Searching for up to 100 curated homologs for WP_002723117.1 NCBI__GCF_000015985.1:WP_002723117.1 (261 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
TC 3.A.1.2.24 / O50504 Probable ABC-transport system ATP binding protein, component of XylFGH downstream of characterized transcriptional regulator, ROK7B7 (Sco6008); XylF (Sco6009); XylG (Sco6010); XylH (Sco6011)) from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
46% identity, 92% coverage of query (221 bits)
XYLG_SULAC / P0DTT6 Xylose/arabinose import ATP-binding protein XylG; EC 7.5.2.13 from Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) (see paper)
45% identity, 90% coverage of query (216 bits)
TC 3.A.1.2.20 / G4FGN3 Monosaccharide-transporting ATPase, component of Glucose porter. Also bind xylose (Boucher and Noll 2011). Induced by glucose (Frock et al. 2012). Directly regulated by glucose-responsive regulator GluR from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
41% identity, 91% coverage of query (199 bits)
FRCA_RHIML / Q9F9B0 Fructose import ATP-binding protein FrcA; EC 7.5.2.- from Rhizobium meliloti (Ensifer meliloti) (Sinorhizobium meliloti) (see paper)
TC 3.A.1.2.7 / Q9F9B0 FrcA, component of Fructose/mannose/ribose porter from Rhizobium meliloti (Sinorhizobium meliloti) (see paper)
43% identity, 92% coverage of query (194 bits)
PGA1_262p00450 glucose transporter, ATPase component from Phaeobacter inhibens BS107
42% identity, 96% coverage of query (193 bits)
Q73KK2 ABC-type D-galactose transporter (EC 7.5.2.11) from Treponema denticola (see paper)
36% identity, 91% coverage of query (184 bits)
MGLA_SALTY / P23924 Galactose/methyl galactoside import ATP-binding protein MglA; EC 7.5.2.11 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 2 papers)
37% identity, 93% coverage of query (179 bits)
RbsA / b3749 ribose ABC transporter ATP binding subunit from Escherichia coli K-12 substr. MG1655 (see 5 papers)
RbsA / P04983 ribose ABC transporter ATP binding subunit from Escherichia coli (strain K12) (see 2 papers)
RBSA_ECOLI / P04983 Ribose import ATP-binding protein RbsA; EC 7.5.2.7 from Escherichia coli (strain K12) (see 3 papers)
TC 3.A.1.2.1 / P04983 RbsA aka B3749, component of Ribose porter from Escherichia coli (see 6 papers)
rbsA / GB|AAC76772.1 ribose transport, ATP-binding protein RbsA; EC 3.6.3.17 from Escherichia coli K12 (see 7 papers)
38% identity, 91% coverage of query (177 bits)
MglA / b2149 D-galactose/methyl-galactoside ABC transporter ATP binding subunit from Escherichia coli K-12 substr. MG1655 (see 6 papers)
MglA / P0AAG8 D-galactose/methyl-galactoside ABC transporter ATP binding subunit from Escherichia coli (strain K12) (see 4 papers)
TC 3.A.1.2.3 / P0AAG8 Galactose/methyl galactoside import ATP-binding protein MglA aka B2149, component of Galactose/glucose (methyl galactoside) porter from Escherichia coli (see 7 papers)
37% identity, 94% coverage of query (176 bits)
TC 3.A.1.2.19 / Q9X051 Ribose import ATP-binding protein RbsA 2, component of D-ribose porter (Nanavati et al., 2006). Induced by ribose from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
40% identity, 91% coverage of query (175 bits)
TC 3.A.1.2.16 / Q1M4Q7 ATP binding component of erythritol ABC transporter, component of The erythritol uptake permease, EryEFG (Yost et al., 2006) (probably orthologous to 3.A.1.2.11) from Rhizobium leguminosarum bv. viciae (strain 3841) (see paper)
36% identity, 96% coverage of query (174 bits)
PGA1_c07320 Inositol transport system ATP-binding protein from Phaeobacter inhibens BS107
41% identity, 92% coverage of query (174 bits)
HSERO_RS05250 ABC transporter for L-fucose, ATPase component from Herbaspirillum seropedicae SmR1
36% identity, 91% coverage of query (172 bits)
HSERO_RS03640 D-mannose ABC transporter, ATPase component from Herbaspirillum seropedicae SmR1
36% identity, 93% coverage of query (169 bits)
eryE / Q2YIY4 putative erythritol ABC transporter ATP-binding protein from Brucella abortus (strain 2308) (see 3 papers)
39% identity, 91% coverage of query (169 bits)
TC 3.A.1.2.13 / A6VKS8 RbsA, component of The probable autoinducer-2 (AI-2;, a furanosyl borate diester: 3aS,6S,6aR)-2,2,6,6a-tetrahydroxy-3a-methyltetrahydrofuro[3,2-d][1,3,2]dioxaborolan-2-uide) uptake porter (Shao et al., 2007) (50-70% identical to RbsABC of E. coli; TC# 3.A.1.2.1) from Actinobacillus succinogenes (strain ATCC 55618 / 130Z)
36% identity, 91% coverage of query (169 bits)
PS417_11890 Inositol transport system ATP-binding protein from Pseudomonas simiae WCS417
38% identity, 91% coverage of query (165 bits)
AO353_21385 m-Inositol ABC transporter, ATPase component (itaA) from Pseudomonas fluorescens FW300-N2E3
37% identity, 94% coverage of query (165 bits)
AlsA / b4087 D-allose ABC transporter ATP binding subunit (EC 7.5.2.8) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
AlsA / P32721 D-allose ABC transporter ATP binding subunit (EC 7.5.2.8) from Escherichia coli (strain K12) (see 2 papers)
ALSA_ECOLI / P32721 D-allose import ATP-binding protein AlsA; EC 7.5.2.8 from Escherichia coli (strain K12) (see paper)
TC 3.A.1.2.6 / P32721 AlsA aka B4087, component of D-allose porter from Escherichia coli (see 5 papers)
alsA / GB|AAC77048.1 D-allose import ATP-binding protein AlsA; EC 3.6.3.17 from Escherichia coli K12 (see 5 papers)
35% identity, 92% coverage of query (162 bits)
RR42_RS03360 fructose ABC transporter, ATPase component (FrcA) from Cupriavidus basilensis FW507-4G11
38% identity, 92% coverage of query (160 bits)
Shewana3_2074 L-arabinose ABC transporter, ATPase component AraV from Shewanella sp. ANA-3
37% identity, 91% coverage of query (160 bits)
FRUK_BIFLO / Q8G847 Fructose import ATP-binding protein FruK; EC 7.5.2.- from Bifidobacterium longum (strain NCC 2705) (see paper)
36% identity, 91% coverage of query (158 bits)
YtfR / b4485 galactofuranose ABC transporter putative ATP binding subunit (EC 7.5.2.9) from Escherichia coli K-12 substr. MG1655 (see paper)
ytfR / Q6BEX0 galactofuranose ABC transporter putative ATP binding subunit (EC 7.5.2.9) from Escherichia coli (strain K12) (see paper)
36% identity, 91% coverage of query (154 bits)
Q6VMN4 ABC-type D-xylose transporter (EC 7.5.2.10) from Thermoanaerobacter ethanolicus (see paper)
33% identity, 91% coverage of query (151 bits)
TC 3.A.1.2.11 / Q92WK2 EryE aka RB0337, component of The erythritol permease, EryEFG (Geddes et al., 2010) (probably orthologous to 3.A.1.2.16) from Rhizobium meliloti (Sinorhizobium meliloti) (see paper)
36% identity, 91% coverage of query (151 bits)
Pf1N1B4_6034 D-ribose ABC transporter, ATPase component RbsA from Pseudomonas fluorescens FW300-N1B4
37% identity, 91% coverage of query (148 bits)
TC 3.A.1.2.9 / Q7BSH4 RhaT, component of Rhamnose porter (Richardson et al., 2004) (Transport activity is dependent on rhamnokinase (RhaK; AAQ92412) activity (Richardson and Oresnik, 2007) This could be an example of group translocation!) from Rhizobium leguminosarum (biovar trifolii)
34% identity, 92% coverage of query (148 bits)
HSERO_RS11485 D-ribose ABC transporter, ATPase component RbsA from Herbaspirillum seropedicae SmR1
37% identity, 92% coverage of query (147 bits)
TC 3.A.1.2.26 / A6LW11 Xylose import ATP-binding protein XylG, component of Xylose transporter, XylFGH (XylF (R), 359 aas; XylG (C), 525 aas; XylH (M), 389 aas from Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052)
32% identity, 91% coverage of query (144 bits)
TC 3.A.1.2.21 / B8H229 Inositol transport ATP-binding protein IatA, component of The myoinositol (high affinity)/ D-ribose (low affinity) transporter IatP/IatA/IbpA. The structure of IbpA with myoinositol bound has been solved from Caulobacter crescentus (strain NA1000 / CB15N)
35% identity, 91% coverage of query (140 bits)
H281DRAFT_01113 deoxynucleoside transporter, ATPase component from Paraburkholderia bryophila 376MFSha3.1
34% identity, 96% coverage of query (140 bits)
NUPO_BACSU / O05253 Guanosine import ATP-binding protein NupO; EC 7.6.2.- from Bacillus subtilis (strain 168) (see paper)
32% identity, 91% coverage of query (139 bits)
PS417_18400 D-ribose ABC transporter, ATPase component RbsA from Pseudomonas simiae WCS417
35% identity, 92% coverage of query (139 bits)
YphE / b2547 putative ABC transporter ATP-binding protein YphE from Escherichia coli K-12 substr. MG1655 (see 4 papers)
34% identity, 92% coverage of query (136 bits)
PS417_12065 xylitol ABC transporter, ATPase component from Pseudomonas simiae WCS417
35% identity, 91% coverage of query (136 bits)
XylG / b3567 xylose ABC transporter ATP binding subunit (EC 7.5.2.13; EC 7.5.2.10) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
XylG / P37388 xylose ABC transporter ATP binding subunit (EC 7.5.2.13) from Escherichia coli (strain K12) (see 2 papers)
XYLG_ECOLI / P37388 Xylose import ATP-binding protein XylG; EC 7.5.2.10 from Escherichia coli (strain K12) (see paper)
TC 3.A.1.2.4 / P37388 XylG aka B3567, component of Xylose porter from Escherichia coli (see 4 papers)
xylG / GB|AAC76591.1 D-xylose ABC transporter, ATP-binding protein; EC 3.6.3.17 from Escherichia coli K12 (see 2 papers)
31% identity, 91% coverage of query (136 bits)
NUPA_LACLM / A2RKA7 Nucleoside import ATP-binding protein NupA; EC 7.6.2.- from Lactococcus lactis subsp. cremoris (strain MG1363) (see paper)
TC 3.A.1.2.17 / A2RKA7 Purine/cytidine ABC transporter ATP-binding protein, component of General nucleoside uptake porter, NupABC/BmpA (transports all common nucleosides as well as 5-fluorocytidine, inosine, deoxyuridine and xanthosine) (Martinussen et al., 2010) (Most similar to 3.A.1.2.12). NupA is 506aas with two ABC (C) domains. NupB has 8 predicted TMSs, NupC has 9 or 10 predicted TMSs in a 4 + 1 (or 2) + 4 arrangement from Lactococcus lactis subsp. cremoris (strain MG1363) (see paper)
32% identity, 93% coverage of query (136 bits)
Pf6N2E2_5969 ABC transporter for D-galactose/L-arabinose, ATPase component from Pseudomonas fluorescens FW300-N2E2
34% identity, 90% coverage of query (132 bits)
AraG / b1900 arabinose ABC transporter ATP binding subunit (EC 7.5.2.13; EC 7.5.2.12) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
AraG / P0AAF3 arabinose ABC transporter ATP binding subunit (EC 7.5.2.13) from Escherichia coli (strain K12) (see paper)
ARAG_ECOLI / P0AAF3 Arabinose import ATP-binding protein AraG; EC 7.5.2.12 from Escherichia coli (strain K12) (see 2 papers)
TC 3.A.1.2.2 / P0AAF3 Arabinose import ATP-binding protein AraG aka B1900, component of Arabinose porter from Escherichia coli (see 6 papers)
araG / RF|NP_416413.1 L-arabinose ABC transporter, ATP-binding protein AraG; EC 3.6.3.17 from Escherichia coli K12 (see paper)
33% identity, 84% coverage of query (132 bits)
TC 3.A.1.2.22 / Q8G3R0 ATP binding protein of ABC transporter for pentoses, component of ABC sugar transporter that plays a role in the probiotic benefits through acetate production from Bifidobacterium longum (strain NCC 2705)
33% identity, 93% coverage of query (132 bits)
TC 3.A.1.2.5 / O05176 GguA aka ATU2347 aka AGR_C_4264, component of Multiple sugar (arabinose, xylose, galactose, glucose, fucose) putative porter from Agrobacterium radiobacter (see paper)
33% identity, 84% coverage of query (130 bits)
BPHYT_RS16930 D-galactose ABC transporter, ATPase component from Burkholderia phytofirmans PsJN
35% identity, 88% coverage of query (128 bits)
BPHYT_RS24015 L-histidine ABC transporter, ATPase component from Burkholderia phytofirmans PsJN
35% identity, 84% coverage of query (128 bits)
4u00A / Q5SJ55 Crystal structure of ttha1159 in complex with adp (see paper)
37% identity, 84% coverage of query (120 bits)
4ymuJ / Q8RCC2 Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
34% identity, 84% coverage of query (115 bits)
MetN / b0199 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
MetN / P30750 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli (strain K12) (see 3 papers)
METN_ECOLI / P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 7 papers)
P30750 ABC-type methionine transporter (subunit 2/2) (EC 7.4.2.11) from Escherichia coli (see 3 papers)
TC 3.A.1.24.1 / P30750 MetN, D-methionine transport ATP-binding protein, component of The L- and D-methionine porter (also transports formyl-L-methionine and other methionine derivatives) (Zhang et al., 2003). The 3.7A structure of MetNI has been solved. An allosteric regulatory mechanism operates at the level of transport activity, so increased intracellular levels of the transported ligand stabilize an inward-facing, ATPase-inactive state of MetNI to inhibit further ligand translocation into the cell from Escherichia coli (see 5 papers)
34% identity, 86% coverage of query (114 bits)
6cvlD / P30750 Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
34% identity, 86% coverage of query (112 bits)
3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form
34% identity, 86% coverage of query (112 bits)
3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form
34% identity, 86% coverage of query (112 bits)
3c4jA Abc protein artp in complex with atp-gamma-s
33% identity, 84% coverage of query (110 bits)
3c41J / D0VWX4 Abc protein artp in complex with amp-pnp/mg2+
33% identity, 84% coverage of query (110 bits)
2olkA Abc protein artp in complex with adp-beta-s
33% identity, 84% coverage of query (110 bits)
2oljA Abc protein artp in complex with adp/mg2+
33% identity, 84% coverage of query (110 bits)
1g6hA / Q58663 Crystal structure of the adp conformation of mj1267, an atp-binding cassette of an abc transporter (see paper)
31% identity, 84% coverage of query (108 bits)
PotA / b1126 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11; EC 7.6.2.16) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
PotA / P69874 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11) from Escherichia coli (strain K12) (see 5 papers)
POTA_ECOLI / P69874 Spermidine/putrescine import ATP-binding protein PotA; EC 7.6.2.11 from Escherichia coli (strain K12) (see 6 papers)
TC 3.A.1.11.1 / P69874 Spermidine/putrescine import ATP-binding protein PotA aka B1126, component of Polyamine (putrescine/spermidine) uptake porter from Escherichia coli (see 9 papers)
potA / MB|P69874 spermidine/putrescine ABC transporter, ATP-binding protein PotA; EC 3.6.3.31 from Escherichia coli K12 (see 10 papers)
33% identity, 85% coverage of query (108 bits)
1g9xB Characterization of the twinning structure of mj1267, an atp-binding cassette of an abc transporter
31% identity, 84% coverage of query (107 bits)
2d62A / O57933 Crystal structure of multiple sugar binding transport atp- binding protein
35% identity, 82% coverage of query (106 bits)
TGD3_ARATH / Q9AT00 Protein TRIGALACTOSYLDIACYLGLYCEROL 3, chloroplastic; ABC transporter I family member 13; ABC transporter ABCI.13; AtABCI13; Non-intrinsic ABC protein 11; AtNAP11 from Arabidopsis thaliana (Mouse-ear cress) (see 6 papers)
TC 3.A.1.27.2 / Q9AT00 Tdg3, component of The chloroplast lipid (trigalactosyl diacyl glycerol (TDG)) transporter, Tdg1,2,3 (Lu et al., 2007). Lipids such as mono- and digalactolipids are synthesized in the endoplasmic reticulum (ER) of plant cells and transferred to the thylakoid membranes of chloroplasts. Mutations in an outer chloroplastic envelope protein with 350 aas and 7 putative TMSs in the last 250 residues may catalyze translocation as part of a lipid transfer complex from Arabidopsis thaliana (Mouse-ear cress) (see 7 papers)
32% identity, 84% coverage of query (105 bits)
8wm7D / Q8YZ75 Cryo-em structure of cyanobacterial nitrate/nitrite transporter nrtbcd in complex with signalling protein pii (see paper)
33% identity, 78% coverage of query (102 bits)
8w9mD Cryo-em structure of the cyanobacterial nitrate transporter nrtbcd in complex with atp
32% identity, 78% coverage of query (101 bits)
1oxvD Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus
32% identity, 82% coverage of query (99.4 bits)
1oxvA Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus
32% identity, 82% coverage of query (99.4 bits)
GLCV_SACS2 / Q97UY8 Glucose import ATP-binding protein GlcV; EC 7.5.2.- from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see 3 papers)
TC 3.A.1.1.13 / Q97UY8 GlcV, component of Glucose, mannose, galactose porter from Sulfolobus solfataricus (see 3 papers)
1oxuA / Q97UY8 Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus (see paper)
32% identity, 82% coverage of query (99.4 bits)
2pclA / O66646 Crystal structure of abc transporter with complex (aq_297) from aquifex aeolicus vf5
31% identity, 85% coverage of query (98.6 bits)
1vciA / O57758 Crystal structure of the atp-binding cassette of multisugar transporter from pyrococcus horikoshii ot3 complexed with atp (see paper)
34% identity, 82% coverage of query (98.6 bits)
1g291 / Q9YGA6 Malk (see paper)
33% identity, 81% coverage of query (98.2 bits)
2pmkA Crystal structures of an isolated abc-atpase in complex with tnp-adp
32% identity, 84% coverage of query (96.7 bits)
2ff7A The abc-atpase of the abc-transporter hlyb in the adp bound state
32% identity, 84% coverage of query (96.7 bits)
Q8TTZ3 ABC-type molybdate transporter (EC 7.3.2.5) from Methanosarcina acetivorans (see paper)
3d31A / Q8TTZ3 Modbc from methanosarcina acetivorans (see paper)
32% identity, 82% coverage of query (96.3 bits)
ABC1_MYCTU / O65934 ABC transporter ATP-binding/permease protein Rv1747; EC 7.-.-.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 4 papers)
33% identity, 83% coverage of query (95.9 bits)
7sgrE / Q8FDZ8 Structure of hemolysin a secretion system hlyb/d complex (see paper)
32% identity, 84% coverage of query (95.9 bits)
FhuC / b0151 iron(III) hydroxamate ABC transporter ATP binding subunit (EC 7.2.2.16) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
FhuC / P07821 iron(III) hydroxamate ABC transporter ATP binding subunit (EC 7.2.2.16) from Escherichia coli (strain K12) (see paper)
FHUC_ECOLI / P07821 Iron(3+)-hydroxamate import ATP-binding protein FhuC; Ferric hydroxamate uptake protein C; Ferrichrome transport ATP-binding protein FhuC; Iron(III)-hydroxamate import ATP-binding protein FhuC; EC 7.2.2.16 from Escherichia coli (strain K12) (see 3 papers)
TC 3.A.1.14.3 / P07821 FhuC aka B0151, component of Iron (Fe3+)-hydroxamate (ferrichrome, coprogen, aerobactin, ferrioxamine B, schizakinen, rhodotorulic acid) porter, albomycin porter from Escherichia coli (see 6 papers)
fhuC / GB|BAB96727.2 ferrichrome transport ATP-binding protein FhuC; EC 3.6.3.34 from Escherichia coli K12 (see 8 papers)
32% identity, 90% coverage of query (95.5 bits)
3b5jA Crystal structures of the s504a mutant of an isolated abc-atpase in complex with tnp-adp
32% identity, 84% coverage of query (95.5 bits)
sugC / P9WQI3 ABC-type trehalose transporter ATP-binding protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
SUGC_MYCTU / P9WQI3 Trehalose import ATP-binding protein SugC; MtbSugC; Nucleotide-binding domain of SugABC transporter; NBD of SugABC transporter; SugABC transporter ATPase SugC; EC 7.5.2.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
TC 3.A.1.1.31 / O50454 PROBABLE SUGAR-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER SUGC, component of The trehalose-recycling ABC transporter, LpqY-SugA-SugB-SugC (essential for virulence) from Mycobacterium tuberculosis (see 2 papers)
33% identity, 81% coverage of query (95.1 bits)
7z18I E. Coli c-p lyase bound to a phnk abc dimer and atp
31% identity, 88% coverage of query (94.7 bits)
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8f5bA / P78363 Human abca4 structure in complex with amp-pnp
29% identity, 88% coverage of query (94.7 bits)
7lkpA Structure of atp-free human abca4
29% identity, 88% coverage of query (94.7 bits)
7e7oA / P78363 Cryo-em structure of human abca4 in nrpe-bound state (see paper)
29% identity, 88% coverage of query (94.7 bits)
ABCA4_HUMAN / P78363 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM proteinv; RmP; Retinal-specific ATP-binding cassette transporter; Stargardt disease protein; EC 7.6.2.1 from Homo sapiens (Human) (see 38 papers)
TC 3.A.1.211.2 / P78363 The retinal-specific ABC transporter (RIM protein, ABCR or ABCA4) (Stargardt's disease protein, involved in retinal/macular degeneration) in the rod outer segment. Changes in the oligomeric state of the nucleotide binding domains of ABCR are coupled to ATP hydrolysis and might represent a signal for the TMDs of ABCR to export the bound substrate (Biswas-Fiss 2006). The ABCA4 porter flips N-retinylidene-phosphatidylethanolamine, a product generated from the photobleaching of rhodopsin, from the lumen to the cytoplasmic side of disc membranes following the photobleaching of rhodopsin, insuring that retinoids do not accumulate in disc membranes (Molday, 2007; Molday et al. 2009; Tsybovsky et al. 2013). It also transports several vitamin A derivatives (Sun, 2011) and phosphatidylethanolamine in the same direction. Mutations, known to cause Stargardt disease, decrease N-retinylidene-phosphatidylethanolamine and phosphatidylethanolamine transport activities (Quazi et al. 2012). It functions as an inwardly directed retinoid flippase in the visual cycle from Homo sapiens (Human) (see 28 papers)
29% identity, 88% coverage of query (94.7 bits)
7z15I / P16678 E. Coli c-p lyase bound to a phnk/phnl dual abc dimer and adp + pi (see paper)
31% identity, 88% coverage of query (94.7 bits)
8dckA Structure of hemolysin a secretion system hlyb/d complex, atp-bound
32% identity, 84% coverage of query (94.4 bits)
7z16I E. Coli c-p lyase bound to phnk/phnl dual abc dimer with amppnp and phnk e171q mutation
31% identity, 88% coverage of query (93.6 bits)
7lkzA Structure of atp-bound human abca4
29% identity, 88% coverage of query (93.6 bits)
MDR3_HUMAN / P21439 Phosphatidylcholine translocator ABCB4; ATP-binding cassette sub-family B member 4; Multidrug resistance protein 3; P-glycoprotein 3; EC 7.6.2.1 from Homo sapiens (Human) (see 28 papers)
TC 3.A.1.201.3 / P21439 Short chain fatty acid phosphatidylcholine translocase (phospholipid flippase), MDR3; AbcB4; Pgy3 from Homo sapiens (Human) (see 15 papers)
32% identity, 88% coverage of query (92.4 bits)
5x40A / O68106 Structure of a cbio dimer bound with amppcp (see paper)
34% identity, 85% coverage of query (92.4 bits)
6xjiC / X5EJW5 Pmtcd abc exporter at c1 symmetry (see paper)
27% identity, 87% coverage of query (92.4 bits)
1xefA Crystal structure of the atp/mg2+ bound composite dimer of hlyb-nbd
31% identity, 84% coverage of query (92.0 bits)
7e7qA / P78363 Cryo-em structure of human abca4 in atp-bound state (see paper)
30% identity, 82% coverage of query (92.0 bits)
6s7pA Nucleotide bound abcb4
32% identity, 88% coverage of query (90.9 bits)
7niwA / P21439 Nanodisc reconstituted human abcb4 in complex with 4b1-fab (posaconazole-bound, inward-open conformation) (see paper)
32% identity, 88% coverage of query (90.9 bits)
6xjhC Pmtcd abc exporter without the basket domain at c2 symmetry
27% identity, 84% coverage of query (90.5 bits)
P0AAH0 Phosphate import ATP-binding protein PstB; ABC phosphate transporter; Phosphate-transporting ATPase; EC 7.3.2.1 from Escherichia coli (strain K12)
32% identity, 84% coverage of query (90.5 bits)
1b0uA / P02915 Atp-binding subunit of the histidine permease from salmonella typhimurium (see paper)
33% identity, 82% coverage of query (90.1 bits)
HISP_SALTY / P02915 Histidine/lysine/arginine/ornithine transport ATP-binding protein HisP; EC 7.4.2.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 4 papers)
TC 3.A.1.3.1 / P02915 HisP aka STM2351, component of Histidine/arginine/lysine/ornithine porter (Heuveling et al. 2014). In contrast to some homologous homodimeric systems, the heterodimeric histidine transporter of Salmonella enterica Typhimurium from Salmonella typhimurium (see 3 papers)
RF|NP_461293.1 histidine transport atp-binding protein hisp from Salmonella enterica subsp. enterica serovar Typhimurium (see 4 papers)
33% identity, 82% coverage of query (90.1 bits)
ABCA4_BOVIN / F1MWM0 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM protein; RmP; Retinal-specific ATP-binding cassette transporter; EC 7.6.2.1 from Bos taurus (Bovine) (see 11 papers)
29% identity, 88% coverage of query (89.4 bits)
1ji0A / Q9X0M3 Crystal structure analysis of the abc transporter from thermotoga maritima
27% identity, 84% coverage of query (88.6 bits)
MALK_SALTY / P19566 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
31% identity, 82% coverage of query (88.2 bits)
3puyA Crystal structure of an outward-facing mbp-maltose transporter complex bound to amp-pnp after crystal soaking of the pretranslocation state
31% identity, 82% coverage of query (88.2 bits)
3puxA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-bef3
31% identity, 82% coverage of query (88.2 bits)
3puwA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-alf4
31% identity, 82% coverage of query (88.2 bits)
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Lawrence Berkeley National Laboratory