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Searching for up to 100 curated homologs for WP_004042115.1 NCBI__GCF_000337315.1:WP_004042115.1 (360 a.a.)

Found high-coverage hits (≥70%) to 47 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

trpD / BAC65124.1 anthranilate phosphoribosyltransferase from Burkholderia multivorans (see paper)
    30% identity, 89% coverage of query (115 bits)

Build an alignment

Build an alignment for WP_004042115.1 and 1 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

BT0530 anthranilate phosphoribosyltransferase (EC 2.4.2.18) from Bacteroides thetaiotaomicron VPI-5482
    26% identity, 91% coverage of query (100 bits)

Q9YGB4 anthranilate phosphoribosyltransferase (EC 2.4.2.18) from Thermococcus kodakarensis (see paper)
5nofA / Q9YGB4 Anthranilate phosphoribosyltransferase from thermococcus kodakaraensis (see paper)
    30% identity, 85% coverage of query (100 bits)

trpD / AAB39009.1 anthranilate phosphoribosyltransferase from Bradyrhizobium japonicum (see paper)
    24% identity, 95% coverage of query (95.1 bits)

TRPD_SACS2 / P50384 Anthranilate phosphoribosyltransferase; EC 2.4.2.18 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see 4 papers)
P50384 anthranilate phosphoribosyltransferase (EC 2.4.2.18) from Saccharolobus solfataricus (see 7 papers)
2gvqD / P50384 Anthranilate phosphoribosyl-transferase (trpd) from s. Solfataricus in complex with anthranilate (see paper)
    25% identity, 88% coverage of query (87.0 bits)

1zxyA Anthranilate phosphoribosyltransferase from sulfolobus solfataricus in complex with prpp and magnesium
    25% identity, 88% coverage of query (87.0 bits)

P00500 anthranilate synthase (subunit 1/2) (EC 4.1.3.27) from Serratia marcescens (see paper)
    24% identity, 92% coverage of query (85.5 bits)

trpD / AAD09118.1 anthranilate phosphoribosyltransferase from Rhodobacter sphaeroides (see paper)
    28% identity, 90% coverage of query (84.7 bits)

1gxbA Anthranilate phosphoribosyltransferase in complex with pyrophosphate and magnesium
    25% identity, 88% coverage of query (83.6 bits)

TRPD_XANCP / Q8PD71 Anthranilate phosphoribosyltransferase; EC 2.4.2.18 from Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
    28% identity, 88% coverage of query (81.3 bits)

5bo3B Bianthranilate-like inhibitor with 5 atom "line" and phosphonate "hook" fishing for hydrogen bond donors in mycobacterium tuberculosis anthranilate phosphoribosyltransferase (anprt; trpd)
    31% identity, 96% coverage of query (81.3 bits)

4zojA Methylsulfanyl-containing inhibitor bound in the active site of mycobacterium tuberculosis anthranilate phosphoribosyltransferase (anprt; trpd)
    31% identity, 96% coverage of query (80.1 bits)

CA265_RS05010 anthranilate phosphoribosyltransferase (EC 2.4.2.18) from Pedobacter sp. GW460-11-11-14-LB5
    24% identity, 91% coverage of query (79.3 bits)

3gbrA Anthranilate phosphoribosyl-transferase (trpd) double mutant d83g f149s from s. Solfataricus
    25% identity, 88% coverage of query (79.3 bits)

TRPD2_NOSS1 / Q8YXQ9 Anthranilate phosphoribosyltransferase 2; EC 2.4.2.18 from Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
    27% identity, 92% coverage of query (78.6 bits)

4owsA Anthranilate phosphoribosyl transferase from mycobacterium tuberculosis in complex with 4-methylanthranilate, prpp and magnesium
    29% identity, 96% coverage of query (78.6 bits)

4yi7A / P00500 Anthranilate bound at active site of anthranilate phosphoribosyl transferase from acinetobacter (anprt; trpd)
    23% identity, 92% coverage of query (78.2 bits)

4n93A Alternative substrates of mycobacterium tuberculosis anthranilate phosphoribosyl transferase
    31% identity, 96% coverage of query (78.2 bits)

4zokA Methylsulfonyl-containing inhibitor bound in the substrate capture site of mycobacterium tuberculosis anthranilate phosphoribosyltransferase (anprt; trpd)
    31% identity, 96% coverage of query (77.8 bits)

4zofA Lobenzarit-like inhibitor bound in the active site of mycobacterium tuberculosis anthranilate phosphoribosyltransferase (anprt; trpd)
    31% identity, 96% coverage of query (77.8 bits)

5c1rA Stereoisomer of prpp bound in the active site of mycobacterium tuberculosis anthranilate phosphoribosyl (anprt; trpd)
    31% identity, 96% coverage of query (77.8 bits)

4n5vA Alternative substrates of mycobacterium tuberculosis anthranilate phosphoribosyl transferase
    31% identity, 96% coverage of query (77.8 bits)

3r88B Anthranilate phosphoribosyltransferase (trpd) from mycobacterium tuberculosis (complex with inhibitor acs145)
    31% identity, 96% coverage of query (77.8 bits)

4ownA Anthranilate phosphoribosyl transferase from mycobacterium tuberculosis in complex with 5-fluoroanthranilate, prpp and magnesium
    31% identity, 96% coverage of query (77.4 bits)

5c7sA Prpp complexed with two mn2+ in the active site of mycobacterium tuberculosis anthranilate phosphoribosyltransferase (anprt; trpd)
    31% identity, 96% coverage of query (77.4 bits)

4m0rA Trianthranilate-like analogue bound to anthranilate phosphoribosyltransferase (anprt; trpd).
    29% identity, 96% coverage of query (77.4 bits)

TRPD_MYCTU / P9WFX5 Anthranilate phosphoribosyltransferase; EC 2.4.2.18 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
A5U4M0 anthranilate phosphoribosyltransferase (EC 2.4.2.18) from Mycobacterium tuberculosis (see paper)
P9WFX5 anthranilate phosphoribosyltransferase (EC 2.4.2.18) from Mycobacterium tuberculosis (see 3 papers)
    30% identity, 96% coverage of query (77.0 bits)

4owmA Anthranilate phosphoribosyl transferase from mycobacterium tuberculosis in complex with 3-fluoroanthranilate, prpp and magnesium
    30% identity, 96% coverage of query (77.0 bits)

4gkmA Bianthranilate-like analogue bound in the outer site of anthranilate phosphoribosyltransferase (anprt; trpd)
    30% identity, 96% coverage of query (77.0 bits)

3r6cA Anthranilate phosphoribosyltransferase (trpd) from mycobacterium tuberculosis (complex with inhibitor acs179)
    30% identity, 96% coverage of query (77.0 bits)

3qsaA Anthranilate phosphoribosyltransferase (trpd) from mycobacterium tuberculosis (complex with inhibitor tamu-a7)
    30% identity, 96% coverage of query (77.0 bits)

3qs8A Anthranilate phosphoribosyltransferase (trpd) from mycobacterium tuberculosis (complex with inhibitor acs174)
    30% identity, 96% coverage of query (77.0 bits)

3qqsA Anthranilate phosphoribosyltransferase (trpd) from mycobacterium tuberculosis (complex with inhibitor acs172)
    30% identity, 96% coverage of query (77.0 bits)

1zvwA The crystal structure of trpd (rv2192c) from mycobacterium tuberculosis in complex with prpp and magnesium
    30% identity, 96% coverage of query (77.0 bits)

4giuA Bianthranilate-like analogue bound in inner site of anthranilate phosphoribosyltransferase (anprt; trpd).
    30% identity, 96% coverage of query (77.0 bits)

3uu1A Anthranilate phosphoribosyltransferase (trpd) from mycobacterium tuberculosis (complex with inhibitor acs142)
    31% identity, 96% coverage of query (77.0 bits)

4owuA Anthranilate phosphoribosyl transferase from mycobacterium tuberculosis in complex with 5-methylanthranilate, prpp and magnesium
    30% identity, 96% coverage of query (77.0 bits)

4owqA Anthranilate phosphoribosyl transferase from mycobacterium tuberculosis in complex with 3-methylanthranilate, prpp and magnesium
    30% identity, 96% coverage of query (77.0 bits)

5bo2A Bianthranilate-like inhibitor with 4-atom "line" and phosphonate "hook" fishing for hydrogen bond donors in mycobacterium tuberculosis anthranilate phosphoribosyltransferase (anprt; trpd)
    31% identity, 96% coverage of query (77.0 bits)

5c2lA / P9WFX5 Magnesium soaked into the active site of mycobacterium tuberculosis anthranilate phosphoribosyltransferase (anprt; trpd)
    30% identity, 96% coverage of query (76.6 bits)

4owoA Anthranilate phosphoribosyl transferase from mycobacterium tuberculosis in complex with 6-fluoroanthranilate, prpp and magnesium
    30% identity, 96% coverage of query (76.6 bits)

4owvA Anthranilate phosphoribosyl transferase from mycobacterium tuberculosis in complex with anthranilate
    30% identity, 96% coverage of query (75.9 bits)

5bo3A Bianthranilate-like inhibitor with 5 atom "line" and phosphonate "hook" fishing for hydrogen bond donors in mycobacterium tuberculosis anthranilate phosphoribosyltransferase (anprt; trpd)
    31% identity, 96% coverage of query (75.5 bits)

1kgzB / Q8VP84 Crystal structure analysis of the anthranilate phosphoribosyltransferase from erwinia carotovora (current name, pectobacterium carotovorum) (see paper)
    23% identity, 90% coverage of query (74.7 bits)

5bneA Bianthranilate-like inhibitor with 6 atom "line" and phosphonate "hook" fishing for hydrogen bond donors in mycobacterium tuberculosis anthranilate phosphoribosyltransferase (anprt; trpd)
    31% identity, 96% coverage of query (74.3 bits)

8bftA / P30177 The e. Coli trpd2 protein ybib in complex with a c-terminal peptide from obge (see paper)
    22% identity, 90% coverage of query (57.8 bits)

YbiB / b0800 nonspecific DNA-binding protein YbiB from Escherichia coli K-12 substr. MG1655 (see 2 papers)
    22% identity, 90% coverage of query (57.8 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory