal structure of a basic membrane lipoprotein from brucella melitensis, iodide soak
    24% identity, 76% coverage of query (52.8 bits)

p48 / CAB43718.1 P48 membrane lipoprotein from Mycoplasma agalactiae (see paper)
    23% identity, 85% coverage of query (48.9 bits)

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