Sites on a Tree

 

Searching for up to 100 curated homologs for WP_008632109.1 NCBI__GCF_000330725.2:WP_008632109.1 (353 a.a.)

Found high-coverage hits (≥70%) to 24 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

hmuU / CAC34394.1 HmuU protein from Rhizobium leguminosarum (see paper)
    47% identity, 89% coverage of query (282 bits)

TC 3.A.1.14.5 / Q56992 HmuU aka YPO0280 aka Y0540, component of Heme (hemin) uptake porter. The receptor, HmuT, binds two parallel stacked heme molecules, and two are transported per reaction cycle from Yersinia pestis (see 4 papers)
    47% identity, 81% coverage of query (262 bits)

TC 3.A.1.14.16 / A8GDS7 HemU, component of The heme-specific uptake porter, HemTUV from Serratia proteamaculans (strain 568)
    45% identity, 82% coverage of query (237 bits)

TC 3.A.1.14.20 / Q7W024 Putative hemin permease, component of Heme-iron (hemin) utilization transporter BhuTUV from Bordetella pertussis (see paper)
    44% identity, 92% coverage of query (236 bits)

TC 3.A.1.14.18 / Q32AY2 Putative permease of iron compound ABC transport system, component of The heme uptake porter, ShuTUV (Burkhard and Wilks, 2008). Transports a single heme per reaction cycle (Mattle et al., 2010). (3-d structure of ShuT is known (2RG7) from Shigella dysenteriae serotype 1 (strain Sd197) (see paper)
    43% identity, 83% coverage of query (233 bits)

TC 3.A.1.14.21 / O68878 ABC-type permease, component of The heme uptake porter, PhuTUV (transports one heme per reaction cycle) from Pseudomonas aeruginosa (see paper)
    49% identity, 91% coverage of query (232 bits)

TC 3.A.1.14.19 / Q93SS2 HugC, component of Heme uptake porter, HugBCD (Villarreal et al., 2008); also called HmuTUV from Plesiomonas shigelloides (see paper)
    45% identity, 90% coverage of query (221 bits)

5b57A / B4EKB4 Inward-facing conformation of abc heme importer bhuuv from burkholderia cenocepacia (see paper)
    47% identity, 97% coverage of query (220 bits)

A0A0H3AMA6 ABC-type vitamin B12 transporter (subunit 3/3) (EC 7.6.2.8) from Vibrio cholerae serotype O1 (see paper)
    40% identity, 82% coverage of query (187 bits)

BtuC / b1711 vitamin B12 ABC transporter membrane subunit (EC 7.6.2.8) from Escherichia coli K-12 substr. MG1655 (see 7 papers)
BtuC / P06609 vitamin B12 ABC transporter membrane subunit (EC 7.6.2.8) from Escherichia coli (strain K12) (see 3 papers)
BTUC_ECOLI / P06609 Vitamin B12 import system permease protein BtuC from Escherichia coli (strain K12) (see paper)
P06609 ABC-type vitamin B12 transporter (EC 7.6.2.8) from Escherichia coli (see 3 papers)
TC 3.A.1.13.1 / P06609 BtuC aka B1711, component of Vitamin B12 porter. The 3-D structure of BtuCDF has been solved to 2.6 Å from Escherichia coli (see 8 papers)
    40% identity, 82% coverage of query (182 bits)

fhuG / GI|2832797 ferrichrome transport system permease protein FhuG from Bacillus subtilis (see paper)
    35% identity, 96% coverage of query (177 bits)

FEUC_BACSU / P40411 Iron-uptake system permease protein FeuC from Bacillus subtilis (strain 168) (see 2 papers)
TC 3.A.1.14.15 / P40411 Iron-uptake system permease protein feuC, component of Uptake transporter for the catecholic trilactone (2, 3-dihydroxybenzoate-glycine-threonine)3 siderophore bacillibactin (for ferric iron scavenging), FeuABC from Bacillus subtilis (see 5 papers)
    34% identity, 92% coverage of query (174 bits)

MOLB_HAEIN / Q57130 Molybdate import system permease protein MolB from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (see 7 papers)
TC 3.A.1.14.11 / Q57130 Probable ABC transporter permease protein HI_1471, component of The molybdate/tungstate ABC transporter, MolABC from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    35% identity, 95% coverage of query (174 bits)

FecD / b4288 ferric citrate ABC transporter membrane subunit FecD (EC 7.2.2.18) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
FecD / P15029 ferric citrate ABC transporter membrane subunit FecD (EC 7.2.2.18) from Escherichia coli (strain K12) (see paper)
FECD_ECOLI / P15029 Fe(3+) dicitrate transport system permease protein FecD; Iron(III) dicitrate transport system permease protein FecD from Escherichia coli (strain K12) (see 4 papers)
TC 3.A.1.14.1 / P15029 FecD aka B4288, component of Iron (Fe3+) or ferric-dicitrate porter from Escherichia coli (see 5 papers)
fecD / GB|AAC77244.1 iron(III) dicitrate transport system permease protein FecD from Escherichia coli K12 (see 6 papers)
    37% identity, 91% coverage of query (169 bits)

BTUCA_HALSA / Q9HQ19 Cobalamin import system permease protein BtuC from Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium) (see paper)
TC 3.A.1.14.9 / Q9HQ19 Iron (III) ABC transporter permease, component of The Corrinoid porter, BtuCDE from Halobacterium salinarium (Halobacterium halobium) (see paper)
    43% identity, 80% coverage of query (167 bits)

YFHA_BACSU / O31569 Probable siderophore transport system permease protein YfhA from Bacillus subtilis (strain 168) (see 2 papers)
    35% identity, 80% coverage of query (162 bits)

Shewana3_3279 Vitamin B12 transporter, permease component (fecCD-like) from Shewanella sp. ANA-3
    34% identity, 99% coverage of query (161 bits)

TC 3.A.1.14.8 / Q8GRB1 PvuD, component of The iron-vibrioferrin uptake porter from Vibrio parahaemolyticus (see paper)
    35% identity, 96% coverage of query (161 bits)

FPUB_BACAN / Q81L64 Petrobactin import system permease protein FpuB from Bacillus anthracis (see paper)
    35% identity, 87% coverage of query (160 bits)

feuC / GI|1256154 iron-uptake system permease protein FeuC from Bacillus subtilis (see 5 papers)
    33% identity, 86% coverage of query (152 bits)

FHUB_BACSU / P49936 Iron(3+)-hydroxamate import system permease protein FhuB; Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein FhuB; Iron(III)-hydroxamate import system permease protein FhuB from Bacillus subtilis (strain 168) (see paper)
fhuB / GI|2832796 ferrichrome transport system permease protein FhuB from Bacillus subtilis (see paper)
    35% identity, 98% coverage of query (148 bits)

YFIZ_BACSU / O31568 Probable siderophore transport system permease protein YfiZ from Bacillus subtilis (strain 168) (see 2 papers)
    34% identity, 85% coverage of query (141 bits)

FecC / b4289 ferric citrate ABC transporter membrane subunit FecC (EC 7.2.2.18) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
FecC / P15030 ferric citrate ABC transporter membrane subunit FecC (EC 7.2.2.18) from Escherichia coli (strain K12) (see paper)
FECC_ECOLI / P15030 Fe(3+) dicitrate transport system permease protein FecC; Iron(III) dicitrate transport system permease protein FecC from Escherichia coli (strain K12) (see 4 papers)
TC 3.A.1.14.1 / P15030 FecC aka B4289, component of Iron (Fe3+) or ferric-dicitrate porter from Escherichia coli (see 5 papers)
    34% identity, 79% coverage of query (137 bits)

Build an alignment

Build an alignment for WP_008632109.1 and 23 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

FhuB / b0153 iron(III) hydroxamate ABC transporter membrane subunit (EC 7.2.2.16) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
FhuB / P06972 iron(III) hydroxamate ABC transporter membrane subunit (EC 7.2.2.16) from Escherichia coli (strain K12) (see 2 papers)
FHUB_ECOLI / P06972 Iron(3+)-hydroxamate import system permease protein FhuB; Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein FhuB; Ferrichrome uptake protein FhuB; Iron(III)-hydroxamate import system permease protein FhuB from Escherichia coli (strain K12) (see 7 papers)
TC 3.A.1.14.3 / P06972 FhuB aka B0153, component of Iron (Fe3+)-hydroxamate (ferrichrome, coprogen, aerobactin, ferrioxamine B, schizakinen, rhodotorulic acid) porter, albomycin porter from Escherichia coli (see 7 papers)
    28% identity, 80% coverage of query (79.0 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory