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Searching for up to 100 curated homologs for WP_004119317.1 NCBI__GCF_000359745.1:WP_004119317.1 (381 a.a.)

Found high-coverage hits (≥70%) to 55 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

5f7qE / Q8YAF1 Rok repressor lmo0178 from listeria monocytogenes bound to operator (see paper)
    31% identity, 99% coverage of query (216 bits)

Build an alignment

Build an alignment for WP_004119317.1 and 1 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

XylR / P16557 Transcription factor XylR (repressor) from Bacillus subtilis 168 (see 2 papers)
    25% identity, 97% coverage of query (177 bits)

XylR / VIMSS822024 XylR regulator of Xylose utilization, effector Xylose (repressor) from Bacillus clausii KSM-K16
    28% identity, 97% coverage of query (171 bits)

5f7rA Rok repressor lmo0178 from listeria monocytogenes bound to inducer
    31% identity, 78% coverage of query (168 bits)

XylR / VIMSS6926953 XylR regulator of Xylose utilization, effector Xylose (repressor) from Paenibacillus sp. JDR-2
    29% identity, 98% coverage of query (166 bits)

XylR / VIMSS854293 XylR regulator of Xylose utilization, effector Xylose (repressor) from Geobacillus kaustophilus HTA426
    30% identity, 92% coverage of query (162 bits)

NagC / b0676 DNA-binding transcriptional dual regulator NagC from Escherichia coli K-12 substr. MG1655 (see 14 papers)
NAGC_ECOLI / P0AF20 N-acetylglucosamine repressor from Escherichia coli (strain K12) (see paper)
NagC / P0AF20 Transcription factor NagC (activator/repressor) from Escherichia coli K12 MG1655 (see 3 papers)
nagC / SP|P0AF20 N-acetylglucosamine repressor from Escherichia coli K12 (see paper)
    29% identity, 88% coverage of query (159 bits)

XylR / VIMSS38296 XylR regulator of Xylose utilization, effector Xylose (repressor) from Bacillus subtilis subsp. subtilis str. 168
    25% identity, 91% coverage of query (159 bits)

XylR / VIMSS279908 XylR regulator of Xylose utilization, effector Xylose (repressor) from Oceanobacillus iheyensis HTE831
    28% identity, 99% coverage of query (156 bits)

NagC / VIMSS3566654 NagC regulator of N-acetylglucosamine utilization, effector N-acetylglucosamine-6-phosphate (repressor) from Aeromonas salmonicida subsp. salmonicida A449
    27% identity, 89% coverage of query (154 bits)

NagC / VIMSS339340 NagC regulator of N-acetylglucosamine utilization, effector N-acetylglucosamine-6-phosphate (activator/repressor) from Vibrio parahaemolyticus RIMD 2210633
    24% identity, 97% coverage of query (152 bits)

XylR / VIMSS3426742 XylR regulator of Xylose utilization, effector Xylose (repressor) from Bacillus pumilus SAFR-032
    25% identity, 91% coverage of query (152 bits)

1z05A / Q9KQJ1 Crystal structure of the rok family transcriptional regulator, homolog of e.Coli mlc protein.
    25% identity, 97% coverage of query (150 bits)

XylR / VIMSS65339 XylR regulator of Xylose utilization, effector Xylose (repressor) from Bacillus halodurans C-125
    25% identity, 86% coverage of query (148 bits)

NagC / VIMSS7700176 NagC regulator of N-acetylglucosamine utilization, effector N-acetylglucosamine-6-phosphate (repressor) from Tolumonas auensis DSM 9187
    27% identity, 89% coverage of query (145 bits)

NanR / VIMSS6110394 NanR regulator of Sialic acid utilization; N-acetylglucosamine utilization, effector N-acetylglucosamine; N-acetylneuraminic acid (repressor) from Bacteroides plebeius DSM 17135
    26% identity, 98% coverage of query (142 bits)

NagC / VIMSS2859304 NagC regulator of N-acetylglucosamine utilization, effector N-acetylglucosamine-6-phosphate (repressor) from Psychromonas sp. CNPT3
    24% identity, 98% coverage of query (142 bits)

XylR / P70928_BACLI Transcription factor XylR (repressor) from Bacillus licheniformis Gibson 46 (see paper)
    27% identity, 88% coverage of query (142 bits)

XylR / VIMSS10362834 XylR regulator of Xylose utilization, effector Xylose; Glucose (repressor) from Thermotoga naphthophila RKU-10
    27% identity, 89% coverage of query (140 bits)

NagC / VIMSS548778 NagC regulator of N-acetylglucosamine utilization, effector N-acetylglucosamine-6-phosphate (activator/repressor) from Photorhabdus luminescens TTO1
    25% identity, 93% coverage of query (140 bits)

XylR / VIMSS730014 XylR regulator of Xylose utilization, effector Xylose (repressor) from Bacillus licheniformis DSM 13
    26% identity, 88% coverage of query (140 bits)

NagC / VIMSS1972937 NagC regulator of N-acetylglucosamine utilization, effector N-acetylglucosamine-6-phosphate (repressor) from Psychromonas ingrahamii 37
    22% identity, 93% coverage of query (140 bits)

XylR / Q9WXW5_THEMA Transcription factor XylR (repressor) from Thermotoga maritima MSB8
    28% identity, 89% coverage of query (138 bits)

NagC / VIMSS79758 NagC regulator of N-acetylglucosamine utilization, effector N-acetylglucosamine-6-phosphate (repressor) from Pasteurella multocida subsp. multocida str. Pm70
    24% identity, 98% coverage of query (137 bits)

CelQ / VIMSS2059852 CelQ regulator of Cellobiose utilization, effector Cellobiose-6-phosphate (repressor) from Streptococcus sanguinis SK36
    25% identity, 96% coverage of query (134 bits)

XylR / VIMSS354812 XylR regulator of Xylose utilization, effector Xylose (repressor) from Enterococcus faecalis V583
    23% identity, 99% coverage of query (132 bits)

NagC / VIMSS4630820 NagC regulator of N-acetylglucosamine utilization, effector N-acetylglucosamine-6-phosphate (repressor) from Moritella sp. PE36
    23% identity, 89% coverage of query (131 bits)

XylR / VIMSS3676564 XylR regulator of Xylose utilization, effector Xylose; Glucose (repressor) from Thermotoga lettingae TMO
    26% identity, 91% coverage of query (129 bits)

Mlc / b1594 DNA-binding transcriptional repressor Mlc from Escherichia coli K-12 substr. MG1655 (see 15 papers)
MLC_ECOLI / P50456 DNA-binding transcriptional repressor Mlc; Making large colonies protein; Membrane linked control from Escherichia coli (strain K12) (see 15 papers)
Mlc / P50456 Transcription factor Mlc (repressor) from Escherichia coli K12 MG1655 (see 4 papers)
mlc / RF|NP_416111.1 protein mlc from Escherichia coli K12 (see 7 papers)
    25% identity, 90% coverage of query (129 bits)

NanR / VIMSS3720738 NanR regulator of Sialic acid utilization; N-acetylglucosamine utilization, effector N-acetylglucosamine; N-acetylneuraminic acid (repressor) from Bacteroides vulgatus ATCC 8482
    26% identity, 90% coverage of query (126 bits)

rokA / Q5GBH5 glucokinase / N-acetylglucosamine kinase / mannokinase (EC 2.7.1.7; EC 2.7.1.1; EC 2.7.1.59) from Bacteroides fragilis (see 2 papers)
    30% identity, 80% coverage of query (125 bits)

NagC / VIMSS2773935 NagC regulator of N-acetylglucosamine utilization, effector N-acetylglucosamine-6-phosphate (repressor) from Reinekea sp. MED297
    24% identity, 96% coverage of query (122 bits)

1z6rA / P50456 Crystal structure of mlc from escherichia coli (see paper)
    25% identity, 87% coverage of query (120 bits)

XylR / VIMSS85562 XylR regulator of Xylose utilization, effector Xylose (repressor) from Mesorhizobium loti MAFF303099
    28% identity, 88% coverage of query (120 bits)

glkA / CAA62003.1 glucokinase from Renibacterium salmoninarum (see 2 papers)
    30% identity, 70% coverage of query (120 bits)

NanR / VIMSS6257414 NanR regulator of Sialic acid utilization; N-acetylglucosamine utilization, effector N-acetylglucosamine; N-acetylneuraminic acid (repressor) from Bacteroides eggerthii DSM 20697
    25% identity, 90% coverage of query (119 bits)

GLK_STRCO / P0A4E1 Glucokinase; Glucose kinase; ORF 3; EC 2.7.1.2 from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) (see paper)
P0A4E1 glucokinase (EC 2.7.1.2) from Streptomyces coelicolor (see paper)
glkA glucokinase; EC 2.7.1.2 from Streptomyces coelicolor (see 2 papers)
    29% identity, 70% coverage of query (116 bits)

XylR / VIMSS1781991 XylR regulator of Xylose utilization, effector Xylose (repressor) from Mesorhizobium sp. BNC1
    27% identity, 88% coverage of query (113 bits)

YphH / b2550 putative DNA-binding transcriptional regulator, NAGC-like from Escherichia coli K-12 substr. MG1655 (see paper)
    25% identity, 89% coverage of query (105 bits)

3vgkB / B1VZT1 Crystal structure of a rok family glucokinase from streptomyces griseus (see paper)
    27% identity, 77% coverage of query (102 bits)

B1VZT1 glucokinase (EC 2.7.1.2) from Streptomyces griseus (see 2 papers)
    27% identity, 77% coverage of query (102 bits)

3vglA Crystal structure of a rok family glucokinase from streptomyces griseus in complex with glucose and amppnp
    27% identity, 77% coverage of query (102 bits)

CelQ / VIMSS115991 CelQ regulator of Cellobiose utilization, effector Cellobiose-6-phosphate (repressor) from Streptococcus pneumoniae TIGR4
    24% identity, 96% coverage of query (98.6 bits)

ManR / VIMSS5475666 ManR regulator of Mannan and beta-mannosides utilization, effector Mannose (repressor) from Thermotoga neapolitana DSM 4359
    25% identity, 90% coverage of query (98.6 bits)

IolR / VIMSS5474541 IolR regulator of Inositol utilization (repressor) from Thermotoga neapolitana DSM 4359
    28% identity, 87% coverage of query (96.3 bits)

GluR / VIMSS7271596 GluR regulator of Glucose utilization; Trehalose utilization, effector Glucose (repressor) from Thermotoga sp. RQ2
    25% identity, 87% coverage of query (94.7 bits)

XylR / VIMSS317479 XylR regulator of Xylose utilization, effector Xylose (repressor) from Bradyrhizobium japonicum USDA 110
    25% identity, 87% coverage of query (92.4 bits)

ManR / Q9X0V1_THEMA Transcription factor ManR (repressor) from Thermotoga maritima MSB8
    25% identity, 88% coverage of query (90.9 bits)

TreR / VIMSS7511727 TreR regulator of Trehalose utilization, effector Trehalose (repressor) from Thermotogales bacterium TBF 19.5.1
    25% identity, 96% coverage of query (90.9 bits)

XylR / VIMSS2205864 XylR regulator of Xylose utilization, effector Xylose (repressor) from Rhizobium leguminosarum bv. viciae 3841
    25% identity, 88% coverage of query (90.9 bits)

BglR / VIMSS927 BglR regulator of Beta-glucosides utilization, effector Cellobiose (repressor) from Thermotoga maritima MSB8
    24% identity, 90% coverage of query (89.4 bits)

XylR / VIMSS132512 XylR regulator of Xylose utilization, effector Xylose (repressor) from Sinorhizobium meliloti 1021
    24% identity, 88% coverage of query (85.1 bits)

BglR / VIMSS3677266 BglR regulator of Beta-glucosides utilization, effector Cellobiose (repressor) from Thermotoga lettingae TMO
    24% identity, 85% coverage of query (85.1 bits)

XylR / VIMSS5502867 XylR regulator of Xylose utilization, effector Xylose (repressor) from Lactobacillus fermentum IFO 3956
    23% identity, 83% coverage of query (82.8 bits)

Y485_MYCTU / P9WKV1 Transcriptional regulator Rv0485 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
    26% identity, 82% coverage of query (78.6 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory